12 results about "Rose bengal" patented technology

The present invention belongs to the field of medicinal chemistry and specifically discloses a light-responsive ion pair composition and its anti-cancer application. The ion pair composition includes a cyclometallic gold (III) complex and a photosensitizer, wherein the photosensitizer includes eosin (EY) or rose bengal (RB), and the structural formula of the cyclometallic gold (III) complex is shown in formula (1). The composition modifies the structure of the known cyclometallic gold (III) complex skeleton by adding hydroxyl groups, morpholine rings and deuteration, thereby improving its water solubility, charge properties, stability and other aspects. It can be efficiently activated by green light or even red light and has anti-cancer applications. The present invention achieves efficient activation of the cyclometallic gold (III) complex by combining the cyclometallic gold (III) complex with eosin (EY) or rose bengal (RB), and can extend the excitation wavelength to the red light range; and based on the ion pair properties and the characteristics of the tumor microenvironment, tumor-specific treatment can be achieved more accurately on the basis of light irradiation.

The present invention relates to a method for treating Gram-negative bacteria that are resistant to colistin (MIC > 50 mg / mL), an antibacterial compound, excluding those of the genera Burkholderia, Proteus, and Serratia, comprising contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of formula I, dissolved or dispersed at a concentration of about 0.01 to about 15 mg / mL, and irradiating the contacted bacteria with light of a wavelength of about 500 nm to about 600 nm for a period of about 1 to about 10 minutes, at a concentration of about 16 to about 160 J / cm². 2 The aim is to create a method that involves obtaining a certain amount of light to treat and kill irradiated bacteria. [Formula 1] JPEG2026511692000028.jpg5864 (where X, R 1 , R 2 (and M+ are defined herein)

The present application belongs to the environmental governance technical field, and particularly relates to a method for removing Microcystis aeruginosa by using rose Bengal. Rose Bengal is added in an environment containing Microcystis aeruginosa; the final concentration of rose Bengal is 5 mg / L-10 mg / L, and Microcystis aeruginosa is removed under visible light. After adding rose Bengal, the highest algae density can remove 85.37% of Microcystis aeruginosa; at 168 h, the effect of stably inhibiting Microcystis aeruginosa is still maintained. The present application discloses a mild drug control mode by using the characteristics of high singlet oxygen yield of RB to target damage the photosynthetic system and core metabolic pathway of Microcystis aeruginosa, and discloses a three-damage mechanism of physiological and biochemical, photosynthetic system and metabolic network of RB photodynamic algae inhibition.

The invention belongs to the technical field of preparation of organic-inorganic hybrid nano materials, and particularly relates to a rare earth composite nano material as well as a preparation method and application thereof. Two photosensitizers, namely chlorin e6 and rose bengal, are simultaneously modified on the surface of the Na-based rare earth nano-particles through ligand exchange, so that an efficient photodynamic treatment effect is realized. The Na-based rare earth nanoparticles with the core-shell-shell structure are synthesized, and the Na-based rare earth nanoparticles with the core-shell-shell structure have relatively strong red and green light emission under the excitation of 1550 nm laser. The light scattering of the 1550nm laser in the biological tissue is extremely small, so that the penetration depth and the focusing capability of the laser can be improved, and the photodynamic treatment of the deep tissue is expected to be realized. Photosensitizers, namely chlorin e6 and rose bengal, are directly modified on the surfaces of the nanoparticles through ligand exchange reaction, and compared with a method of coating with an amphiphilic surfactant or loading with silicon dioxide, the energy transfer efficiency between rare earth ions and the photosensitizers can be remarkably improved, and the photodynamic effect is improved.

The invention discloses a construction method and application of a zebra fish tail fin ischemia injury model with both inflammatory response and regeneration capacities, rose bengal is injected into the abdominal cavity of a zebra fish, then the zebra fish tail fin ischemia injury model is constructed by performing local fluorescence irradiation on the tail fin of the zebra fish and performing photochemical induced injury, the operation is simple and convenient, and the construction method is suitable for large-scale popularization and application of the zebra fish tail fin ischemia injury model. And the death rate of the zebrafish in one day after modeling of the zebrafish is very low (only 5.3%), and the method has good repeatability and operability. The photochemically induced caudal fin injury model has pathological characteristics closer to clinical tissue injury, can simulate inflammation and regeneration processes at the same time, and has dual application potentials of drug screening and mechanism research.

The invention provides a photodynamic sterilization material driven by a mechanoluminescent material, a sterilization method and a sterilization toothbrush assembly. The photodynamic bactericidal material based on mechanoluminescent material driving comprises a mechanoluminescent material and a photosensitizer, a mechanoluminescent material is used as an excitation source, rose-bengal is used as an efficient photosensitizer to generate active oxygen, and the active oxygen is used for sterilization, so that efficient photodynamic sterilization is realized; the method does not depend on an external light source, has the advantages of simplicity and convenience in operation, environment friendliness and the like, and can realize efficient and stable sterilization effect in a dynamic environment; according to the photodynamic sterilization method disclosed by the invention, the sterilization efficiency is remarkably improved, the chemical residue risk is effectively reduced, a brand new application path is opened up for the development of a real-time photodynamic sterilization technology, and wide market application prospects and industrialization potential are shown.

The present invention contemplates a method of treating a mammalian skin wound that extends at least into the epidermal layer of the skin of a subject mammal that comprises treating the wound in the substantial absence of actinic light by topical application of an aqueous pharmaceutical composition containing a wound closure-assisting amount of rose bengal, a lactone, salt, ester or amide hereof dissolved or dispersed therein as well as gel-inducing amount of a thickening agent (gellant) that causes the aqueous pharmaceutical composition to gel at a temperature of about 33° to about 40° C. The treated wound is thereafter covered with a dressing that is opaque to actinic light at least in the area over the wound. This treatment method is repeated a plurality of times over the following up to about fifteen days or until the wound is closed, whichever time of time is shorter.

The application discloses an RB@PDA hydrogel precursor for treating skin infection, a preparation method and application, and belongs to the technical field of biomedical materials. The RB@PDA hydrogel precursor comprises a sodium alginate aqueous solution and RB@PDA nanoparticles dispersed in the sodium alginate aqueous solution, wherein the RB@PDA nanoparticles are prepared through a hydrothermal synthesis reaction of a dopamine precursor and rose Bengal under alkaline conditions. 2+ The material can realize photothermal therapy and photodynamic therapy under 808 nm near-infrared laser irradiation, effectively destroy the structure of bacteria and biofilms, and has excellent antibacterial performance. The hydrogel has good biocompatibility and can significantly accelerate the healing process of bacterial infection wounds.

This invention contemplates combined use of a rose bengal (RB ) derivative with irradiation of bacteria with light to treat and kill the irradiated bacteria. In one aspect, Gram-positive bacteria are treated in a method in which the bacteria are contacted with an aqueous pharmaceutical composition containing a rose bengal (RB ) compound of Formula I, discussed within, dissolved or dispersed therein at about 0. 2 to about 3. 1 μg / mL. Those contacted bacteria are contacted with light of the wavelength about 500 nm to about 600 nm for a time period of about 1 to about 10 minutes to provide a light dose of about 0. 7 to about 7. 2 J / cm2 . A similar method is contemplated for treating Gram-negative bacteria that are one or more of Burkholderia, Salmonella, and Proteus using an aqueous pharmaceutical composition containing about 2 to about 15 μM concentration of the RB compound.

The present invention contemplates a method of treating a mammalian skin wound that extends at least into the epidermal layer of the skin of a subj ect mammal that comprises treating the wound in the substantial absence of actinic light by topical application of an aqueous pharmaceutical composition containing a wound closure-assisting amount of rose bengal, a lactone, salt, ester or amide hereof dissolved or dispersed therein as well as gel-inducing amount of a thickening agent (gellant ) that causes the aqueous pharmaceutical composition to gel at a temperature of about 33° to about 40° C. The treated wound is thereafter covered with a dressing that is opaque to actinic light at least in the area over the wound. This treatment method is repeated a plurality of times over the following up to about fifteen days or until the wound is closed, whichever time of time is shorter.

The present invention relates to a gadolinium-based compound of a Chemical Formula 1, a method for producing the same, and an MRI contrast agent containing the same. [Chemical Formula 1] [structural formula] In chemical formula 1, A and Linker represent linking groups, and RB represents a Rose Bengal-derived part.

The application discloses a Coptis alkaloid iridium photosensitizer, a preparation method and application thereof, and belongs to the technical field of antitumor drugs, and provides a Coptis alkaloid iridium photosensitizer with high phototoxicity, a preparation method thereof, and application of the Coptis alkaloid iridium photosensitizer in photodynamic therapy of tumors. The iridium photosensitizer prepared by the application has super-high singlet oxygen generation capacity, is higher than a reference substance Rose Bengal B (RB), and shows high phototoxicity (half inhibitory concentration IC 50 = 1.65 micromoles, and an in-vivo phototumor inhibition rate is 58.21%), can achieve excellent photodynamic therapy effect at an extremely low concentration, and has low toxicity to normal liver cancer cells.