4 results about "Rose bengal" patented technology

The present invention relates to a method for treating Gram-negative bacteria that are resistant to colistin (MIC > 50 mg / mL), an antibacterial compound, excluding those of the genera Burkholderia, Proteus, and Serratia, comprising contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of formula I, dissolved or dispersed at a concentration of about 0.01 to about 15 mg / mL, and irradiating the contacted bacteria with light of a wavelength of about 500 nm to about 600 nm for a period of about 1 to about 10 minutes, at a concentration of about 16 to about 160 J / cm². 2 The aim is to create a method that involves obtaining a certain amount of light to treat and kill irradiated bacteria. [Formula 1] JPEG2026511692000028.jpg5864 (where X, R 1 , R 2 (and M+ are defined herein)

The present application belongs to the environmental governance technical field, and particularly relates to a method for removing Microcystis aeruginosa by using rose Bengal. Rose Bengal is added in an environment containing Microcystis aeruginosa; the final concentration of rose Bengal is 5 mg / L-10 mg / L, and Microcystis aeruginosa is removed under visible light. After adding rose Bengal, the highest algae density can remove 85.37% of Microcystis aeruginosa; at 168 h, the effect of stably inhibiting Microcystis aeruginosa is still maintained. The present application discloses a mild drug control mode by using the characteristics of high singlet oxygen yield of RB to target damage the photosynthetic system and core metabolic pathway of Microcystis aeruginosa, and discloses a three-damage mechanism of physiological and biochemical, photosynthetic system and metabolic network of RB photodynamic algae inhibition.

The invention discloses a construction method and application of a zebra fish tail fin ischemia injury model with both inflammatory response and regeneration capacities, rose bengal is injected into the abdominal cavity of a zebra fish, then the zebra fish tail fin ischemia injury model is constructed by performing local fluorescence irradiation on the tail fin of the zebra fish and performing photochemical induced injury, the operation is simple and convenient, and the construction method is suitable for large-scale popularization and application of the zebra fish tail fin ischemia injury model. And the death rate of the zebrafish in one day after modeling of the zebrafish is very low (only 5.3%), and the method has good repeatability and operability. The photochemically induced caudal fin injury model has pathological characteristics closer to clinical tissue injury, can simulate inflammation and regeneration processes at the same time, and has dual application potentials of drug screening and mechanism research.

The application discloses an RB@PDA hydrogel precursor for treating skin infection, a preparation method and application, and belongs to the technical field of biomedical materials. The RB@PDA hydrogel precursor comprises a sodium alginate aqueous solution and RB@PDA nanoparticles dispersed in the sodium alginate aqueous solution, wherein the RB@PDA nanoparticles are prepared through a hydrothermal synthesis reaction of a dopamine precursor and rose Bengal under alkaline conditions. 2+ The material can realize photothermal therapy and photodynamic therapy under 808 nm near-infrared laser irradiation, effectively destroy the structure of bacteria and biofilms, and has excellent antibacterial performance. The hydrogel has good biocompatibility and can significantly accelerate the healing process of bacterial infection wounds.