92 results about "Rose bengal" patented technology

The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided.

The invention discloses a method for preparing a 2-iodine amyl -2-ene-1,4-diketone derivative by adopting visible light catalysis. The method comprises the steps of adding allene, perfluorobutyl iodide, an additive and a photocatalyst as shown in a formula (I) to an organic solvent at the molar ratio of 1:(1-2):(1-2):(0.005-0.1), stirring under the conditions of an oxygen atmosphere, visible light illumination, room temperature and ordinary pressure for 10-20h, carrying out post-treatment on a reaction liquid to obtain a 2-iodine amyl -2-ene-1,4-diketone derivative as shown in a formula (II), wherein the additive is NaI, NH4I or KI; the organic solvent is ethanol, dichloromethane, benzene, methylbenzene, tetrahydrofuran or acetonitrile; the photocatalyst is selected from one of the following components: Ir(ppy)3, Eosin Y, Rose Bengal, [Ir(dF-CF3-ppy)2(dtbbpy)]PF6, [Ir(ppy)2(tbbpy)]PF6, Ru(bpy)3(BF4)2. The method is mild in reaction condition, simple in operation, high in selectivity and good in yield; a substituent group can be expanded; and visible light catalysis is adopted, so that the method has the characteristics of being free of pollution and environment-friendly. The formulas are as shown in the specification.

The invention relates to a preparation method of a cerium dioxide nanorod doped titanium dioxide nanoparticle photocatalyst. According to the preparation method, cerous chloride heptahydrate, sodium hydroxide, deionized water, titanium trichloride and ethyl alcohol are utilized as raw materials, and the cerium dioxide nanorod doped titanium dioxide nanoparticle photocatalyst can be prepared by a hydrothermal method. The cerium dioxide nanorod doped titanium dioxide nanoparticle photocatalyst has simpleness in preparation, low cost, good catalyzing and adsorbing performance and can completely catalyze and degrade organic pollutants under normal temperature, normal pressure and sunlight irradiation; degradation products have no pollution; furthermore, the catalyst can adsorb inorganic pollutant, for example, heavy metal ions. The invention further discloses research on photocatalytic performance and adsorptive property of the prepared photocatalyst. According to experiments, rose bengal and lead nitrate are respectively utilized as photocatalyst to adsorb experimental pollutants, and the research shows that the catalyst has good performance.

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

The invention discloses an aqueous semitransparent pigment type colorant used for carpentry paint and a preparation method thereof. The aqueous semitransparent pigment type colorant contains the following materials by weight percent: 20-40% of aqueous linseed oil, 20-40% of anba powder or transparent ferric oxide pigment and organic pigment, i.e. permanent yellow, rose Bengal and black pigment, 2-5% of aerosil, 1-3% of aqueous dispersant, 10-20% of propanediol and 10-20% of water. The preparation method of the aqueous semitransparent pigment type colorant comprises the following steps: (1) adding the aqueous linseed oil into a container; (2) then, adding the propanediol and the water into the container; (3) then, adding the aqueous dispersant into the container, and uniformly stirring and mixing the materials; (4) finally, adding the aerosil, the anba powder or the transparent ferric oxide pigment into the container; (5) uniformly stirring the materials, and then grinding the materials into 15 UM to be qualified by a grinder so as to be used. The invention can be used for the wiping and coating process of pseudo-classic furniture or American furniture.

The invention discloses a double-functional nano-composite spheres based on metal ion-inducing polypeptide self-assembly and a preparation method thereof. In the invention, by means of a one-step reaction synthesis method, with [alpha]-lactalbumin hydrolyzed polypeptide as a carrier, the nano spheres are self-assembled under induction by Ca<2+> and Gd<3+> together, wherein the nano spheres, during self-assembly, are wrapped by a photosensitive agent, rose Bengal. The particle size of the nano-composite spheres can be adjusted and controlled in the range of 100-500 nm. The Gd<3+> which participates in the inductive sphere forming is used as a contrast medium unit of magnetic resonance imaging and the T1-weighted nuclear magnetic resonance signal response can be effectively increased so that the magnetic resonance imaging diagnosis to a tumor site can be performed. The rose Bengal wrapping the nano-composite spheres can release singlet oxygen to kill tumor cells under excitation illumination at 550 nm, thereby achieving the effect of photodynamic treatment. The nano-composite spheres are toxic-free without illumination. Meanwhile, the treatment process allows tracing through the magnetic resonance imaging. In addition, the nano-composite spheres are low in preparation cost, are simple in processes, and have a potential wide application prospect in the bio-medicinal field.

The invention discloses a method for making health-care red wine. It comprises rinsing 10-20 parts of fresh high-quality rose red grapes, drying the water, crushing them and putting them into wine jars, adding 3-5 parts of rock sugar and 5 -10 portions of wolfberry, then seal the wine jar, store it in a cool place, let it ferment naturally for 20-40 days, and unseal it; wash the onion, remove the brown skin on the surface, cut it into filaments, put it in the wine jar, put Seal the wine jar again, place it in a cool place for 2-8 days, filter to remove the dregs, take the filtrate into a wine bottle, and refrigerate. This product has the effect of softening blood vessels and ruddy complexion. Drink a small amount with meals, especially for dinner.

The invention discloses an application of a photochemically-induced cerebral arterial thrombosis model for zebra fish. The cerebrum tissue is taken as an identification index of cerebral arterial thrombosis model for zebra fish. The principle of forming photochemically-induced thrombus is adopted. A rose-bengal solution is injected to abdominal cavities of zebra fish. Therefore, complete local infarction in cortex areas of zebra fish is caused by illumination within short time. Accordingly, an in vivo animal model is established. In the model, blood coagulation is caused by damaging vascular endothelial cells due to singlet oxygen released by the rose-bengal solution under light irradiation. The pathological process of cerebral arterial thrombosis is effectively simulated. According to anexperiment result of an observational index, the cerebrum area tissue of zebra fish has evident loose and infarct phenomena. Swimming behaviors of dysneuria such as whirling and standing upright occurto zebra fish. The method is simple and high in success rate and convenient to promote. Damage sensitivity of cerebrum tissue is high and repeatability is good. The photochemically-induced cerebral arterial thrombosis model for zebra fish can act as a practical tool index for screening medicine, for blood vessel protection after cerebral infarction and thrombolytic therapy.

A 3,3'-diindolyl acetate compound and a derivative thereof are discovered to have extensive activities of immunity resistance, inflammation resistance, edema inhibition and the like. Meanwhile, The 3,3'-diindolyl acetate compound is also an important intermediate raw material which belongs to the field of organic preparation. The compound can be used for synthesizing multiple bioactive molecules with 3,3'-bis-indolymethane structure, and has quite high organic synthesis application value. The invention provides a quite simple preparation method of a visible light catalyzed 3,3'-diindolyl acetate compound. The preparation method comprises the following specific steps: taking a glycine derivative and an indole derivative as raw materials, taking an organic photosensitizer (eosin Y, rose-bengal or rhodamine 6G) as a photocatalyst, reacting for 10-30 h at the room temperature under illumination of visible light, and separating and purifying to obtain a product. Compared with the prior art,the preparation method has the advantages of simple steps, high yield, cheap and easily obtained raw materials and catalysts, zero metal, mild reaction condition, simplicity in reaction operation andthe like, and is more suitable for pilot scale-up and large-scale preparation of the 3,3'-diindolyl acetate compound.

The invention discloses a biomass absorbing agent for treating rose-bengal dye wastewater as well as a preparation method and an application of the biomass absorbing agent. The biomass absorbing agent with the appropriate grain size is prepared by steps as follows: washing camphor tree leaves, drying, smashing and sieving. According to the invention, camphor tree leaf biomass adopted as the absorbing agent for rose-bengal dye wastewater is simple in preparation technology and low in cost, still has better absorbing capacity in a wider pH range, has a better rose-bengal dye removal effect under the coexistence condition of different metal positive ions and negative ions, and has wide application prospect.

The invention discloses a photo-sensitive medicine sensitive to weak light and a preparation method of the photo-sensitive medicine. The photo-sensitive medicine sensitive to weak light is formed by amide condensation reaction of oxygen-carrying protein and a water-soluble sensitizer, wherein the oxygen-carrying protein is hemoglobin or myoglobin; and the water-soluble sensitizer is rose-bengal, photofrin, methylene blueor chlorophyll. The preparation method of the photo-sensitive medicine comprises the following steps of (1) preparing a solution of the photo-sensitive medicine and a solution of the oxygen-carrying protein; (2) sequentially adding a coupling activator and a stabilizer to the solution of the photo-sensitive medicine; and (3) adding the solution of the oxygen-carrying protein to the system in the step (2) and carrying out light-proof stirring reaction to obtain the photo-sensitive medicine. The photo-sensitive medicine has a certain oxygen-carrying function and can be activated under the weak light irradiation condition. Compared with a traditional photo-sensitive medicine, the photo-sensitive medicine disclosed by the invention has the advantages that the speed of generating singlet oxygen is faster after activation, the yield is higher, and the photo-sensitive medicine is expected to be used for photodynamics therapy of internal tissue tumors.

The invention discloses an antitumor drug based on a PGA-RB (Polyglutamic Acid-Rose Bengal) bound compound and a preparation method and application of the antitumor drug. The structural formula of the antitumor drug is shown as Formula I, wherein the bonding rate of RB is 5-30 percent. According to the invention, RB is modified to obtain an RB derivative, the RB derivative is bound with PGA to obtain the antitumor drug, the antitumor drug can be self-assembled in a water solution into nanometer particles of 100-200 nm, and the nanometer particles have the advantages of high stability, good biocompatibility, long in-vivo circulation time, obviously enhanced toxicity to cancer cells under light, and the like; and the preparation method has simple steps and is convenient to operate.

The invention relates to the technical field of alloys and in particular relates to rose-bengal 18 K gold. The rose-bengal 18 K gold comprises the following ingredients in percentage by weight: 15.5-20.8 percent of copper, 1.5-2.8 percent of sliver, 0.11-0.25 percent of cerium, 0.13-0.21 percent of titanium, 0.04-0.16 percent of cobalt, 0.1-0.17 percent of indium, 0.1-0.5 percent of neodymium and the balance of gold and inevitable impurities. The invention further provides a synthetic method of the rose-bengal 18 K gold alloy. The rose-bengal 18 K gold alloy is good in high temperature tolerance and long in service life and resists high temperature, oxidation and creep deformation. The manufactured gold jewelry is low in price, high in hardness and lasting in color and luster and can be worn for a long term.

The present invention relates to compositions having a light activated antimicrobial material connected to an environmental surface, such as fabric, through a linking moiety and a mediator polymer. Also taught herein are surfaces to which the compositions of this invention are attached to impart antimicrobial activity to those surfaces. The present invention facilitates or makes possible the attachment of certain light activated antimicrobial material such as Rose Bengal dye to a surface to achieve antimicrobial activity.

The invention discloses a silver phosphate composite photocatalyst for treating rose bengal B in high-salt wastewater and a preparation method and application of the photocatalyst. The silver phosphate composite photocatalyst is prepared from a silver phosphate/polyaniline composite material, the silver phosphate/polyaniline composite material is loaded with chromium-doped strontium titanate, andpolyaniline silver phosphate is a carrier of the silver phosphate/polyaniline composite material and is loaded with silver phosphate. The preparation method of the photocatalyst comprises the step that a silver phosphate/polyaniline composite material solution is prepared and compounded with a chromium-doped strontium titanate solution to prepare the photocatalyst. The silver phosphate composite photocatalyst has the advantages of low cost, good photocatalytic performance, good stability, environmental protection and the like; the preparation method of the photocatalyst has the advantages thatthe process is simple, the raw materials are easy to obtain, the operation is easy, the preparation conditions are controllable, and the preparation method is environmentally friendly and free of pollution; the photocatalyst can effectively degrade and remove pollutants in the wastewater, especially has a good removal effect on the rose bengal B in the high-salt wastewater, and has high use valueand good application prospects.

The invention relates to a method for determining the cobalt content in a tungsten matrix while separately adding cobalt or simultaneously adding other additives. The method is characterized in that a sample is slightly heated by mixture of nitric acid and hydrochloric acid to be decomposed rapidly until cobalt is completely decomposed into cobalt ions and the matrix tungsten and other additives almost retain the original states and exist in the precipitated form, only a small number of matrix tungsten and other additives are decomposed and the determination cannot be affected, the decomposed sample is filtered in a constant volume way to prepare cobalt solution, an appropriate amount of citric acid is added for complexing in order to completely eliminate the interference of a small amount of the decomposed matrix tungsten, an appropriate amount of solution is taken separately, a color is developed by the cobalt ions and an appropriate quantity of EDTA (ethylene diamine tetraacetic acid) and hydrogen peroxide under the acidity of pH being 1-3 to form a stable rose-bengal ternary complex, the color depth is proportional to the amount of cobalt, and the cobalt content is determined according to colorimetric results. The method can be implemented simply, rapidly and accurately, the detection accuracy is high, analysis errors, inadequacy in results and poor reproducibility can be avoided, and the influence of the experience of operators on the accuracy of results can be eliminated completely.

The invention discloses a preparation method for a thiocyanide compound. The preparation method comprises the following steps: taking a sulfhydryl compound, thiocyanate as raw materials, taking rose-bengal, eosine Y or eosin B as a catalyst, performing illumination, generating a thiocyanide compound after the illumination reaction. According to the preparation method provided by the invention, thiocyanide is decomposed into thiocyanate ions; the sulfhydryl compound generates sulfhydryl radical under the action of light and the catalyst, and the sulfhydryl radical is used for attacking carbon atoms in thiocyanate ions to obtain a intermediate; sulfide is removed from the intermediate to obtain the thiocyanide compound. The rose-bengal, the eosine Y or the eosin B used by the method containno heavy metal ion, and the adverse effect on the performance of the thiocyanide compound by the heavy metal ion residue is avoided; in addition, the catalyst is easily removed, so that a favorable condition is provided for the preparation of the thiocyanide compound with higher purity.

A culture medium used for separating penicillium comprises glucose, yeast cream, rose bengal, sodium nitrate, magnesium sulfate, monopotassium phosphate, agar, streptomycin and distilled water. The culture medium is named as a yeast cream glucose agar culture medium or YDA for short. Components of the culture medium are all common chemical agents, so that the culture medium is low in cost and easy to obtain. Penicillium cultured by adopting the culture medium is short in period and easy-to-identify in colonial shape, and time is saved for strain selecting at the initial stage of penicillium classifying. In addition, compared with other selective culture media, the culture medium has the advantages that types of selected penicillium are various, and the culture medium is a selective culture medium excellent in comprehensive penicillium separating effect.

The invention relates to a preparation method of rose-bengal B/polystyrene/silicon dioxide fluorescent microspheres. The preparation method comprises the steps that 1, polystyrene/silicon dioxide composite particles are dispersed in a swelling medium, and ultrasound and swelling are performed to obtain polystyrene/silicon dioxide dispersion liquid; 2, rose-bengal B is dissolved in a swelling agentto prepare a rose-bengal B solution; 3, the rose-bengal B solution obtained in the step 2 is mixed with the polystyrene/silicon dioxide dispersion liquid obtained in the step 1, stirring reaction isperformed, and washing, centrifugation and drying are performed to obtain the rose-bengal B/polystyrene/silicon dioxide fluorescent microspheres. The preparation method has the advantages of being simple in preparation process, convenient to operate, low in reaction temperature, capable of saving energy and the like.