The invention discloses a method for measuring solvent compositions in nicotine liquid by combining gas chromatography and mass spectrometry. The method comprises the following steps of preparing a series of standard solutions simultaneously containing ethanol, 1,2-propylene glycol, glycerin, diethylene glycol, triethylene glycol, tetraethylene glycol and pentaethylene glycol by taking a methanol solution of 1,3-butylene glycol as an internal standard solution which serves as a solvent, detecting the series of standard solutions by utilizing gas chromatography-mass spectrometer, and establishing a standard curve; pre-treating the nicotine liquid to obtain a sample solution to be detected, detecting the sample solution to be detected by utilizing the gas chromatography-mass spectrometer, and calculating the solvent compositions in the nicotine liquid according to the corresponding standard curve. According to the method, ethanol, 1,2-propylene glycol, glycerin, diethylene glycol, triethylene glycol, tetraethylene glycol and pentaethylene glycol in a smokeless tobacco product can be simultaneously detected, and the method is easy to operate and high in sensitivity and reproducibility.