The invention belongs to the technical field of
sarcosine detection, and provides a bionic electric sensor, a preparation method thereof and application of the bionic electric sensor in ultrasensitive detection of
sarcosine. The method comprises the following steps: mixing a
red blood cell solution and a bionic active substance, and carrying out co-incubation to obtain bionic red blood cells, and mixing the bionic red blood cells with a
conductive polymer (
dopamine,
pyrrole,
aniline or
thiophene), and carrying out an in-situ
polymerization reaction to obtain the bionic electric sensor. The
conductive polymer is combined with natural cells, the excellent
conductivity of the
conductive polymer is utilized, and meanwhile, based on the high-
oxygen microenvironment of the cells, the bionic active substance has better electrocatalytic property and can be used for rapid, sensitive and efficient monitoring of Sar. The bionic electric sensor has the advantages of being high in
reaction speed, low in cost, easy to miniaturize, good in
biocompatibility, simple in sample pretreatment and the like, and a novel, rapid, accurate and stable diagnostic tool can be provided for the morbidity and development law of
prostate diseases.