10 results about "Thromboelastography" patented technology

The application belongs to the technical field of in-vitro diagnostic reagents, and particularly relates to thrombelastography quality control products and a preparation method and application in preparation of coagulation detection products, a coagulation detection product and a coagulation detection method. The application realizes high adhesion of quality control product coagulation parameters and clinical actual measurement values by optimizing plasma proportioning and screening special excipients, can simulate six typical clinical coagulation states from normal coagulation to low coagulation, high coagulation, fibrinogen abnormality, DIC and the like, and simultaneously has the characteristics of simple preparation process and excellent long-term stability.

The invention relates to the field of blood coagulation detection, and provides a thrombelastogram heparin detection reagent and application thereof. The thrombelastogram heparin detection reagent provided by the invention comprises a substrate reagent and a heparinase reagent, the substrate reagent is an amino polysaccharide substance, and through combination of the two reagents, the heparinase reagent can be effectively fixed into a sample cup, adsorption of the inner wall of the sample cup to heparinase is reduced, the activity of the heparinase is protected, and meanwhile the heparinase reagent can be rapidly released during detection. The invention also provides an application of the thrombelastogram heparin detection reagent in preparation of a thrombelastogram heparinase cup.

The invention belongs to the technical field of in-vitro diagnostic reagents, and particularly relates to a thrombelastogram quality control product, a preparation method of the thrombelastogram quality control product, application of the thrombelastogram quality control product in preparation of a blood coagulation detection product, the blood coagulation detection product and a blood coagulation detection method. By optimizing the plasma proportion and screening special auxiliary materials, the blood coagulation parameters of the quality control product are highly attached to clinical measured values, six typical clinical blood coagulation states from normal blood coagulation to hypocoagulation, hypercoagulation, fibrinogen abnormality and DIC can be simulated, and meanwhile the preparation method has the advantages of being simple in preparation process and excellent in long-term stability.

This invention relates to the field of coagulation testing technology, and more specifically, to a miniaturized multi-station thromboelastography (TEG) instrument. The invention discloses a miniaturized multi-station thromboelastography (TEG) instrument, comprising: a base plate, N blood storage devices, N pressure rods, a lifting device, and a measuring device. The invention uses the lifting device to reciprocately compress the blood samples to be tested via the pressure rods. The blood samples act on a magnetic sensor, generating an induced current in the coil and reflecting the magnitude of the thromboelastic force in real time, thus reflecting the entire process of blood coagulation and fibrinolysis. The invention has a simple structure and is easy to manufacture; moreover, some components can be reused, avoiding unnecessary waste. The multi-station design of this invention allows for multiple tests with a single instrument, while each blood sample does not interfere with others, thereby achieving miniaturization of the thromboelastography instrument. This invention solves the problem that existing thromboelastography instruments have complex structures and cannot simultaneously test multiple blood samples.

The present application belongs to the technical field of in vitro diagnostic reagents, and particularly relates to a thromboelastography composite activated coagulation detection reagent, a preparation method thereof and a thromboelastography activated coagulation detection kit. Compared with the prior art, the present application uses two activators, tannic acid and kaolin, is compounded, uses tannic acid to solve the problem of precipitation, and uses kaolin to supplement the traditional endogenous activation effect, has better synergistic effect, uses a biological buffer, a water-soluble polymer, an osmotic buffer and a preservative as a composite stabilizer, further improves the stability of the reagent, and further uses a freeze-drying protective agent to freeze dry to solve the problems of liquid reagent transportation and storage, avoid the problems of easy dryness and evaporation failure of the liquid reagent.

The application discloses a preparation method and product of a thromboelastography rapid detection cup reagent, and comprises the following steps: adding purified water into washed or calcined kaolin, adding glycine, mannitol, dextran and bovine serum albumin while stirring, and then adding a Tris-HCl system to adjust the pH to 6.5-7.8; finally, adding a recombinant lipidized tissue factor and uniformly stirring to obtain the reagent; wherein, the content of the washed or calcined kaolin is 0.01-0.8% based on 100% of the mass of each raw material, the content of the glycine is 2-6%, the content of the mannitol is 4-8%, the content of the dextran is 2-6%, the content of the bovine serum albumin is 0.2-5%, the content of the recombinant lipidized tissue factor is 0.2-1.5%, and the balance is made up to 100% by the purified water. The application provides a preparation method of the thromboelastography rapid detection cup reagent, and the prepared reagent can be stored for a long time, has good stability, and has good freeze-drying form and solubility.

The application provides a thromboelastography testing device based on visual detection, which comprises a rack, an industrial control unit, a cup feeding unit, a sample feeding unit, a detection unit, a reagent unit, a sampling unit, a cover feeding unit, a cover taking unit and a moving unit. The application has the characteristics of automatic operation of thrombus detection, reduced labor cost and visual monitoring of the detection unit during operation of the device.

The invention discloses a thromboelastogram blood coagulation activation detection reagent as well as a preparation method and application thereof. The thromboelastogram blood coagulation activation detection reagent comprises an endogenous blood coagulation activator and a composite solvent, the endogenous blood coagulation activator is selected from any one or more of ellagic acid, an ellagic acid hydrate, ellagic acid salt and a metal complex of the ellagic acid; the composite solvent comprises an organic solvent and an aqueous solvent, and the organic solvent comprises dihydrolevoglucose ketone (Cyreene) and one or more of gamma-valerolactone (GVL) and N, N-diethyl formamide (DEF); the aqueous solvent is selected from one of water, normal saline and a buffer solution, and the buffer solution is selected from any one or more of HEPES, TAPS, MOPS, BES, TES and Tris buffer solutions.

This application relates to the field of coagulation detection and discloses a triboelectric sensor and a thromboelastography instrument. The triboelectric sensor includes a housing, an electrode module, and a static friction layer. The housing includes a shell and a cover, with an opening at one end of the shell. The cover closes to the opening and has a through hole for dripping blood into the shell. The electrode module is attached to the bottom of the shell and includes a first electrode layer and a second electrode layer, which are spaced apart. The static friction layer is in close contact with the side surface of the electrode module facing away from the bottom of the shell and covers the electrode module. The housing is rotatable about a first axis to drive the blood droplet to move along the surface of the static friction layer toward the cover toward either the first or second electrode layer. When the blood droplet moves, the electrode module generates a voltage signal. The above-mentioned triboelectric sensor has a simple structure, low cost, and facilitates the miniaturization of thromboelastography instruments.

This invention relates to the field of in vitro coagulation detection technology, specifically to a thromboelastography coagulation activation assay reagent and its application. The coagulation activation assay reagent provided by this invention comprises a buffer solution, an intrinsic coagulation activator, tissue factor, a stabilizer, and a preservative; the stabilizer includes three types: component 1, component 2, and component 3. This invention effectively improves the stability of the assay reagent by using a combination of three types of stabilizers, avoiding the problem of failure during long-term storage and transportation. Due to the improved reagent stability, kaolin and tissue factor can effectively activate both intrinsic and intrinsic coagulation activation pathways, ensuring the accuracy of thromboelastography detection.