23 results about "Thromboelastography" patented technology

The invention discloses a multi-parameter thrombelastogram instrument for animal blood coagulation function evaluation. The multi-parameter thrombelastogram instrument comprises a magnetic suspension driving and sensing module, a multi-dimensional signal processing module, a species characteristic database module, a dynamic calibration and quality control module, an artificial intelligence decision module and a multi-mode interaction output module, the magnetic suspension driving and sensing module realizes high-precision blood coagulation monitoring through electromagnetic driving and nanoscale displacement detection; the multi-dimensional signal processing module adopts a composite algorithm to extract key parameters such as an R value and an MA value; the species characteristic database module is used for hierarchically storing multi-species blood coagulation data and supporting dynamic correction; the dynamic calibration and quality control module ensures the stability of the system through a three-level joint control mechanism; the artificial intelligence decision module provides blood coagulation risk assessment and medication suggestions based on the hybrid neural network; and the multi-modal interaction output module dynamically presents a detection result through a visual engine. The system has the characteristics of high sensitivity, interference resistance, cross-species adaptability and low output delay, and is suitable for blood coagulation function evaluation of various animals.

The application discloses a thromboelastography microfluidic chip and a droplet forming method, relates to the technical field of instant detection products, and discloses the thromboelastography microfluidic chip which comprises a cover sheet, an elastic film and a bottom sheet arranged in sequence from top to bottom, wherein the bottom sheet is provided with a flow channel and a plurality of groups of containing cavities; each containing cavity comprises a first reagent chamber, a second reagent chamber, a mixing chamber and a detection cavity which are sequentially connected in gas path through a second valve body, a third valve body and a fourth valve body; the first reagent chamber is connected in gas path with the flow channel through a first valve body; the elastic film is provided with a first gas-permeable through hole which is connected in gas path with the containing cavities and is located between the fourth valve body and the mixing chamber; and the cover sheet is provided with a first window, a second window, a third window, a fourth window, a mixing chamber window and a fifth window which is connected with the first gas-permeable through hole; the valve body control and pneumatic driving technology can ensure the full-process automation of sample quantification, activation, mixing and detection, and is suitable for the instant detection scene requirement.

The invention discloses a thrombelastogram calibration method, device, system and equipment and a storage medium, and the method comprises the steps: generating an initial thrombelastogram in a process that a blood sample rotates along with a container, through a mechanical torsion signal which drives a suspension wire to move in and after a process that the blood sample forms a blood clot, and collecting the initial thrombelastogram through a mechanical sensor; the method comprises the following steps: generating a light intensity time change chart through near-infrared light signals collected by a spectrograph, and extracting an attenuation rising rate representing a blood sample coagulation rate, an attenuation value representing blood sample coagulation intensity and an attenuation recovery rate representing fibrinolysis after blood sample coagulation, so as to calibrate an initial thromboelastogram and obtain a calibrated thromboelastogram. Therefore, on the basis of the thrombelastogram measured on the basis of the mechanics principle, the attenuation signal measured by the near-infrared optical principle is utilized to calibrate the thrombelastogram, the influence of non-coagulation factor interference on only mechanical signals is reduced, and the accuracy and the reliability of generating the thrombelastogram are improved.

The application belongs to the technical field of in-vitro diagnostic reagents, and particularly relates to thrombelastography quality control products and a preparation method and application in preparation of coagulation detection products, a coagulation detection product and a coagulation detection method. The application realizes high adhesion of quality control product coagulation parameters and clinical actual measurement values by optimizing plasma proportioning and screening special excipients, can simulate six typical clinical coagulation states from normal coagulation to low coagulation, high coagulation, fibrinogen abnormality, DIC and the like, and simultaneously has the characteristics of simple preparation process and excellent long-term stability.

The application discloses a method and system for identifying abnormalities in the coagulation process based on big data analysis, comprising: combining standard coagulation detection and thromboelastography dynamic monitoring to realize the leap from static indicators to functional whole-process evaluation, while combining patient individual characteristics to screen similar historical cases, and accurately identifying key coagulation indicators; introducing correlation analysis to dynamically screen key indicators, and using clustering analysis to establish an adaptive normal range, and finally evaluating abnormalities by quantifying the degree of deviation, the application significantly improves the accuracy and timeliness of coagulation state monitoring, provides individualized early warning and intervention basis for clinical practice, effectively prevents bleeding or thrombosis risk, and promotes the intelligent and refined development of coagulation management.

The invention relates to the field of blood coagulation detection, and provides a thrombelastogram heparin detection reagent and application thereof. The thrombelastogram heparin detection reagent provided by the invention comprises a substrate reagent and a heparinase reagent, the substrate reagent is an amino polysaccharide substance, and through combination of the two reagents, the heparinase reagent can be effectively fixed into a sample cup, adsorption of the inner wall of the sample cup to heparinase is reduced, the activity of the heparinase is protected, and meanwhile the heparinase reagent can be rapidly released during detection. The invention also provides an application of the thrombelastogram heparin detection reagent in preparation of a thrombelastogram heparinase cup.

The invention belongs to the technical field of in-vitro diagnostic reagents, and particularly relates to a thrombelastogram quality control product, a preparation method of the thrombelastogram quality control product, application of the thrombelastogram quality control product in preparation of a blood coagulation detection product, the blood coagulation detection product and a blood coagulation detection method. By optimizing the plasma proportion and screening special auxiliary materials, the blood coagulation parameters of the quality control product are highly attached to clinical measured values, six typical clinical blood coagulation states from normal blood coagulation to hypocoagulation, hypercoagulation, fibrinogen abnormality and DIC can be simulated, and meanwhile the preparation method has the advantages of being simple in preparation process and excellent in long-term stability.

The embodiment of the application discloses a thromboelastography generation method based on a magnetic bead method, and the method is characterized in that the method comprises the following steps: acquiring magnetic bead oscillation waveform data detected based on the magnetic bead method; and performing conversion calculation based on the magnetic bead oscillation waveform data to obtain the thromboelastography. The thromboelastography generation method greatly reduces the cost, and greatly improves the timeliness due to the simple detection method. In addition, a thromboelastography generation device based on the magnetic bead method, a sample analyzer and a storage medium are also provided.

This invention relates to the field of coagulation testing technology, and more specifically, to a miniaturized multi-station thromboelastography (TEG) instrument. The invention discloses a miniaturized multi-station thromboelastography (TEG) instrument, comprising: a base plate, N blood storage devices, N pressure rods, a lifting device, and a measuring device. The invention uses the lifting device to reciprocately compress the blood samples to be tested via the pressure rods. The blood samples act on a magnetic sensor, generating an induced current in the coil and reflecting the magnitude of the thromboelastic force in real time, thus reflecting the entire process of blood coagulation and fibrinolysis. The invention has a simple structure and is easy to manufacture; moreover, some components can be reused, avoiding unnecessary waste. The multi-station design of this invention allows for multiple tests with a single instrument, while each blood sample does not interfere with others, thereby achieving miniaturization of the thromboelastography instrument. This invention solves the problem that existing thromboelastography instruments have complex structures and cannot simultaneously test multiple blood samples.

The present application belongs to the technical field of in vitro diagnostic reagents, and particularly relates to a thromboelastography composite activated coagulation detection reagent, a preparation method thereof and a thromboelastography activated coagulation detection kit. Compared with the prior art, the present application uses two activators, tannic acid and kaolin, is compounded, uses tannic acid to solve the problem of precipitation, and uses kaolin to supplement the traditional endogenous activation effect, has better synergistic effect, uses a biological buffer, a water-soluble polymer, an osmotic buffer and a preservative as a composite stabilizer, further improves the stability of the reagent, and further uses a freeze-drying protective agent to freeze dry to solve the problems of liquid reagent transportation and storage, avoid the problems of easy dryness and evaporation failure of the liquid reagent.

The application discloses a preparation method and product of a thromboelastography rapid detection cup reagent, and comprises the following steps: adding purified water into washed or calcined kaolin, adding glycine, mannitol, dextran and bovine serum albumin while stirring, and then adding a Tris-HCl system to adjust the pH to 6.5-7.8; finally, adding a recombinant lipidized tissue factor and uniformly stirring to obtain the reagent; wherein, the content of the washed or calcined kaolin is 0.01-0.8% based on 100% of the mass of each raw material, the content of the glycine is 2-6%, the content of the mannitol is 4-8%, the content of the dextran is 2-6%, the content of the bovine serum albumin is 0.2-5%, the content of the recombinant lipidized tissue factor is 0.2-1.5%, and the balance is made up to 100% by the purified water. The application provides a preparation method of the thromboelastography rapid detection cup reagent, and the prepared reagent can be stored for a long time, has good stability, and has good freeze-drying form and solubility.

The embodiment of the application discloses a thromboelastogram detection method based on a magnetic bead method, which is applied to a sample analyzer, and the method comprises the following steps: when it is found that the detection item to be detected contains thromboelastogram detection, the sample is detected by using the magnetic bead method, and magnetic bead oscillation waveform data is obtained; the thromboelastogram is drawn according to the magnetic bead oscillation waveform data, and a thromboelastogram is generated. The thromboelastogram detection method greatly reduces the cost, and greatly improves the timeliness due to the simple detection method. In addition, a thromboelastogram detection device based on the magnetic bead method, a sample analyzer and a storage medium are also provided.

1. The name of the design product: the graphical user interface of the application task list interaction of the electronic device. 2. The use of the design product: an electronic device. 3. The design points of the design product: the part of the graphical user interface in the electronic device. 4. The picture or photo that best indicates the design points: the front view. 5. The electronic device is a conventional design, and other views are omitted. 6. The use of the graphical user interface: the product interface is the interface for displaying and interacting with the task list of the thromboelastography; the main view interface is the interaction interface of the home page of the thromboelastography; in the main view interface, after clicking the "task list" button on the right upper side, the interface change state diagram is displayed.

The application provides a thromboelastography testing device based on visual detection, which comprises a rack, an industrial control unit, a cup feeding unit, a sample feeding unit, a detection unit, a reagent unit, a sampling unit, a cover feeding unit, a cover taking unit and a moving unit. The application has the characteristics of automatic operation of thrombus detection, reduced labor cost and visual monitoring of the detection unit during operation of the device.

1. Name of the product in this design: Thromboelastography instrument. 2. Purpose of this design: It is a medical device with four internal detection channels for functional analysis and clinical diagnosis of whole blood samples, including coagulation, anticoagulation, fibrinolysis, and antifibrinolysis. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a thromboelastogram blood coagulation activation detection reagent as well as a preparation method and application thereof. The thromboelastogram blood coagulation activation detection reagent comprises an endogenous blood coagulation activator and a composite solvent, the endogenous blood coagulation activator is selected from any one or more of ellagic acid, an ellagic acid hydrate, ellagic acid salt and a metal complex of the ellagic acid; the composite solvent comprises an organic solvent and an aqueous solvent, and the organic solvent comprises dihydrolevoglucose ketone (Cyreene) and one or more of gamma-valerolactone (GVL) and N, N-diethyl formamide (DEF); the aqueous solvent is selected from one of water, normal saline and a buffer solution, and the buffer solution is selected from any one or more of HEPES, TAPS, MOPS, BES, TES and Tris buffer solutions.

This invention provides a cup-cap removal mechanism and a thromboelastography instrument, relating to the technical field of blood testing equipment. The cup-cap removal mechanism includes a toothed ring, a first cup-cap removal ring, a second cup-cap removal ring, and a bracket. The first cup-cap removal ring has a top tooth, and the second cup-cap removal ring has a moving tooth. The toothed ring has a first working groove corresponding to the moving tooth. The bracket can drive the first cup-cap removal ring to move upwards. When the top tooth moves upwards, it can cooperate with the moving tooth, causing the moving tooth to move above the first working groove. When the bracket moves downwards, the moving tooth can move downwards and insert into the first working groove, driving the top tooth downwards, causing the first cup-cap removal ring to press against the cup cap and move downwards until the cup cap separates from the probe. The thromboelastography instrument includes a cup-cap removal mechanism. The cup-cap removal mechanism of this invention can achieve automated separation of the cup cap and the probe.

This application relates to the field of coagulation detection and discloses a triboelectric sensor and a thromboelastography instrument. The triboelectric sensor includes a housing, an electrode module, and a static friction layer. The housing includes a shell and a cover, with an opening at one end of the shell. The cover closes to the opening and has a through hole for dripping blood into the shell. The electrode module is attached to the bottom of the shell and includes a first electrode layer and a second electrode layer, which are spaced apart. The static friction layer is in close contact with the side surface of the electrode module facing away from the bottom of the shell and covers the electrode module. The housing is rotatable about a first axis to drive the blood droplet to move along the surface of the static friction layer toward the cover toward either the first or second electrode layer. When the blood droplet moves, the electrode module generates a voltage signal. The above-mentioned triboelectric sensor has a simple structure, low cost, and facilitates the miniaturization of thromboelastography instruments.

This invention relates to the field of in vitro coagulation detection technology, specifically to a thromboelastography coagulation activation assay reagent and its application. The coagulation activation assay reagent provided by this invention comprises a buffer solution, an intrinsic coagulation activator, tissue factor, a stabilizer, and a preservative; the stabilizer includes three types: component 1, component 2, and component 3. This invention effectively improves the stability of the assay reagent by using a combination of three types of stabilizers, avoiding the problem of failure during long-term storage and transportation. Due to the improved reagent stability, kaolin and tissue factor can effectively activate both intrinsic and intrinsic coagulation activation pathways, ensuring the accuracy of thromboelastography detection.

The utility model relates to the technical field of blood sample detection equipment, and discloses a detection device of a thrombelastogram instrument, which is arranged on a thrombelastogram instrument body and comprises a bracket, a detection head, a control panel and an automatic lifting mechanism, an adjusting plate and a driving assembly used for driving the adjusting plate to move are connected to the connecting plate in a sliding mode, and the bracket is installed at the end, away from the connecting plate, of the adjusting plate; the problems that in the prior art, ascending and descending of a bracket are manually controlled, operation control is not convenient enough, and meanwhile blood samples and related reagents are inconvenient to add into a sample cup are solved.