33 results about "Blood coagulation testing" patented technology

The invention relates to the field of quality control of blood coagulation testing items and provides a 3-level thrombelastogram quality control product. The quality control product is prepared by the following steps: respectively mixing pig blood with 3 different concentrations of sodium citrate, centrifuging, taking blood plasma, respectively adding a coagulation activator and a tissue factor and lyophilizing to prepare a powdery quality control product I, adding a coagulation activator and lyophilizing to prepare a powdery quality control product II, and adding a coagulation activator and human lyophilized platelets and lyophilizing to prepare a powdery quality control product III. The 3-level thrombelastogram quality control product provided by the invention is shaped as a lyophilized powder, can be used to monitor R and MA values simultaneously, is better used for quality control of an thromboelastography instrument and a thrombelastogram detection kit, is fast to detect, has accurate results and is simple to operate.

The invention discloses a piezoelectric thin-film resonator for blood coagulation detection. The piezoelectric thin-film resonator comprises a piezoelectric film layer and an annular groove. In addition, the invention also discloses a method for manufacturing the piezoelectric thin-film resonator for blood coagulation detection. The method includes: the inner surface of an annular groove is coated with a hydrophilic polymer material; oxygen plasma treatment or ultraviolet light irradiation is carried out on the inner surface of the annular groove; a piezoelectric thin-film resonator is placed in a sodium carbonate solution and a calcium chloride solution is added into the solution; and the piezoelectric thin-film resonator is baked until the piezoelectric thin-film resonator is dried. Besides, the invention also discloses a method for blood coagulation detection by using a piezoelectric thin-film resonator. The method for blood coagulation detection comprises: dripping mixed liquid having a blood sample and a blood coagulation testing regent into the center of an annular groove; measuring the resonant frequency of a piezoelectric thin film resonator; and according to the recorded stabilized resonant frequency, calculating a second derivative of the resonant frequency to a time change and taking a maximum value of the second derivative as blood coagulation time. The method for blood coagulation detection by using a piezoelectric thin-film resonator is suitable for household application.

A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a red blood cell lysate that is free of plasma, leukocytes, and platelets with a platelet-free plasma of human origin and an antimicrobial agent.

The invention discloses a coupling type blood coagulation testing system and method. The system comprises a light source device, a coupling device used for collecting light to be tested, emitted by the light source device and illuminating an objected to be measured, a measuring device used for measuring an optical signal of the object to be measured and a controller used for controlling the lightsource device and processing the optical signal of the object to be measured; the coupling device comprises an optical fiber coupling regulation component, first beam splitting optical fibers, a dodging device and second beam splitting optical fibers which are connected in sequence; the optical fiber coupling regulation component is connected with the light source device and is used for regulatinga distance between the first beam splitting optical fibers and the light source device; and the second beam splitting optical fibers are connected with the measuring device. As the distance between the first beam splitting optical fibers and the light source device is regulated by the optical fiber coupling regulation component, the optical fiber coupling efficiency is maximized; and dodging is performed on the light to be tested through the dodging device, the consistency of each testing channel is improved.

A blood coagulation testing apparatus for determining compatibility between donor's blood and patient's blood before blood transfusion. The blood coagulation testing apparatus includes: a cylindrical main body connected at one end thereof to a supply tube for delivering donor's blood and connected at the other end thereof to a blood transfer tube for introduction of patient's blood, wherein the main body is divided into two sections by a barrier film extending in a longitudinal direction of the main body such that blood is introduced into the main body through two paths, wherein the donor's blood and the patient's blood are introduced into one of the two sections through one end of the main body and the other end of the main body, respectively, and wherein the barrier film is formed on a surface thereof with a blood coagulation indicator for checking coagulation.

The invention relates to the technical field of medical instruments, and particularly relates to a blood coagulation reagent management method and system. The management system comprises a first reagent container, the first reagent container is provided with at least two first reagent containing cavities, and the at least two first reagent containing cavities are independently arranged so as to contain set reagents needed by blood coagulation test items in a one-to-one correspondence mode so that the first reagent container can independently complete the blood coagulation test items of the preset number of times. Therefore, reagents can be managed through each blood coagulation test item in the reagent management and detection process, and a situation that one reagent is still available and the other reagent is insufficient in the traditional method is avoided so that the detection efficiency is improved, and the reagent cost is saved. Meanwhile, the blood coagulation test items of thepreset number of times are independently completed through the first reagent container, the reagents needed by the corresponding blood coagulation test items can be conveniently loaded and replaced at a time, and the reagent loading and replacing efficiency of a user is effectively improved.

The invention provides an instrument for viscoelasticity analysis, for example, an instrument for coagulation testing of a sample liquid (such as blood and/or a component thereof). In the instrument for viscoelasticity analysis, a rotating device is disposed below a cup, a pin, and a cup accommodating element. The invention further provides a capacitance detection device and temperature control equipment. The capacitance detection device and the temperature control equipment can be used in the instrument for viscoelasticity analysis. The invention further provides a method of performing viscoelastic analysis (e.g., coagulation analysis) on the sample by using the equipment and instrument.

The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.

Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device, in some embodiments, the blood coagulation testing system can operate as an automated thrornboelastometry system that is particularly useful, for example, at a point-of-care site.

The invention relates to the technical field of blood coagulation detection, and discloses a full-automatic blood coagulation tester. The full-automatic blood coagulation tester comprises a test platform, a sample adding arm unit and a test cup conveying unit, wherein the test platform includes a bath temperature position used for loading a test cup and heating, a first reagent position used for storing an R1 reagent, a sample position used for storing a sample, a test position used for a cup conveying test and a second reagent position used for storing an R2 reagent; the sample adding arm unit is used for adding the reagent R1 and the sample into the test cup at the bath temperature position and adding the reagent R2 into the test cup at the test position; and the test cup conveying unitis used for conveying the test cup at the bath temperature position to the test position and discarding the tested test cup to a specified position. The full-automatic blood coagulation tester provided by the invention is compact in structure, excellent in performance and high in reliability.

The invention relates to the technical field of clinical blood coagulation testing, and discloses a physical quality control product as well as a preparation method and application thereof. Physical quality control products in the scheme comprise agar and water, the agar and the water are separately stored, and the quality control products are divided into a quality control product I, a quality control product II and a quality control product III according to agar solutions with different concentrations. When in use, agar and water are uniformly mixed and then heated and melted to prepare a colorless, transparent and uniformly dispersed quality control product in a solution state; the quality control product gradually forms a clot along with the cooling of the solution, the clot is described by a thrombelastogram instrument to obtain various parameters (R, K, Angle, MA and the like), and the quality of the thrombelastogram instrument is accurately evaluated by comparing the assignment range of the quality control product. The quality control product has the advantages that the raw materials are convenient to store and transport, the cost is low, the stability is good, the manufacturing process is simple, the detection result is stable and the like, different working states of the thrombelastogram can be accurately evaluated through agar solutions with different concentrations, and the quality control product is very suitable for evaluating and detecting the thrombelastogram in clinic.

A coagulation test for determining the activated clotting time (ACT) of blood in the presence of heparin that produces test results that are substantially insensitive to the drug aprotinin. The activator is formulated to be a combination of celite and bentonite. The ACT results obtained with this formulation are similar to celite ACT tests on heparinized blood while simultaneously being unaffected by aprotinin. Additionally, a method for quantifying the aprotinin effect of different ACT formulations is disclosed.

Some components and methods for the determination of coagulation parameters using trace amounts of blood are provided. Advantageously, the methods described herein can be assayed in a single drop of blood (approximately 20 [mu]L), while generally reserving a sufficient amount of sample for performing other assays, optionally in a multiplex assay format. The method and device do not require an experienced operator and can be performed in a designated service location, which is very important for the management and treatment of coagulation abnormalities.

The invention discloses a blood coagulation time calculation method, device and system and a readable storage medium. The method comprises the following steps: obtaining a current amplitude data segment generated by the movement of a small steel ball in a blood coagulation test according to a preset period, and calculating a median and a first kurtosis set corresponding to a wave crest set according to the wave crest set in the current amplitude data segment; comparing the first kurtosis set with a preset kurtosis threshold to obtain a first comparison result, and based on the first comparison result, obtaining a second kurtosis set and a third kurtosis set corresponding to the first two amplitude data segments; comparing the second kurtosis set and the third kurtosis set with a preset kurtosis threshold to obtain a second comparison result, and comparing the median with a blood coagulation threshold based on the second comparison result to obtain a third comparison result; based on the first comparison result, the second comparison result and the third comparison result, blood coagulation time is determined; the blood coagulation time is determined according to the three continuous amplitude data segments, and the accuracy of determining the blood coagulation time is improved.

The invention is suitable for the field of thrombus detecting technology, and provides a remote monitoring system for thrombus and a method thereof. The method comprises the following steps of receiving recorded identity information and disease type, controlling a measuring module detect coagulation data of a blood sample in a whole coagulation process; storing thrombus detecting information and detecting time by a cloud platform, wherein the thrombus detecting information and the detecting time are transmitted from each thromboelastography instrument; and calling related coagulation data by terminal equipment based on a searching condition from a cloud platform. The remote monitoring system realizes big data sharing based on the cloud platform. Medical personnel can call the current coagulation testing data, historical coagulation testing data of the patient and the coagulation data of other patient with the same disease type, thereby supplying more abundant data support for clinicalpredicting and realizing high accuracy in clinical predicting.

Embodiments of a blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. In some embodiments, the blood coagulation testing system includes a single-use cartridge component configured to measure and mix reagents with blood received from a blood sample reservoir. A mixing chamber in the single-use cartridge includes different reagent beads that, when exposed to a pre-determined volume of blood, dissolve and mix specific reagents with the blood. The assembled blood cartridge further includes configurations that are designed to prevent blood from prematurely mixing with reagent beads in the mixing chamber and to guide blood flow in the mixing chamber to dissolve reagent beads in a desired order.Thus, the mixture obtained from the mixing chamber can be readily utilized to generate results for the blood coagulation testing system.

The invention provides a correction method for testing four blood coagulation items. The method comprises the following steps of testing the to-be-tested samples for four blood coagulation items on aspecified blood coagulation test system to obtain an initial test result; performing correction calculation on the initial test result through a correction equation to obtain a final test result, wherein the correction equation is determined according to the following methods of a) determining the correlation between the specified blood coagulation test system and a standard blood coagulation testsystem to obtain a correlation equation; b) calibrating the standard blood coagulation test system to obtain a calibration equation for four blood coagulation items; and c) substituting the correlation equation obtained in the step a) into the calibration equation for four blood coagulation items obtained in the step b) to obtain a correction equation. According to the calibration method, the correlation is established between the specified blood coagulation test system and the standard blood coagulation test system, and then the standard blood coagulation test system is calibrated, so that the calibration process of the specified blood coagulation test system is transferred to the standard blood coagulation test system, and the calibration method has higher accuracy.