Piezoelectric thin-film resonator, method for manufacturing the same, and method for detecting blood coagulation time

Abstract

The invention discloses a piezoelectric thin-film resonator for blood coagulation detection. The piezoelectric thin-film resonator comprises a piezoelectric film layer and an annular groove. In addition, the invention also discloses a method for manufacturing the piezoelectric thin-film resonator for blood coagulation detection. The method includes: the inner surface of an annular groove is coated with a hydrophilic polymer material; oxygen plasma treatment or ultraviolet light irradiation is carried out on the inner surface of the annular groove; a piezoelectric thin-film resonator is placed in a sodium carbonate solution and a calcium chloride solution is added into the solution; and the piezoelectric thin-film resonator is baked until the piezoelectric thin-film resonator is dried. Besides, the invention also discloses a method for blood coagulation detection by using a piezoelectric thin-film resonator. The method for blood coagulation detection comprises: dripping mixed liquid having a blood sample and a blood coagulation testing regent into the center of an annular groove; measuring the resonant frequency of a piezoelectric thin film resonator; and according to the recorded stabilized resonant frequency, calculating a second derivative of the resonant frequency to a time change and taking a maximum value of the second derivative as blood coagulation time. The method for blood coagulation detection by using a piezoelectric thin-film resonator is suitable for household application.

Description

technical field [0001] The invention belongs to the field of clinical medical detection, and in particular relates to a piezoelectric thin film resonator, a manufacturing method thereof and a method for detecting coagulation time. Background technique [0002] Blood clotting time detection is one of the important routine examinations before surgery, and its clinical results indicate the risk of various thrombotic diseases or bleeding diseases. In addition, for patients using anticoagulant drugs, the test results of coagulation time are an important reference for adjusting the dosage of anticoagulant drugs. Especially for some oral anticoagulant drugs that need to be taken for a long time, such as warfarin, the anticoagulant effect varies greatly among individuals, and the interaction with other drugs is complicated, and natural food also affects its anticoagulant effect. Therefore, in order to ensure the anticoagulant effect and avoid the risk of bleeding, patients need to ...

AI Technical Summary

Problems solved by technology

[0009] The disadvantages of the above-mentioned technical solution are: (1) the structure of the instrument is complex and difficult to manufacture; (2) the amount of blood samples used is large, which requires special blood collection and processing, which is not suitable for home use; (3) the external The noise is large, the method of determining the coagulation time point is not reliable enough, and the test results need to be further calibrated

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