46 results about "Blood coagulation analyzer" patented technology

The invention relates to an in vitro diagnostic kit for the determination of activated partial thromboplatin time (APTT) in clinical test. The invention consists of a partial thromboplatin reagent and a calcium chloride solution, which is used for the detection of the defects of the intrinsic coagulation pathway factors and the screening test of the related inhibitors, and the invention is also a primary means for the current coagulation factor and heparin anticoagulant treatment and the detection of lupus anticoagulant. The invention has the advantages of long stability time and good repeatability of the partial thromboplatin reagent after a re-dissolution, at the same time, the invention has better consistency of the measurement results of a blood coagulation analyzer by using an optical method and a magnetic bead method, therefore, the invention is applicable to large, medium and small hospitals, and the test results of different hospitals have comparability, therefore the invention has important meaning for implementing the one general report of test reports, provides the reliable experimental data for the clinical diagnosis and the treatment of diseases and improves the efficiency and value of the basic studies of thrombosis and hemostasis.

In order to improve accuracy of determination of a blood coagulation time without requiring complicated work, a measurement unit 2 of a blood coagulation analyzer 1 irradiates a measurement specimen prepared by mixing a blood specimen and a reagent together, with lights of a plurality of wavelengths including light of a wavelength λ1 and light of a wavelength λ2, obtains information regarding an amount of transmitted light that transmits through the measurement specimen, and transmits the obtained information to a control device 4. The control device 4 calculates a blood coagulation time of the blood specimen based on information regarding a transmitted light amount based on light of the wavelength λ1. Moreover, the control device 4 determines whether a blood coagulation time can be appropriately obtained through the measurement, based on information regarding transmitted light amounts based on light of wavelength λ1 and light of wavelength λ2.

The invention discloses an integrated blood inspection platform and a using method thereof. The integrated blood inspection platform comprises a sample feeding center and inspection instruments, wherein each inspection instrument is fixed on a bracket; the sample feeding center is connected with the inspection instruments through a uniform interface; the sample feeding center comprises a sample feeding arm, a sample rack, a cleaning center, a temperature control system and a reagent rack; the inspection instruments comprise a blood rheology/ blood sedimentation instrument, a biochemical analyzer, a blood cell analyzer and a blood coagulation analyzer; the integrated blood inspection platform further comprises inspection modules corresponding to the inspection instruments, wherein the inspection modules are used for controlling the inspection instruments; and the inspection modules respectively comprise a blood rheology/ blood sedimentation instrument, a biochemical analysis module, a blood cell analysis module and a blood coagulation analysis module. The inspection devices of various detection methods are integrated into the detection modules with the uniform interface and integrated in the inspection platform, so that the project detection of various detection methods can be realized by using only one inspection platform, the spatial dimensions of the devices are greatly reduced, and the using cost is also reduced.

A blood coagulation analyzer is provided by which, while the measurement using reagent for measuring a Fbg (fibrinogen concentration) is being minimized, the result of a measurement such as a PT measurement can be used to accurately acquire a fibrinogen concentration. The blood coagulation analyzer (1) includes a detector for detecting a transmitted light intensity from a first measurement sample prepared from a blood and a PT measurement reagent; a dFbg acquisition means for acquiring, based on the light detected from the first measurement sample, a dFbg value reflecting a Fbg in the blood; a determination means for determining whether the dFbg value is within a predetermined range or not; a detector for detecting a transmitted light intensity from a second measurement sample prepared from the blood and a Fbg measurement reagent when the dFbg value is outside the predetermined range; and a Fbg acquisition means for acquiring, based on a transmitted light intensity from the second measurement sample detected, a Fbg concentration in the blood sample.

Provided is a blood coagulation analyzer whereby both of an adequate dynamic range and a high sensitivity can be achieved in analyzing blood coagulation, without using any complicated device, by selecting an appropriate detection angle depending on the scattering light intensity of each specimen. The blood coagulation analyzer comprises: a reactor (101) in which a sample and a reagent are mixed together and reacted; a light source (102) for irradiating the reactor (101) with light; multiple detectors (103a, 103b), which are positioned around the reactor (101) at different angles to the light axis of the light from the light source (102), for detecting scattering light generated from the liquid mixture of the sample and the reagent; a memory unit (107) for inputting and memorizing multiple light intensity change data over time obtained from the detectors (103a, 103b); a determination unit (106) for selecting, depending on the amount of light intensity change, light intensity change data to be used in calculating blood coagulation time from among various light intensity change data stored in the memory unit (107); and a calculation unit (108) for calculating the blood coagulation time based on the light intensity change data selected by the determination unit (106).

The invention discloses a waste liquid discharging device, a blood coagulation analyzer with waste liquid discharging device and a discharging method. The waste liquid discharging device comprises: atransfer tank assembly, used for storing waste liquid, a first liquid level sensor which is arranged in the transfer tank assembly and is used for detecting the liquid level in the transfer tank assembly; a waste liquid pump, which comprises an inlet and an outlet, wherein the inlet is communicated with the lower end surface of the transfer tank assembly; a waste liquid barrel which is communicated with the outlet and is used for storing waste liquid; and a controller which is connected with the waste liquid pump and is used for controlling the start and stop of the waste liquid pump; the controller is also connected with the first liquid level sensor; when the first liquid level sensor detects that the liquid level in the transfer tank assembly reaches a preset liquid level, the first liquid level sensor issues an on signal to the controller, and the controller receives the signal and controls the waste liquid pump to start. The waste liquid discharging device, the blood coagulation analyzer with the waste liquid discharging device and the waste liquid discharging method realize the semi-automatic liquid discharge of the analyzer and prolong the service life of the waste liquid pump.

A blood coagulation analyzer providing an online interface relates to the technical field of blood coagulation analyzers. According to the technical scheme, the blood coagulation analyzer comprises areagent bin module, a detection module, a needle movement module, a needle cleaning module, a reaction cup transportation module, a sample inlet, a power supply control module in signal connection with the modules, and a sample transportation module. The blood coagulation analyzer is communicated with an on-line track, so that a sample rack loaded with blood sample tubes can enter the blood coagulation analyzer from the on-line track, returns to the on-line track after being sampled in the blood coagulation analyzer and is sent to the next inspection instrument. The workload of inspection personnel is reduced, and meanwhile, the residence time of a blood sample in the blood coagulation analyzer is shortened, that is to say, the total time for completing all the detection items is shortened. The addition of the sample transportation module also changes the overall layout of the blood coagulation analyzer, and the other modules of the blood coagulation analyzer are redistributed in position according to the sample transportation module, so that the structural layout of the instrument is more scientific and reasonable.

The invention discloses a full-automatic blood coagulation analyzer and an analysis method thereof. The full-automatic blood coagulation analyzer comprises a rack, a cup supply mechanism, an incubation mechanism, a photoelectric detection mechanism, a waste material mechanism, a three-dimensional needle mechanism and a three-dimensional mechanical arm mechanism, wherein the cup supply mechanism, the incubation mechanism, the photoelectric detection mechanism and the waste material mechanism are arranged on the bottom of the rack in sequence; the three-dimensional needle mechanism is arranged on the top of the rack; the three-dimensional mechanical arm mechanism is arranged on the rack and is positioned between the incubation mechanism and the three-dimensional needle mechanism; one side ofthe incubation mechanism is provided with a sample mechanism used for storing samples, and a reagent mechanism used for storing reagent; and the three-dimensional mechanical arm mechanism is used forconveying a reaction cup on an incubation position to a detection position to be detected, and then, the reaction cup is conveyed to the waste material mechanism. When the three-dimensional mechanical arm mechanism is used for conveying the reaction cup, the cup supply mechanism, the incubation mechanism, the photoelectric detection mechanism and the waste material mechanism are arranged in sequence, the operation frequencies of the three-dimensional mechanical arm mechanism are few, and conveying difficulty is lower so as to be favorable for the reaction cup conveying reliability of the three-dimensional mechanical arm mechanism, and time is saved.

The invention relates to a blood sample analyzer and relates to the technical field of blood coagulation analyzers. According to the technical schemes of the invention, the blood sample analyzer comprises a main body rack, a detection module, a reagent refrigeration disc, a reaction cup incubation disc, a sample frame conveying module, a sampling and sample adding module, an emergency treatment module and a reaction cup conveying module; the reaction cup incubation disc is arranged on the outer side of the reagent refrigeration disc in a surrounding manner and is rotationally connected with the main body rack; the detection module, the sample frame conveying module, the emergency treatment module and the reaction cup conveying module are distributed on the main body rack around the reaction cup incubation disc; the sampling and sample adding module comprises a first sample adding device, a second sample adding device and a third sample adding device. According to the Blood sample analyzer of the invention, the layout is optimized, so that the installation positions of the modules are orderly and clear, the installation, maintenance and upgrading of the instrument are facilitated, and the overall size and weight of the instrument are reduced.

The invention discloses a novel vibratory uniform mixing device for a blood coagulation analyzer. The novel vibratory uniform mixing device comprises a shell, a blood coagulation cup, a vibration device and clamping devices, wherein the top of the shell is provided with an opening; an inner side of the opening is fixedly provided with a guide barrel; the top of the blood coagulation cup penetratesthrough the guide barrel to be placed at the top of the vibration device; the vibration device comprises a supporting spring, a mounting plate and a vibrator; the bottom of the supporting spring is fixed with the inner wall of the bottom of the shell; the top of the supporting spring is fixed with the mounting plate; the vibrator is fixedly arranged at the top of the mounting plate; the blood coagulation cup is placed at the top of the vibrator; the clamping devices comprise fixed barrels, telescopic barrels, compression springs, electromagnets, iron blocks and clamping heads; certain ends ofthe fixed barrels are fixed with inner walls of the shell; the telescopic barrels are connected with inner walls of the fixed barrels in a sliding manner; the compression springs are located on innersides of the fixed barrels and the telescopic barrels. By using a semi-automatic vibratory uniform mixing device for the blood coagulation analyzer, a vibratory agitation effect on the blood coagulation cup can be achieved; a reagent is more uniformly mixed, and a workload of a medical worker is lightened.

The invention relates to a blood coagulation analyzer, which comprises: a cup feeding unit for continuously loading reaction cups; a reaction cup conveying unit provided with a first grabbing position and a sample adding position; a sample unit used for storing a large number of to-be-detected samples, wherein the sample unit conveys the to-be-detected samples to the sample needle sample sucking position or the puncture sample needle sample sucking position of the sample unit; a sample needle unit used for sucking the to-be-detected sample at the sample needle sample sucking position or the puncture sample needle sample sucking position of the sample unit into the first reaction cup; an incubation tray carrying unit used for incubating the to-be-detected sample carried on the first reaction cup; a cup taking rotating arm unit used for grabbing the reaction cup to a first grabbing position; a reagent bin unit used for storing reagents; a reagent needle unit used for sucking the reagent into the first reaction cup; and a detection unit used for detecting the reacted to-be-detected sample carried in the first reaction cup. According to the invention, a large number of samples can be stored and automatically conveyed, and the storage and conveying efficiency is improved.

The invention discloses an electrochemical detection method for activating blood coagulation time, which comprises the following specific steps: S1, fixing a detection reagent on an electrode substrate, pasting a membrane, cutting the electrode substrate into strips, and packaging a test card finished product; s2, during detection, inserting the test card into a coagulation analyzer, and adding ablood sample to be detected; s3, after the blood coagulation analyzer detects that the to-be-detected blood sample enters the reaction cavity of the test card, applying alternating voltage, starting aheating piece of the detection module for heating, wherein the temperature is controlled to be 37 DEG C +/-0.5 DEG C; s4, in the detection process, along with solidification of the blood sample, enabling a current signal in a reaction cavity of the test card to change, enabling a detection module of the coagulation analyzer to receive the current signal, converting the current signal into a voltage signal through an operational amplifier chip, carrying out data acquisition and processing, and finally, adopting a mathematical algorithm to obtain an inflection point of a coagulation reaction curve; and calibrating the inflection point to obtain a detection result. The electrochemical detection method of the activated blood coagulation time is simple and controllable to operate and can improve the detection accuracy and stability.

The invention relates to a communication system for a full-automatic blood coagulation analyzer based on a CAN bus. The communication system comprises a PC client side, a USB-CAN module, a blood sample conveying module, a test cup conveying module, a reagent position module, a three-dimensional motion control module and a detection module; management of a blood sample to be tested, a test reagent, three-dimensional motion control and the like is realized through the PC client side, wherein each module can be used as independent equipment; the modules are communicated through the CAN bus; and the USB-CAN module and the PC are communicated through a USB line.

The invention provides a full-automatic blood coagulation analyzer which is high in safety and reliability and convenient to operate. The full-automatic blood coagulation analyzer comprises a sample rack module for storing a blood sample, a reagent refrigerating module which is used for refrigerating and storing reagents, a detection module, an arm group module and a master control module; the detection module comprises a tray, a cover body, a light sensation detection assembly which is used for detecting the loading state and the non-loading state of an analysis disc in the tray, and a microswitch which is used for detecting the contact state and the non-contact state of the front end of the cover body and the front end of the tray; and the arm group module comprises a sampling needle, an advancing mechanism, and a safety device which is used for connecting the sampling needle and the advancing mechanism, measuring the stress value of the front end of the sampling needle, and switching the movable connection relation between the sampling needle and the advancing mechanism from a fixed state to a movable state when the stress value of the front end of the sampling needle exceeds a preset threshold value. The full-automatic blood coagulation analyzer is high in safety and reliability and convenient to operate.

The invention discloses a blood coagulation analyzer reagent calibration method based on immunoturbidimetry, and the method comprises the following steps: carrying out multiple experiments by using calibration samples with different concentrations of measured components according to the direct proportion of absorbance difference to the concentration of the calibration samples, calculating the absorbance difference of plasma samples with different concentrations of measured components, respectively adopting a two-point method and a rate method to calculate absorbance difference values for calibration samples with different concentrations of measured components, and respectively obtaining two calibration curves. According to the reagent calibration method for the blood coagulation analyzer based on the immunoturbidimetry, two different calibration curves are used on the basis of combining actual clinical application conditions and experimental experience accumulation aiming at detected component samples with different concentrations, and two calibration methods are adopted, so that the calibration method is more flexible, accurate and high in applicability.

The invention discloses a two-way light splitting blood coagulation test device. The device comprises a base plate and a first light source device arranged on the base plate. The base plate is successively connected to a light collecting device for collecting polychromatic light emitted by the first light source device, a light splitting device for dividing the polychromatic light into monochromatic light with different wavelengths, a light guiding device for conducting the monochromatic light to a test area and a first measuring device for measuring the optical signal of an object to be tested. The light splitting device comprises a two-way light splitting component so as to realize the multi-project detection of a sample. The polychromatic light is converted into the monochromatic lightwith different wavelengths to be detected through the light splitting device and the light guiding device, and a motor and a driver which filter rotation wheel movement in a traditional blood coagulation analyzer depends on are eliminated. Working is reliable and cost is low.

The invention relates to a multi-layer blood sample analyzer and relates to the technical field of blood coagulation analyzers. According to the technical schemes of the invention, the multi-layer blood sample analyzer comprises a multi-layer rack, a detection module, a reagent refrigeration disc, a reaction cup incubation disc, a sample frame conveying module, a sampling and sample adding module, an emergency treatment module and a reaction cup conveying module; the multi-layer rack comprises a detection layer and a sample layer arranged at the bottom of the detection layer; the reaction cup incubation disc is arranged on the outer side of the reagent refrigeration disc in a surrounding manner and is rotationally connected with the detection layer; and the sampling and sample adding module comprises a first sample adding device, a second sample adding device and a third sample adding device which are distributed around the reaction cup incubation disc and are detachably connected to the detection layer. With the multi-layer structure adopted, the occupied area of the whole instrument is greatly reduced; and the layout of each module of the detection layer is redesigned, so that the installation, maintenance and upgrading of the instrument are facilitated, and the overall size and weight of the instrument are reduced.

The invention discloses a cleaning fluid and application thereof.The cleaning fluid comprises an anti-reprecipitation agent and an auxiliary surfactant, the anti-reprecipitation agent comprises a water-soluble high-molecular polymer containing strong polar groups, and the auxiliary surfactant comprises at least one of an anionic surfactant and a nonionic surfactant; the cleaning solution is used for cleaning the blood coagulation analyzer, the cleaning effect is better, and the cleaning solution has no influence on the detection result.

The invention discloses a reagent shelf, a storage device and a blood coagulation analyzer, the storage device comprises a mounting rack, the mounting rack comprises a placing surface for placing the reagent shelf, the placing surface is inclined relative to a horizontal plane, and an included angle between the placing surface and the horizontal plane is a first angle. A plurality of mounting hole sites for placing reagent containers are formed in the reagent shelf, when the reagent containers are respectively accommodated in the mounting hole sites, the bottommost ends of the reagent containers are positioned in a working plane, the reagent shelf comprises a contact bottom surface, when the contact bottom surface is parallel to the horizontal plane, the working plane is inclined relative to the horizontal plane, the included angle between the working plane and the horizontal plane is the first angle, and the inclination direction of the placing face relative to the horizontal plane is opposite to the inclination direction of the working plane relative to the horizontal plane. According to the storage device and the blood coagulation analyzer, the normal suction of a reagent is not influenced while condensed water is conveniently treated.