295 results about "End stages" patented technology

Existing multi-band/multi-mode (MB/MM) power amplifiers (PAs) use separate signal paths for the different covered frequency bands. This results in a large degree of hardware duplication and to a large die size and cost. Solutions that achieve hardware sharing between the different signal paths of MB/MM PAs are shown. Such sharing includes bias circuit and bypass capacitors sharing, as well as sharing front-end stages and the output stage of the PA. Signal multiplexing may be realized in the transmitter or at the PA front-end while the signal de-multiplexing can be realized either in the PA output stage or at the front-end of the output stage. Such circuits can be applied with saturated and linear MB/MM PAs with adjacent or non-adjacent bands.

The present invention provides methods of treating TNF-α-mediated disorders, the methods generally involving administering to an individual in need thereof effective amounts of pirfenidone or a pirfenidone analog and a second therapeutic agent that reduces TNF-α synthesis or that reduces TNF-α binding to a TNF receptor. The present invention further provides methods for treating non-alcoholic steatohepatitis, the method generally involving administering to an individual in need thereof an effective amount of pirfenidone. The present invention further provides methods of treating end-stage or advanced Type II diabetes, the methods generally involving administering to an individual in need thereof effective amounts of pirfenidone and insulin.

The combination of a HMG CoA reductase inhibitor like a statin, such as simvastatin, with a pFox inhibitor such as trimetazidine (“Simetazidine”) is particularly advantageous for treatment of end-stage complications, such as acute coronary syndrome (ACS) and chronic angina, especially in type II diabetics. The combination therapy is also useful in the treatment and/or prevention of chronic heart failure (CHF) and peripheral arterial disease (PAD). The combination of a nitric oxide (NO) mechanism with increased NO production with pFox inhibition simultaneously treats both the effect and the cause of angina. One or more oral hypoglycemic compounds (biguanides, insulin sensitizers, such as thiazolidinediones, α-glucosidase inhibitors, insulin secretagogues, and dipeptidyl peptidase IV inhibitors), protein kinase C (PKC) inhibitors, and acetyl-CoA carboxylase inhibitors can also be used in combination with the HMG CoA reductase inhibitors and/or pFox inhibitors, especially in type II diabetics, to control glucose levels and treat endothelial dysfunction. The drugs can be given in combination (e.g. a single tablet) or in separate dosage forms, administered simultaneously or sequentially. In the preferred form the statin is given in a dose of between 5 and 80 mg/day in two separate doses, and the pFox inhibitor is administered in a sustained or extended dosage formulation at a dose of 20 mg three times a day or 35 mg two times a day. The dose of the oral hypoglycemic, PKC inhibitor, or acetyl-CoA carboxylase inhibitor varies with the type of drug used.

The invention discloses a CIK cell, as well as a preparation method and a cell preparation thereof. The method for preparing the CIK cell comprises the following steps: placing a separated mononuclear cell in a culture fluid containing phytohemagglutinin; transplanting the mononuclear cell into a culture flask enveloped by antiCD3 monoclonal antibody and antiCD28 monoclonal antibody after the cell is cultured for 24 to 72 hours; and adding a culture fluid containing IL-1alpha and IL-2 into the culture flask to keep on culturing for 5 to 15 days, and separating the cells into different flasks to be cultured every 2 to 3 days. The CIK cell prepared by the method has the characteristics of obvious improved cell proliferation, great increase of CD8 cell proportion, wide antineoplastic spectrum and strengthened antineoplastic activity. The CIK cell and the cell preparation can effectively prevent the metastasis and the recrudescence for of postoperative patients with tumor, can be combined with chemicotherapy to effectively reduce toxic and side effects of the chemicotherapy, strengthens the survivability tolerance of the patients to improve healing efficacy, and can obviously prolong lifecycle to of end-stage patients so as to improve the life living quality.

A display panel drive circuit includes a shift register constructed of unit circuits connected in stages. The unit circuits generate signal line selection signals, respectively, which signal line selection signals are made active for a respective certain period of time to form a respective pulse, and the pulses are outputted successively from respective unit circuits in order of ordinal number starting from a first stage until an end stage. In at least one embodiment, each of the unit circuits receive (i) clock signals generated based on a sync signal received from outside of the display panel drive circuit, (ii) a start pulse signal generated based on the sync signal, or a signal line selection signal generated in a stage different from its own stage, and (iii) a clear signal. The clear signal is made active in a case where anomalousness is included in the sync signal, and no pulse is outputted from the shift register until a subsequent vertical scanning period starts. This configuration achieves a display panel drive circuit which prevents display disorder or holds down increase in load given to a power source, each of which occurs in a case where anomalousness is included in the sync signal.

A freestanding candle has a flame-resistant sheet adhered to a wick support and to a fuel body in a location proximate to the lower end of a wick. The sheet reduces the risk of fire hazards that arise during the later stages of candle burning, which are characterized by a thin candle floor and a pool of liquid fuel surrounding the wick support. The wick support is made longer and sealingly adhered to the sheet to further reduce the risk of fire hazards. The structural combination of the wick support, the sealant, and the sheet facilitates even burning during the life of the candle and self-extinguishment of the flame at the end stage of burning.

A system and method for converting an analog signal to a digital signal is provided. The analog to digital conversion is achieved without a dedicated sample-and-hold circuit. An ADC stage, preferably the front-end stage in the case of a pipeline ADC, samples the input voltage within a quantizer and within a residue generator. The sampling is performed with associated clocking signals and with switch capacitors also fulfilling the comparison with threshold voltages, within the quantizer and the generation of a residue signal within the residue generator.

Disclosed are a method for adequately sorting used secondary batteries; a rebuilt battery pack that incorporates the used batteries sorted by the sorting method and have identical characteristics; a vehicle and a battery operated device which use the rebuilt battery pack; and a method for manufacturing a rebuilt battery pack which employs used batteries having identical characteristics. The method for sorting used secondary batteries includes a resistance measurement step for measuring the battery resistance of a battery the characteristics of which show a bathtub curve with respect to the period of use. The method further includes a resistance distinguishing step for distinguishing whether the battery resistance of the battery is greater or less than a period threshold value for identifying to which one of the following periods the battery belongs: an initial-stage high-resistance period, and end-stage high-resistance period, and a middle-stage low-resistance period.

The invention discloses a debug method based on substation integrated automation and relaying protection system integration. The method comprises the following steps that at a previous preparation stage, substation primary equipment and secondary equipment are known preliminarily, comprehensive automatic system performance, specific devices and protection screen functions are grasped comprehensively, and the requirement for system debug is met. In a debug stage, comprehensive detailed tests are carried out combined with the design requirement and the system functions, and accordingly pilot run requirements of a substation are met. In a pilot run stage, whether a protection device, a back stage and telecontrol information are correct under the situation that all of the primary equipment and the secondary equipment are put into operation. In a debug ending stage, problems found in pilot run are dealt with, whole work is cleared up and about to end, and the comprehensive automatic system functions are improved.

A transponder receiver for detecting different radio frequency (RF) interrogation mode signals having relatively wide and narrow bandwidths about a common RF center or carrier frequency. A front end stage of the receiver has a preselector with a wide band RF filter for passing both of the wide and the narrow bandwidth interrogation mode signals about the RF center frequency, and a mixer for converting signals from the preselector to frequencies within an intermediate frequency (IF) band. A first IF channel has a narrow band IF filter with a pass band sufficiently wide to pass first IF signals corresponding to the narrow bandwidth interrogation mode signals, but to reject signals corresponding to undesired interfering signals at frequencies near the narrow bandwidth interrogation mode signals. A second IF channel has a wide band IF filter with a pass band sufficiently wide to pass second IF signals corresponding to the desired wide bandwidth interrogation mode signals. The receiver may be incorporated in a transponder for operation in narrow IFF Modes 1-4, C and S, and in wide IFF Mode 5, with optimum performance in all modes.

There are provided a process and the like for judging a residual lifetime of a run-flat tire and an end stage of the residual lifetime thereof during continuous running at a run-flat state. The process for judging the residual lifetime of the tire of the invention is characterized in that in a vehicle equipped with a run-flat tire system comprising run-flat tires 2 and detection units 4 each arranged in the respective tire 2 and capable of measuring an atmosphere temperature in at least an interior 3 of the tire 2, when the tire 2 is continuously run at the run-flat state by an extreme lowering of an internal pressure accompanied with the occurrence of puncture or the like, after a limit temperature being statistically an occurrence of trouble is previously set, the atmosphere temperature inside tire of the run-flat tire continuously running at the run-flat state is measured, and a runnable time and/or distance until the run-flat tire results in trouble is predicted by using the atmosphere temperature inside tire measured and data calculated therefrom.

The invention relates to a parallel coupling method for a global system mode, belonging to the technical field of coupling of the global system mode. The parallel coupling method comprises the following three stages of: firstly, an initial coupling stage based on a subdomain mapping relation, wherein a running process in a given initial coupling stage is modified to generate a dynamic subdivisionand a parallel route which are based on an interpolation algorithm and used for parallel communication and parallel interpolation; secondly, a coupling operation stage which is based on subdomain mapping and is realized by correspondingly modifying running processes of the parallel communication and the parallel interpolation in a given coupling operation stage; and thirdly, a coupling end stage which adopts a given method. The parallel coupling method is based on the subdomain mapping and considers the parallel communication and the parallel interpolation of a coupler in a combined manner toeliminate a communication operation in the parallel interpolation process of the coupler, so that the communication frequency of an entire system is reduced. The parallel coupling method is applied to the coupler and aims to improve the coupling property of the global system mode.