A safe and fuel-efficient automatic pressure-regulating wheel is characterized in that the safe and fuel-efficient automatic pressure-regulating wheel comprises a sealing mechanism, a wheel mechanism and a pressure-regulating mechanism; the sealing mechanism is provided with a seal and a sealing ring; the wheel mechanism comprises a main wheel and an auxiliary wheel, wherein the main wheel is provided with a rim supporting ring while the auxiliary wheel is provided with an auxiliary rim supporting ring; and the pressure-regulating mechanism is provided with a bi-metal drum inside which a surge chamber is disposed, and a plenum chamber is arranged outside the bi-metal drum. The safe and fuel-efficient automatic pressure-regulating wheel has the advantages that with the functional material bi-metal drum as the tire pressure-regulating device, an air chamber of the tire is divided into the plenum chamber and the surge chamber, and when the temperature of the tire rises, an active layer on the inner wall of the bi-metal drum swells, and the drum waist of the bi-metal drum depresses toward the surge chamber along with the active layer, so that the volume of the plenum chamber of the tire increases, and tire pressure drops, and when the temperature of the tire drops, the active layer of the bi-metal drum shrinks, the drum waist of the bi-metal drum returns the plenum chamber, and the pressure in the plenum chamber recovers, so that the purposes of automatically regulating pressure, preventing a flat tire and driving with fuel-efficient effect are realized.