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Blood coagulation analyzer

A technology of blood coagulation and analysis equipment, which is applied in the direction of analysis materials, measurement equipment, and material analysis through optical means, and can solve the problems that the influence of interfering substances cannot be ignored

Active Publication Date: 2012-08-15
HITACHI HIGH-TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] When using optical means, the influence of interfering substances (heme, bilirubin, chyle) in the sample cannot be ignored, and efforts have been made to eliminate these influences

Method used

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Embodiment Construction

[0028] Hereinafter, embodiments of the present invention will be described with reference to the drawings.

[0029] figure 1 An overview of a blood coagulation analysis device embodying the present invention is shown. A sample is dispensed into the optically transparent reaction container 101 by a sample dispensing mechanism (not shown), and a reagent is dispensed into the reaction container 101 by a reagent dispensing mechanism (not shown).

[0030] Light is irradiated from a single-wavelength light source 102 (LED, laser, etc.) to the mixed solution of the sample and reagent in the reaction container 101, and the multiple detectors 103a-103b (photodiodes, phototransistors, etc.) Scattered light from this liquid mixture is received. In this embodiment, the detectors 103a to 103b are set to be arranged on a horizontal plane including the optical axis of the single-wavelength light source 102, and the direction coincident with the optical axis is set to 0°.

[0031] That is,...

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Abstract

Provided is a blood coagulation analyzer whereby both of an adequate dynamic range and a high sensitivity can be achieved in analyzing blood coagulation, without using any complicated device, by selecting an appropriate detection angle depending on the scattering light intensity of each specimen. The blood coagulation analyzer comprises: a reactor (101) in which a sample and a reagent are mixed together and reacted; a light source (102) for irradiating the reactor (101) with light; multiple detectors (103a, 103b), which are positioned around the reactor (101) at different angles to the light axis of the light from the light source (102), for detecting scattering light generated from the liquid mixture of the sample and the reagent; a memory unit (107) for inputting and memorizing multiple light intensity change data over time obtained from the detectors (103a, 103b); a determination unit (106) for selecting, depending on the amount of light intensity change, light intensity change data to be used in calculating blood coagulation time from among various light intensity change data stored in the memory unit (107); and a calculation unit (108) for calculating the blood coagulation time based on the light intensity change data selected by the determination unit (106).

Description

technical field [0001] The present invention relates to a blood coagulation analysis device which mixes plasma and blood coagulation reagent to precipitate fibrin, and measures blood coagulation time by optical means. Background technique [0002] Blood flows fluidly inside the blood vessel, but when bleeding occurs, coagulation factors present in plasma and / or platelets are activated in a chain, fibrinogen in plasma is converted into fibrin and precipitated, thereby achieving hemostasis. [0003] Such blood coagulation properties include an intrinsic coagulation property for hemostasis in tissue internal bleeding and an exogenous coagulation property for hemostasis in bleeding caused by trauma or the like. As the measurement items related to blood coagulation, there are prothrombin time (PT) of extrinsic blood coagulation reaction test, activated partial thromboplastin time (APTT) of endogenous blood coagulation reaction test, fibrinogen amount ( Fbg) etc. These items are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/86G01N21/75G01N33/49
CPCG01N33/4905G01N33/86G01N2021/825G01N21/532G01N21/82G01N2021/4711G01N21/51G01N33/18G01N33/1826
Inventor 牧野彰久三村智宪田村辉美足立作一郎
Owner HITACHI HIGH-TECH CORP
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