41 results about "Coagulation analyzers" patented technology

The invention discloses a detection method for heparin content. The detection method comprises the steps of mixing a sample to be tested with an FXa activity detection reagent by a developing substrate method to obtain a mixture, incubating the mixture, and detecting the signal intensity of a developing substrate; and finally calculating signal intensity and comparing the calculated signal intensity with a standard curve to obtain the heparin content of the sample to be tested, wherein the developing substrate is a developing substrate of an activated factor X (FXa) and is selected from any one of the following substrates of Benzoyl-Ile-Glu-Gly-Arg-p-nitroanilide.HCl, CH3O-CO-D-CHA-Gly-Arg-p-nitroanilide.AcOH, Acetyl-D-Arg-Gly-Arg-p-nitroanilide.2HCl and 4-Nz-D-Arg-Gly-Arg-p-nitroanilide.2HCl. The detection method disclosed by the invention can be used for detecting general non-graded heparin, low-molecular-weight heparin and fondaparinux; furthermore, according to the detection method, the detection stability and the repetitiveness are high, the heparin content can be reflected accurately, the sensitivity and the accuracy are extremely high, and the optimal dosage range of the heparin can be found out quickly, so that a patient does not need to be detected for multiple times. Moreover, the detection method can be also used on an automatic instrument such as a coagulation analyzer or a biochemical analyzer, so that automation is realized, and clinical popularization and application can be assisted; the detection method has the characteristics of simplicity in operation, high sensitivity and high repetitiveness.

The invention provides a coagulation analyzer, a sample conveying device and a cup conveying method. The sample cup conveying device comprises a sample cup feeding mechanism, a sample cup bearing mechanism and a sample cup conveying mechanism, wherein the sample cup feeding mechanism is used for supplying sample cups with magnetic beads to loading positions; the sample cup bearing mechanism comprises a feeding block used for bearing the sample cups and a magnetic piece arranged on the feeding block, the feeding block has a bearing cavity, the bearing cavity is used for accommodating the samplecups supplied by the sample cup feeding mechanism at the loading position, and the magnetic piece is used for attracting magnetic beads of the sample cup located in the bearing cavity; and the samplecup conveying mechanism is used for enabling the sample cup bearing mechanism to move between the loading position and an unloading position so as to convey the sample cups from the loading positionto the unloading position. In the sample cup conveying process, the magnetic part can attract the magnetic beads in the sample cup in the bearing cavity, so that the positions of the magnetic beads are fixed, the magnetic beads are prevented from moving along the arc-shaped bottom part of the sample cup, the magnetic beads are prevented from falling off, and the detection accuracy rate is improved.

The invention relates to a blood coagulation factor and fibrinolysis measuring method, which is used for testing by using a semi-automatic blood coagulation analyzer. The blood coagulation factor and fibrinolysis measuring method comprises the following testing steps of: collecting a patient blood sample and separating blood plasma out; injecting the blood plasma into a testing cup by using a sample feeding gun; putting the testing cup in a blood coagulation factor measuring device, adding a reagent, starting a timing button of the blood coagulation factor testing device, and testing the blood plasma in the testing cup by the blood coagulation factor testing device according to a double magnetic circuit magnetic bead method; and injecting the blood plasma into a fibrinolysis testing cup by the sample feeding gun, putting the fibrinolysis testing cup in a fibrinolysis testing device, adding a reagent, starting a timing button of the fibrinolysis testing device, testing the blood plasmain the fibrinolysis testing cup by the fibrinolysis testing device according to a photoelectric turbidimetry, and printing and outputting fibrinolysis data after the testing by the fibrinolysis testing device is ended. The blood coagulation factor and fibrinolysis measuring method disclosed by the invention is simple and convenient and greatly reduced in cost.

Provided are a method and an apparatus that enable rapid and automatic determination of the coagulant injection rate in a process of water treatment through coagulation and sedimentation. Using a coagulation analyzer comprising sample tanks 1 A to 1 D each for keeping a predetermined amount of raw water, a water supply pump 7 , water supply / discharge valves 4, 6 for raw water and washing water, mixers 3 A to 3 D, a coagulant injection unit 21 , and a detector 30 for determining the particle size and the particle number of flocs, the time within which the coagulant 20 injected into the sample tanks is dispersed by mixing and the particles begin to agglomerate (agglomeration start time) is determined, and based on the thus-determined agglomeration start time, the coagulant injection rate is determined, or the amount of the coagulant to be injected is controlled.

The invention provides a thrombin-like enzyme titer determination method. According to the invention, blood coagulation quality control plasma is adopted as a substrate, and determination is carried out by using a blood coagulation analyzer. With the thrombin-like enzyme, fibrinogen in the plasma can be directly hydrolyzed into fibrin, such that the plasma is coagulated. With a principle that plasma coagulation time is inversely proportional to the thrombin-like enzyme titer within a certain thrombin-like enzyme concentration range, the titer of the thrombin-like enzyme is obtained. With the method provided by the invention, product titer differences caused by different criteria of surveyors upon coagulation terminal points and differences in human-citric acid plasma are avoided. Therefore, highly efficient and accurate determinations upon thrombin-like enzyme are realized.

The invention discloses a preparation method and application of D-dimer immuno latex microspheres. In the preparation method of D-dimer immuno latex microspheres, a chemical crosslinking method is optimized, the carboxyl of polystyrene microsphere is activated in a low-pH condition and then coupled with amino of an antibody dissolved in a high-pH condition, and the mixture of the two is neutral and is coupled for 12-24h at a low temperature, so that not only can the coupling efficiency of the antibody be guaranteed, but also the damage of the antibody activity caused by an activator is reduced to a great extent. A latex enhanced turbidimetric immunoassay D-dimer test kit prepared from the immuno latex microspheres prepared by the method has the characteristics of high sensitivity, accurate quantification, good repeatability and stable property, and the lowest detection limit can reach 0.01mg / L; the latex enhanced turbidimetric immunoassay D-dimer test kit can be applied to a full-automatic biochemical analyzer or coagulation analyzer, is quick and easy to operate, only needs 5-10 minutes from detection to result collection and has relatively good clinical application prospect.

The invention provides an acceleration sensor signal compensation method for a thrombelastograph coagulation analyzer. Interference of sampling noise signals is eliminated through N-point mean filtering; meanwhile, a piezoelectric sensor technology is used, a vibration signal digital model is analyzed, vibration noise caused by vibration is eliminated, and effective dynamic signals are reserved; the frequency and amplitude of vibration have periodicity and randomness, and a good effect cannot be achieved under special conditions completely through a digital signal processing technology when the vibration is overlapped with effective signals, so that when feedback signals of a piezoelectric sensor are highly related with the vibration noise, the feedback signals of the piezoelectric sensorare input to compensate the dynamic signals to achieve a better filtering effect.

The invention provides a portable mobile blood clotting analyzing system, and belongs to the technical field of mobile medical treatment. The portable mobile blood clotting analyzing system comprises a blood clotting analyzer and a mobile terminal, wherein the blood clotting analyzer is connected with the mobile terminal and is used for testing a sample; and after the blood clotting analyzer is wirelessly connected with a mobile terminal APP (application), a testing result is transmitted to a mobile terminal, the mobile terminal displays data, and measurement control is carried out. Terminal equipment such as a smart phone and a tablet personal computer and a Bluetooth communication function of a wireless medical piezoelectric sensing system are used, a display and functional keys of the blood clotting analyzing device are omitted, the blood clotting analyzing device is simple in structure and is stable in system, the size of the blood clotting analyzing device is reduced, the power consumption is low when the blood clotting analyzing device runs normally, and the feasibility of application is high.

The invention discloses a fully automatic coagulation analyzer and an analysis method thereof. The fully automatic coagulation analyzer comprises: a frame, a cup supply mechanism, an incubation mechanism, a photoelectric detection mechanism and a waste material mechanism arranged in sequence at the bottom of the frame , a three-dimensional needle mechanism arranged on the top of the rack and a three-dimensional manipulator mechanism arranged on the rack and between the incubation mechanism and the three-dimensional needle mechanism; one side of the incubation mechanism is provided with a A sample mechanism and a reagent mechanism for storing reagents; the three-dimensional manipulator mechanism is used to transport the cuvettes on the incubation position to the detection position for detection and then to the waste mechanism. When the cuvette is transported by the three-dimensional manipulator mechanism, the cup feeding mechanism, the incubation mechanism, the photoelectric detection mechanism and the waste mechanism are arranged in sequence, the three-dimensional manipulator mechanism has fewer operations, and the transportation difficulty is lower, which is beneficial to the three-dimensional manipulator mechanism for transporting the cuvette. reliability and saves time.