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Controlled blood delivery to mixing chamber of a blood testing cartridge

A blood box and mixing chamber technology, applied in the field of controlled mixing of reagents and blood, can solve problems such as blood leakage and inability to provide reagents, and achieve efficient utilization

Active Publication Date: 2019-08-09
CA卡西索有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the task is manually intensive
Many automated systems for testing blood have been implemented, but they suffer from blood leakage problems, adding reagents to the blood prematurely or failing to deliver the proper reagents to the blood in the correct order

Method used

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  • Controlled blood delivery to mixing chamber of a blood testing cartridge
  • Controlled blood delivery to mixing chamber of a blood testing cartridge
  • Controlled blood delivery to mixing chamber of a blood testing cartridge

Examples

Experimental program
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Embodiment Construction

[0034] refer to Figure 1A to Figure 3 , some embodiments of the blood testing system 100 include an analyzer console 140 and one or more cartridges 120 configured to releasably engage the analyzer console 140 . In this embodiment, blood testing system 100 is a thromboelastometry system configured to determine a plurality of blood clotting properties of a blood sample input into cartridge 120 . For example, cartridge 120 may be configured as a single-use cartridge that includes a vacutainer sample tube or other blood container structure for use with blood sample container 10 (e.g., supplied by Becton, Dickinson & Company of Franklin Lakes, NJ). ) matched blood sample receiver 122. In some cases, adapters may be used to couple other types of blood sample containers 10 to cartridge 120 (eg, tubes may be used through which blood may be injected into cartridge 120, etc.). The thromboelastometry system 100 may be used as a whole blood coagulation analysis system, which is particu...

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PUM

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Abstract

Embodiments of a blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. In some embodiments, the blood coagulation testing system includes a single-use cartridge component configured to measure and mix reagents with blood received from a blood sample reservoir. A mixing chamber in the single-use cartridge includes different reagent beads that, when exposed to a pre-determined volume of blood, dissolve and mix specific reagents with the blood. The assembled blood cartridge further includes configurations that are designed to prevent blood from prematurely mixing with reagent beads in the mixing chamber and to guide blood flow in the mixing chamber to dissolve reagent beads in a desired order.Thus, the mixture obtained from the mixing chamber can be readily utilized to generate results for the blood coagulation testing system.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Patent Application No. 15 / 253,121 filed August 31, 2016, which is hereby incorporated by reference in its entirety for all purposes. technical field [0003] This document relates to systems and methods for testing properties of blood samples, and more particularly to controlled mixing of reagents with blood in blood cartridge devices for blood coagulation analysis. Background technique [0004] Hemostasis is the body's response to blood vessel damage and bleeding. Hemostasis involves the coordinated efforts between platelets and a number of clotting proteins (or clotting factors) that lead to the formation of a blood clot and subsequent cessation of bleeding. [0005] Various methods have been introduced to assess the potential of blood to form an adequate clot and to determine clot stability. Common laboratory tests, such as platelet count or determination of fibrin concentrat...

Claims

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Application Information

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IPC IPC(8): B01L3/00A61M39/00G01N33/48
CPCG01N35/1097G01N35/1079G01N2035/0436B01L3/502746B01L2200/0621B01L2200/0668B01L2400/086G01N1/38G01N33/86B01F33/452B01F33/813
Inventor 罗伯特·希尔曼迈克尔·M·戈林科里·李·麦克拉斯基胡贝特·马丁·施魏格尔
Owner CA卡西索有限公司
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