343 results about "Plasma viscosity" patented technology

A medical device with an implantable blood pump and a control and sensing unit configured to determine the flow rate generated by the blood pump when driven by an electric motor, wherein the flow rate is determined using peak-to-peak current data generated by the electric motor and, in some cases, associated heart rate data. In some embodiments, the validity of pulsatility of the resulting blood flow is determined and, if out of predetermined limits, an alarm may be actuated.

The invention relates to the technical field of hemodialysis monitoring, and provides a hemodialysis on-line monitoring system and method, and the system comprises a data acquisition module which is used for collecting blood physiological parameters in a dialysis pipeline in real time; the blood component analysis module is connected with a blood loop of the dialysis machine and is used for detecting serum iron, ferritin and ferritin saturation indexes on line; and the data processing module is used for calculating the risk index of anemia, evaluating the iron utilization rate, constructing a model for measuring the iron deficiency erythropoiesis trend according to the collected and analyzed data, and training and optimizing the model. According to the method, individual parameters of patients are fused, personalized calculation is performed for iron metabolism rates and dialysis parameters of different patients, and data such as iron content, blood flow and dialysis fluid volume are acquired online in real time, so that iron concentration and infusion rate are accurately matched with real-time iron metabolism requirements of the patients, and anemia of the patients in the dialysis process is reduced.

The invention relates to an adjusting system applied to continuous kidney replacement treatment of acute kidney injury patients. Comprising the following steps: capturing the blood flow velocity and vascular endothelial permeability of glomerular capillaries in real time by using a micro sensor or a nano-scale optical imaging technology; the method comprises the following steps: pre-judging a risk time point of insufficient tissue perfusion through dynamic modeling of a capillary structure and a functional relationship; combining the microcirculation data with conventional biochemical indexes of the patient to create an early intervention model; when it is monitored that microcirculation perfusion is greatly reduced or kidney oxygen supply is insufficient, continuous renal replacement therapy CRRT parameter fine adjustment is triggered in advance; the method comprises the following steps: collecting plasma toxins of different patients at clinical and molecular levels, and constructing a common toxin map of the acute kidney injury AKI; whether the specific toxin concentration exceeds the standard or not is judged by combining a real-time sensor, and the removal priority is output in real time; a membrane material with an adjustable aperture or a special coating is adopted, so that inflammatory mediators and bacterial endotoxin molecules are adsorbed or intercepted, and the permeability of micromolecular electrolyte is kept.

The invention relates to the field of medical materials and medical instruments, and discloses a dry bioprosthetic valve and a preparation method thereof.The preparation method comprises the following steps that S1, pericardium and a cross-linking agent solution are mixed for a cross-linking reaction; s2, carrying out first dehydration treatment on the crosslinked pericardium by adopting a first dehydration solution with gradually increased concentration gradient under an ultrasonic condition; and S3, carrying out second dehydration treatment on the pericardium subjected to the first dehydration treatment by adopting a second dehydration solvent, so as to obtain the dried bioprosthetic valve. According to the preparation method provided by the invention, ethanol, isopropanol and water in a specific proportion are adopted to prepare a dehydration solution with gradient concentration, and two-step dehydration drying is carried out in combination with the physical effect of an ultrasonic technology and glycerol, so that rapid rehydration of the bioprosthetic valve is realized, and the original shape and mechanical property of the bioprosthetic valve can be better recovered after rehydration; and the immediate hemodynamic stability of the valve is improved.

The invention relates to the technical field of medical monitoring, and discloses an intelligent monitoring device for a blood return end of hemodialysis, the device is in communication connection with a dialyzer for hemodialysis, and the device comprises an alarm trigger module, a temperature compensation module and a screen display module. According to the application, the alarm triggering module accurately monitors the blood return temperature, the blood return flow velocity and the induced blood flow velocity, captures abnormity in real time and triggers alarm; the temperature compensation module not only guarantees life safety of the patient, but also improves temperature control adaptability; the screen display module displays core parameters and trend curves in real time, space limitation is broken through, and medical workers are assisted in remote quick response; the portability of the device is realized by the micro clamping and fixing module; the clinical flexibility is enhanced through threshold adjustment; the power-on self-test further ensures the operation safety of the equipment; therefore, full-process optimization from data monitoring, intelligent control to remote monitoring is realized, and accurate, safe and personalized dialysis support is provided for patients.

The invention discloses a COF electrostatic spinning wound dressing with near-infrared response and antioxidant activity and a preparation method of the COF electrostatic spinning wound dressing, and belongs to the field of application materials and technologies. The COFs are synthesized from cobalt hexafluorophthalocyanine (CoPcF16) and ellagic acid (EA). The COFs is prepared into the spinning membrane, and the COFs spinning membrane has very strong oxidation resistance, can effectively remove excessive endogenous ROS, can respond to near infrared to generate exogenous ROS, and can effectively kill bacteria at a wound and improve blood flow and healing of the wound. The COFs spinning membrane prepared by the invention is simple and convenient in preparation method, good in biocompatibility, strong in oxidation resistance and capable of responding to near infrared to produce ROS, and has strong application potential in the field of treatment of a series of infected wounds, especially treatment of diabetic foot ulcers.

A blood pump-oxygenator system (250A, 250B, 250C) for increasing perfusion and oxygen levels in the body of a patient (P), comprising: a blood inlet (80) and a blood outlet (90) connected to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of the blood of the patient; a first blood pump (11) and a first oxygenator (20), wherein the first blood pump (11) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the first oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The system further comprises a second blood pump (13) and a second oxygenator (21), wherein the second blood pump (13) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the second oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The circuit comprises a first branch (101) and a second branch (102) arranged in parallel with each other, the first branch (101) accommodating the first blood pump (11) and the first oxygenator (20), and the second branch (102) accommodating the second blood pump (13) and the second oxygenator (21). The system further comprises a pump control unit (290) wherein the first and second blood pumps (11, 13) are configured to be controlled by the pump control unit (290) to increase or decrease the blood flow through the corresponding oxygenator (20, 21) by changing the proportion of the blood flow through the first and second oxygenator (20, 21).

The invention provides a balloon endoscopic system for intravascular direct vision examination, and relates to the technical field of medical instruments, the balloon endoscopic system comprises a catheter, a balloon capable of being filled and discharged, an endoscope lens, a light source assembly and an image transmission processing module, a cavity channel used for containing the endoscope lens and a conduction component of the light source assembly is formed in a catheter body of the catheter, and the catheter body of the catheter is internally provided with a cavity channel used for containing the endoscope lens and the conduction component of the light source assembly; the filling pipeline is used for supplying liquid to the inflatable and deflatable balloon; the inflatable and deflatable balloon is fixedly connected to the outer surface of the front end of the catheter, and the inflatable and deflatable balloon is used for bulging after being conveyed to a target position in a blood vessel. The inflatable and deflatable balloon can block blood flow and open the blood vessel wall after bulging and is matched with transparent filling liquid injected into the filling pipeline, residual blood can be further removed, a blood-free observation window is formed, interference of blood on imaging is avoided, and a foundation is laid for clearly observing the condition of the blood vessel wall. The inner wall of the balloon is coated with a nano anti-fog coating, so that the penetrability of a light source is ensured, and the fogging surface influence caused by blood residue or temperature difference can be avoided.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

Described herein are sensors for measuring various parameters. The sensors may be used in systems, devices, and methods for controlling blood flow or for measuring (e.g., monitoring) blood pressure, pH, or analyte levels such as a lactate level, an oxygen level, and / or a carbon dioxide level. The sensors may include a membrane configured to generate a measurable response (e.g., a change in an electrical signal such as resistance, capacitance, current, voltage) when the membrane interacts with a parameter of interest. In some instances, the sensors may include a piezoresistive MEMS subassembly. In other instances, the sensors may include an electrochemical membrane.

A containing element is used to capture material in a blood vessel for removal. The containing element is advanced through the blood vessel or a catheter in a constricted configuration. A control body is coupled to the containing element which assists moving the containing element. In some embodiments, the containing element is used for restricting blood flow within a vessel.

The present invention provides a traditional Chinese medicine composition for clearing heat, removing blood stasis, stopping bleeding and regulating menstruation, and a preparation method thereof, relating to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention comprises the following components: catalpol, aucubin, β-sitosterol, emodin, chrysophanol, sanguisorba officinalis extract, Panax notoginseng saponins, septamine, cuttlefish scaly, rubiacin, typhaneuroside, and p-coumaric acid; the components synergistically work together to significantly reduce plasma prothrombin time and plasma recalcification time, and significantly reduce the whole blood viscosity, plasma viscosity, and hematocrit of rats with blood stasis syndrome. The traditional Chinese medicine composition of the present invention is used in the preparation of drugs for menstrual disorders or menstrual bleeding and metrorrhagia, and has a significant therapeutic effect on irregular menstruation, excessive menstrual bleeding, or metrorrhagia.

The invention relates to the field of medical instruments and public health, in particular to an artificial blood vessel with anticoagulation, endothelium promotion and bending resistance functions and a preparation method of the artificial blood vessel, and the artificial blood vessel is used for various blood vessel replacement and blood vessel bypass operations and has the characteristics of anticoagulation, endothelium promotion and bending resistance. The copper-containing material and the degradable magnesium-based metal material are respectively integrated on the inner surface of the artificial blood vessel and in the interlayer of the vessel wall, so that the functions of anticoagulation, endothelium promotion and bending resistance of the artificial blood vessel are realized. According to the artificial blood vessel with the anticoagulation, endothelium promotion and bending resistance functions, in the initial stage of use, due to the spiral structure of the magnesium alloy wire, the blood vessel cannot collapse after being bent, the blood flow is kept smooth, copper ions, magnesium ions and a small amount of hydrogen can be released to surrounding tissues in the use process, the microenvironment of the surrounding tissues is adjusted to be alkalescent, and the blood circulation is kept smooth. Through the synergistic effect of the copper ions and the magnesium alloy, the effects of promoting endothelialization, resisting blood coagulation and adjusting the acid-base property of the microenvironment are achieved at the same time, and therefore the functions of resisting blood coagulation, promoting endothelium and resisting bending are achieved.

Described herein are sensors for measuring various parameters. The sensors may be used in systems, devices, and methods for controlling blood flow or for measuring (e.g., monitoring) blood pressure, pH, or analyte levels such as a lactate level, an oxygen level, and / or a carbon dioxide level. The sensors may include a membrane configured to generate a measurable response (e.g., a change in an electrical signal such as resistance, capacitance, current, voltage) when the membrane interacts with a parameter of interest. In some instances, the sensors may include a piezoresistive MEMS subassembly. In other instances, the sensors may include an electrochemical membrane.

The invention relates to the technical field of blood purification, in particular to an anticoagulation pump which comprises a bottom plate, an injection pushing mechanism and a liquid medicine feeding mechanism, a hemodialysis machine is fixedly installed on the upper side of the bottom plate, a blood drawing pipe is fixedly arranged on one side of the hemodialysis machine, and an infusion tube is fixedly arranged on the other side of the hemodialysis machine; a round seat frame and a box body are fixedly connected to the upper side of the bottom plate, an injector is clamped in the round seat frame, heparin can be supplemented to the injector through the injection pushing mechanism, the injector, the box body and a piston rod, heparin can be continuously injected, blood is prevented from being coagulated in the hemodialysis machine, and the hemodialysis efficiency is improved. The hemodialysis purification device has the advantages that smooth flow of blood is guaranteed, the injector does not need to be replaced, time and labor are saved during operation, long-time interruption of heparin injection is avoided, improvement of the anticoagulation effect of hemodialysis purification is facilitated, the hemodialysis purification process can be smoothly performed, and meanwhile, the working efficiency of the anticoagulation pump is improved.

The present invention belongs to the field of preparation of diabetes complication remission agents, and particularly relates to a combined preparation for improving microcirculation of diabetic foot and a preparation method thereof. Starting from platelet-rich plasma, the present invention obtains exosomes containing rich active substances such as growth factors through stimulation with calcium gluconate and the like, and loads protamine nanoparticles to obtain bioactive substances with strong antibacterial ability, which can resist the development process of diabetic foot ulcers. The present invention uses bioactive glass, hydroxyethyl cellulose and the like to stabilize the bioactive substances, prolong the in vitro lifespan of the bioactive substances, and modified carboxymethyl cellulose provides better biodegradation effect. The combined preparation prepared by the present invention has less cytotoxicity, better antibacterial effect, can promote wound healing quickly, and the microcirculation index shows that it can stimulate the change of foot blood flow and improve the condition of foot artery blockage, etc.

The invention relates to an intravascular blood pump comprising a pumping device having a pump portion and a drive portion, wherein the pump portion comprises a pump housing having a primary blood flow inlet and a primary blood flow outlet hydraulically connected by a primary passage, and the drive portion comprises a stator and a rotor rotatable about a rotational axis and configured to rotate a primary impeller configured to convey a primary blood flow along the primary passage from the primary blood flow inlet to the primary blood flow outlet, the drive portion further comprising a secondary blood flow inlet and a secondary blood flow outlet hydraulically connected by a secondary passage extending through an axial gap between the rotor and the stator and a secondary impeller arranged at a drive portion end of the rotor and rotatable about the rotational axis together with the rotor.

The present application discloses a hemoperfusion device, which includes a cylinder body. A filter element assembly is arranged inside the cylinder body. A flexible blood bag is arranged at the top of the cylinder body. A flexible liquid bag is arranged inside the cylinder body and is internally connected to the filter element assembly. The volume of the flexible liquid bag can change under the action of an external force. A filter membrane assembly internally connected to the filter element assembly is arranged inside the flexible blood bag. An inlet and an outlet are arranged on the flexible blood bag. Two one-way valves arranged in the same direction are respectively arranged on both sides of the filter membrane assembly. A partition is arranged inside the blood bag. A reflux channel is formed between the partition and the filter membrane assembly, and the interior of the blood bag is divided into a first inner cavity and a second inner cavity. After the blood enters the first inner cavity through the inlet, it flows into the cylinder body from one one-way valve. After the blood is filtered by the filter membrane assembly and the filter element assembly, it flows to the second inner cavity from the other one-way valve. Part of the blood flows out through the outlet, and part of the blood can flow back to the first inner cavity through the reflux channel.

A system may include an outer frame. A system may include an expandable member, wherein the expandable is at least one or both of: disposed in the outer frame, and coupled to a lumen of the outer frame. A system may include a compressible bladder. A system may include a conduit configured to fluidly couple the expandable member to the compressible bladder, wherein forcing an inflation fluid from the compressible bladder to the expandable member is configured to manipulate the expandable member to a restricted blood flow state and forcing the fluid from the expandable member to the compressible bladder is configured to manipulate the expandable member to an unrestricted blood flow state.

The utility model provides a bubble catcher and a blood purification system, and relates to the technical field of medical equipment.The bubble catcher comprises a shell, the shell comprises a top wall and a first side wall, the first side wall is obliquely arranged relative to the top wall, a liquid inlet hole is formed in the top wall, the first side wall is located on the extension side in the axial direction of the liquid inlet hole, and the first side wall is located in the extension side in the axial direction of the liquid inlet hole; liquid flowing out of the liquid inlet hole can fall on the first side wall; the fixing part is arranged on the outer wall of the shell, and the fixing part is used for being fixedly connected with the outside. According to the bubble capturer provided by the embodiment of the invention, the installation work of the bubble capturer can be simplified, and the situation that bubbles are generated or blood cells are damaged due to large fall during blood return can be reduced; meanwhile, due to the fact that the first side wall which is obliquely arranged can play a certain buffering role when the blood flows into the bubble catcher, the blood flow speed can be further increased, and the blood coagulation condition can be reduced.

The utility model discloses an instrument for negative pressure extraction and filtration of thrombus of an artery. Comprising a sheathing canal, a blocking balloon, a blood collection bag, a pipeline and a negative pressure providing structure, the blocking balloon is arranged on the outer side of the thrombus treatment sheathing canal, then the blood collection bag is connected to the outer side of the sheathing canal through the pipeline, the sheathing canal is connected with the blood collection bag through the pipeline, and a thrombus filter screen is arranged in the pipeline; a negative pressure providing structure is further arranged, the negative pressure providing structure is a structure with a cavity which is arranged on the outer side of the blood collection bag and used for constructing negative pressure by extracting gas in the blood collection bag, power is provided through the negative pressure to lead blood in the arterial blood vessel out into the blood collection bag, and thrombus is blocked at the position of the filter screen after the blood passes through the thrombus filter screen. The filtered safe blood flows into the blood collecting bag, the blood in the blood collecting bag can be transfused back to the patient again in a transfusing mode, and the blood in the blood collecting bag can also provide a blood source for substances for extracting platelet rich plasma (PRP) therapy.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction and a preparation method and application thereof. The traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction is prepared from the following raw materials in parts by weight: 15 to 25 parts of herba taxilli, 18 to 22 parts of semen cuscutae, 8 to 15 parts of radix angelicae sinensis, 3 to 6 parts of radix salviae miltiorrhizae, 18 to 22 parts of radix dipsaci, 8 to 15 parts of herba leonuri, 12 to 18 parts of radix paeoniae alba, 25 to 35 parts of rhizoma dioscoreae, 6 to 12 parts of rhizoma chuanxiong, 3 to 8 parts of radix aucklandiae, 6 to 12 parts of fructus nelumbinis, 10 to 15 parts of radix scutellariae and 12 to 20 parts of roasted rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition obtained through the composition, the dosage and the proportion of the components can remarkably reduce the whole blood viscosity, hematocrit and plasma viscosity of a rat with a blood stasis syndrome, can remarkably reduce the twisting frequency of an experimental dysmenorrhea model rat, has the effects of activating blood, resisting inflammation, dredging collaterals and relieving pain, and has the effect superior to that of each pair of components.

The invention relates to an intravascular blood pump (1) comprising a pumping device (11) having a pump portion (3) and a drive portion (4), wherein the pump portion (3) comprises a pump housing (2) having a primary blood flow inlet (211) and a primary blood flow outlet (22) hydraulically connected by a primary passage (30) and the drive portion (4) comprises a stator (40) and a rotor (41) rotatable about a rotational axis (10) and configured to rotate a primary impeller (31) configured to convey a primary blood flow along the primary passage (30) from the primary blood flow inlet (211) to the primary blood flow outlet (22), the drive portion (4) further comprises a secondary blood flow inlet (23) and a secondary blood flow outlet (24), the secondary blood flow inlet (23) and the secondary blood flow outlet (24) are hydraulically connected by a secondary passage extending through an axial gap (401) between the rotor (41) and the stator (40) and a secondary impeller (42) arranged at a drive portion end (DSE) of the rotor (41) and rotatable about the rotational axis (10) together with the rotor (41), the secondary impeller (42) comprises one or more secondary impeller blades (421) configured to convey a secondary blood flow along the secondary passage from the secondary blood flow inlet (23) to the secondary blood flow outlet (24) in a direction towards a pump portion end (PSE) of the pumping device (11), the rotor (41) is mounted in a blood cleaning radial slide bearing (47) having an inner rotor bearing surface (4211) and an outer rotor bearing surface (4311), and the secondary impeller (42) forms the inner rotor bearing surface (4211) of the radial slide bearing (47).

The utility model discloses a container shell for a blood filter, which is characterized in that a second shell is inserted into one side of a first shell, a volume cavity is formed by the first shell and the second shell, and a filter membrane is arranged on the inner side of the volume cavity; a first flow guide structure is arranged on the inner wall of the first shell, a second flow guide structure is arranged on the inner wall of the second shell, and the first flow guide structure and the second flow guide structure guide liquid in the volume cavity; according to the device, the flow channels of the liquid inlet and the liquid outlet are additionally arranged, the flow guide structures are arranged on the two sides of the flow channels, blood enters the liquid inlet, flows out of the first flow channels and diffuses to the upper surface of the whole filter membrane along a path formed by the first flow guide structures arranged in the first shell in parallel, the blood filtering path is prolonged, the filter membrane and the edge part are fully utilized, and the blood filtering efficiency is improved. The second flow guide structure is arranged continuously or discontinuously and corresponds to the position of the part, with the maximum blood flow, of the liquid inlet.

An oxygenerator (4) has a blood side (2), a gas side (6) and a semi-permeable membrane (8), where the membrane (8) separates the blood side (2) from the gas side (6), the blood side (2) has an inlet (18) and an outlet (20), the gas side (6) has an inlet (14) and an outlet (16), and during operation of the oxygenerator (4), the gas side (6) has an inlet (14) and an outlet (16). A flow of gas flows into the inlet (14) to the outlet (16) at a gas flow rate and a flow of blood flows into the inlet (18) to the outlet (20) at a blood flow rate, where gas flowing into the inlet (14) of the gas side (6) and blood flowing into the inlet (18) of the blood side (2) flow along the membrane (8) in the same direction to their respective outlets (16, 20).

A method for preventing, ameliorating or treating one or more disease or disorders selected from the group consisting of a skin disease, skin aging or steroid-induced skin atrophy, erectile dysfunction, and hair loss, comprises transdermally administering a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof.WhereinR1 is C1-C3alkyl;R2 is H, CHO or CH═N—OH;R3 is C1-C4alkyl;R4 is C1-C6alkyl;R5 is SO2NR6R7;wherein R6 and R7 are together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein said heterocyclic ring is selected from piperidine and piperazine, wherein said heterocyclic ring is substituted with at least one R8, and wherein said R8 is independently selected from C1-C6alkyl optionally substituted with OH, ONO2, wherein at least one of said at least one R8 comprises at least one ONO2 moiety.

The utility model discloses a fixed blood sampling device, and relates to the technical field of medical blood sampling. The fixed blood sampling device comprises a blood sampling needle, a tail needle, a connecting piece and a filter element, the connecting piece is made of a transparent material, a flowing channel is formed in the connecting piece, the fixed ends of the blood sampling needle and the tail needle are fixed to the flowing channel in a sealed mode, and the filter element can adjust the communication relation between internal air of the connecting piece and external air; when the filter element does not make contact with liquid, the communication relation between internal gas of the connecting piece and external air is opened, blood of a patient can flow out more easily under the action of atmospheric pressure, when the filter element makes contact with the liquid, the communication relation between the internal gas of the connecting piece and the external air is closed, and the blood flows through the connecting piece; meanwhile, medical staff can know the flowing condition of the blood by observing the connecting piece made of the transparent material, and the collecting end of the tail needle punctures the protective sleeve in time and then is inserted into the vacuum blood collecting tube, so that the blood collection is completed.

Provided is a method and a system for noninvasive measurement of blood viscosity based on oxygen saturation and blood flow rate, which may easily and quickly calculate the blood viscosity by using the method and the system for noninvasive measurement of blood viscosity based on oxygen saturation and blood flow rate, thereby enabling immediate obtaining of the blood viscosity.

A medical device and method used for patient temperature management, wherein the device is designed to cool the patient's head and blood flow to the head and neck including the two carotid and the two vertebral arteries of a patient after trauma in order to prevent inflammation and reduce swelling in the brain. It is portable with a rapid cooling capability feature, does not require an ICU setting, eliminates certain complications that could affect the patient otherwise, and can be quickly and easily placed on the patient with little training or expertise.