170 results about "Plasma viscosity" patented technology

The invention relates to the field of medical materials and medical instruments, and discloses a dry bioprosthetic valve and a preparation method thereof.The preparation method comprises the following steps that S1, pericardium and a cross-linking agent solution are mixed for a cross-linking reaction; s2, carrying out first dehydration treatment on the crosslinked pericardium by adopting a first dehydration solution with gradually increased concentration gradient under an ultrasonic condition; and S3, carrying out second dehydration treatment on the pericardium subjected to the first dehydration treatment by adopting a second dehydration solvent, so as to obtain the dried bioprosthetic valve. According to the preparation method provided by the invention, ethanol, isopropanol and water in a specific proportion are adopted to prepare a dehydration solution with gradient concentration, and two-step dehydration drying is carried out in combination with the physical effect of an ultrasonic technology and glycerol, so that rapid rehydration of the bioprosthetic valve is realized, and the original shape and mechanical property of the bioprosthetic valve can be better recovered after rehydration; and the immediate hemodynamic stability of the valve is improved.

A blood pump-oxygenator system (250A, 250B, 250C) for increasing perfusion and oxygen levels in the body of a patient (P), comprising: a blood inlet (80) and a blood outlet (90) connected to form a circuit operable as a cardiopulmonary bypass system suitable for extracorporeal treatment of the blood of the patient; a first blood pump (11) and a first oxygenator (20), wherein the first blood pump (11) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the first oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The system further comprises a second blood pump (13) and a second oxygenator (21), wherein the second blood pump (13) is configured to deliver blood from the patient (P) through the circuit to the blood inflow port (80), through the second oxygenator (20), out of the blood outflow port (90) and back to the patient (P). The circuit comprises a first branch (101) and a second branch (102) arranged in parallel with each other, the first branch (101) accommodating the first blood pump (11) and the first oxygenator (20), and the second branch (102) accommodating the second blood pump (13) and the second oxygenator (21). The system further comprises a pump control unit (290) wherein the first and second blood pumps (11, 13) are configured to be controlled by the pump control unit (290) to increase or decrease the blood flow through the corresponding oxygenator (20, 21) by changing the proportion of the blood flow through the first and second oxygenator (20, 21).

The invention provides a balloon endoscopic system for intravascular direct vision examination, and relates to the technical field of medical instruments, the balloon endoscopic system comprises a catheter, a balloon capable of being filled and discharged, an endoscope lens, a light source assembly and an image transmission processing module, a cavity channel used for containing the endoscope lens and a conduction component of the light source assembly is formed in a catheter body of the catheter, and the catheter body of the catheter is internally provided with a cavity channel used for containing the endoscope lens and the conduction component of the light source assembly; the filling pipeline is used for supplying liquid to the inflatable and deflatable balloon; the inflatable and deflatable balloon is fixedly connected to the outer surface of the front end of the catheter, and the inflatable and deflatable balloon is used for bulging after being conveyed to a target position in a blood vessel. The inflatable and deflatable balloon can block blood flow and open the blood vessel wall after bulging and is matched with transparent filling liquid injected into the filling pipeline, residual blood can be further removed, a blood-free observation window is formed, interference of blood on imaging is avoided, and a foundation is laid for clearly observing the condition of the blood vessel wall. The inner wall of the balloon is coated with a nano anti-fog coating, so that the penetrability of a light source is ensured, and the fogging surface influence caused by blood residue or temperature difference can be avoided.

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The invention relates to the field of medical instruments and public health, in particular to an artificial blood vessel with anticoagulation, endothelium promotion and bending resistance functions and a preparation method of the artificial blood vessel, and the artificial blood vessel is used for various blood vessel replacement and blood vessel bypass operations and has the characteristics of anticoagulation, endothelium promotion and bending resistance. The copper-containing material and the degradable magnesium-based metal material are respectively integrated on the inner surface of the artificial blood vessel and in the interlayer of the vessel wall, so that the functions of anticoagulation, endothelium promotion and bending resistance of the artificial blood vessel are realized. According to the artificial blood vessel with the anticoagulation, endothelium promotion and bending resistance functions, in the initial stage of use, due to the spiral structure of the magnesium alloy wire, the blood vessel cannot collapse after being bent, the blood flow is kept smooth, copper ions, magnesium ions and a small amount of hydrogen can be released to surrounding tissues in the use process, the microenvironment of the surrounding tissues is adjusted to be alkalescent, and the blood circulation is kept smooth. Through the synergistic effect of the copper ions and the magnesium alloy, the effects of promoting endothelialization, resisting blood coagulation and adjusting the acid-base property of the microenvironment are achieved at the same time, and therefore the functions of resisting blood coagulation, promoting endothelium and resisting bending are achieved.

The invention relates to an intravascular blood pump comprising a pumping device having a pump portion and a drive portion, wherein the pump portion comprises a pump housing having a primary blood flow inlet and a primary blood flow outlet hydraulically connected by a primary passage, and the drive portion comprises a stator and a rotor rotatable about a rotational axis and configured to rotate a primary impeller configured to convey a primary blood flow along the primary passage from the primary blood flow inlet to the primary blood flow outlet, the drive portion further comprising a secondary blood flow inlet and a secondary blood flow outlet hydraulically connected by a secondary passage extending through an axial gap between the rotor and the stator and a secondary impeller arranged at a drive portion end of the rotor and rotatable about the rotational axis together with the rotor.

A system may include an outer frame. A system may include an expandable member, wherein the expandable is at least one or both of: disposed in the outer frame, and coupled to a lumen of the outer frame. A system may include a compressible bladder. A system may include a conduit configured to fluidly couple the expandable member to the compressible bladder, wherein forcing an inflation fluid from the compressible bladder to the expandable member is configured to manipulate the expandable member to a restricted blood flow state and forcing the fluid from the expandable member to the compressible bladder is configured to manipulate the expandable member to an unrestricted blood flow state.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction and a preparation method and application thereof. The traditional Chinese medicine composition for promoting blood circulation to remove meridian obstruction is prepared from the following raw materials in parts by weight: 15 to 25 parts of herba taxilli, 18 to 22 parts of semen cuscutae, 8 to 15 parts of radix angelicae sinensis, 3 to 6 parts of radix salviae miltiorrhizae, 18 to 22 parts of radix dipsaci, 8 to 15 parts of herba leonuri, 12 to 18 parts of radix paeoniae alba, 25 to 35 parts of rhizoma dioscoreae, 6 to 12 parts of rhizoma chuanxiong, 3 to 8 parts of radix aucklandiae, 6 to 12 parts of fructus nelumbinis, 10 to 15 parts of radix scutellariae and 12 to 20 parts of roasted rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition obtained through the composition, the dosage and the proportion of the components can remarkably reduce the whole blood viscosity, hematocrit and plasma viscosity of a rat with a blood stasis syndrome, can remarkably reduce the twisting frequency of an experimental dysmenorrhea model rat, has the effects of activating blood, resisting inflammation, dredging collaterals and relieving pain, and has the effect superior to that of each pair of components.

The invention relates to an intravascular blood pump (1) comprising a pumping device (11) having a pump portion (3) and a drive portion (4), wherein the pump portion (3) comprises a pump housing (2) having a primary blood flow inlet (211) and a primary blood flow outlet (22) hydraulically connected by a primary passage (30) and the drive portion (4) comprises a stator (40) and a rotor (41) rotatable about a rotational axis (10) and configured to rotate a primary impeller (31) configured to convey a primary blood flow along the primary passage (30) from the primary blood flow inlet (211) to the primary blood flow outlet (22), the drive portion (4) further comprises a secondary blood flow inlet (23) and a secondary blood flow outlet (24), the secondary blood flow inlet (23) and the secondary blood flow outlet (24) are hydraulically connected by a secondary passage extending through an axial gap (401) between the rotor (41) and the stator (40) and a secondary impeller (42) arranged at a drive portion end (DSE) of the rotor (41) and rotatable about the rotational axis (10) together with the rotor (41), the secondary impeller (42) comprises one or more secondary impeller blades (421) configured to convey a secondary blood flow along the secondary passage from the secondary blood flow inlet (23) to the secondary blood flow outlet (24) in a direction towards a pump portion end (PSE) of the pumping device (11), the rotor (41) is mounted in a blood cleaning radial slide bearing (47) having an inner rotor bearing surface (4211) and an outer rotor bearing surface (4311), and the secondary impeller (42) forms the inner rotor bearing surface (4211) of the radial slide bearing (47).

An oxygenerator (4) has a blood side (2), a gas side (6) and a semi-permeable membrane (8), where the membrane (8) separates the blood side (2) from the gas side (6), the blood side (2) has an inlet (18) and an outlet (20), the gas side (6) has an inlet (14) and an outlet (16), and during operation of the oxygenerator (4), the gas side (6) has an inlet (14) and an outlet (16). A flow of gas flows into the inlet (14) to the outlet (16) at a gas flow rate and a flow of blood flows into the inlet (18) to the outlet (20) at a blood flow rate, where gas flowing into the inlet (14) of the gas side (6) and blood flowing into the inlet (18) of the blood side (2) flow along the membrane (8) in the same direction to their respective outlets (16, 20).

The utility model discloses a fixed blood sampling device, and relates to the technical field of medical blood sampling. The fixed blood sampling device comprises a blood sampling needle, a tail needle, a connecting piece and a filter element, the connecting piece is made of a transparent material, a flowing channel is formed in the connecting piece, the fixed ends of the blood sampling needle and the tail needle are fixed to the flowing channel in a sealed mode, and the filter element can adjust the communication relation between internal air of the connecting piece and external air; when the filter element does not make contact with liquid, the communication relation between internal gas of the connecting piece and external air is opened, blood of a patient can flow out more easily under the action of atmospheric pressure, when the filter element makes contact with the liquid, the communication relation between the internal gas of the connecting piece and the external air is closed, and the blood flows through the connecting piece; meanwhile, medical staff can know the flowing condition of the blood by observing the connecting piece made of the transparent material, and the collecting end of the tail needle punctures the protective sleeve in time and then is inserted into the vacuum blood collecting tube, so that the blood collection is completed.

Provided is a method and a system for noninvasive measurement of blood viscosity based on oxygen saturation and blood flow rate, which may easily and quickly calculate the blood viscosity by using the method and the system for noninvasive measurement of blood viscosity based on oxygen saturation and blood flow rate, thereby enabling immediate obtaining of the blood viscosity.

Devices and methods divert blood flow from a first vessel to a second vessel and maintain blood flow in the first vessel. The device includes a first segment and a second segment. The first segment is configured to anchor in the first vessel. The first segment includes a window to allow blood to flow into the first segment, through the window, and distal in the first vessel. The second segment is configured to anchor in the second vessel. The second segment is configured to allow blood to flow into the first segment, through the second segment, and into the second vessel.

The invention discloses a temperature-controllable magnetic separation blood transfusion pipeline, and belongs to the technical field of blood separation pipelines. The blood transfusion pipeline comprises an inner-layer pipe and an outer-layer sleeve arranged on the periphery of the inner-layer pipe in a sleeving mode. A gap between the inner-layer tube and the outer-layer sleeve is arranged to be a first channel and is used for transporting a cooling medium, and the inner-layer tube is arranged to transport blood to be separated; one end of the inner-layer pipeline is provided with a non-return tip, one side of the non-return tip is provided with a non-return bead, and the non-return bead and the non-return tip are sequentially arranged in the blood transportation direction. The non-return ball and the non-return tip are matched with each other, so that only blood can pass through the non-return ball, and magnetized cells or non-magnetic particles with relatively large particle sizes are prevented from entering back-section blood circulation; the first channel directly cools the blood flowing through the inner-layer tube, the cooling efficiency is high, cooling is uniform, heat exposure of the blood is reduced to the maximum extent from the path, and the heat injury risk is reduced.

According to the bleeding cage and the blood pump thereof, the blood mixing loss can be reduced, the supporting strength is good, the whole bleeding cage is in a circular tube shape, a far-end opening of the bleeding cage forms a blood inlet, a bleeding opening and a flushing outlet are formed in the outer wall of the bleeding cage, and the bleeding opening and the flushing outlet are formed in the axial direction at intervals. Normal blood pumped by the blood pump flows out from the blood outlet, and flushing fluid flows out from the flushing outlet after flushing the gap, so that energy loss caused by blood mixing is reduced, and the hydraulic performance of the blood pump is improved; the bleeding cage has a certain length in the axial direction, and the bleeding opening and the flushing outlet are arranged at an interval, so that the overall structural strength of the bleeding cage is ensured, and the bleeding cage is prevented from being deformed due to stress; meanwhile, the turbulence influence generated when blood flows through the bleeding cage is reduced, stable rotation of the magnet is improved, and then the rotation stability of the whole blood pump is guaranteed.

Provided is a hemostasis operation assistance system capable of more reliably preventing the occurrence of a complete occlusion of a blood vessel during a hemostasis operation. A hemostasis operation assistance system (100) is provided with: a detection unit (130) that detects information relating to blood flow before a hemostasis operation is started; a control unit (140) that determines a compression condition on the basis of the detection result of the detection unit; and a drive unit (150) that adjusts the amount of compression in accordance with the compression conditions.

This utility model belongs to the field of medical device technology, specifically relating to a double-lumen central venous catheter with anti-wall adhesion and anticoagulation functions, including an extension tube, a double-lumen catheter, and a connector; the extension tube is connected to the double-lumen catheter through the connector; the double-lumen catheter is divided into two inlet lumens by a diaphragm, and the two inlet lumens are connected to two corresponding extension tubes; a side hole and a main hole are provided at the end of the double-lumen catheter, and the end of the double-lumen catheter has a C-shaped segment, with the side hole located on the concave side of the C-shaped segment, and the main hole located at the end of the double-lumen catheter. The C-shaped segment in this design reduces the occurrence of the side hole adhering to the blood vessel wall, reducing the probability of local coagulation and thrombosis when used for pediatric hemodialysis blood drainage; the biomimetic sharkskin microgrooves etched on the outside of the double-lumen catheter reduce resistance to blood flow and thrombus formation; the biomimetic sharkskin microgrooves can be filled with covalently grafted sulfonated heparin-hydrogel, continuously releasing anticoagulant factors, further reducing the formation of wall-attached thrombi.

The present application relates to the field of medical devices, in particular to a self-perfusion drug-eluting balloon and a self-perfusion drug-eluting device, the self-perfusion drug-eluting balloon comprising a balloon body, the balloon body extending axially and being open at both ends, a blood flow channel being arranged along the axial direction of the balloon body, the blood flow channel being arranged on the wall of the balloon body, the balloon body comprising an outer balloon and an inner balloon arranged in the outer balloon, the blood flow channel being arranged on the wall of the outer balloon. The self-perfusion drug-eluting device comprises the self-perfusion drug-eluting balloon and a delivery assembly. The self-perfusion drug-eluting balloon does not block blood flow in the inflated state, avoiding the situation that the physical rebound of the blood vessel is fast due to short-time adhesion and short support time.

This utility model relates to a blood vessel occlusion device, which includes a support body, a membrane covering the support body and forming a hollow cavity with closed ends together with the support body, multiple isolation membranes arranged axially at intervals in the hollow cavity and dividing the hollow cavity into several independent chambers, and expansion particles filling each chamber. The membrane has several through holes that connect the hollow cavity to the external environment and allow water molecules to pass through. Water in the blood enters the hollow cavity through the through holes. The expansion particles inside absorb water in the blood and expand, thereby forming a stable and reliable support for the support body, making the device fit more closely to the blood vessel, effectively enhancing the anchoring performance of the device, and significantly reducing the risk of device displacement caused by blood flow impact. The isolation membranes divide the hollow cavity into several chambers, which can prevent the expansion particles from being unevenly distributed in the cavity.

An extracorporeal membrane oxygenation (ECMO) system including a blood oxygenator having an outer shell surrounding an oxygenator fiber bundle, a heating element, a closed loop control system, and a temperature sensor. The blood oxygenator defining a blood inlet and a blood outlet. The blood oxygenator has a blood flow path that is bifurcated between a first channel and a second channel. The heating element disposed around or within the outer shell. The closed loop control system configured to regulate the heating element. The temperature sensor is electronically linked to the control system. The heating element extends alongside at least one of the first channel and the second channel.

The invention belongs to the technical field of medical equipment, and particularly discloses a clinical hemodialysis device and a using method thereof.The clinical hemodialysis device comprises a dialysis box, and a dialysis assembly is arranged on one side of the dialysis box; the dialysis assembly comprises a dialyzer, a liquid inlet pipe, a liquid outlet pipe, a dialysate inlet, a dialysate outlet, a dialysis membrane, an inner partition plate and an adjusting structure. By means of the flow guiding structure, flow guiding can be conducted when blood enters the dialysis cavity, the situation that blood easily flows in a deviated mode after entering the dialysis cavity, so that no blood passes through the surface of a dialysis membrane on one side, the blood and dialysis efficiency is affected is prevented, the treatment duration is shortened, complications are reduced, and the treatment effect is improved by heating the blood. Therefore, the blood is kept at the temperature acceptable by the human body, the comfort of a patient during treatment is improved, and the dialysis treatment is safely and efficiently carried out.

The utility model relates to the technical field of vein blood sampling, in particular to an anti-backflow vein blood sampling device. The utility model provides an anti-backflow vein blood sampling device which can effectively prevent blood from flowing back and ensure normal blood sampling work. An anti-backflow vein blood sampling device comprises a needle head, a connecting piece, a needle wing, a connecting pipe, a fixing assembly and the like, the connecting piece is connected to the left portion of the needle head, the needle wing is connected to the upper side of the right portion of the connecting piece, the connecting pipe is connected to the left side of the connecting piece, and the fixing assembly capable of being fixed to an arm is arranged on the connecting piece. After blood flows into the control cylinder, the blood flows into the conical thin film and the hard tube, the conical thin film and the hard tube are kept in linear communication and then flow out of the collecting head, and after the blood stops flowing into the conical thin film, the hard tube droops under the action of gravity to block the conical thin film, so that the blood can be effectively prevented from flowing back; and the effect of normal blood sampling work is ensured.

The present disclosure provides an embolic protection device comprising a metal wire or metal ribbon with an elliptical or flat cross-section, pre-formed into a spiral structure wound around its short axis. The formed embolic protection device can be deployed within a tubular object and introduced into the target blood vessel through the tube. The elasticity of the material enables it to revert to a predetermined shape, thereby effectively intercepting emboli. The device is characterized by a smaller curvature, enhanced recovery to the preset shape, and reduced interference with blood flow.

An intravascular blood pump (1) comprises a pump casing (2) having a blood flow inlet (21) and a blood flow outlet (22), and an impeller (3) arranged in said pump casing (2) so as to be rotatable about an axis of rotation, wherein the impeller (3) has blades (31) sized and shaped for conveying blood from the blood flow inlet (21) to the blood flow outlet (22). The blood pump (1) further comprises a drive unit (104) for rotating the impeller (3), the drive unit (104) comprising a plurality of posts (140) arranged about the axis of rotation (10). Coil windings (47) around the posts are sequentially controllable so as to create a rotating magnetic field. The shaft portion (141) of each of the posts (140) comprises a soft magnetic material which is discontinuous in cross-section transverse to the longitudinal axis of the respective post (140).

Customizable and intuitive user interfaces are provided for medical systems and devices, such as cardiopulmonary bypass systems, perfusion systems, extracorporeal circulation apparatus, and heart-lung machines, that allow easy access to critical patient data to facilitate blood perfusion, as well as monitoring and adjusting various physiological parameters of the patient and extracorporeal blood flow circuit during procedures such as cardiopulmonary bypass and extracorporeal membrane oxygenation (ECMO).

The invention relates to the technical field of medical instruments, in particular to a targeted balloon coating capable of prolonging the release period in a dynamic environment and a preparation method of the targeted balloon coating. The renaturable xerogel can be quickly rehydrated after being dried, and a temporary membrane is formed on the inner wall of a blood vessel to resist blood flow scouring. The exosome enhances the vascular endothelium targeting through RGD peptide targeted modification. The polydopamine-hyaluronic acid composite adhesion coating improves the flexibility and adhesion of the coating. Therefore, the drug retention rate within 1 hour after expansion is greater than or equal to 85%, and the vascular endothelium uptake efficiency of the RGD modified exosome is improved by 3 times.

In the present invention, a control unit (90) of an extracorporeal circulation device (1) capable of ensuring an ideal blood flow rate for a patient when performing VA-ECMO comprises: a calculation unit (91) that calculates an ideal flow rate and pump head pressure from patient-specific information; and a transmission unit (92) that transmits, to a fluid replacement device (70) for performing fluid replacement, water amount data obtained through measurement by a measurement device (80) for measuring the water amount of the patient. The control unit (90) gives a fluid replacement instruction to the fluid replacement device (70) via the transmission unit (92) on the basis of the pressure of the inside of a blood circuit (20) measured by pressure measurement units (45, 46), the flow rate of the inside of the blood circuit (20) measured by a flow rate measurement unit (47), and the water amount data obtained through measurement by the measurement device (80).

The application discloses a diabetes thrombosis risk prediction method and system based on combined analysis of blood rheology characteristics and vessel wall state, relates to the technical field of medical data processing, and obtains a target blood vessel segment image sequence to extract endothelial contour node coordinates and node radial displacement, and converts and combines to generate a vessel wall state boundary tensor; collects blood indexes to calculate red blood cell rigidity aggregation yield stress and plasma viscoelasticity relaxation time, and maps to generate a blood rheology characteristic tensor along a cardiac cycle; the two tensor spaces are aligned, an instantaneous wall shear stress vector is calculated based on a fluid-solid coupling mechanism, an oscillatory shear index and a local blood flow stasis time proportion are extracted through time domain integration to construct a rheology-vessel wall combined feature map; the feature map is input into a graph convolutional neural network to extract thrombus precursor topological features, and a risk prediction level is output through classification mapping. The system is used for implementing the above method.

A renal replacement apparatus (100), having a hemofilter (108); an extracorporeal blood circuit (102) configured to communicate blood from a patient (104), through the hemofilter, and back to the patient; and a flow measuring device (150) configured to measure at least one blood flow property as the blood is leaving the hemofilter and before the blood returns to the patient at a flow measuring device location (152), wherein the flow measuring device comprises at least one of a viscometer and a rheometer. Alternately, or in addition, the renal replacement apparatus may include thermomodulator system (222) including at least one thermomodulator configured to selectively heat and cool the blood in the extracorporeal blood circuit. The renal replacement apparatus (100) may have a controller (160). The controller may use artificial intelligence. Other embodiments are described herein.