41 results about "Venous valve" patented technology

The invention discloses an integrated interventional venous valve and a preparation method thereof. The integrated interventional venous valve comprises a valve stent, a valve leaflet and a skirt; the valve stent comprises a first annular grid stent, a second annular grid stent and a straight rod for connecting the first annular grid stent and the second annular grid stent; the skirt edge covers the inner and outer surfaces of the first annular grid bracket and the second annular grid bracket; the valve leaflet is arranged on the straight rod, one side of the valve leaflet is connected with the skirt edge, and the free surface of the other side of the valve leaflet is arc-shaped; according to the integrated interventional venous valve, the valve leaflet and the skirt edge cover the inner surface and the outer surface of the valve support, so that the valve support, the valve leaflet and the skirt edge do not need to be fixed through sewing, the problems of complexity and potential tearing risk of split type processing are solved, and by arranging the material and the structure of the valve support, the integral interventional venous valve can be manufactured. And the valve leaflet free surface has a bionic arc shape, so that the integrated interventional vein valve can adapt to the diameter change of a blood vessel.

Single and dual frame prosthetic venous valve assemblies, and catheter delivery systems and methods, are disclosed. A representative dual frame venous valve assembly includes an outer valve frame having a lumen and a frame and venous valve assembly arranged within the lumen. The frame and venous valve assembly, which also may be a stand- alone prosthetic venous valve assembly, includes an inner valve frame having a frame matrix forming lateral valve supports and valve commissure supports; a polymeric frame coating encapsulating the frame matrix; and a one or more polymeric leaflets integrally formed with or coupled to the polymeric frame coating, with each leaflet moveable between an open or partially open state and a closed or partially closed state. A delivery catheter includes keys or slots for insertion of locking tabs of the outer valve frame, and a deployment control handle for controlling deployment of the venous valve assembly.

The utility model relates to a simulation display device for thrombus formation, which belongs to the technical field of medical simulation, and comprises a display assembly, the display assembly comprises a display box, a blood transfusion simulation assembly for simulating blood vessels is arranged in the display box, the blood transfusion simulation assembly comprises a semicircular tube for simulating the blood vessels, and the rear side wall of the semicircular tube for simulating the blood vessels is communicated with two transfusion tubes. One infusion tube is communicated with a water pump, a transparent plate is fixedly connected between the front side wall of the semicircular tube for blood vessel simulation and the inner wall of the front side of the display box, an elastic piece for venous valve simulation is fixedly connected into the semicircular tube for blood vessel simulation, and the upper end of the semicircular tube for blood vessel simulation is communicated with a trigger thrombus simulation assembly for simulating thrombus. According to the device, blood and blood coagulation components in the blood can be simulated, and the blood and the blood coagulation components are mutually gathered by utilizing magnetic force, so that the formation of thrombus is conveniently simulated.

To provide tissue grasping devices and related methods.SOLUTION: A clip for immobilizing leaflets of a cardiac or a venous valve includes a hub having a pair of tangle resistant spring-biased outer arms coupled to an inferior end of the hub and a pair of tangle resistant spring-biased inner arms adjacent to the outer arms and coupled to a superior end of the hub. A delivery catheter may be used to position the valve clip adjacent to a target valve while the outer and inner arms are biased in an opened position relative to each other. After the valve leaflets are located between the opened outer and inner arms, biasing force may be released to allow the clip to self-close the clip over the valve leaflets.SELECTED DRAWING: Figure 70

A catheter for forming a fistula between two vessels. The catheter comprises a catheter body having a longitudinal axis, an electrode extending radially from the catheter body for contacting a vessel wall and forming the fistula, and a cutting unit disposed proximally or distally of the electrode for cutting a venous valve.

A DVT prevention and / or mitigation device includes a wearable band having an inflatable bladder with an inflatable portion. When the wearable band is disposed about a user's leg, a majority of the inflatable portion of the inflatable bladder is positionable between the user's knee and a midpoint of the user's gastrocnemius muscle. The inflatable bladder is also inflatable to apply pressure to a portion of the user's gastrocnemius muscle, and a source of compressed air is coupled to the wearable band to deliver continuous compression cycles to the inflatable bladder at a frequency of at least 3 cycles per minute, each compression cycle having a compression period and a peak inflation pressure to induce cyclic flow in the user's venous valve sinuses from each successive inflation.

The invention relates to a turbine disc cavity imitated venous valve type sealing structure and a design method thereof, an axial sealing gap simulates human body vein vascular tissue, and a sealing structure assembly is located in the axial sealing gap where a disc cavity is connected with a main flow channel and comprises two rows of imitated venous valve teeth on the static disc side and two rows of imitated venous valve teeth on the rotary disc side. Furthermore, the two groups of sealing structures are matched with each other, so that the gap is gradually shrunk outwards in the radial direction, a large amount of invading gas at the joint of the disc cavity and the main flow channel is blocked, and the gas is rectified by a vortex structure and enters the main flow channel again. By means of the modeling design of the sealing assembly, fluid, namely high-temperature fuel gas, is prevented from flowing into the disc cavity in the radial direction while the fluid is guided to flow outwards in the radial direction, mixing of high-temperature invasion fuel gas and sealing cold air is enhanced, the sealing cooling efficiency of the connecting area of the disc cavity and the main flow channel is improved, and the high-temperature heat load borne by the position is reduced; and the method is of great significance to safe operation of the whole gas turbine.

A system for forming a fistula between two vessels, the system comprising a first catheter. The first catheter comprises a catheter shaft with a housing. The first catheter further comprises an electrode disposed at least partially within the housing, the electrode comprising a distal portion, a proximal portion and an intermediate portion therebetween for contacting a vessel wall and forming the fistula. The first catheter further comprises a plurality of teeth for cutting a venous valve, wherein the plurality of teeth extend radially from the catheter shaft and are angled in a proximal direction.

This application generally relates to an transcatheter anti-reflux venous valve endoprosthesis system, including a replacement valve, a valve support frame, crimping system, and delivery system to treat patients with chronic venous insufficiency, and method for using such a system.

This application generally relates to an transcatheter anti-reflux venous valve endoprosthesis system, including a replacement valve, a valve support frame, crimping system, and delivery system to treat patients with chronic venous insufficiency, and method for using such a system.

The invention relates to a venous valve destruction structure for deep vein transcatheter arterization, and belongs to the technical field of medical devices, the venous valve destruction structure comprises a transcatheter, a venous valve knife and a limiting device, the venous valve knife is inserted in the transcatheter, the venous valve knife is provided with a moving rod, one end of the moving rod is provided with a venous valve blade with an expandable or contractible volume, and the other end of the moving rod is provided with the limiting device. The vein valve blade is retracted into the transcatheter, or the vein valve blade extends out of the transcatheter, and a handle is arranged at the other end of the moving rod; the limiting device is used for limiting the moving position of the venous valve knife and can be rotatably arranged outside the transcatheter, the venous valve knife penetrates through the interior of the limiting device, and the limiting device is connected with the moving rod through threads; the device has the advantages that the limiting device is rotated, the handle is controlled, the vein valve blade moves in one direction, the vein valve blade extends out of the transcatheter, and the vein valve is damaged through linear movement and rotation of the vein valve blade.

The present application discloses tissue grasping devices and related methods, particularly a clip for securing leaflets of a heart valve or venous valve, including a hub having a pair of anti-entanglement spring biased outer arms coupled to a lower end of the hub and a pair of anti-entanglement spring biased inner arms adjacent the outer arms and coupled to an upper end of the hub. A delivery catheter with a reinforcing member configured to position the valve clip proximate a target valve while the outer arms and inner arms are biased in an open position relative to one another. The delivery catheter or clip includes a suture that facilitates bailout. After the valve leaflets are positioned between the open outer arms and inner arms, the biasing force can be released to allow the clip to self-close the clip on the valve leaflets, thereby cinching and coapting the leaflets atraumatically and effectively.

The present invention relates to the field of medical devices, and in particular to a thrombus cutting assembly and a thrombus cutting device; wherein the thrombus cutting assembly includes a shielding portion, a knife rod, and a cutting tool, wherein the shielding portion includes an integrally formed bullet-shaped shell and a crisscross bowl-shaped baffle, the knife rod is connected to the end of a transmission tube, and the front end of the knife rod is rotatably connected to the crisscross bowl-shaped baffle. The present invention, by providing the bullet-shaped shell and the crisscross bowl-shaped baffle, on the one hand, plays a role in blocking the blood vessel wall, that is, during the thrombus removal process, the blood vessel wall and venous valve can be isolated outside the crisscross bowl-shaped baffle, so as to reduce the blood vessel wall and venous valve from entering the interior of the thrombus suction tube during the cutting process, and on the other hand, the crisscross bowl-shaped baffle and the bullet-shaped shell facilitate the introduction into the blood vessel to reach the designated position for thrombus removal, effectively reducing the entry resistance during the entry process, and facilitating operation.

A catheter for forming a fistula between two vessels. The catheter comprises a housing, an electrode disposed at least partially within the housing. The electrode comprises a distal portion, a proximal portion and an intermediate portion therebetween for contacting a vessel wall and forming the fistula. The catheter further comprises a valve destruction wire disposed at least partially within the housing for contacting and destroying a venous valve.

The present invention provides a valve material having synergistic anti-coagulation and anti-calcification functions and a preparation method therefor. The preparation method comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material; immersing the treated valve material in a blocking solution containing an amine compound for 0.5-6 h, thereby blocking the remaining aldehyde groups after glutaraldehyde cross-linking; then placing the valve material into a reaction solution containing an anticoagulant and a cross-linking agent, and performing cross-linking treatment for 6-24 h at 4° C.-37° C.; and finally washing and obtaining the valve material, and storing the valve material in a mixed solvent of glutaraldehyde or isopropyl alcohol / glycerol. The method can effectively solve the problem of calcification and thrombosis caused by residual aldehyde groups in a valve material prepared by the existing method. The valve material prepared by the present method can be used as a valve material required for aortic valve, pulmonary valve, venous valve, mitral valve and tricuspid valve replacement.

A bioprosthetic valve for repairing a deep venous insufficiency in a subject includes a single leaflet from a xenogeneic heart valve attached at natural margins of attachment to a patch of valve wall tissue. The patch may extend axially above and below the leaflet and circumferentially on either side of the leaflet to provide a region for attaching the patch to a fenestration in a host vein. A bioprosthetic valve may be manufactured by excising a portion of a xenogeneic heart valve including a single leaflet and contiguous wall tissue, and may further comprise shaving off excess leaflet tissue from adjacent leaflets. A method of replacing a malfunctioning venous valve in a subject includes providing a bioprosthetic valve as described above and inserting it to the host vein.

The invention relates to a lower limb deep vein thrombus cleaning device, and belongs to the technical field of medical instruments. The thrombus removal device comprises a thrombus removal mesh basket assembly, the front end is inserted into a catheter in the blood flowing direction and penetrates through a vein valve and thrombus, and the thrombus removal mesh basket assembly is used for cleaning and containing the thrombus at the front end of the vein valve; the rotary telescopic assembly is arranged at the rear end of the thrombus extraction mesh basket assembly and used for controlling the thrombus extraction mesh basket assembly to stretch out, draw back and rotate in the target blood vessel so as to cut or scrape thrombus; the front end of the collecting assembly is inserted into the catheter in the blood flowing direction, abuts against the rear end of the vein valve and is used for cleaning and collecting thrombus at the front end and the rear end of the vein valve. The problem of cleaning blind areas caused by irregular outlines of the vein valve areas is effectively solved, and the thrombus cleaning device has the advantages that thrombus at the front end and the rear end of the vein valve can be cleaned at the same time, cleaning blind areas are effectively reduced, thoroughness of thrombus cleaning is improved, and thrombus residual risks are reduced.

The present invention belongs to the technical field of medical devices, and specifically relates to a deep vein stent. A deep vein stent includes a stent structure and an artificial valve leaflet; the stent structure includes: at least two valve supports, which are S-shaped structures, symmetrically arranged, forming a circle of convex artificial venous sinus area in the outflow section, and the valve support members pass through the artificial valve leaflet, supporting the artificial valve leaflet at the middle bend of the valve support members. The present invention adopts multiple valve supports with S-shaped structures, which can support the artificial valve leaflet, and can naturally form an artificial venous sinus area in the convex part near the outflow section. When applied to the vein, under the action of multiple valve supports, a circle of convex artificial venous sinus area can be formed on the vein, thereby achieving the same use effect as the actual venous valve, so that the artificial venous sinus area is formed at the position of the artificial valve leaflet.

The invention discloses a preparation method of a biogenic vein containing a venous valve, and belongs to the technical field of biomedical functions.The preparation method of the biogenic vein containing the venous valve comprises the following steps that firstly, a pig or cattle jugular vein pipeline containing a complete valve is cut, cleaned, disinfected and flushed for use; sequentially carrying out cell lysis, cell digestion and nucleic acid digestion treatment; immersing into a 1 mol / L hydroxylamine sulfate solution to carry out heparin covalent cross-linking; immersing into a treating fluid to obtain a biogenic vein containing a venous valve; wherein the treating fluid is a PBS (Phosphate Buffer Solution) containing 4wt% of hydroxyethyl starch and 0.1 wt% of polyhexamethylene biguanide. According to the preparation method of the biogenic vein containing the venous valve, provided by the invention, the treatment liquid containing 4wt% of hydroxyethyl starch and 0.1 wt% of polyhexamethylene biguanide is introduced in the preparation process, so that the technical problem of insufficient dehydration and bacteriostasis in the background technology is remarkably solved, and meanwhile, the valve functionality of the biogenic vein is remarkably improved.

Single and dual frame prosthetic venous valve assemblies, and catheter delivery systems and methods, are disclosed. A representative dual frame venous valve assembly includes an outer valve frame having a lumen and a frame and venous valve assembly arranged within the lumen. The frame and venous valve assembly, which also may be a stand- alone prosthetic venous valve assembly, includes an inner valve frame having a frame matrix forming lateral valve supports and valve commissure supports; a polymeric frame coating encapsulating the frame matrix; and a one or more polymeric leaflets integrally formed with or coupled to the polymeric frame coating, with each leaflet moveable between an open or partially open state and a closed or partially closed state. A delivery catheter includes keys or slots for insertion of locking tabs of the outer valve frame, and a deployment control handle for controlling deployment of the venous valve assembly.

The application provides a thrombus crushing device and a thrombus removing system. The thrombus crushing device comprises a thrombus crushing unit and a separation unit. The separation unit is connected with the proximal end of the thrombus removing head, and part of the separation unit is located between the transmission pipe and the thrombus crushing knife to shield part of the opening. The separation unit plays a role of blocking the blood vessel wall. That is, the separation unit can block the blood vessel wall and the venous valve from entering the thrombus removing head during the thrombus removing process, thereby reducing the damage. Moreover, the separation unit can separate the mural thrombus from the blood vessel wall while blocking the blood vessel wall during the thrombus removing process, thereby increasing the removing efficiency of the mural thrombus and improving the thrombus removing effect. In addition, the thrombus crushing knife, the separation unit and the thrombus removing head form a multi-layer cutting structure during the thrombus removing process, so that repeated cutting of the thrombus is realized, the thrombus crushing efficiency is improved, and the operation time is reduced. Therefore, the thrombus crushing device and the thrombus removing system provided by the application not only can protect the blood vessel wall, but also can improve the thrombus crushing efficiency and the thrombus removing effect.

The invention relates to a cutting knife which comprises a cutting assembly, a collecting assembly and an outer pipe assembly, the cutting assembly and the collecting assembly are contained in the outer pipe assembly in a compressible mode, and the cutting assembly and the collecting assembly can move relative to the outer pipe assembly and are released outside the outer pipe assembly. The collecting assembly is released on one side of the vein valve, the cutting assembly is released on one side of the vein valve, and the cutting assembly can move towards the collecting assembly so as to cut the vein valve and store cut valve fragments in the cutting assembly and the collecting assembly. After the cutting knife cuts a vein valve, cut valve fragments are stored in the cutting assembly and the collecting assembly and withdrawn from the human body along with the outer tube assembly, and then the cut valve fragments are prevented from flowing along with blood to escape into the artery. Serious consequences such as sudden cardiac arrest and cerebral anoxia caused by the fact that valve fragments enter the artery are avoided.

The present invention provides an interventional venous valve stent, comprising a support body and a connecting frame, wherein the support body comprises a first annular support frame, the connecting frame being connected to the end of the first annular support frame, the connecting frame being arranged along the circumference of the first annular support frame and being disconnected in the circumference of the connecting frame to form a notch, at least a portion of the connecting frame being convex outward to form a protrusion, the inner side of the protrusion forming a sinus area. The notch can give the interventional venous valve stent better flexibility, making it easier for the interventional venous valve stent to pass through complex and circuitous blood vessels, thereby reducing surgical risks; the leaflets cause the returning blood to form vortices in the area covered by the leaflets in the sinus area, preventing blood from flowing back, thereby improving the clinical effect of the venous valve prosthesis. The present invention also provides a venous valve prosthesis provided with the interventional venous valve stent.

The present invention provides a venous valve stent and a venous valve prosthesis. The venous valve stent includes a stent body and a sinus cavity frame; the stent body is in a hollow cylindrical structure and is radially expandable and contractible; a window is provided on the side of the stent body; the sinus cavity frame has a relative fixed end and a free end; the fixed end is connected to the window; the free end extends outside the stent body; a sinus area is formed inside the sinus cavity frame, and the sinus area communicates with the inside of the stent body through the window. The venous valve prosthesis includes a valve and the venous valve stent, the valve is fixed inside the stent body and covers at least part of the area of the sinus area, and the side of the valve facing away from the sinus area is a free edge. The present invention can improve the reliability of the one-way conduction function, avoid excessive stimulation to blood vessels, and is also convenient for manufacturing.

The present application provides an artificial venous valve, comprising a stent, a leaflet structure, and a sealing membrane; the stent is elastic and can be radially expanded to be positioned in a venous vessel; the leaflet structure is sutured to the stent, and can be expanded under the action of blood pressure flowing in the positive direction, and can be closed under the action of blood pressure flowing in the reverse direction; the sealing membrane is sutured to the stent, and the sealing membrane is sleeved on the periphery of the leaflet structure and is sealed to the leaflet structure, and the sealing membrane can be expanded by the stent to seal against the inner wall of the venous vessel. The artificial venous vessel of the present application, through the arrangement of the stent, the leaflet structure, and the sealing membrane, enables it to be inserted into or implanted in the venous blood of the human body to replace the native venous valve, thereby achieving the purpose of treating venous reflux.

The invention relates to the technical field of medical instruments, and discloses a lower limb vein valve support and a prosthesis, the lower limb vein valve support comprises a support body, the support body is provided with a first positioning part and a second positioning part, the support body is internally provided with an axial flow channel, the first positioning part and the second positioning part are both located at the downstream end of the flow channel, and the first positioning part and the second positioning part are located at the downstream end of the flow channel. The first positioning part and the second positioning part extend outwards in the radial direction of the support body. The lower limb vein valve prosthesis comprises first skirt cloth, a plurality of valve leaflets and the lower limb vein valve support, the valve leaflets are arranged at the upstream end of the lower limb vein valve support, the valve leaflets are arranged in the flow channel of the support body through the first skirt cloth, and the valve leaflets are movably connected. And the opening and closing of the plurality of valve leaflets control the circulation of the inlet end of the flow channel. The intravenous stent and prosthesis can solve the problems that an existing intravenous stent and prosthesis are poor in stability, prone to displacement in vivo and poor in treatment effect.

A bioprosthetic valve for repairing a deep venous insufficiency in a subject includes a single leaflet from a xenogeneic heart valve attached at natural margins of attachment to a patch of valve wall tissue. The patch may extend axially above and below the leaflet and circumferentially on either side of the leaflet to provide a region for attaching the patch to a fenestration in a host vein. A bioprosthetic valve may be manufactured by excising a portion of a xenogeneic heart valve including a single leaflet and contiguous wall tissue, and may further comprise shaving off excess leaflet tissue from adjacent leaflets. A method of replacing a malfunctioning venous valve in a subject includes providing a bioprosthetic valve as described above and inserting it to the host vein.

Provided in the present disclosure are a prosthetic venous valve, a stent, and a prosthetic venous valve leaflet and a design method therefor, relating to the technical field of medical instruments. The stent involved in the present disclosure comprises a proximal segment support frame, a valve leaflet fixing assembly, a pocket-shaped support rod, and a distal segment support frame. The valve leaflet fixing assembly is connected between the proximal segment support frame and the distal segment support frame, and is configured for fixing the valve leaflet. A first end of the pocket-shaped support rod is connected to the proximal segment support frame, and a second end of the pocket-shaped support rod is connected to the distal segment support frame. When the stent is expanded, the pocket-shaped support rod can protrude along a radial direction of the stent in a direction away from the central axis of the stent, so as to form a pocket-shaped space on a proximal side of the valve leaflet fixing assembly.

A venous valve prosthesis for transporting a flow of body fluid in a vessel in a predetermined direction includesincludes a hollow-cylindrical support structure. A skirt is connected to the support structure and forms a closed, circumferential jacket of the support structure. The prosthesis also includes a valve leaflet arrangement with a first valve leaflet and a second valve leaflet, each being connected to the skirt. A downstream edge of the first valve leaflet and a downstream edge of the second valve leaflet are opposite to each other and configured in such a manner that in a first state of the valve leaflet arrangement they form an opening for blood to flow through in the predetermined direction and in a second state of the valve leaflet arrangement the opening is closed and to prevent a backflow of blood in a direction opposite to the predetermined direction. A ratio of the inner diameter of the support structure to its length in the predetermined direction is at most 1.

The present application provides a venous valve prosthesis, comprising a stent body and a valve; the stent body has an inner cavity, and the stent body comprises a proximal positioning part, a supporting part and a distal positioning part; the valve is connected to at least the supporting part and divides the inner cavity into a first segment and a second segment arranged from the proximal end to the distal end; the valve has a first position and a second position; the venous valve prosthesis is used for implanting into a target lumen for the target liquid to flow through; when the valve is subjected to a pressure from the target liquid pointing from the distal end to the proximal end, the valve is in the first position, so as to make the first segment and the second segment communicate to allow the target liquid to flow from the second segment into the first segment; when the valve is subjected to a pressure from the target liquid pointing from the proximal end to the second segment, the valve is in the second position, so as to make the first segment and the second segment isolated to prevent the target liquid from flowing from the first segment into the second segment. The venous valve prosthesis can be implanted into a venous vessel and replace a diseased venous valve, thereby preventing blood reflux.