140 results about "Artificial valve" patented technology

The present invention comprises a percutaneously implantable replacement heart valve device and a method of making same. The replacement heart valve device comprises a stent member made of stainless steel or self-expanding nitinol, a biological tissue artificial valve means disposed within the inner space of the stent member. An implantation and delivery system having a central part which consists of a flexible hollow tube catheter that allows a metallic wire guide to be advanced inside it. The endovascular stented-valve is created from a glutaraldehyde fixed biocompatible tissue material which has two or three cusps that open distally to permit unidirectional blood flow. The present invention also comprises a novel method of making a replacement heart valve by taking a fragment of biocompatible tissue material and treating, drying, folding and rehydrating it in such a way that forms a two- or three-leaflet / cusp valve with the leaflets / cusps formed by folding, thereby eliminating the extent of suturing required, providing improved durability and function.

An artificial mitral valve is anchored in the left atrium by placing the valve between the annulus of the natural mitral valve and an artificial annulus. The artificial annulus is formed by inserting a tool into the coronary sinus, and adjusting the tool to force the wall of the left atrium to form an annulus above the artificial valve, this locking it in place and forming a hemostatic seal.

A multiple-sided medical device comprises a closed frame of a single piece of wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration that comprises a self-expanding stent. The stent is pushed from a delivery catheter into the lumen of a duct or vessel. One or more barbs are attached to the frame of the device for anchoring or to connect additional frames. A covering of fabric or other flexible material such as DACRON, PTFE, or collagen, is sutured or attached to the frame to form an occlusion device, a stent graft, or an artificial valve such as for correcting incompetent veins in the lower legs and feet. A partial, triangular-shaped covering over the lumen of the device allows the valve to open with normal blood flow and close to retrograde flow.

The holding device of the endoscope allows suspension of the tissue while it is held and fixed securely. Use of holding device with large distal ends will not damage tissue and allows holding and suspension of a large area. A needle pierces at least the proper muscularis, thereby forming a large protrusion including the proper muscularis of the stomach and the esophagus as artificial valve to prevent reflux effectively. The holding device, formed extending out of the distal end of the endoscope, can touch the tissue easily under observation of the endoscope. Treatment is simple, and takes a shorter time.

An artificial mitral valve is made of a short piece of elastomeric tubing having a one round end and one flattened end. The tubing can be rolled up to a small diameter and fits snuggly into the mitral valve opening when expanded. The tubing attaches to a few rings made of thin flexible wire. When the rings are expanded inside the left atrium, they form a support structure holding the artificial valve in the correct position. The rings can be flattened and delivered via a catheter together with the valve. The artificial valve contains no rigid component, therefore it does not deform or damage the area around the defective mitral valve and can be installed even in highly calcified or deteriorated valves.

An artificial mitral valve is anchored in the left atrium by placing the valve between the annulus of the natural mitral valve and an artificial annulus. The artificial annulus is formed by inserting a tool into the coronary sinus, and adjusting the tool to force the wall of the left atrium to form an annulus above the artificial valve, this locking it in place and forming a hemostatic seal.

The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligaments, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fibers of collagen as its basic unit.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

In an artificial heart valve for the replacement of an aortic or a mitral valve, including an annular body, which is provided at its outer circumference with means for mounting the artificial valve in place by surgical procedures and which defines in its interior a blood flow passage in which valve flap elements are pivotally supported so as to open or close the blood flow passage depending on their pivot positions, the annular body includes circumferentially spaced projections extending into the flow passage and being provided at their inner ends with pivot joints on which the valve flap elements are pivotally supported.

A biological function assist apparatus composed an electromechanically-based system wrapped in protective coating and controlled by a controller, which also provides power to the electromechanically-based system. The electromechanically-based system can be formed as a mesh using MEMS or a larger electromechanically grid and wrapped around a failing heart, or the electromechanical system can be formed in a circle forming an artificial valve (e.g., sphincter). The electromechanically-based system can operate as a bone-muscle interface, thereby functioning in place of tendons.

The novel amidino derivatives of the formula (I):wherein all the symbols are as in specification defined;have an inhibitory activity of a blood coagulation factor VIIa and are useful for treatment and / or prevention of several angiopathy caused by enhancing a coagulation activity, such as disseminated intravascular coagulation, coronary thrombosis, cerebral infarction, cerebral embolism, transient ischemic attack, cerebrovascular disorders, pulmonary vascular diseases, deep venous thrombosis, peripheral arterial obstruction, thrombosis after artificial vascular transplantation and artificial valve transplantation, post-operative thrombosis, reobstruction and restenosis after coronary artery bypass operation, reobstruction and restenosis after PTCA or PTCR, thrombosis by extracorporeal circulation and procoagulative diseases such as glomerlonephriitis.

A gastrointestinal implant device comprises a sleeve for extending into the duodenum and an artificial valve for placement at the pylorus to control flow from the stomach into the duodenal sleeve. The implant device also comprises a support structure for the valve.

The invention discloses a stent of an artificial valve displacement device. The stent is in a mesh cylindrical structure formed by an aorta stent, a valve stent and an outflow channel stent which are sequentially connected. Three hollow-out areas are distributed on the side wall of the valve stent and respectively correspond to the top ends of three valves during opening. At least two fixed lugs are arranged on the top edge of the aorta stent. The heights of the top edges of the fixed lugs are different from each other. The shape of a hollow-out area is round, oval or diamond. The artificial valve displacement device can be used for displacing a pathological heart valve without a surgical operation, passes through blood vessels during displacement and is transplanted into the heart through femoral artery; and the heart and the aorta are incised without the operation. It is convenient to transplant, has long service life and favorable positioning effect, not only reduces the difficulty of the operation, but also realizes the recovery.

A biomedical device assembly, such as a stent, for the targeted treatment of a tissue, such as the inhibition of restentosis. The stent is coated with an antigen, which is an example of a lock. The antigen can be bound by a labelled antibody, which is an example of a key and an effector. The antibody is preferably labelled with a radioactive source. According to one method of preparing the biomedical device assembly, after the stent has been placed in the blood vessel of the subject, the antibody is injected. The antibody then binds to the antigen on the stent, thereby localizing the radioactive source to the area to be treated, for example for restenosis. Other biomedical devices, such as a coil, an artificial valve or a vascular graft, could also be used in the place of the stent. The biomedical device could be placed in another biological passageway, such as the gastrointestinal tract, an airway or the genitourinary tract.

An artificial valve is delivered percutaneously in the form of a hollow inflatable shell, which is later filled in situ with a suitable elastomer, similar to inflating a balloon. Since the shell is a flexible and mostly hollow balloon, it can be compressed and transported via a relatively small catheter. In order to inflate to the correct shape the hollow shell requires some ties between its walls. These ties are formed from a low density open cell foam or a specialized manufacturing process. The valve can combine elements with different stiffness as well as different materials. A positioning balloon can also be used in the process of placing the valve. The invention is particularly suited for cardiac valves but can be used for other artificial valves.

A gastrointestinal implant device 600 comprises a sleeve 601 for extending into the duodenum and an artificial valve 602 for placement at the pylorus 603 to control flow from the stomach into the duodenal sleeve 601. A support structure for the valve comprises a scaffold 605 to which the valve 602 is mounted and a luminal prosthesis 606. The luminal prosthesis 606 comprises a proximal flare 620 for location at the antrum of the pylorus, a bulbous region 621, and a scaffold receiving region 606.

Artificial valves for use as a venous valve or a heart valve are disclosed. The valve includes a frame including a platform and a valve material coupled to the frame. The valve material is a plurality of filaments or a flap. The valve material is coupled to the frame such that in response to a force in a first direction, e.g. blood flow, the valve material extends in the direct of the force to allow blood to flow past the valve material. In absence of the force in the first direction, the valve material rests against the platform to block blood flow in a direction opposite the first direction.

The invention relates to artificial valve prosthesis with a valve leaflet clamping device. The manual valve prosthesis comprises a bracket and an artificial valve, wherein the bracket comprises an auxiliary support clamping section and a valve sewing section; the artificial valve is fixedly connected to the valve sewing section; the auxiliary support clamping section is composed of a support bracket, a valve leaflet clamping device and an upper connection fixing section; the leaflet clamping device, the support bracket and the upper connection fixing section are integrally cut; a lower connection fixing section matched with the upper connection fixing section is arranged on the valve sewing section; the bracket is embedded and connected with the lower connection fixing section into a whole through the upper connection fixing section; one part of the valve leaflet clamping device is overlapped with the valve sewing section; the overlapped part is tightly attached to the outer surface of the valve sewing section in a natural state; a bump which protrudes outwards along the radial direction is arranged on a skeleton structure of the valve sewing section in the overlapped region; and a bending section which bends towards the axis direction of the bracket along the radial direction of the bracket is arranged on the valve leaflet clamping device or the support bracket or the upper connection fixing section.

A biological function assist apparatus composed a linear electronmechanical device or system wrapped in protective coating and controlled by a controller, which also provides power to the electromechanically-based system. The electromechanically-based system can be formed as a mesh using linear motors or linear actuators, or a larger electromechanically grid and wrapped around a failing heart. The electromechanical system can be formed in a circle forming an artificial valve (e.g., sphincter). The electromechanically-based system can operate as a bone-muscle interface, thereby functioning in place of tendons.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

An external indirect artificial valve for vein is composed of upper valve body, lower valve body and two side valve axles for connecting said upper valve body with said lower one. The both ends of the artificial valve have respectively the far-end and near-end pressing points to the wall of blood vessel, which are respectively fixed to the far end and near end of vein b suture.

An artificial mitral valve 10 is provided with a ring 12 divided along the circumferential direction into two; an anterior cusp-side region 44 and a posterior cusp-side region 45 and an artificial valve leaflet 11 connected along an outer edge of the ring 12. The artificial valve leaflet 11 is made up of a symmetric anterior cusp forming member 14 connected to the anterior cusp-side region 44 and a symmetric posterior cusp forming member 15 connected to the posterior cusp-side region 45. The anterior cusp forming member 14 is provided with an upper edge 17 joined to the ring 12 and a lower edge 22 connected to the upper edge 17 and forming a bifurcated portion 20. The upper edge 17 is made up of a pair of right and left inclined edges 24 inclined inward and upward from the right and left sides and a curved edge 25 interposed between the inclined edges 24 and curve-shaped along a reference region 48 of the anterior cusp-side region 44. The posterior cusp forming member 15 is provided with an upper edge 31 joined to the ring 12 and a lower edge 37 connected to the upper edge 31 and forming a bifurcated portion 35.

A compound represented by formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4  (1)[wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group:(wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof.The compound is useful as an agent for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The invention relates to a pulmonary valve stent with an anchor mechanism, which comprises a valve suture section (1) and an artificial valve (2), wherein the artificial valve (2) is connected with the valve suture section (1), and the valve suture section (1) is positioned at a right ventricular outflow tract or a main pulmonary artery (10) after being released. The pulmonary valve stent further comprises the anchor mechanism (3), wherein the near end of the anchor mechanism (3) is connected with the far end of the valve suture section (1) by a transition connecting rod (4), and the anchor mechanism (3) is positioned in a pulmonary artery branching vessel (30) after being released. According to the pulmonary valve stent, as the anchor mechanism is placed in the pulmonary artery branching vessel and connected with the valve suture section positioned at the right ventricular outflow tract or the main pulmonary artery by the transition connecting rod, the stability of the valve stent can be improved significantly, and displacement of the pulmonary valve stent is avoided.

Artificial valves for use as a venous valve or a heart valve are disclosed. The valve includes a frame including a platform and a valve material coupled to the frame. The valve material is a plurality of filaments or a flap. The valve material is coupled to the frame such that in response to a force in a first direction, e.g. blood flow, the valve material extends in the direct of the force to allow blood to flow past the valve material. In absence of the force in the first direction, the valve material rests against the platform to block blood flow in a direction opposite the first direction.