330 results about "Angiopathy" patented technology

The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, bone disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

A method for reconstructing 3D blood vessels belongs to the field of medical detection technology for solving the accuracy problem in blood vessel reconstruction. The technical scheme is that the method can accurately reconstruct the anatomic structure of a blood vessel by combining cross section information of the blood vessel acquired by an IVUS image sequence and ultrasonic duct spatial geometrical information obtained by 3D reconstruction based on X-ray angiographic images. Compared with the reconstruction result obtained by using two single images, the method can completely and accurately reflect the actual shapes of blood vessels and possibly-existing plaques, thus providing more reliable basis for clinical treatment of coronary heart diseases and other angiopathies.

The invention discloses a non-invasive central aortic blood pressure measuring method and device. The non-invasive central aortic blood pressure measuring method includes, according to a human artery network model based on viscous fluid mechanics, a method of calculating artery network model personalized parameters of a measured person through measured radial artery and brachial artery pulse wave signals and arm blood pressure values, a method of calculating an ascending aorta-radial artery transfer function and a method of calculating central arterial pressure waveforms through measured central arterial pressures. The non-invasive central aortic blood pressure continuous measuring device comprises a pulse wave signal processing and analysis unit and a radial artery and brachial artery pulse wave signal acquisition unit worn on a wrist. The method is different from an existing general transfer function method, the artery network model parameters of each person to be measured are measured and calculated and the artery network model parameters are numerical characteristics of the cardiovascular system states of the person to be measured with the calculated central arterial pressure waveforms, and the method and device has important meanings in prevention, curing and control of cardiovascular diseases, especially high-risk diseases, such as hypertensions and coronary heart diseases.

The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma. The formula I-II is shown in the description.

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

Novel ANP polypeptides and polynucleotides encoding same are provided. Also provided are methods and pharmaceutical compositions which can be used to treat ANP-related diseases and disorders including cardiovascular disorders using the polypeptides and polynucleotides of the present invention.

The invention relates to a method and device for measuring the autonomic nerve heart regulation and control function. The wearable device, an autonomic nerve heart regulation and control function mathematical model and an autonomic nerve heart regulation and control system parameter calculation method are involved in the method. The wearable device is used for measuring motion data, continuous blood pressure and a heart rate value sequence in a human body standing-up or inclining test. The autonomic nerve heart regulation and control function mathematical model is used for quantitatively describing the blood pressure and heart rate regulation and control process in the standing-up process. According to the autonomic nerve heart regulation and control system parameter calculation method, a series of autonomic nerve heart regulation and control system parameters such as pressure sensor sensitivity and sympathetic nerve and parasympathetic nerve activity are solved based on the autonomic nerve heart regulation and control function mathematical model and the continuous blood pressure and the heart rate value sequence measured in the standing-up or inclining test through the wearable device. Autonomic nerve regulation and control disorders are represented by reduction of the pressure sensor sensitivity and reduction of the sympathetic nerve and parasympathetic nerve activity, which are the occurrence origins and independent indexes of many lethal cardiovascular diseases. Quantitative measurement of the pressure sensor sensitivity and the sympathetic nerve and parasympathetic nerve activity is of great significance on effective diagnosis and prevention of cardiovascular diseases, evaluation of treatment effects and recovery of patients.

The present invention relates to a medical health data collection based intelligent health forecasting and decision-making system. The system is characterized by comprising the following steps: 1) data collection; 2) transmission of data to a cloud server, wherein a cloud ICVD paroxysm evaluation module processes the data; 3) doctor platform information processing; and 4) patient platform information processing. The cloud part of the scheme comprises a 10-year ischemic cardiovascular disease (abbreviated as ICVD) probability forecasting and doctor decision-making system. According to the scheme of the present invention, a cloud technology platform can assist doctors to collect health data of a patient, establish health records, and forecast a 10-year ICVD probability, so that a personalized health program is created for the patient, and the treatment decision-making system is established.

The invention discloses heart-protection and blood-nourishing flour and a preparation method thereof. The heart-protection and blood-nourishing flour is prepared from 60-70 parts by weight of wheat, 30-40 parts by weight of wheat germ, 25-30 parts by weight of black soya bean, 20-25 parts by weight of Chinese yam, 21-25 parts by weight of water chestnut, 22-26 parts by weight of banana, 20-30 parts by weight of carrot, 10-14 parts by weight of gingko seed, 16-20 parts by weight of dried bean curd, 20-25 parts by weight of shepherd's purse, 18-20 parts by weight of green plum, 8-10 parts by weight of sweet osmanthus, 1-2 parts by weight of tree peony bark, 2-3 parts by weight of rhizoma alismatis, 3-4 parts by weight of lotus leaf, 2-3 parts by weight of stigma croci, 5-6 parts by weight of ginkgo leaf, 1-2 parts by weight of a food modifier and a proper amount of water. The heart-protection and blood-nourishing flour utilizes wheat, wheat germ and black soya bean as main raw materials. Wheat germ has effects of softening blood vessels, preventing and treating cardiovascular and cerebtovascular diseases, adjusting blood pressure, controlling blood sugar, protecting heart, improving human immunity, moistening intestines and relaxing bowel, delaying aging and expelling toxins. Chinese yam, water chestnut, banana and carrot having good health care performances are used in the heart-protection and blood-nourishing flour. Water chestnut has effects of strengthening spleen and tonifying qi, strengthening thigh and knee, improving physical power and tonifying qi, resisting cancers, reducing fat, inducing diuresis, promoting lactation and relieving or neutralizing the effect of alcohol. Ginkgo leaf has effects of promoting blood circulation, preventing cardiovascular diseases, promoting blood circulation to remove blood stasis, and whitening skin and removing wrinkles.

The invention discloses a CA-(PLA-ran-PCL)-b-PEG star amphiphilic copolymer, and a preparation method and an application thereof. The star copolymer adopts the structure as shown in the formula I, wherein R' refers to the specification. The method comprises the following steps: 1, preparing CA-(PLA-ran-PCL); 2, carboxylation of PEG; and 3, preparing the CA-(PLA-ran-PCL)-b-PEG star copolymer. The copolymer provided by the invention has favourable biocompatibility and biological degradability, and can be applied to the field of pharmaceutical preparations and tissue engineering, particularly the field of antitumor drugs preparations or anti-cardiovascular disease drugs preparations.

The invention discloses a feed for inducing high-level expression of a reactive protein C of an animal and application thereof. The feed for inducing high-level expression of the reactive protein C of the animal comprises the following components in percentage by mass: 10-20% of leaf lard, 1-2% of cholesterol and the balance of a basal feed in growing period, totaling 100%. Researches on high expression of CRP of machin diet-induced by the feed for inducing high-level expression of the reactive protein C of the animal have related important research significance and application value. The feed further has important actual meaning on research of inflammatory diseases and mechanism research of inflammatory diseases such as atherosclerosis, cardiovascular disease and even diabetes and arthritis, research on early warning and efficacy evaluation after pharmacological intervention. The raw materials of the feed for inducing high-level expression of the reactive protein C of the animal disclosed by the invention are low in cost, wide in source, easily available and good in stability, and the feed for inducing high-level expression of the reactive protein C of the animal is simple in preparation method, easy to convey and store and has relatively good application and popularization prospects.