777 results about "Convulsion" patented technology

This invention relates to a pharmaceutical composition comprising or consisting essentially of the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD). The composition is particularly safe and efficacious for use in the treatment of neurological conditions, characterized by hyper-excitability of the central nervous system, convulsions or seizures such as occur in epilepsy. Preferably the CBDV and the CBD are present with at least one non-cannabinoid component of cannabis such as one or more terpenes or a terpene fraction. More particularly the composition further comprises one or more cannabichromene type compounds. Particularly cannabichromene propyl variant (CBCV) and/or cannabichromene (CBC). More particularly still the composition is absent or substantially absent of other cannabinoids, including in particular tetrahydrocannabinol (THC) and tetrahydrocannabivarin (THCV), which would normally be present in significant amounts in cannabis chemotypes bred to contain a significant amount of CBDV and/or CBD.

Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and certain structurally related compounds exhibit clinically significant pharmacological properties which implicate a treatment for a variety of pathological conditions, including spasticity and convulsions, which are ameliorated by effecting a modulation of CNS activity. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.

The present invention includes a transdermal composition which contains a pharmaceutically effective amount of a cannabinoid for delivery of the cannabinoid to the bloodstream of a user. The composition may comprise the following components: a surfactant-lecithin organogel; and a cannabinoid. The composition may also comprise an exogenous terpene. The cannabinoid is capable of diffusing from the composition into the bloodstream of the user, and may be used in methods for treating a patient suffering from a condition such as pain, nausea and emesis, convulsions, muscle spasm, inflammation, depression, and cachexia.

Methods of treating or preventing chronic pain or convulsion are disclosed by administering to an animal a sodium channel blocker and at least one of gabapentin and pregabalin. Also disclosed are pharmaceutical compositions and kits for the treatment or prevention of chronic pain or convulsion.

The invention discloses a bionic enzymatic product of horns and application thereof, which belong to the field of Chinese medicament. The bionic enzymatic product is characterized in that a bionic enzymatic method is adopted, and comprises the following steps: taking horns; grinding the horns into fine powders; adding water into the fine powders; evenly stirring the mixture; under appropriate condition, performing heat preservation by using pepsin; performing heat preservation by using pancreatin or trypsase; and preparing obtained zymolyte into preparations according to different preparationrequirements. The product of the invention has good effects in the aspects of clearing away heat and toxic material, cooling blood and hemostasis, diminishing inflammation, resisting infection and virus, arresting convulsion, and easing pain.

The invention reveals that endogenous cholesterol metabolic product cholestane-3 beta, 5 alpha, 6 beta-triol (YC-5) has protection function for neuronal damage caused by cerebral ischemia, ischemia ofspinal cord, epileptic seizure and convulsion and relates to an application of YC-5 in preparation of neuronal protection medicine. The YC-5 can be prepared from cholesterol through two steps. The primitive cell culture in vitro and spinal cord ischemia animal model proves that YC-5 has protection function for neuronal damage caused by cerebral ischemia, ischemia of spinal cord, epileptic seizureand convulsion. YC-5 in effective dose has no toxic and side reactions. YC-5 is an effective neural protectant which aims to multiple molecular mechanism and cures cerebral ischemia damage, spinal cord ischemia damage, epileptic seizure and convulsion.

The present invention provides a helical soft capsule. Every capsule contains 5-200mg of helical, the rest is solvent matrix, the described solvent matrix is one of PEG 300-1000, propylene alcohol, soybean oil and peanut oil or their composition. According to the requirements the medicinal color matter and flavor agent can be added into its liquid medicine. Said invented soft capsule has the sedation, can obviously reduce coriamyrtin convulsion incidence rate, prolong its generative latent period, reduce frequency of attack and shorten the time and process of attack, and has the actions of stopping pain and resisting inflammation, and has a certain action of relieving vasoconstriction and raising oxygen consumption of heart muscle, and its biological utilization rate can be raised by 10-59%.

The invention provides a myoelectric signal-controlled master-slave wireless functional electric stimulation rehabilitation system in the technical field of rehabilitation medical treatment. The system comprises a master unit and a slave unit, wherein the master unit is connected with a master side to transmit myoelectric information; the master unit is in wireless connection with the slave unit to transmit motion mode information; and the slave unit is connected with a slave side to transmit electrical pulse information. The master unit comprises a plurality of EMG electrode plates, an amplifier, a filter, an encoder and a wireless transmitter; and the slave unit comprises a wireless receiver, a controller, an electrical stimulator and a plurality of FES electrode plates. By using the system, a physical therapist assists a paralyzed patient to do training without physical contact, and a plurality of patients can do rehabilitation trainings following the same physical therapist, so the workload of the physical therapist is greatly lightened; meanwhile, the system can keep the muscle vitality of the patient, prevent muscular atrophy, reduce convulsion and help the patient achieve more ideal rehabilitation effect.

The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.

The invention discloses application of eucommia ulmoides extracts in the preparation of compositions for tranquilizing and inducing sleep and application of the eucommia ulmoides extracts in the preparation of compositions for treating insomnia, anxiety neurosis or convulsion. The eucommia ulmoides extracts are continuously extracted from eucommia bark, eucommia leaves, eucommia male flowers and\or eucommia whole plants by petroleum ether, ethyl acetate, normal butanol, ethanol and water. The eucommia ulmoides extracts are obtained by extracting from eucommia plants. And results of researcheson the application of the eucommia ulmoides extracts in the field of tranquilization and sleep induction show that the eucommia ulmoides extracts have remarkable effects of tranquilizing and inducingsleep and resisting convulsion, wherein the ethyl acetate extract of eucommia and the normal butanol extract of the eucommia have more obvious effects. The eucommia ulmoides extracts are natural active materials for researching and developing novel health-care foods and new drugs for tranquilizing and inducing sleep, and can be applied to the treatment of nervous system diseases such as insomnia,anxiety neurosis and convulsion without side effects and psychic dependence.

Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.

The invention belongs to a healthy protection wine, which is composed of notopterygium root, radix sileris, angelica, cassia twig, achyranthes, teasel root, wild celery, asarum, prepared rhizome of adhesive rehmannia, tuckahoe, radix codonopsitis, coix seed, qinjiu, hemlock parsley, eucommia bark, root of herbaceous peony, astragalus root, liquorice, lycopodium calvatum, Stringy Stonecrop Herb, Gambir Plant, pawpaw and xungufeng; and the above materials are smashed and dipped in high purity wine to prepare the healthy wine. The wine has functions of supplementing qi and nourishing Blood, removing rheumatism, strengthening bones and muscles, relieving convulsion, inducing diaphoresis, expelling wind and relieving convulsion, clearing away heat to stop liver, sumplementing qi and generating yang, strengthening exterior and reducing sweat, promoting urination and reducing swelling, strengthening the middle Burner and replenishing qi, promoting fluid and benefiting blood, activate yang converting qi, removing stasis and adjusting menstruation, activating articulation, nourishing liver and kidney, and cycling blood, and the wine can regulate the internal secretion from various reaspects; and improve radically human body unity and can supply nourishment reasonably; thus having special effect for curing the rheumatism and rheumatoid disease, lumbar disc herniation, arthritis, sciatica, vasculitis, impotence and cardiovascular and cerebrovascular disease.

The present invention includes a transdermal patch which contains a pharmaceutically effective amount of a cannabinoid for delivery of the cannabinoid to the bloodstream of a user. The patch may comprise the following components: a backing; and a skin-adhesive polymer matrix attached to one side of the backing, which includes a cannabinoid, a carrier agent, a terpene, and a permeation agent. The cannabinoid is capable of diffusing from the matrix in the transdermal patch into the bloodstream of the user, and may be used in methods for treating a patient suffering from a condition such as pain, nausea and emesis, convulsions, muscle spasm, inflammation, depression, and cachexia.

The invention discloses a preparation method of an ultramicro gastrodia elata decoction piece. The preparation method comprises selection of raw materials, cleaning of the raw materials, boiling, slicing, secondary boiling, drying, ultramicro wall breaking, obtaining of a preparation, and the like. Gastrodia elata processed by employing the processing and ultramicro fragmentation method has relatively high effective-composition dissolution rate, the bioavailability of a medicine is improved, the medicine effect is relatively good, and the toxicity is relatively low. The invention also discloses the decoction piece prepared by employing the method, and application of the decoction piece to prepare medicines for treating headache dizziness, numbness of limbs, infantile convulsion, epilepsy, twitch, tetanus and other diseases.

The invention discloses a far-infrared ceramic ball and a preparation method thereof. The far-infrared ceramic ball comprises the following raw materials in parts by weight: 65-85 parts of loess stone, 40-60 parts of medical stone, 25-45 parts of hexacyclic stone, 18-26 parts of stone needle, 10-15 parts of malthacite, 12-16 parts of bamboo charcoal powder, 8-14 parts of actinolite, 5-10 parts of pitchstone, 10-15 parts of muyu stone, 6-12 parts of vermiculite, 4-8 parts of nanometer zinc oxide, 16-22 parts of moire stone, and 14-18 parts of attapulgite. The far-infrared ceramic ball provided by the invention can emit far infrared rays of which wavelength is 4-16 microns, the emission rate is more than 90%, and the efficacy is long-lasting at room temperature, can effectively destroy a hydrogen bond between water molecules so as to reduce the degree of association between the water molecules and generate small molecular grouping water to improve penetration of drinking water, and can dissolve out macroelements such as potassium, sodium, calcium, magnesium and phosphorus as well as microelements such as zinc, iron, lithium, iodine and selenium, which are essential elements of a human body; efficacies of warming the kidney and tonifying Yang, relieving convulsion and calming the nerves, and removing nebula and improving eyesight can be realized after water which soaked with the far-infrared ceramic ball is drank for a long time.

Disclosed are A₃ adenosine receptor antagonists and/or partial agonists and A₁ adenosine receptor agonists and/or partial agonists of formula (I):

wherein R¹ to R⁵ are as described herein, as well as pharmaceutical compositions thereof and methods of use thereof. The A₃ AR antagonists or partial agonists find use in treating a number of diseases such as cancer, glaucoma, and inflammatory diseases, as well as in preventing cardiac ischemia. Also disclosed are radiolabeled compounds of formula (I) and the use thereof in diagnostic imaging of tissues and organs. The A₁ AR agonists and partial agonists find use in treating diseases such as seizures, convulsion, stroke, diabetes, pain, arrhythmias, depression, and anxiety and in cardioprotection or neuroprotection.

The invention discloses an externally-used plaster for treating infantile febrile convulsion. The externally-used plaster is characterized in that bulk pharmaceutical chemicals of the formula weight are grinded into powder, then wine with the alcoholic strength lower than 40 degrees is slowly dropped into the medicine powder to stir the medicine into paste while the wine is dropped. The bulk raw materials comprises by weight proportion: 0.5-2 parts of amber, 2 parts of pearl, 1 part of bezoar, 1 part of rhinoceros horn, 1 part of stiff silkworm, 1 part of periostracum cicada, 1 part of bulbus fritilariae, 1 part of pericarpium citri reticulatae, 0.5-1 part of bryozoatum, 2 parts of fructus piperis alba, 0.5-2 parts of fructus evodiae or 0.5-2 parts of concretio silicea bambusae and/or 0.5-2 parts of arisaema cum bile, 2 parts of sticky rice, 0.5-2 parts of jasmine or 0.5-2 parts of rheum officinale and 0.5-2 parts of uncaria rhynchophylla or 0.5-2 parts of gastrodia elata. The externally-used plaster for treating infantile febrile convulsion is good in effect of preventing and treating infantile convulsion, free of side and toxic effects, wide in medicine source and moderate in cost, has the effect of wind dispelling, resuscitation inducing, dizziness relieving, convulsion relieving, tranquilizing and excitement allaying, phlegm cleansing and spasmolysis, and is suitable for children patients, and the cure rate is as high as 95%.

The present invention discloses a medical composition comprising effective amount of otilonium Br for treating irritable bowel syndrome or stomach convulsion. Said composition will disperse into small granules within five minutes in water and the in vitro dissolve-out will be above 90%, which will hence dispel the convulsion rapidly. The preferred composition is of capsule type.

The invention discloses traditional Chinese medicine heal-care tea with the effects of moistening lung and lowering blood pressure, overcoming the defects of poor taste and unobvious blood pressure lowering effect of the traditional Chinese medicine heal-care tea in the prior art. The traditional Chinese medicine heal-care tea comprises the following Chinese medical herbs: chrysanthemums, apocynum venetum, selfheal, honey mulberry leaves, gynostemma pentaphyllum, lofty wallich wedelia herbs, ligusticum wallichii, lofty hedgehog hydnum, lofty hawthorns, and the like. A preparation method of the traditional Chinese medicine heal-care tea comprises the following steps of: mixing the Chinese medical herbs and then grinding or respectively grinding the Chinese medical herbs and then mixing; carrying out germicidal treatment; and placing into a brewing bag made of tea filter paper for brewing drinking. The selected raw Chinese medical herbs jointly act and have the effects of clearing heat and moistening the lung, activating blood and dissolving stasis and obviously lowering blood pressure ; and in addition, after the traditional Chinese medicine heal-care tea is drunk for a long time, symptoms, i.e. giddiness, headaches, dizziness, insomnia, frightened epilepsy, convulsion, and the like which are caused by blood pressure diseases, are obviously relieved or dispelled.