224 results about "Cannabivarin" patented technology

This invention relates to a pharmaceutical composition comprising or consisting essentially of the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD). The composition is particularly safe and efficacious for use in the treatment of neurological conditions, characterized by hyper-excitability of the central nervous system, convulsions or seizures such as occur in epilepsy. Preferably the CBDV and the CBD are present with at least one non-cannabinoid component of cannabis such as one or more terpenes or a terpene fraction. More particularly the composition further comprises one or more cannabichromene type compounds. Particularly cannabichromene propyl variant (CBCV) and/or cannabichromene (CBC). More particularly still the composition is absent or substantially absent of other cannabinoids, including in particular tetrahydrocannabinol (THC) and tetrahydrocannabivarin (THCV), which would normally be present in significant amounts in cannabis chemotypes bred to contain a significant amount of CBDV and/or CBD.

Pharmaceutical compositions comprising the cannabinoid active pharmaceutical ingredient, crystalline trans-(±)-Δ⁹-tetrahydrocannabinol, and formulations thereof are disclosed. The invention also relates to methods for treating or preventing a condition such as pain comprising administering to a patient in need thereof an effective amount of crystalline trans-(±)-Δ⁹-tetrahydrocannabinol. In specific embodiments, the crystalline trans-(±)-Δ⁹-tetrahydrocannabinol administered according to the methods for treating or preventing a condition such as pain can have a purity of at least about 98% based on the total weight of cannabinoids.

The present invention is generally directed to substantially pure cannabidiol, stable cannabinoid pharmaceutical formulations, and methods of their use.

A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.

Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is C₂₁H₃₀O₂ and its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in the Cannabis sativa L. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents. The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD treatment. Such CBD preparations are characterized by chemical components and/or funtional properties that distinguish them from prior CBD compositions. One or more components of the preparations described herein provide an unexpectedly synergistic effect when utilized in combination.

The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with childhood-onset epilepsy who are concurrently taking one or more antiepileptic drugs that works via GABA receptor agonism. Preferably the AED is stiripentol. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

The invention discloses a method for extracting and separating high-purity cannabidiol (CBD) from low-content industrial hemp floral leaves. The method adopts the modes of digestion, macroporous resinadsorption and desorption, reverse chromatography and crystallization to finally obtain a cannabidiol pure product with the purity of 99% or above. In order to separate other cannabinoids, extractionand decoloration processes can be added between the digestion process and the macroporous resin adsorption and desorption process, and a polymer reversed-phase filler is used for reversed-phase chromatography, so that cannabidivarin (CBDV), cannabinol (CBN) and tetrahydrocannabinol (THC) in the floral leaves can be separated. The method disclosed by the invention is high in digestion, extractionand decoloration process yield and high in impurity removal rate; the macroporous resin and reversed-phase column chromatography have the advantages of high loading capacity and favorable separation effect. Requirements of development of a plurality of industrial hemp products are met, and the method has great application advantages in the pharmaceutical field and is suitable for industrial popularization.

The present invention relates to the use of cannabidiol (CBD) for the treatment of tumours associated with Tuberous Sclerosis Complex (TSC). In particular the CBD was able to decrease the number and size of marker cells, pS6, in a zebrafish model of TSC. This is5 suggestive of a disease modifying effect whereby treatment with CBD could result in the reduction or prevention of the benign tumours that occur in TSC patients. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially 10 removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD. In use the CBD is given concomitantly with one or more other drugs used in the treatment of TSC. Such drugs may include rapamycin and/or everolimus.

The present invention provides a stable oil-in-water submicron emulsion oral cannabinoid composition, comprising at least one cannabinoid in a pharmaceutically acceptable carrier, at least one triglyceride oil, at least two emulsifiers, at least one taste-enhancing excipient and water, wherein the composition is essentially free of bitter taste, and is essentially free of phospholipids, liposomes and/or micelles. The present invention also encompasses methods and a kit based on said composition.

Disclosed is a topical composition including essential combination of synergistically acting phyto-active materials, non-psychotropic phytocannabinoids from the plant of Cannabis sativa: Cannabidiol, Cannabidiolic acid, Cannabivarin Cannabigerol in combination with extract of Calendula flower and the formulation of the base to ensure the features of anti-inflammation, anti-oxidation, emollient, and bactericidal components. The topical composition is an emollient dedicated for reduction of skin lesions caused by atopic dermatitis, urticaria, radiotherapy and UV induced skin damage and acne. In addition the topical composition could reduce secretion of fats, facilitate deep skin hydration, reduce pores and exert soothing effect.

The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with Lennox-Gastaut syndrome (LGS) who are deemed to be treatment failures on their existing medication. In particular the use of CBD was found to provide a statistically significant reduction in both drop seizures and total seizure frequency in patients who have tried and failed anti-epileptic drugs (AEDs) or those who were currently taking AEDs but have uncontrolled seizures. Preferably the AEDs which have been shown to be treatment failures are one or more of rufinamide, lamotrigine, topiramate and/or felbamate. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

The invention discloses a pure natural high-stability cannabinoid nano-emulsion and a production method thereof. The problem of dispersion of cannabinoids of oil-soluble cannabidiol (CBD) and the likein water is solved, so that a technical solution is provided for subsequent development of water-soluble cannabinoid-related products. The nano-emulsion is produced from the following raw materials in percentage by mass: 0.5-20% of a cannabinoid, 5-40% of an emulsion stabilizer, 0.5-10% of a non-ionic emulsifier, 0.5-30% of matrix oil and the balance deionized water; the sum of the percentages ofthe components is 100%; and the emulsion stabilizer is selected from at least one of Arabic gum and derivatives of the Arabic gum. The production method comprises the following steps: dissolving thecannabinoid in the matrix oil at a room temperature to obtain an oil phase, dissolving the emulsion stabilizer and the non-ionic emulsifier in the deionized water to obtain an aqueous phase, and evenly mixing and stirring the oil phase and the aqueous phase; and processing obtained mixed liquid by adopting a high-pressure homogenizer, an ultrasonic generator or a high-pressure microjet nanometer homogenizer until the mixed liquid becomes a stable emulsion and the viscosity does not decrease any more.

This disclosures relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heatings material to a first temperature and a second temperature.

A combination of THC, CBD and Cobalamin (in a ratio of about 63%, 27% and 10%, respectively) is used with a topical carrier such as Shea butter cream to relieve pain. The THC and CBD mixture is extracted from a Cannabis Indica dominant strain using high pressure and carbon dioxide (CO₂) as a solvent and comprises: Tetrahydrocannabinol “THC” (9-Tetrahydrocannabinol (delta-9 THC), 8-Tetrahydrocannabinol (Delta-8 THC) and 9-THC Acid), Cannabidiol “CBD”, Cannabinol “CBN”, Cannabichromene (“CBC”), Cannabigerol (“CBG”), terpenoids and flavonoids. The Shea butter is an extract from the Shea nut from the Shea tree (Vitellaria paradoxa).

Cannabis products and industrial methods for production thereof. A homogeneous composition comprising cannabinoid-containing comminuted cannabis plant material, where at least 70 weight % of the comminuted cannabis plant material is of a size greater than 0.3 millimeter and less than 4.2 millimeters; the composition comprises at least 1% by weight moisture and less than 20% by weight moisture; and the cannabinoid concentration in a 1 gram fraction of at least 10 gram sample of said homogeneous composition, is within 15% of the cannabinoid concentration in a separate 1 gram fraction of said 10 gram sample.

The invention relates to the field of protection of injuries from environmental stress factors, in particular to an efficient moisturizing and allergy-relieving repairing composition and application thereof. The high-efficiency moisturizing and allergy-relieving repair composition comprises the following components in percentage by mass: a) ectoin; b) ergothioneine or a pharmaceutically acceptablesalt or ester thereof; and c) cannabinoid as an active ingredient, wherein the content of the active ingredient in the composition is 0.5-5%. The composition has the effects of relieving sensitivity,repairing skin micro-damage and repairing after sun exposure, and can also be used for repairing a skin barrier after household acid brushing; by matching with 4D hyaluronic acid, the skin can be moistened immediately, an invisible protection film is established, external stimulation is resisted, a skin protective layer is built, the active ingredient is locked, and the purposes of efficiently moisturizing, relieving allergy and repairing are achieved.