28 results about "Benzenediol" patented technology

The present application relates to the technical field of high polymer, in particular to a kind of anti-aging high-performance composite material and its injection molding process.The acidized spirocyclic phosphate is prepared by adding phosphorus oxychloride, pentaerythritol and formic acid.A kind of composite flame retardant is prepared by mixing reaction of acidized spirocyclic phosphate, phosphorus heteroheptacyclo-acrylamide double bond derivative, phosphorus heteroheptacyclo-allyloxy double bond derivative and phosphorus hetero-link-benzenediol diallyl double bond derivative.Then, high-performance composite material is obtained by adding polypropylene, acrylonitrile-butadiene-styrene copolymer, compatibilizer, inorganic filler, antioxidant, anti-aging agent, composite flame retardant and lubricant, and by melt extrusion and granulation.The high-performance composite material is injection molded to obtain finished product.The finished product prepared by the present application has good flame retardancy, anti-aging property and mechanical property, so it has wide application prospect in the technical field of high polymer.

A method of forming an implantable biomaterial comprising the steps of providing a polyether-diisocyanate prepolymer, reacting the prepolymer with one or more chain extender molecules typically including benzene 1,4-diol to form a mouldable polymer selected from a polyurethane or polyurethane-urea polymer or a polyurethane-urea block copolymer; placing the mouldable polymer into an implantable biomaterial shaped mould, and shaping and curing the mouldable polymer in the implantable biomaterial shaped mould to form the implantable biomaterial. An implantable biomaterial such as a heart valve leaflet is also disclosed.

The present invention relates to a process for the industrial-scale production of 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol hemifumarate, a salt consisting of two molecules of 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol and one molecule of fumaric acid, and having the following formula: 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol hemifumarate is a useful intermediate in the synthesis of 5-[(1RS)-2-[(1RS)-2-(4-hydroxyphenyl)-1-methylethyl]-amino-1-hydroxyethyl]benzene-1,3-diol hydrobromide, which is used in the pharmaceutical field under the is known by the common name fenoterol hydrobromide.

The invention belongs to the technical field of oil exploitation, and particularly relates to a foaming agent for oil exploitation and a preparation method thereof. The preparation method comprises the following steps: (1) adding 5-heptylbenzene-1, 3-diol and a catalyst into a high-pressure reaction kettle, purging a pipeline and the reaction kettle with nitrogen, vacuumizing, stirring, heating to 80-85 DEG C, stopping vacuumizing, adding epoxypropane at one time, carrying out heating and heat preservation reaction for the first time, introducing ethylene oxide, carrying out heating and heat preservation reaction for the second time, and cooling to room temperature; and (2) adjusting the pH value to 5-6 by using phosphoric acid, cooling to below 10 DEG C, dropwise adding chlorosulfonic acid, and controlling the temperature to react to obtain the foaming agent. Based on 1 mole part of 5-heptylbenzene-1, 3-diol, the dosage of the propylene oxide is 4-20 mole parts, the dosage of the ethylene oxide is 10-80 mole parts, and the dosage of the chlorosulfonic acid is 1.8-2.8 mole parts. The foaming agent has the advantages of large foaming volume, long drainage half-life period, salt resistance, hardness resistance and temperature resistance.

The present disclosure provides hydrophobically-modified biopolymers, including hydrophobically-modified chitosans, which comprise benzenediol groups, optionally where a portion are oxidized to the corresponding quinone. The biopolymers demonstrate a surprising ability to tune mucoadhesive properties, material cohesive properties, and hemostatic action of the material, to provide next generation hemostats, among other uses. Accordingly, in other aspects, the disclosure provides compositions comprising the modified biopolymers of the disclosure as well as methods for bleed and wound treatment.

The invention discloses a multiple nested framework material MNF-2 constructed based on a dynamic B <-N bond and a preparation method of the multiple nested framework material MNF-2. The material MNF-2 is prepared from monomer molecules, 1, 4-phenylenediboronic acid and 4-chlorocatechol as raw materials; wherein 1, 4-benzene diboronic acid and 4-chlorocatechol are dehydrated to generate a boric acid ester structure, and B atoms of boric acid ester are combined with N atoms in monomer molecules to form B <-N coordinate bonds. A monomer molecule 4, 4, 8, 8, 12, 12-hexamethyl-2, 6, 10-tri (4-pyridyl)-8, 12-dihydro-4H-benzo [9, 1] quinolizino [3, 4, 5, 6, 7-defg] anthracene (monomer molecule M1 for short) is synthesized firstly, the monomer molecule M1 and a lewis acid molecule (4-chlorocatechol) are subjected to a one-pot method through a B <-N bond in a solution to effectively generate an MNF material, and a two-dimensional lamellar structure is formed. The lamellar material has excellent mechanical properties. The acting force range of the two-dimensional MNF material is further widened, and a new strategy is provided for preparation of the two-dimensional MNF material.

The application discloses a connecting peptide and application thereof in promoting glucose methylation modification of a compound. Glycosyltransferase-methyltransferase fusion protein genes connected by connecting peptides, genes LtLasS1 and LtLasS2 encoding benzenediol lactone synthetase are co-expressed, and it is determined through liquid phase and mass spectrum analysis of fermentation products that the fusion protein can realize glucose methylation modification on benzenediol lactone. The conversion efficiency of the fusion protein using DL-4 connecting peptide on benzenediol lactone is the highest, and the relative conversion rate is 65.54+ / -3.75%. In addition, the glucose methylation conversion efficiency of the artificial fusion protein constructed by feeding the substrate kaempferol is tested, and the conversion efficiency of the fusion protein using DL-4 connecting peptide on the substrate is 6 times that of the conversion efficiency of the substrate by using a single glycosyltransferase and methyltransferase respectively, and the relative conversion rate is increased to 60.12+ / -4.79%.

The application relates to the technical field of benzenediols, and discloses a method for preparing benzenediols, which comprises the following steps: carrying out an oxidation reaction of benzene and an oxidant in the presence of a titanium silicalite and an optional organic solvent; wherein the titanium silicalite comprises a doped metal element which enters the skeleton structure of the titanium silicalite, the bond length between the doped metal element and O atoms in the skeleton of the titanium silicalite is 0.02-0.55 nm, and the doped metal element comprises a group VIII and / or group IB metal element. By adopting the titanium silicalite containing the doped element as a catalyst, the conversion rate of benzene in the process of preparing phenol by benzene hydroxylation, the total yield of benzenediols and the selectivity of hydroquinone can be effectively improved.

The invention belongs to the technical field of cables, and particularly relates to a polyvinyl chloride fire-resistant power cable and a preparation method thereof. And extruding and granulating the premix to obtain the polyvinyl chloride fire-resistant power cable material. The preparation method of the hybrid modified bisphenol A epoxy resin comprises the following steps: carrying out phosphate esterification reaction on phosphorus trichloride, 3-(vinyloxy) benzene-1, 2-diol and an acid-binding agent to obtain a flame retardant; performing Claisen rearrangement on the flame retardant to obtain a flame retardant precursor, and finally performing addition reaction on the flame retardant precursor and 1, 3-bis (aminopropyl) tetramethyldisiloxane to obtain the heat-stable flame retardant. The preparation method comprises the following steps: pre-curing hybrid bisphenol A epoxy resin with a heat-stable flame retardant, an antioxidant, phthalic anhydride and tetrabutyl titanate under a vacuum condition to obtain hybrid modified bisphenol A epoxy resin; the cable material disclosed by the invention can effectively improve the flame retardance, heat resistance, toughness and interface bonding capacity of the polyvinyl chloride cable.

The invention discloses a preparation method of a low-VOC (volatile organic compound) polyurethane structural adhesive, and relates to the technical field of adhesives. The low-VOC polyurethane structural adhesive prepared by the invention comprises a component A and a component B, wherein the component A is prepared from castor oil, polyester glycol, a dimethyl alcohol composite flame retardant, modified aluminum oxide and a catalyst; the component B is prepared from an isocyanate terminated prepolymer, polymethylene polyphenyl polyisocyanate and a water removal agent; the dimethyl alcohol composite flame retardant is prepared by carrying out a reaction on 5-(aminomethyl)-2-furfuryl alcohol, 5-hydroxymethylfurfural and diethyl phosphite; the modified aluminum oxide is prepared by sequentially reacting aluminum oxide with aminopropyltriethoxysilane, triglycidyl isocyanurate and 4-(2H-benzo [D] [1, 2, 3] triazole-2-yl) benzene-1, 3-diol, and the modified aluminum oxide is prepared by sequentially reacting aluminum oxide with aminopropyltriethoxysilane, triglycidyl isocyanurate and 4-(2H-benzo [D] [1, 2, 3] triazole-2-yl) benzene-1, 3-diol. The low-VOC polyurethane structural adhesive prepared by the invention has the advantages of flame retardance, heat conduction and ultraviolet aging resistance.

The invention relates to the technical field of biology, in particular to a method for extracting ulinastatin in urine. According to the prepared composite adsorbent, porous ferroferric oxide magnetic microspheres serve as cores, the surfaces of the porous ferroferric oxide magnetic microspheres are coated with silicon dioxide, amination and formylation modification are carried out, then the porous ferroferric oxide magnetic microspheres react with triethylene tetramine and 3-fluoro-4-formylphenylboronic acid in sequence, finally, ulinastatin serves as a template molecule, and 4-(2-aminoethyl)-1, 2, 4-triazolo [3, 4-b]-1, 2, 4-triazolo [3, 4-b]-1, 2, 4-triazolo [3, 4-b]-1, 2, 4-b]-1, the ulinastatin composite adsorbent is prepared from ulinastatin and 1, 2-benzenediol hydrochloride as functional monomers, the prepared composite adsorbent accurately recognizes and captures ulinastatin molecules, and adsorbs little other impure proteins and interfering substances, so that the yield and purity of ulinastatin are effectively improved; moreover, the use of strong acid and strong base is avoided, the denaturation and inactivation of ulinastatin in the treatment process can be reduced to the greatest extent by adopting the technical means of combining vacuum concentration and freeze drying, and the biological activity of the final product is effectively guaranteed.

The present disclosure provides a process for the preparation of 3, 5-dihydroxy-4-isopropyl-trans-stilbene [Benvimod] and related compounds. The present disclosure provides a process for the preparation of 3, 5-dihydroxy-4-isopropyl-trans-stilbene [Benvimod]. Aromatic hydrocarbon receptor (AHR) agonists are novel drugs for the topical treatment of adult plaque psoriasis. AHR agonists are considered to inhibit the release of pro-inflammatory proteins (cytokines) and to down-regulate inflammatory responses. The present invention relates to nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, nematodes, in particular, their bacterial symbionts.

The application belongs to the technical field of cables, and particularly relates to a polyvinyl chloride fire-resistant power cable and a preparation method thereof; the polyvinyl chloride fire-resistant power cable material is obtained by extruding and granulating premix; wherein, the preparation of the hybrid modified bisphenol A type epoxy resin comprises: obtaining a flame retardant by phosphate esterification reaction of phosphorus trichloride, 3-(ethylenoxy) benzene-1,2-diol and an acid binding agent; then obtaining a flame retardant precursor by Claisen rearrangement of the flame retardant, and finally obtaining a thermal stability type flame retardant by addition reaction of the flame retardant precursor and 1,3-di(amino propyl) tetramethyl disiloxane; the hybrid modified bisphenol A type epoxy resin is obtained by pre-curing the hybrid bisphenol A type epoxy resin under vacuum conditions and with the thermal stability type flame retardant, an antioxidant, phthalic anhydride and tetrabutyl titanate; the cable material can effectively improve the flame retardance, heat resistance, toughness and interface bonding capacity of the polyvinyl chloride cable.

The present application relates to the field of rubber auxiliaries, and relates to a rubber auxiliary with reinforcing and anti-aging functions. The main components of the rubber auxiliary include, but are not limited to, one or more of styrene bisphenol, benzenediol tar, polybutyl bisphenol, furan phenol tar, and benzenediol tar-formaldehyde oligomer, and one or more of dioctyl phthalate, white carbon black, phenyl silicone oil, and silane coupling agent. The composite auxiliary prepared by the method of the present application is a reactive auxiliary, which participates in the cross-linking reaction of natural rubber or synthetic rubber, and has the characteristics of a rubber plasticizer. Since it does not contain polycyclic aromatic hydrocarbons, it has the green advantage of environmental friendliness. The rubber compound prepared using the composite auxiliary has reduced energy consumption during mixing, good dimensional stability of the semi-finished product, and improved surface smoothness of the calendered rubber compound. Compared with the rubber vulcanizate without using the auxiliary, the use of the auxiliary improves the tear resistance and aging resistance of the rubber product.

The present invention relates to a co-crystal of dexamethasone (DEX) and a benzenediol, the co-crystal consisting of a 1:1 molar ratio of DEX and a benzenediol. The benzenediol can be catechol (CAT) or resorcinol (RES). The co-crystal of DEX and a benzenediol is formed by milling crystalline DEX with crystalline benzenediol combined in a 1:1 molar ratio. The milling can be performed at room temperature. The co-crystal can be heat annealed or exposed to moisture to enhance co-crystal formation. The DEX-CAT or DEX-RES co-crystal can be included in a medicament for the treatment of allergy, asthma, rhinitis, cancer, diabetes, anemia, ulcer, and viral infection. The DEX-benzenediol co-crystal can be screened to provide particles in the range of 10 to 45 pm, which can be used for intranasal administration, with improved dissolution properties.

The invention relates to the technical field of modified petroleum resin, in particular to modified petroleum resin with a high softening point and high cohesiveness and a preparation method of the modified petroleum resin. The preparation method of the modified petroleum resin comprises the following steps: under the action of a Lewis acid catalyst, benzenediol and divinyl benzene are subjected to an alkylation reaction, and a product is subjected to flash evaporation at 210 DEG C and-90 kPa to remove unreacted raw materials and is recycled; and mixing the resin liquid with polyisobutylene succinic anhydride according to a mass ratio of (1-20): 1, and reacting to obtain the product. The softening point of the modified petroleum resin is 125-170 DEG C, the Gardner color number is smaller than 3, the VOC content is smaller than 0.5%, the modified petroleum resin has excellent initial viscosity, damp-heat aging resistance and high-temperature thermal stability, the compatibility with a rubber matrix is good, the Mooney viscosity of a rubber material can be effectively reduced, the mechanical property can be guaranteed, and the modified petroleum resin can be applied to the rubber industrial fields of tire production, waste tire recycling and the like.

The application provides a high-performance liquid chromatography detection method for cosmetic intermediates resorcinol, ferulic acid, phenethyl resorcinol and benzoyl peroxide, which comprises the following steps: accurately weighing resorcinol, phenethyl resorcinol, benzoyl peroxide and ferulic acid standard products respectively to prepare a mixed standard solution, and precisely pipetting the mixed standard solution to obtain a series of standard working solutions by gradient concentration dilution; mixing and stirring the sample to be detected and methanol, vortexing, centrifuging, taking the supernatant, filtering, and reserving the filtrate; and injecting the standard working solution and the treated sample solution into a liquid chromatograph respectively to perform quantitative analysis and testing. The detection method is simple in operation, rapid in analysis, strong in specificity, high in separation degree, and can be used as a detection method for the four whitening components in cosmetics, thereby providing technical support for the efficacy component detection of cosmetics.

The invention discloses a mixed solvent composition, the mixed solvent composition contains ketone, alcohol and nitrile, the mass ratio of the ketone to the alcohol to the nitrile is 1: 0.1-10: 0.1-10, the mixed solvent composition is especially suitable for being used as a solvent for hydroxylation reaction of phenolic compounds, and is especially suitable for being used as a solvent for synthesis of benzenediol through hydroxylation of phenol. The reaction system has the advantages of high phenol conversion rate, high benzenediol selectivity, high ratio of hydroquinone to catechol, and good catalyst stability.

The invention relates to a molecular sieve preparation technology, in particular to a preparation method of a short b-axis flaky TS-1 molecular sieve with controllable titanium content. The preparation method comprises the following steps: preparing an S-1 seed crystal, mixing a silicon source and a titanium source, adding the S-1 seed crystal and an ammonium solution, and carrying out a crystallization reaction to obtain the short b-axis TS-1. The reaction process is simple, and the titanium content of the TS-1 molecular sieve can be increased. The synthesized TS-1 molecular sieve is in a sheet shape, has a short b axis and a large surface area, and has a high phenol conversion rate and benzenediol selectivity when being used for preparing benzenediol through phenol hydroxylation.

The invention provides a method for preparing catechol and hydroquinone through in-situ reaction of hydrogen and oxygen, and belongs to the technical field of organic chemistry. The invention provides a one-step green synthesis method of catechol and hydroquinone by taking hydrogen and oxygen as raw materials, which is characterized in that a specially designed Pd / Au-TS-1 bifunctional catalyst is adopted to realize in-situ generation of hydrogen peroxide from hydrogen and oxygen in a microchannel reactor, and the hydrogen peroxide and phenol are subjected to hydroxylation reaction immediately. Through cooperation of the high-performance bifunctional catalyst, the safe and efficient micro-reaction system and the green in-situ reaction process, a series of key problems of poor safety, serious environmental pollution, long process flow, high cost and the like in the prior art are successfully solved; and a new clean benzenediol production route with a high industrial application prospect is provided.

A method of forming an implantable biomaterial comprising the steps of providing a polyether-diisocyanate prepolymer, reacting the prepolymer with one or more chain extender molecules typically including benzene 1,4-diol to form a mouldable polymer selected from a polyurethane or polyurethane-urea polymer or a polyurethane-urea block copolymer; placing the mouldable polymer into an implantable biomaterial shaped mould, and shaping and curing the mouldable polymer in the implantable biomaterial shaped mould to form the implantable biomaterial. An implantable biomaterial such as a heart valve leaflet is also disclosed.

The application discloses a preparation method of low-VOC polyurethane structural adhesive and relates to the technical field of adhesives. The low-VOC polyurethane structural adhesive prepared by the method comprises component A and component B, the component A is composed of castor oil, polyester dihydric alcohol, dimethyl alcohol composite flame retardant, modified alumina and a catalyst, the component B is composed of isocyanate-terminated prepolymer, polymethylene polyphenyl polyisocyanate and a water-removing agent, the dimethyl alcohol composite flame retardant is prepared by reacting 5-(aminomethyl)-2-furfuryl alcohol, 5-hydroxymethyl furfural and diethyl phosphite, and the modified alumina is prepared by sequentially reacting alumina with aminopropyl triethoxysilane, isocyanuric acid triglycidyl ester and 4-(2H-benzo[D][1,2,3]triazol-2-yl)benzene-1,3-diol. The low-VOC polyurethane structural adhesive prepared by the method has the advantages of flame retardation, heat conduction and ultraviolet aging resistance.

The present invention provides processes for the preparation of 2-isopropyl-5-(isoquinolin-3-yl)benzene-1,3-diol or a pharmaceutically acceptable salt or pharmaceutically acceptable cocrystal thereof and novel intermediates used therein.

The application provides a production method and a production device of a benzenediol. The production method comprises the following steps: feeding phenol and hydrogen peroxide into a first shell-and-tube reactor provided with a catalyst to perform a hydroxylation reaction; feeding a first circulating medium into the shell of the first shell-and-tube reactor to make the initial bed temperature be 25-30 DEG C; removing the heat generated by the hydroxylation reaction through the first circulating medium; detecting the inflow temperature and the outflow temperature of the first circulating medium; obtaining a first temperature rise estimation value of the first shell-and-tube reactor according to the specific heat of the material entering the first shell-and-tube reactor, the mass flow of the phenol and the hydrogen peroxide, the specific heat of the first circulating medium, the flow of the first circulating medium, the inflow temperature and the outflow temperature of the first circulating medium; when the first temperature rise estimation value is lower than a preset temperature rise value, increasing the inflow temperature of the first circulating medium by a first preset temperature value; and replacing the catalyst of the first shell-and-tube reactor when the bed temperature of the first shell-and-tube reactor reaches 45-50 DEG C.

The application discloses a kind of coal mine exploitation with high consolidation type dust suppressant of anti-spraying, it is related to coal mine spray dust suppression technical field, preparation raw materials include: tamarind gum 5~7 parts, 2~3 parts of p-benzenediol boronic acid, polyacrylamide 4~6 parts, 2~3 parts of glutaraldehyde, fatty alcohol polyoxyethylene ether sodium sulfate 5~10 parts, glycerol 3~5 parts.The beneficial effects of the application are that by introducing p-benzenediol boronic acid, the hydroxyl groups on tamarind gum and the boronic acid groups are dehydrated and condensed to form borate ester bonds, forming a dynamic crosslinking structure, so that the water sensitivity of the material itself is improved;The dynamic crosslinking of borate ester bond makes there be a certain free hydroxyl group on modified product I all the time, another aldehyde group on glutaraldehyde reacts with the hydroxyl group of modified product I to form a more stable crosslinking structure, and glutaraldehyde crosslinks polyacrylamide and modified product I, so that the film-forming property, tensile resistance, water retention and the like of modified product II are further improved.

The invention belongs to the field of compound preparation, and particularly relates to a synthetic method of 4-((4-hydroxyphenyl) sulfonyl) benzene-1, 2-diol, 4-iodo-1, 2-dimethoxybenzene and 4-methoxythiophenol are used as raw materials, and the 4-((4-hydroxyphenyl) sulfonyl) benzene-1, 2-diol is synthesized through three-step reaction of Ullmann thioether synthesis, thioether oxidation and demethylation protection. The 4-((4-hydroxyphenyl) sulfonyl) benzene-1, 2-diol with a definite structure is synthesized and obtained through a self-designed chemical synthesis method, a brand new and efficient synthetic route with regioselectivity is developed, the 4-((4-hydroxyphenyl) sulfonyl) benzene-1, 2-diol is determined to be a hydroxylation conversion product of bisphenol S through comparison by means of mass spectrum and nuclear magnetism, and the application of the 4-((4-hydroxyphenyl) sulfonyl) benzene-1, 2-diol has the advantages of being simple in preparation process, low in cost and wide in application prospect. And a raw material is provided for subsequent accurate quantification and toxicity evaluation of the converted product.

Representative xanthohumol derivatives have been made and have been tested in vivo in mice. Such derivatives have a number of important medicinal benefits, including improving glucose tolerance and decreasing weight gain by increasing energy expenditure and locomotor activity in treated subjects. Disclosed derivatives also may function as mitochondrial uncouplers. Representative compounds include 4-(5-(4-hydroxyphenyl)-1-methyl-1H-pyrazol-3-yl)-5-methoxy-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol and 4-(5-(4-hydroxyphenyl)isoxazole-3-yl)-5-methoxy-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol.

The present invention provides a powder of 2,2',3,3',5,5'-hexamethyl-biphenyl-4,4'-diol-bis(trimellitic anhydride) having good handling properties and a method for producing the same. As a solution, a powder of 2,2',3,3',5,5'-hexamethyl-biphenyl-4,4'-diol-bis(trimellitic anhydride) having an average particle diameter of 10 to 40 μm is provided.