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Preparation method of conductive adhesive hydrogel

A conductive adhesion and hydrogel technology, applied in the field of materials, can solve the problems of lack of biological signals, less cell interaction, etc., and achieve the effects of low cytotoxicity, good biocompatibility, and good structural stability.

Inactive Publication Date: 2021-01-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Compared with natural polymers, synthetic polymers have the advantages of controllable molecular structure and physical and chemical properties, but the disadvantages are the lack of biological signals and less interaction with cells, so they can be combined with natural polymers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of modified carboxymethyl chitosan: Weigh 10 g of oxidized carboxymethyl chitosan in a reaction kettle, add 1000 ml of MES buffer solution at pH 5.5, and stir evenly at 35°C to make it completely Dissolve and make a CMC solution with a mass fraction of 2.5%. Then 2g of NHS and 2g of EDC were added sequentially to activate the reaction for 20 min, then 5g of dopamine was added, the pH of the reaction system was adjusted to 5.0±0.5 with 1 M dilute hydrochloric acid, and the reaction was stirred for 24 h. The whole reaction process was always under nitrogen protection. After the reaction, put it into a dialysis bag with a molecular weight cut-off of 3000 Da, dialyze with distilled water for 3 days, and change the liquid 4 to 5 times a day. The product is then freeze-dried and stored for subsequent use;

[0025] (2) Preparation of conductive adhesive hydrogel: Weigh 15 g of modified carboxymethyl chitosan, dissolve it in 700 ml of distilled water, add 200 ...

Embodiment 2

[0027] (1) Preparation of catechol-containing oxidized hyaluronic acid: Preparation of catechol-containing oxidized hyaluronic acid: 5.0 g oxidized hyaluronic acid was dissolved in MES buffer solution with pH 5.5, Add 2.91g NHS and 4.84g EDC to activate the reaction for 30 min. 2 Under protection, add 2g of dopamine, stir and react for 24 hours, then dialyze with a dialysis bag with a molecular weight cut-off of 3000Da for 5 days, change the water 4 to 5 times a day, and obtain oxidized hyaluronic acid grafted with dopamine after freeze-drying;

[0028] (2) Preparation of conductive adhesive hydrogel: Dissolve collagen in 0.1 mol / L acetic acid to prepare 2 ml of collagen solution with a mass concentration of 6 mg / mL, and adjust the pH of the collagen solution to 7.4 with NaOH. Add 7 ml of oxidized hyaluronic acid containing 0.1 g of grafted dopamine to the collagen solution, stir and react at 4 °C for 4 h, weigh 2.5 g of acrylamide and add it to the above solution, add 1 ml of...

Embodiment 3

[0030] (1) Preparation of modified sodium alginate: Weigh 2.5Kg of oxidized sodium alginate into a reaction kettle with nitrogen as a protective gas, add 97.5 Kg of MES buffer solution with a concentration of 20mmol / L and a pH of 5.5, at 35 Stir evenly at ℃ to make it dissolve completely, and prepare a solution with a mass fraction of 2.5%. Then add 1.5Kg of NHS and 2.5kg of EDC in turn, activate the reaction for 20 minutes, then add 2Kg of dopamine, adjust the pH of the reaction system to about 5.0 with hydrochloric acid, and stir for 24 hours. The whole reaction process was always under nitrogen protection. After the reaction, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Da, dialyzed in distilled water for 3 days, and the solution was changed 4 to 5 times a day. The product is then freeze-dried and stored for subsequent use;

[0031] (2) Preparation of conductive adhesive hydrogel: Dissolve 150 g of modified sodium alginate in 7...

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PUM

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Abstract

The invention discloses a preparation method of conductive adhesive hydrogel. The preparation method comprises the following steps of: grafting dopamine to carboxyl-containing oxidized polysaccharidethrough amidation reaction; and adding catechol group-containing oxidized polysaccharide and iron ions into collagen (or gelatin) and a polyacrylamide system, so as to make benzenediol groups and ironions form a redox pair, so as to initiate free radical polymerization of acrylamide and crosslinking of collagen (or gelatin) to form the double-network hydrogel with electric conduction and adhesionfunctions. The hydrogel has the advantages of good porosity, swelling rate, electrical conductivity, adhesion performance and good biocompatibility. The method can be used for preparing the conductive hydrogel in the fields of biomedicine, electronic skin, human-computer interface, human body activity monitoring, wearable electronic equipment and the like.

Description

technical field [0001] The invention relates to a preparation method of conductive adhesive hydrogel, which belongs to the field of materials. Background technique [0002] Hydrogels are elastic cross-linked polymer networks filled with abundant fluids. Conductive hydrogel is a new type of hydrogel that combines a hydrophilic matrix with conductive fillers. Due to the conductive hydrogel's ability to conduct electricity and the inherent functions of hydrogels, it can cope with a wide range of environmental conditions. Therefore, conductive hydrogels are widely used in many fields such as renewable energy, flexible electronics, tissue engineering, and drug delivery systems. Both have broad application prospects and potential. Generally, the preparation strategies of conductive hydrogels are as follows: one is to combine conductive fillers, such as carbon-based materials, ions, conductive nanoparticles, conductive polymer monomers, etc. After the polymers are mixed, they ar...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/06C08F222/38C08J3/075C08L51/02
CPCC08F251/00C08J3/075C08J2351/02C08F220/06C08F222/385
Inventor 陈一宁但年华但卫华余国飞
Owner SICHUAN UNIV
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