The invention relates to a lappaconitine gel patch and a preparation method thereof. The gel patch sequentially comprises a non-woven fabric layer, a patch matrix layer and a protective layer, wherein the patch matrix layer consists of the following components in parts by weight: 1.0-2.5 parts of lappaconitine, 5-12 parts of a cross-linked matrix, 0.2-0.4 parts of a cross-linking agent, 0.2-0.4 parts of a cross-linking regulator, 0.5-3 parts of a hydrophilic matrix, 0.5-3 parts of a filler, 20-35 parts of moisturizer, 0.5-3 parts of a transdermal promoter, 8-25 parts of a solubilizer and 25-55 parts of water. The gel patch prepared by the invention is high in drug loading amount, long in moisture content, strong in moisture retention, high in transdermal rate, long-acting, good in sustained-release effect and low in toxic and side effects, and the gel patch can dredge meridians and viscera, so as to take effects on a whole body; the gel patch is free from allergy or irritation and convenient to use; the gel patch cannot contaminate clothes and is unnecessary to pull hairs; and the gel patch can be repeatedly used and is low in production cost.