3 results about "Hydrophilic matrix" patented technology

The present disclosure allows for an anaerobic biofilm also known as a beneficial biofilm, to be grown on a hydrophilic substrate surface and contained within the varied surface and surface-accessible interior of the substrate. This allows for the anaerobic biofilm to remain intact and functional while being exposed to an aerobic environment. The present disclosure further allows for the constituent microbes to interact with an oxygen-rich surrounding without perishing. The present disclosure allows anaerobic biofilm constituent microbes to exist side-by-side with aerobic biofilm constituent microbes and employ various mechanisms to starve or eliminate unhealthy biofilms and sessile and free-floating unwanted microbes, and / or deliver substances to soil to improve soil health or to the body to assist in repair of injuries such as microbial infections, lesions, tumors, cuts, abrasions, burns, and nerve damage.

This invention belongs to the field of hydrogel technology, specifically relating to an organosilicon-reinforced high-strength and tough hydrogel, its preparation method, and its applications. The organosilicon-reinforced high-strength and tough hydrogel and its preparation method involve first preparing a hydrophobic amino-functionalized polysiloxane (APSi) using aminosilane as a raw material. Then, APSi is mixed with polymerizable monoacids and hydrophilic matrix monomers. Uniform dispersion and strong interfacial bonding of the organosilicon are achieved through salt-forming ion interactions. The high-strength and tough hydrogel is obtained through photo-initiated or thermally-initiated polymerization. This invention overcomes the technical bottleneck of limited improvement in the strength and toughness of hydrogels by traditional methods, completely solving the industry problems of poor mechanical properties, weak puncture resistance, poor tear resistance, uneven organosilicon dispersion, and weak interfacial bonding in traditional hydrogels. The resulting hydrogel exhibits high tensile strength, good toughness, excellent puncture and tear resistance, fatigue resistance, and strong stability. The preparation process is mild and simple, and it can be widely applied in high-end fields such as biomedicine, flexible electronics, soft robotics, and smart wearables.

Described herein are solid oral sustained release Kv7.2 / 7.3 potassium channel activator formulations for oral administration. In certain aspects, the formulations have a specific dissolution rate profile and / or a specific peak-to-valley ratio. In one aspect, the formulation comprises an intragranular portion comprising a Kv7.2 / 7.3 potassium channel activator, a hydrophilic matrix polymer, a filler, and a binder; and an extragranular fraction comprising a sustained release polymer, optionally a hydrophilic matrix polymer, and a lubricant. The Kv7.2 / 7.3 potassium channel activator has a formula I or a pharmaceutically acceptable salt of the Kv7.2 / 7.3 potassium channel activator. I