The invention provides mesalazine dripping pills and a preparation method thereof. According to the invention, mesalazine and a substrate are combined according to a weight ratio of 1:1-100, such that the dripping pills are obtained. According to the invention, a mesalazine preparation form is changed from tablets unto dripping pills, such that the medicine is dispersed into the substrate in a state of molecules, colloid or microcrystalline. Medicine total surface area is increased. The substrate is hydrophilic, such that a wetting effect is provided for the medicine, and the medicine can be rapidly dispersed into micro-particles or solution. Therefore, medicine dissolving and absorption are accelerated, and bioavailability and medicine stability are improved. The dripping pills are highly efficient and convenient. Therefore, the mesalazine dripping pills provided by the invention has the advantages of accelerated dissolving and absorption, convenient application, high bioavailability and medicine stability, reduced adverse reaction, fast effect, convenient carrying, simple production process, and suitability for large-scale productions.