4 results about "Mesalazine" patented technology

The present application relates to a new use of halogenophenol compound 4,5,2'-trihydroxy-2,5'-dibromobenzophenone, in particular in the preparation of a drug for treating inflammatory bowel disease. The halogenophenol compound of the present application can significantly alleviate the weight loss and colon shortening of the colonitis model, reduce the disease activity index of the colonitis model, reduce the inflammatory cell infiltration of the colonitis model, reduce the expression of inflammatory factors, has an immune regulation function on the intestinal tract, and is superior to the clinical first-line drug mesalazine in most indicators, and has application prospects in the treatment of inflammatory bowel disease.

The application belongs to the technical field of medicine synthesis and specifically relates to a preparation method of mesalamine. In the application, ethylene glycol is used to replace water as a reaction solvent in a substitution reaction, the reaction temperature can be increased to 130-140 DEG C, the reaction time is shortened to 3-4 hours, after the substitution reaction is completed, direct cooling and crystallization are carried out, 5-nitrosalicylate is separated, and the mother liquor can be directly used for the next batch of substitution reaction after adding alkali, so that the ethylene glycol and excess alkali can be reused, no waste water and waste liquid are generated, the production cycle is short, the process is simple, the operation is simple, the "three wastes" are less, and the application is green and environmentally friendly.

The present application relates to a kind of pump control administration system and its execution method for mesalamine enema preparation, belong to the technical field of drug delivery and intelligent administration control. Among them, system includes holding / adapting component, drive assembly, controller, user interaction unit;Holding / adapting component is used to position commercial packaging container, so that commercial packaging container is in sealing communication with output passage, and commercial packaging container is in the driving range of drive assembly, drive assembly is used to apply action to commercial packaging container to output liquid medicine;At least one set of candidate delivery parameter set associated with mesalamine enema preparation is stored or called in controller, and a set of target delivery parameters in candidate delivery parameter set is determined, and local safety check is carried out on target delivery parameter;After local safety check passes and user actively confirms, control drive assembly executes output operation according to target delivery parameter. Pumping execution control to mesalamine enema preparation existing commercial package is realized.

The invention relates to microparticles comprising a solid core that comprises mesalazine and a polymeric binder, wherein the core has a particle size distribution with d50 of 20-100 µm and span lower than 2.5, and wherein the core comprises at least 75 wt% of mesalazine based on the total weight of the core. The invention also refers to a method for the manufacture of the microparticles, to a pharmaceutical composition comprising the microparticles and to the use of the microparticles in the prevention or treatment of an inflammatory bowel disease, such as ulcerative colitis or Crohn's disease.