The invention discloses a preparation method of Wenxin Formulation, which relates to a preparation method of a traditional Chinese medicinal composition for treating the syndrome of heart-qi insufficiency and solves the problem in the prior art that there is no a pharmaceutical preparation process for Wenxin Formulation. The method comprises (1) taking white ginseng, cassia twig, Trichosanthes kirilowii, Allium macrostemon, Ternate pinellia, Paeonia lactiflora, Ophiopogon japonicas and Coptis chinensis, reflux-extracting with ethanol, and cooling and then filtering the extraction liquid; (2) adding ethanol into the extraction residues for reflux-extraction, cooling and then filtering the extraction liquid, adding ethanol into the extraction residues again for reflux-extraction, mixing all the filtrates, recovering the filtrates under reduced pressure, concentrating until no ethanol smell is detected, evaporate to dryness in an evaporating dish, and then vacuum-drying. The preparation method of Wenxin Formulation (a traditional Chinese medicinal composition for treating the syndrome of heart-qi insufficiency), disclosed in the invention, has a simple and convenient process, conforms to the requirements in real production, and solves the problem in the prior art that there is no a pharmaceutical preparation process for Wenxin Formulation. The prepared Wenxin Formulation has definite efficacy on the syndrome of heart-qi insufficiency, and the total effectiveness reaches 90.8%.