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Ultraviolet light blocking type hydrogel containing immobilized nanoparticles and preparation method of hydrogel

A nanoparticle and hydrogel technology, which is applied in the field of ultraviolet light blocking hydrogel and its preparation, can solve the problems of phase separation, agglomeration, and biological toxicity, and achieves the solution of spillover and agglomeration, mild reaction conditions, and controlled reaction. degree of effect

Active Publication Date: 2021-09-21
LISHUI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In long-term use, there will be problems of overflow, phase separation and agglomeration
In addition, the preparation methods and defects of hydrogels with the function of encapsulating nanoparticles to achieve drug release are basically the same, which not only affects the transparency of hydrogels, but also leads to biological toxicity.

Method used

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  • Ultraviolet light blocking type hydrogel containing immobilized nanoparticles and preparation method of hydrogel
  • Ultraviolet light blocking type hydrogel containing immobilized nanoparticles and preparation method of hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Step 1: Add 50ml of water and ethylene glycol mixed solvent with a volume ratio of 3:1 into the beaker, add 30g of hydroxyethyl methacrylate and ethylene glycol dimethacrylate with a mass ratio of 1:0.05:0.015 And 1-allylpiperazine mixture, ultrasonically dispersed at low temperature for 15 minutes, then added 0.1g of azobisisobutyronitrile and ultrasonically dispersed at low temperature for 45 minutes, after ultrasonic dispersion was completed, poured into the mold, and stood at 40°C for 9 hours , heated up to 60°C and kept for 12h to obtain an intermediate product;

[0029] Step 2: Put the intermediate product obtained in Step 1 into a three-necked flask, add 200ml of deionized water to soak for 2 days, replace the deionized water every 8 hours, and then pass nitrogen gas for 30 minutes, and then move the whole system into a shaking shaker. Adjust the oscillation speed to 200rpm / min, first add 60mlm of sodium borohydride solution with a concentration of 0.3g / ml, then ...

Embodiment 2

[0033] Step 1: Add 60ml of water and ethylene glycol mixed solvent with a volume ratio of 3:1 into the beaker, add 30g of hydroxyethyl methacrylate and ethylene glycol dimethacrylate with a mass ratio of 1:0.05:0.05 And N-ethylmethacrylamine mixture, ultrasonically disperse at low temperature for 25 minutes, then add 0.07g of azobisisobutyronitrile and ultrasonically disperse at low temperature for 40 minutes, after the ultrasonic dispersion is completed, pour it into a mold, and let it stand at 50°C for 10 hours Afterwards, the temperature was raised to 60°C and kept for 24h to obtain an intermediate product;

[0034] Step 2: Put the intermediate product obtained in Step 1 into a three-necked flask, add 200ml of deionized water to soak for 3 days, and replace the deionized water every 8 hours during this period, and then pass nitrogen for 50 minutes, and then move the whole system into a vibrating shaker. Adjust the shaking speed to 200rpm / min, first add 100ml of sodium boroh...

Embodiment 3

[0038] Step 1: Add 65ml of water and ethylene glycol mixed solvent with a volume ratio of 4:1 into the beaker, add 45g of hydroxyethyl methacrylate and ethylene glycol dimethacrylate with a mass ratio of 1:0.05:0.015 And 1-allylpiperazine mixture, ultrasonically disperse at low temperature for 30 minutes, then add 0.8g of azobisisobutyronitrile and ultrasonically disperse at low temperature for 50 minutes, after ultrasonic dispersion is completed, pour it into the mold, and let it stand at 55°C for 18 hours , heated up to 80°C and kept for 30h to obtain an intermediate product;

[0039] Step 2: Put the intermediate product obtained in Step 1 into a three-necked flask, add 300ml of deionized water to soak for 2 days, replace the deionized water every 8 hours, and then pass nitrogen for 50 minutes, and then move the whole system into a vibrating shaker. Adjust the shaking speed to 250rpm / min, first add 125ml of sodium borohydride solution with a concentration of 0.3g / ml, then dr...

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Abstract

The invention belongs to the technical field of functional hydrogel materials, and discloses ultraviolet light blocking type hydrogel containing immobilized nanoparticles and a preparation method of the ultraviolet light blocking type hydrogel. A redox initiator formed by nano iron oxide oxidized by zero-valent iron particles and persulfate is adopted to initiate microemulsion polymerization of a monomer with an ultraviolet light blocking function and a carboxyl-containing monomer in the hydrogel to form nano particles with ultraviolet light blocking performance, and EDC / NHS is utilized to realize immobilization of the nano particles in the hydrogel. The zero-valent iron nanoparticles can slowly provide Fe < 2 + > as a slow-release agent to form a redox system with the persulfate after being oxidized, so that the nanoparticles with a light barrier effect are ensured to be formed in the hydrogel under a relatively mild condition, and the curing condition in the next step is relatively mild and is unlikely to damage the hydrogel structure. According to the hydrogel and the method of the invention, the nano particles with the ultraviolet light barrier performance are fixed in a hydrogel system through EDC / NHS, so that the problems of overflow and agglomeration of the nano particles after long-term use are solved.

Description

Technical field: [0001] The invention belongs to the technical field of functional hydrogel materials, and in particular relates to an ultraviolet light blocking hydrogel containing immobilized nanoparticles and a preparation method thereof. Background technique: [0002] Polymer hydrogels can be used in fields such as corneal contact angle and artificial tissue. When it is applied to contact lenses, hydrogels with light-blocking ultraviolet rays and drug release functions have more popularization value and application prospects, but the traditional light-blocking hydrogels are made by combining small molecules or inorganic nanoparticles The photoblocker is added to the hydrogel raw material by physical blending method, and the raw material remains in the hydrogel after reaction. In long-term use, there will be problems of overflow, phase separation and agglomeration. In addition, the preparation methods and defects of hydrogels with the function of encapsulating nanoparti...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L51/00C08K3/22C08F265/06C08F220/18C08F220/26C08F220/36C08F220/20C08F222/14C08F226/06C08F226/02
CPCC08J3/075C08F265/06C08F220/20C08J2351/00C08K2003/2265C08K2201/011C08F220/1804C08F220/26C08F220/36C08F222/102C08F226/06C08F226/02
Inventor 张玲于健兰巧巧毛小雨
Owner LISHUI UNIV
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