161results about How to "Avoid sudden release" patented technology

The invention relates to a photosensitive PRP (platelet-rich plasma) gel and a preparation method and application thereof. The preparation method comprises the following steps of mixing a biocompatible medium solution of a macromolecule modified by an o-nitrobenzyl photo response group and an extracted PRP according to a certain ratio, so as to form a gel precursor solution; then, radiating the gel precursor solution by light, and enabling the o-nitrobenzyl group in the macromolecule modified by the o-nitrobenzyl photo response group to generate photochemical reaction under the excitation action of a light source, so as to produce an aldehyde functional group; generating coupling reaction with amino distributed at the surface of the protein in the PRP to form an imine bond, so as to realize the preparation of the photosensitive PRP gel. Compared with the prior art, the photosensitive PRP gel prepared by the method has the advantages that the internal cell factors can be slowly released, and the tight and seamless bonding between the PRP gel and wounds is realized.

The invention provides a cisplatin complex which is formed by complexing cisplatin with polymer with a structure as a formula (I), and further provides a preparation method of the cisplatin complex. The cisplatin and the polymer with the structure as the formula (I) are in complex reaction in aqueous media to generate the cisplatin complex. The cisplatin complex has fine biocompatibility and is degradable, and polyethylene glycol is grafted on a side chain of the polymer, so that the prepared cisplatin complex has fine dissolvability. When the cisplatin complex is dissolved in the aqueous media, the cisplatin is protected by a hydrophilic polyethylene glycol chain segment and a hydrophobic amino acid chain segment, and accordingly sudden release of cisplatin caused by influences of a blood circulation system after intravenous injection can be effectively avoided, and stability of the cisplatin complex is improved. In addition, carboxyl contained in the cisplatin complex has pH sensitivity and deprotonation tendency in a low-pH environment, medicine release is facilitated, and medicine curative effect can be improved.

A covering assembly for a seat, including a cover adapted to cover a support frame of the seat and an inflatable member adapted to assume a resting deflated condition and an active inflated condition is described. The inflatable member is located on a side of the cover intended to be faced towards the support frame. The cover is adapted to contain the inflatable member both in the deflated condition and in the inflated condition.

The invention provides a core-shell type pre-charged chemotherapy medicine embolization microsphere and a preparation method thereof. The method comprises the following steps of using water/oil/water(W/O/W) complex emulsion type or oil/water/oil (O/W/O) complex emulsion type emulsified micro liquid drips as templates; coating tiny liquid drips containing medicine into outer layer liquid drips; high molecular polymers in the inner and outer layer liquid drips are converted through measures such as physical measures and chemical measures to form an inner layer core and an outer layer shell. Theformed core-shell structure medicine microsphere is formed by polymers of two-layer structures; the inner core contains medicine; the outer shell is favorable for maintaining the activity of the inner core medicine; the stable medicine release is realized; the sudden release is prevented; the safety is enhanced. The medicine carried microsphere prepared by the method has the advantages that the particle diameter range is 10 to 1000 micrometers; the sphere degree is good; the particle diameter is uniform; (the dimension deviation is 5 percent); the medicine encapsulation rate is high; the structure/carried medicine is controllable; meanwhile, the preparation method of the pre-charged chemotherapy medicine embolization microsphere can provide a novel idea for the clinic application study ofthe transcatheter arterial embolization.

The invention belongs to the technical field of preparation of biomedical high molecular polymer materials and discloses a cholesterol modified amphiphilic pH response pennicuius copolymer and a preparation method and a micelle system prepared based thereof. The copolymer has a structure shown in the formula I in the specification, wherein x is 10-36, y is 15-40 and z is 8-30. The copolymer is obtained by virtue of irregular copolymerization of a hydrophilic block hydroxyethyl methylacrylate, hydrophobic cholesterol and pH response block methacrylic acid N, N-diethyl aminoethyl combined with hydrophilic poly(ethylene glycol) methyl ether methacrylate. The copolymer is dissolved in a solvent to obtain a nanoscale micelle system, wherein the inner layer is a cholesterol modified hydrophobic chain segment, the middle layer is a pH response chain segment and the shell is a hydrophilic chain segment, so that the function of high entrapment performance, stable existence of a neutral condition and quick release in a weak acidic condition is achieved. By adjusting the proportions of the blocks in the polymer, the release rates of medicines can be regulated to satisfy the release requirements on different drugs.

A ticagrelor solid dispersion and preparation method thereof; the solid dispersion is prepared via dispersing the ticagrelor into a carrier material, the carrier material comprising one or more of polyvinylpyrrolidone, copovidone and crospovidone.

The invention discloses water-retention and slow-release fertilizer based on a coal gangue micron-grade hollow sphere and a preparation method of the fertilizer. The novel water-retention and slow-release fertilizer based on the coal gangue micron-grade hollow sphere consists of a coal gangue hollow sphere shell layer and a fertilizer core layer, wherein the shell layer is a coal gangue micron-grade hollow sphere or a coal gangue micron-grade hollow sphere coated with an organic coating material on the surface, and the core layer consists of a fertilizer material or a composite material simultaneously containing organic fertilizer and a water-retention material. The material of the core layer is dissolved in water, and is loaded in a hollow cavity of the coal gangue hollow sphere through vacuum, ultrasonic or pressurized impregnation; and the organic coating material covers the coal gangue hollow sphere to seal a shell porous structure, so as to enhance a slow-release effect. The water-retention and slow-release fertilizer disclosed by the invention obviously enhances slow-release performance of the fertilizer, improves utilization rate of the fertilizer and makes full use of solid waste coal gangue, and has relatively strong water-absorption and water-retention properties; and the fertilizer is low in cost, simple in process and environment-friendly and has wide application prospect.

The invention relates to the preparation of a growth factor porous micro-sphere compound system coated by an injectable hydrogel. The preparation is characterized by comprising a first component, namely HA-ADH sol obtained by cross-linking of hyaluronic acid (HA) and adipic dihydrazide (ADH), and polylactic acid (PLLA) porous micro-spheres which are carried with growth factors and loaded in the first component. The compound system is capable of degrading and slowly releasing the growth factors under physiological conditions, so that the slow releasing of the growth factors in a body is realized, and the problems that the growth factors are released too fast and an action period is too short are solved, thereby reaching the effect of neural restoration.

The invention, which is suitable for the technical field of the flexible display screen, discloses a manufacturing method for a flexible display screen and a preparing device for a flexible display screen. The manufacturing method comprises: preparing a carrier substrate and a stripping device; setting a stripping separation layer on the carrier substrate; arranging a flexible display screen layer on the stripping separation layer; arranging a support membrane adhering to the flexible display screen layer on the surface of the stripping device; and driving the stripping device, enabling the support membrane to adhering to the flexible display screen layer, and stripping the flexible display screen layer from the stripping separation layer. In addition, the preparing device consists of a stripping device and a flexible display screen layer forming component for forming a flexible display screen layer on a stripping separation layer; and a support membrane that adheres to the flexible display screen layer to strip the flexible display screen layer from the stripping separation layer is arranged on the surface of the stripping device. According to the invention, non-destructive stripping is realized; the product yield is high; the performances are excellent; and the cost is low.

The invention provides a compound of co-carried cis-platinum and adriamycin, micelle and a preparation method of the micelle. The compound is compounded by cis-platinum, adriamycin and a segmented copolymer, wherein the cis-platinum and the segmented copolymer are compounded through coordination; the adriamycin and the segmented copolymer are compounded through electrostatic interaction; and the segmented copolymer has the structure of formula (I) or formula (II). The compound micelle of the co-carried cis-platinum and adriamycin comprises the compound of the co-carried cis-platinum and adriamycin and an aquosity medium. The preparation of the compound micelle comprises the step of reacting the adriamycin, the cis-platinum and the segmented copolymer having the structure of formula (I) or formula (II) in the aquosity medium so as to obtain the micelle of the co-carried cis-platinum and the adriamycin. The compound micelle can stably carry the cis-platinum and the adriamycin under physiological conditions, and the release of the compound micelle has pH value sensitivity.

The invention provides a preparation method of an intelligent controlled release essence capsule with an ambient temperature response function. The preparation method comprises the following steps: (1) fully stirring and dissolving (methyl) alkyl acrylate monomers with different alkyl chain lengths, an oil-soluble initiator and essence to prepare a homogeneous oil phase; (2) adding the prepared organic oil into an aqueous solution containing an emulsifier for full stirring and shearing emulsification to obtain emulsified drops with the particle size of 10nm-5mm; (3) heating emulsion to generate polymerization reaction by the (methyl) alkyl acrylate monomers to form essence-wrapped capsule wall, and performing filtering and washing to obtain the essence capsule with a nuclear shell structure. The synthesis technology is simple, and the energy consumption is low; the requirement on equipment is low, and reaction conditions are easy to control; the preparation method has a large-scale production prospect. The capsule capable of intelligently adjusting the release speed has a great application prospect in the field of cosmetics and the field of intelligent heat storage and temperature adjustment textiles.

The invention provides adriamycin nano-particles. The adriamycin nano-particles are prepared by compounding adriamycin and a block copolymer with a structure shown as a formula (I) or a formula (II) through electrostatic interaction. A preparation method for the adriamycin nano-particles comprises the following step of: electrostatically compounding the adriamycin and the block copolymer with thestructure shown as the formula (I) or the formula (II) in an aqueous medium to obtain the adriamycin nano-particles. In the aqueous medium, a poly(gamma-propargyl-L-glutamate-g-mercaptosuccinic acid)segment and a polyethylene glycol segment which are contained in the block copolymer wrap the adriamycin into cores of the nano-particles, so the adriamycin composite particles are high in stability.The nano-particles are expected to be gathered at tumor sites in blood circulation through an 'enhanced permeability and retention effect' so as to improve the targeting effect of the adriamycin on the tumor sites. Meanwhile, the electrostatic interaction between a carboxyl group of the block copolymer and an amino group of the adriamycin is easy to eliminate under the condition of low intracellular pH values, so that the intracellular release can be accelerated, and the medicinal effect can be improved.

The invention discloses a preparation method of high-strength self-healing hydrogel and belongs to the technical field of preparation of medical materials. The preparation method comprises the following steps: dissolving polyvinyl alcohol, adding an acrylamide solution, by taking N,N'-methylene bisacrylamide as a crosslinking agent and nano titanium dioxide as a free radical initiator, firstly polymerizing acrylamide under ultraviolet light condition to form polyacrylamide network gel, then carrying out freeze-thraw cycle to form polyvinyl alcohol network gel, then carrying out oxidation crosslinking on the surface of a prefabricated hydrogel network by utilizing self-polymerization effect of dopamine, so that a polydopamine composite layer strongly adhered on the surface of a gel network is formed, and self-made nano hydroxy calcium phosphate is adsorbed, and the aim of further strengthening the hydrogel network is achieved. Meanwhile, the formed polydopamine surface layer and the adsorbed nano hydroxy calcium phosphate have good biocompatibility, and the problem that the traditional self-healing hydrogel is poor in mechanical strength and biocompatibility is effectively solved, so that the high-strength self-healing hydrogel has better application prospect.

The invention belongs to the technical field of medicine, and provides a PLGA (poly(lactic-co-glycolic acid)) porous composite microsphere preparation embedded with BMP-2 and TGF-beta1 containing microspheres therein, which not only can bring about benefits for the adhesion and the growth of seed cells by virtue of a 3D porous structure but also can undergo controlled- and sustained-release and can be applied to injection. The invention also provides a preparation method of the porous composite microsphere preparation as well as application of the porous composite microsphere preparation in preparing bone or cartilage tissue defect repairing materials. The porous composite microsphere disclosed by the invention, which can serve as a good carrier for cell adhesion and proliferation and can be directly injected to a target part, can offer a possibility of non-surgical repair to bone and cartilage tissue injuries; and the porous composite microsphere preparation is extensive in clinical application and market prospect.

The invention provides a preparation method of an anti-adhesion medical antibacterial gauze for treating burns, and belongs to the field of medical dressing processing. The preparation method comprises the following steps of antibacterial extracting solution preparation, gauze activation and modification treatment, mixed soak solution preparation and gel layer infusion. According to the preparation method, natural antibacterial matters in the traditional Chinese medicines are extracted through a boiling mode and are then filtered and concentrated to obtain an antibacterial medical solution, then the antibacterial medical solution, citric acid, glycerol and a sodium alginate solution are mixed, then an ordinary medical gauze with polyacrylic acid surface modification is soaked in mixed liquid, and the gauze soaked with the mixed liquid is taken out after being fully soaked and is treated by freeze drying to obtain a novel anti-adhesion high moisture-absorbent medical antibacterial gauze for treating the burns. The preparation method is simple and is liable in industrialization.

The invention relates to a choline fenofibrate film-controlled enteric slow-release pellet capsule. A slow-release film of the choline fenofibrate film-controlled enteric slow-release pellet utilizes Eurdragit RS 30D as a film-formation material. A pellet core of the choline fenofibrate film-controlled enteric slow-release pellet contains low-substituted hydroxypropyl cellulose having high expansibility, and also contains a pharmaceutically acceptable common excipient for the slow-release pellet, wherein preferably, the excipient comprises microcrystalline cellulose, and the pellet core comprises 10 to 40wt% of the low-substituted hydroxypropyl cellulose. The slow-release film comprises Eurdragit RS 30D, triethyl citrate as a plasticizer and talcum powder as an antiplastering aid, wherein preferably, a ratio of urdragit RS 30D to triethyl citrate to talcum powder is 30: 3: 4 and a film weight increasing ratio is in a range of 20 to 38%. The choline fenofibrate film-controlled enteric slow-release pellet comprises the pellet core containing low-substituted hydroxypropyl cellulose having high water expansibility and thus after absorbing water, the choline fenofibrate film-controlled enteric slow-release pellet expands so that the slow-release film is stretched; the thickness of the slow-release film is reduced; the water-permeable micropore size is increased; and permeability is improved and the permeability reduction caused by film aging is counteracted. Therefore, in middle and later stages, the choline fenofibrate film-controlled enteric slow-release pellet release rate is basically constant; in the last stage, residues are less; and stable release performances can be kept in the period of validity.

The invention relates to a venlafaxine hydrochloride film-controlled slow-release pellet capsule. A slow-release film of the venlafaxine hydrochloride film-controlled slow-release pellet utilizes Kollicoat SR30D as a film-formation material. A pellet core of the venlafaxine hydrochloride film-controlled slow-release pellet contains low-substituted hydroxyprepyl cellulose having high expansibility, and also contains a pharmaceutically-acceptable common excipient for the slow-release pellet, wherein preferably, the excipient comprises microcrystalline cellulose, and the pellet core comprises 10 to 40wt% of low-substituted hydroxyprepyl cellulose. The slow-release film comprises Kollicoat SR30D, triethyl citrate as a plasticizer and talcum powder as an antiplastering aid, wherein preferably, a ratio of Kollicoat SR30D to triethyl citrate to talcum powder is 30: 1: 4 and a film weight increasing ratio is in a range of 21 to 39%. The venlafaxine hydrochloride film-controlled slow-release pellet comprises the pellet core containing low-substituted hydroxyprepyl cellulose having high water expansibility and thus after absorbing water, the venlafaxine hydrochloride film-controlled slow-release pellet obviously expands so that the slow-release film is stretched; the thickness of the slow-release film is reduced; the water-permeable micropore size is increased; and permeability is improved and the permeability reduction caused by film aging is counteracted. Therefore, in middle and later stages, the venlafaxine hydrochloride film-controlled slow-release pellet release rate is basically constant; in the last stage, residues are less; and stable release performances can be kept in the period of validity.

The invention provides a biodegradable drug-loaded nanofiber medical bandage for burn department and a preparation method thereof. The medical bandage is of a double-layer structure composed of a surface supporting layer and an inner hydrophobic layer. A common gauze bandage subjected to carboxymethylation modification is used as a main body structure to serve as the surface supporting layer; a coaxial electrostatic spinning method is adopted, the surface supporting layer serves as a receiving layer of coaxial electrostatic spinning, and the inner hydrophobic layer with shell/core structure coaxial nanofibers is constructed on the fiber surface of the common gauze bandage subjected to carboxymethylation modification; in the coaxial nanofiber with the shell/core structure, a shell layer material is a mixture of gelatin and zein, and a core layer material is a mixture of chitosan and active ingredients. The medical bandage has excellent biocompatibility, degradability, hemostatic and antibacterial properties, anti-adhesion performance and drug sustained release performance. The preparation method is simple and controllable, and has huge application value.

The invention relates to a glipizide film-controlled slow-release pellet capsule. A slow-release film of the glipizide film-controlled slow-release pellet utilizes Eurdragit RL 30D as a film-formation material. A pellet core of the glipizide film-controlled slow-release pellet contains sodium carboxymethyl starch having high expansibility, and also contains pharmaceutically-acceptable common excipients for the slow-release pellet, wherein preferably, the excipients comprise microcrystalline cellulose, lactose and sodium dodecyl sulfate, and the pellet core comprises 5 to 20wt% of sodium carboxymethyl starch. The slow-release film comprises Eurdragit RL 30D, triethyl citrate as a plasticizer and talcum powder as an antiplastering aid, wherein preferably, a ratio of Eurdragit RL 30D to triethyl citrate to talcum powder is 30: 3: 4 and a film weight increasing ratio is in a range of 17 to 36%. The glipizide film-controlled slow-release pellet comprises the pellet core containing sodium carboxymethyl starch having high water expansibility and thus after absorbing water, the glipizide film-controlled slow-release pellet obviously expands so that the slow-release film is stretched; the thickness of the slow-release film is reduced; the water-permeable micropore size is increased; and permeability is improved and the permeability reduction caused by film aging is counteracted. Therefore, in middle and later stages, the glipizide film-controlled slow-release pellet release rate is basically constant; in the last stage, residues are less; and stable release performances can be kept in the period of validity.