Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof
A drug-loaded nanotechnology, biodegradable technology, used in bandages, medical science, pharmaceutical formulations, etc., can solve the problems of insufficient functionality, anti-adhesion film does not have antibacterial and hemostatic properties, etc., to achieve good biocompatibility, excellent biological phase. Capacitance, enhance the effect of adhesion sites
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[0030] The present invention also provides a preparation method for the above-mentioned biodegradable drug-loaded nanofiber burn medical bandage, comprising the following steps:
[0031] S1, preparation of the surface support layer: the fiber surface of the ordinary gauze bandage is modified by carboxymethylation, and then freeze-dried to prepare a soluble hemostatic gauze bandage, the surface support layer is obtained, and placed on the electrospinning receiving plate above as the receiving layer;
[0032] S2. Spinning solution preparation: Dissolve gelatin and zein in the first acetic acid solution according to a predetermined ratio, stir well, and prepare a gelatin / zein mixed solution with a predetermined mass fraction as the shell spinning solution Dissolving the chitosan powder and the active ingredient powder in the second acetic acid solution, fully stirring at room temperature to obtain a chitosan mixed solution with a predetermined mass fraction as the core layer spin...
Embodiment 1
[0043] A method for preparing a biodegradable drug-loaded nanofiber burn medical bandage, comprising the steps of:
[0044] S1, preparation of surface support layer: carry out carboxymethylation modification treatment on the fiber surface of the ordinary gauze bandage, the main steps are: soak 10g of ordinary gauze bandage in 200mL95% ethanol solution for 10min, then add 100mL25wt% hydrogen Sodium oxide solution was alkalized at 20°C for 30 minutes; then, 12wt% chloroacetic acid solution was added to the reaction system, and etherified at 60°C for 4 hours; then, the bandage was taken out and washed with acetic acid / ethanol mixed solution until neutral , and then washed with ethanol aqueous solution for 2 to 3 times, and freeze-dried to obtain the surface support layer, which was placed on an electrospinning receiving plate as a receiving layer.
[0045] S2, preparation of spinning solution: gelatin and zein (mass ratio 1:1) were dissolved in 80% acetic acid solution by volume,...
Embodiment 2-5
[0052] The difference from Example 1 is: the mass ratio of gelatin and zein is different, and the mass fraction of gelatin / zein mixture in the shell spinning solution is different, and the others are the same as in Example 1, where No more details, as shown in Table 1.
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Abstract
Description
Claims
Application Information
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