Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof

A drug-loaded nanotechnology, biodegradable technology, used in bandages, medical science, pharmaceutical formulations, etc., can solve the problems of insufficient functionality, anti-adhesion film does not have antibacterial and hemostatic properties, etc., to achieve good biocompatibility, excellent biological phase. Capacitance, enhance the effect of adhesion sites

Active Publication Date: 2020-06-19
安徽迈德普斯医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anti-adhesion film does not have effective antibact...

Method used

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  • Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof
  • Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof
  • Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof

Examples

Experimental program
Comparison scheme
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preparation example Construction

[0030] The present invention also provides a preparation method for the above-mentioned biodegradable drug-loaded nanofiber burn medical bandage, comprising the following steps:

[0031] S1, preparation of the surface support layer: the fiber surface of the ordinary gauze bandage is modified by carboxymethylation, and then freeze-dried to prepare a soluble hemostatic gauze bandage, the surface support layer is obtained, and placed on the electrospinning receiving plate above as the receiving layer;

[0032] S2. Spinning solution preparation: Dissolve gelatin and zein in the first acetic acid solution according to a predetermined ratio, stir well, and prepare a gelatin / zein mixed solution with a predetermined mass fraction as the shell spinning solution Dissolving the chitosan powder and the active ingredient powder in the second acetic acid solution, fully stirring at room temperature to obtain a chitosan mixed solution with a predetermined mass fraction as the core layer spin...

Embodiment 1

[0043] A method for preparing a biodegradable drug-loaded nanofiber burn medical bandage, comprising the steps of:

[0044] S1, preparation of surface support layer: carry out carboxymethylation modification treatment on the fiber surface of the ordinary gauze bandage, the main steps are: soak 10g of ordinary gauze bandage in 200mL95% ethanol solution for 10min, then add 100mL25wt% hydrogen Sodium oxide solution was alkalized at 20°C for 30 minutes; then, 12wt% chloroacetic acid solution was added to the reaction system, and etherified at 60°C for 4 hours; then, the bandage was taken out and washed with acetic acid / ethanol mixed solution until neutral , and then washed with ethanol aqueous solution for 2 to 3 times, and freeze-dried to obtain the surface support layer, which was placed on an electrospinning receiving plate as a receiving layer.

[0045] S2, preparation of spinning solution: gelatin and zein (mass ratio 1:1) were dissolved in 80% acetic acid solution by volume,...

Embodiment 2-5

[0052] The difference from Example 1 is: the mass ratio of gelatin and zein is different, and the mass fraction of gelatin / zein mixture in the shell spinning solution is different, and the others are the same as in Example 1, where No more details, as shown in Table 1.

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Abstract

The invention provides a biodegradable drug-loaded nanofiber medical bandage for burn department and a preparation method thereof. The medical bandage is of a double-layer structure composed of a surface supporting layer and an inner hydrophobic layer. A common gauze bandage subjected to carboxymethylation modification is used as a main body structure to serve as the surface supporting layer; a coaxial electrostatic spinning method is adopted, the surface supporting layer serves as a receiving layer of coaxial electrostatic spinning, and the inner hydrophobic layer with shell/core structure coaxial nanofibers is constructed on the fiber surface of the common gauze bandage subjected to carboxymethylation modification; in the coaxial nanofiber with the shell/core structure, a shell layer material is a mixture of gelatin and zein, and a core layer material is a mixture of chitosan and active ingredients. The medical bandage has excellent biocompatibility, degradability, hemostatic and antibacterial properties, anti-adhesion performance and drug sustained release performance. The preparation method is simple and controllable, and has huge application value.

Description

technical field [0001] The invention relates to the field of processing and preparation of medical materials, in particular to a biodegradable drug-loaded nanofiber burn medical bandage and a preparation method thereof. Background technique [0002] Burns are common in daily life. Improper treatment of wounds after burns can lead to infection, slow healing, and scarring. Traditional dressings include ordinary gauze, absorbent cotton, cotton pads, etc. In order to promote the healing of burn wounds and effectively control wound infection, clinically, combined with local application of antibiotics and burn ointment are often used. However, even with the combination of drugs, there are still many limitations, such as difficulty in keeping the burn wound moist, bandage fiber components are easy to fall off and cause foreign body rejection, dressings are easy to invade pathogens when soaked, tissue damage is caused during dressing changes, and dressing changes are difficult. [...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/32A61L15/425A61L15/44A61L15/46A61L2300/404A61L2300/418A61L2300/604A61L2400/12C08L5/08C08L89/00
Inventor 张丙起
Owner 安徽迈德普斯医疗科技有限公司
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