The invention discloses a biodegradable magnetic nano gold shell
microsphere as well as a preparation method and application thereof. The nano gold shell
microsphere has a core-shell structure, wherein the inner core is a
gelatin magnetic ferroferric
oxide microsphere, and the core layer is a gold nano shell; and the
diameter of the nano gold shell microsphere is 55-1000 nanometers, the
diameter of the inner core is 50-800 nanometers, and the thickness of the shell layer is 5-200 nanometers. The microsphere prepared by the method disclosed by the invention is good in
magnetism, narrow in
particle size distribution and controllable in outer shell thickness and particle size. Because
gelatin is a good
in vivo biodegradable material, along with the degradation of the magnetic inner core, the outside nano gold shell layer is disintegrated into gold nano particles and is discharged out of a body at last. The preparation method is simple and convenient in process, simple to operate, low in cost and easy for large-scale production. Meanwhile, the biodegradable magnetic nano gold shell microsphere has functions of magnetic
resonance targeted imaging and photo-
thermal treatment, and more importantly, the biodegradability of the microsphere greatly reduces the toxic or side effects of the gold shell on human bodies, so that the biodegradable magnetic nano gold shell microsphere has a very good clinical application value.