9results about How to "Good clinical value" patented technology

This invention relates to the field of biotechnology, and in particular to a primer-probe combination for detecting methylation sites in cancer and its applications. This invention is the first to discover that abnormal methylation at specific sites of the TRIB3 gene is significantly associated with the occurrence and development of colorectal cancer, and abnormal methylation at specific sites of the MAPT gene is significantly associated with the occurrence and development of gastric cancer. This correlation has not been publicly reported in the prior art, possessing novelty and significant clinical application value. The primer-probe combination provided by this invention is used to detect the methylation status of the TRIB3 gene or the MAPT gene in a sample. Specifically, when the primer-probe combination is used to detect the methylation level at specific sites of the TRIB3 gene, it can be used for the auxiliary diagnosis, early screening, or risk assessment of colorectal cancer; when the primer-probe combination is used to detect the methylation level at specific sites of the MAPT gene, it can be used for the auxiliary diagnosis, early screening, or risk assessment of gastric cancer.

This invention relates to a method for constructing a prognostic assessment model for acute myeloid leukemia (AML) with NPM1 mutations. The method includes the following steps: (1) collecting and detecting gene mutation data required for the prognostic assessment system of AML patients with NPM1 mutations, including the mutation status of FLT3-ITD, IDH1, and SRSF2 genes; (2) assigning values ​​according to the mutation status of FLT3-ITD, IDH1, and SRSF2; (3) substituting the values ​​assigned in step (2) into the formula: mNPM1 AML risk score = 1.077 × FLT3-ITD - 0.800 × IDH1 + 1.512 × SRSF2, and performing grouped and parallel prognostic assessments on the calculated values. This invention provides a prognostic assessment model for AML with NPM1 mutations, providing important guidance for the treatment of such patients and having good clinical application value.

The application discloses a kind of risk factors prediction model of occurrence of initial treatment bacterium positive pulmonary tuberculosis lung cavity, belong to medical data processing technical field, the clinical data of initial treatment bacterium positive pulmonary tuberculosis patient is collected in the application, using single factor analysis, Lasso regression analysis and multivariate Logistic regression analysis, male, diabetes, smoking, white blood cell count and platelet / hemoglobin ratio are screened as the independent risk factors of initial treatment bacterium positive pulmonary tuberculosis causing lung cavity, and based on this, nomogram prediction model is constructed.H-L goodness-of-fit test, receiver operating characteristic curve and decision curve analysis are verified, the model has higher prediction efficiency and clinical practical value.The application can help clinical advance to predict and intervene the cavity caused by high-risk population of pulmonary tuberculosis, provide new ideas for the diagnosis and treatment of bacterium positive pulmonary tuberculosis causing cavity.

The utility model discloses a kind of embedding boxes for congenital megacolon specimen, it is related to the field of tissue embedding technology.It includes box body with filter hole, circular ring, tight knob column, helical segmentation strip and box cover.Circular ring is fixed along inside of side plate, helical segmentation strip is coiled in spiral, one end is connected with the tight knob column of center, the other end is fixed in circular ring, can adjust interval with knob column rotation to hold or release specimen.Tight knob column contains shaft sleeve, shaft cap and split type knob spoon, through hexagonal structure cooperation and the bistable clamping of arc spring and clamping groove, the clutch and stable rotation of knob spoon and shaft cap are realized, control helical strip tightness.Box body, circular ring, helical strip etc.are provided with round hole to ensure reagent penetration, box cover buckle sealing, label area is provided in front.The design realizes specimen integration fixation, maintains morphological continuity, simplifies material taking, embedding process, improves pathological diagnosis efficiency and accuracy.

This invention discloses a positioning pad for maintaining body position after total hip arthroplasty. The positioning pad includes a first support pad and a second support pad, which are fixedly connected at a 90° angle or rotatably connected via a rotating mechanism. The end of the second support pad away from the first support pad has a lifting adjustment mechanism configured to adjust the angle between the first support pad and the horizontal direction by adjusting the height of the second support pad. The first support pad has a pair of anti-rotation pillows extending along a 30° hip abduction direction. The second support pad, away from the first support pad, has a T-shaped shoe extending along a 30° hip abduction direction. This positioning pad, by providing appropriate support and comfort, ensures that the patient maintains this specific position during recovery, which not only helps reduce sciatic nerve tension and displacement, lowering the incidence of postoperative complications, but also helps promote the patient's rehabilitation process.

The application discloses a novel morphological staining solution and a human microecological detection method based on artificial intelligence, and relates to the technical field of medical detection. The novel morphological staining solution comprises a composite staining solution A and a composite staining solution B, the composite staining solution A comprises the following components: 0.05-1.5 wt% thiazine dye, 0.05-1.5 wt% composite stabilizer, 0.051-1.05 wt% permeability regulator and 0.001-0.05 wt% multifunctional blueing agent; and the composite staining solution B comprises the following components: 0.01-0.5 wt% eosin, 0.001-1 wt% methylene blue and 0.001-0.05 wt% permeability regulator. The novel morphological staining solution is composed of the composite staining solution A and the composite staining solution B, can present different markers under visible light and fluorescent dark field at the same time, and can be quantitatively measured by a computer; in addition, rare earth is used to enhance blueing, Eu 3+ is added in the blueing solution to coordinate with the DNA phosphate groups of cell nuclei, so that nuclear staining produces red fluorescence under 360 nm ultraviolet excitation, and the nuclear-cytoplasm contrast under a low-power lens can be improved, thereby providing specific staining effects for subsequent computer recognition.

The application discloses an incomplete multi-omics cancer subtype identification method, system, device and medium, and belongs to the technical field of bioinformatics and artificial intelligence. The method comprises the following steps: incomplete multi-omics data acquisition and preprocessing; constructing an entry-level observation mask matrix and a view availability mask matrix; constructing a feature module in the omics based on a granulocyte division; extracting a module-level skeleton representation; recovering an entry-level missing value based on the skeleton structure; constructing a multi-expert skeleton recovery integrated result; constructing a central feature matrix of the feature module; constructing a cross-omics consensus structure space; performing a mask-aware skeleton consensus alignment; performing adaptive view weighting based on structure reliability; performing sample-level mask-aware fusion; and outputting a cancer subtype clustering result. The application provides reliable technical support for cancer typing research, patient stratification analysis, prognosis evaluation and precision medicine auxiliary decision-making.

This invention relates to the field of medical and nursing device technology, and discloses a hammock-type assisted turning bed and a turning method, including a bed frame body. The bed frame body includes multiple functional segments arranged sequentially along its length. Each functional segment is equipped with a bed surface driving mechanism and a support adjustment mechanism. The bed surface driving mechanism includes a roller winding device and a bed surface. Two roller winding devices are symmetrically arranged on both sides of the bed frame body of the functional segment. The two ends of the bed surface are wound around the rollers of the corresponding roller winding devices. The support adjustment mechanism is located below the bed surface and includes multiple electric cylinders arranged along the width direction of the bed frame body. The hammock-type assisted turning bed and turning method provided by this invention solve the problems of high risk of shear friction injury, high risk of pressure sores, poor comfort, and insufficient safety and adaptability in the practical application of existing technologies.

This invention relates to the field of clinical virus detection, and more particularly to a protein dot blot detection kit, detection method, and application for varicella-zoster virus (VZV). The kit includes: a solid-phase carrier membrane for binding and immobilizing proteins in the sample; a blocking agent for blocking non-specific binding sites on the solid-phase carrier membrane; a first antibody that specifically recognizes the VZV antigen; an enzyme-labeled second antibody that binds to the first antibody; and a chromogenic solution for generating a detection signal. This kit is based on protein dot blot technology, detecting proteins with high specificity and a low false-positive rate. The experimental cycle is short, taking only 2-3 hours from sample pretreatment to signal detection, much faster than virus culture (requiring 4-7 days) and PCR detection (although fast, prone to false positives or false negatives), providing rapid evidence for clinical treatment, and is particularly suitable for the diagnosis of acute herpes zoster.