SARS-Cov gene vaccine based on epi-position and its contruction

A gene vaccine and epitope technology, applied in the fields of bioengineering and immunology, can solve the problems of inefficient expression of short peptides, achieve high specificity, good expected clinical value, and overcome poor expression efficiency
CN1657102AInactive Publication Date: 2005-08-24FUDAN UNIV
0 Cites 11 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2005-08-24
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

A SARS-Cov gene vaccine based on epitope is configured from the carrier which is a plasmid able to be used for human body and the target antigen which is several B cell epitopes in the extrinsic B protein antigen of human SARS coronavirus through codon optimizing and genetic engineering. Its preparing process is also disclosed.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the fields of bioengineering and immunology, and relates to a genetic vaccine. Further, the invention relates to an epitope-based SARS-Cov genetic vaccine constructed by means of genetic engineering. Background technique

[0002] A newly isolated coronavirus (SARS-Cov) is currently recognized as the causative agent of the outbreak of atypical pneumonia. It poses a huge threat to human health and causes huge losses to the economy of our country. It has infected more than 8,000 people on five continents and caused a mortality rate greater than 10%. According to the results of genome sequencing analysis, it is currently known that the main structural proteins of the virus include Spike (S), M and E proteins on the membrane surface, and the N protein connected to the RNA genome, which may become the main target for the development of vaccines. As an infectious disease caused by a virus, vaccines are widely considered to be the mos...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More