SARS coronary virus resistant cell vaccine and its uses

A coronavirus and cell technology, used in antiviral agents, respiratory diseases, antibody medical components, etc., can solve the problems of poor vaccine antigenicity, short half-life, hidden safety hazards, etc., to promote killing effect, strong antigen processing and delivery. the effect of ability
CN1990042AInactive Publication Date: 2007-07-04THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Publication Date
2007-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an anti-SARS coronavirus cell vaccine and its application, said cell vaccine (1) containing all or part gene fragment of SARS coronavirus S protein all length gene order and 5 specific eukaryotic expression vector of cDNA fragment; (2) expressing the heterogenetic antigen presenting cells of said SARS coronavirus gene corresponding protei; (3) inactivating the heterogenetic antigen presenting cells expressing SARS coronavirus related protein. Use said cell vaccine for immuning host containing humans and rodents such as mice in order to making them generate protective humoral immunity and cellular immunity and resisting the SARS coronavirus infection which causes atypical pneumonia contagion. The security and stability of the invention are fine, production is convenient and price is low, it can induce the body generating the effective humoral immunity and cellular immunity of SARS coronavirus causing atypical pneumonia at the same time; provide effective and cheap vaccines for treating and preventing SARS.
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Description

technical field

[0001] The invention relates to the field of vaccines for preventing and treating atypical pneumonia caused by SARS coronavirus, in particular to a cell vaccine expressing SARS coronavirus S and five specific proteins. Also relate to the purposes of this vaccine in anti-SARS coronavirus. Background technique

[0002] Severe Acute Respiratory Syndrome (SARS) is spreading in China as an emerging severe infectious disease. Effective prevention and treatment of SARS is the most important task of the country at present, but no very effective treatment drug has been found so far. Therefore, effective prevention and treatment of SARS is imminent.

[0003] In terms of prevention and treatment, vaccine preparation is one of the most promising methods, which includes the following technologies: attenuated or inactivated virions, genetically engineered recombinant vaccines, polypeptide vaccines, and DNA vaccines. In addition to inducing the body to produce specific an...

Claims

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