928 results about "Infectious illness" patented technology

The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes a synthetic glycolipid compound of Formula I, as described herein. According to the present invention, the use of a compound of Formula I as an adjuvant is attributed at least in part to the enhancement and/or extension of antigen-specific Th1-type responses, in particular, CD8+ T cell responses. The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.

Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.

The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1 beta (IL-B) gene (IL-1B (-3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as periodontal disease and Alzheimer's disease.

The invention discloses an immunochromatographic test strip for full quantitative detection of C-reactive protein and a preparation method thereof. The test strip is composed of a sample pad, a mark pad, a coating film and absorbent paper which are successively overlapped and adhered on a baseplate, wherein the mark pad is coated with C-reactive protein (CRP) monoclonal antibody labelled by fluorescent latex particles and rabbit IgG labelled by fluorescent latex particles; and the coating film is composed of a detection region and a quality control region, and the detection region is coated with another CRP monoclonal antibody which is at different epitope with the CRP monoclonal antibody labelled by fluorescent latex particles. The C-reactive protein immunochromatographic test strip can perform sensitive quantitative detection on the full CRP in 10 seconds, can diagnose diseases and identify infection more rapidly and accurately, and can detect infectious illness state and determine the curative effect of antibiotics; and the full CRP has two detection results, namely hs-CRP and conventional CRP, comprehensive linear range and good detection sensitivity and less required sample amount, and is very convenient to operate.

The invention discloses a method for tracking close contact persons in an infectious disease epidemic situation. The method is a method for recording intimate contacts and establishing contact historyin a digital mode based on common non-contact equipment such as Bluetooth, a direct and indirect contact history relation graph of a confirmed patient can be drawn in an extremely short time, and coordination of epidemic prevention and control is facilitated. In addition to epidemic prevention and control, the method also has a plurality of other application scenes for assisting criminals in chasing and the like, and is of great social significance.

Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.

The invention relates to a city-wide infectious disease simulation method and a city-wide infectious disease simulation device. The method includes the steps of: 1) partitioning the city and classifying the people; 2) building a 4p ordinary simultaneous differential equation set which describes the dynamic process of the transmission of the disease in p (number) areas; 3) discretizing the equation set to obtain a difference equation set; 4) converting the discretized difference equation set into an open equation set by taking the connections of other cities into consideration; and 5) resolving the parameters of the equation set and visually expressing the infected people in the manner of dot density and piled bar graph. According to the epidemiological characteristics of the infectious disease and based on the data of interregional population flow across the city, the city-wide infectious disease simulation method and the city-wide infectious disease simulation device can predict and simulate the dynamic contagion process of the disease spatially in a period of time in the future, and the spatial propagation process of a typical infectious disease can be analyzed on a map in a visual way. The city-wide infectious disease simulation method and the city-wide infectious disease simulation device provide a decision support to infectious disease propagation prevention and control.

The invention provides a collagen and a collagen polypeptide, wherein, the weight percentage of hydroxylysine is more than 1.3 percent. The invention also provides the preparation technology and the application of the collagen and the collagen polypeptide. The invention can make full use of inexpensive raw materials including the fish skin and fish scale of tilapias to produce products with high added value. The collagen polypeptide is used for treating arthritis with a definite drug effect, and the clinical dose is considerably less than other collagen polypeptides. The collagen polypeptide can solve the pollution problem of fish skin wastes, and at the same time avoid the risk of infectious diseases which can be caused by the collagen of land animals. The collagen and the collagen polypeptide have the advantages of considerable economic benefits, energy conservation and environmental protection, simple process equipment, low cost and easy industrialization.

An exemplary embodiment providing one or more improvements includes feeding animals with probiotic microbes encapsulated in a mixture of xanthan gum and chitosan, or in gelatin, specifically Pediococcus acidilactici and Saccharomyces boulardii. Such encapsulation protects the viability of the probiotic microbes against unfavorable temperatures. An exemplary embodiment providing one or more improvements includes methods of using viable probiotics in therapy of birds and mammals infected with infectious diseases. Probiotics acted as adjuvants in stimulating antibody reaction and stimulated a cellular immunity response. In particular, probiotics were shown to reduce the number of viable oocytes from fecal samples, stimulate antibody production, and stimulate of proliferation of splenocytes in chickens infected with Elimeria. In addition, probiotics were shown to relieve symptoms of parvovirus infection in dogs.

The invention discloses an epidemic infectious disease virus field visualization method based on space-time trajectory data. The method comprises the following steps: S1, airspread infectious diseaseurban diffusion modeling; s2, collecting, cleaning and processing space-time trajectory data and infection attack data of virus carrying crowds; s3, obtaining position semantic information of a viruscarrier; s4, calculating the virus distribution density by taking the virus carrier as the position center; s5, mapping the time, space and virus distribution density data of the virus carrying population; and S6, constructing an epidemic infectious disease virus field cloud platform based on temporal GIS. The invention further provides an epidemic infectious disease virus field visualization system based on the space-time trajectory data. According to the method, space-time trajectory data and infection attack data of virus carrying crowds are processed into a virus distribution density map with the virus carrier as the position center, spatial position semantic information is added and mapped to a temporal GIS, and an epidemic infectious disease virus field is visually processed.

The present invention relates to a novel bacteriophage, more precisely a Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious disease in human and animals, a pharmaceutical composition for the prevention and treatment of the disease caused by Staphylococcus aureus, an antibiotic and a disinfectant containing the bacteriophage as an active ingredient.

The invention relates to a mobile throat swab robot system, and specifically relates to a mobile throat swab sampling robot, a supporting system and operation software. The sampling robot is mainly used for the throat swab sampling operation of mobile detection points, so that doctors can achieve process interference and sampling position correction. The whole system can guarantee the separation of doctors and patients during throat swab sampling, can complete operations such as contact judgment, sampling quality judgment, throat swab sampling, throat swab head cutting and transferring and hand disinfection under fully automatic or partial manual intervention and can synchronously record data including but not limited to collection strength and positions, so that the influences of highly infectious diseases represented by the novel coronavirus on medical staff can be greatly reduced, physical and mental burden of the medical staff can be relieved, and medical resources such as protective suits and gloves can be saved; and the sampling robot can be directly connected to a mobile platform, so that the rapid moving of throat swab collection place construction and the collection and sampling of throat swabs can be realized.

Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.

The invention discloses an early epidemic risk situation analysis method for an infectious disease based on an input-diffusion function, which comprises the steps of 1, identifying the scale of an infectious disease input risk source; 2, simulating a risk source propagation spread function; and 3, conducting short-term forecasting on the epidemic risk situation. According to the invention, population flow big data trend judgment and disease propagation and diffusion rules are fused; firstly, the morbidity differences of different regions are explored in the spatial dimension to describe the disease distribution pattern, and the inter-regional population flow scale and trend are analyzed based on population flow big data; then, the potential input risk case scale is measured and calculatedbased on the population flow; the function relationship between the number of potential input cases and the number of locally accumulatively diagnosed cases is counted; and the epidemic situation development characteristics and internal rules are revealed. The development of the epidemic situation is simply, rapidly and accurately monitored, the epidemic risk development situation in the future ispre-judged, and more accurate, more durable and more effective decision support can be provided for prevention and control of infectious diseases.

Methods for diagnosis of Kawasaki disease (KD) are disclosed. In particular, the invention relates to the use of biomarkers for aiding diagnosis, prognosis, and treatment of KD, and more specifically to biomarkers that can be used to distinguish KD from other inflammatory diseases, including infectious illness and acute febrile illness.

The invention provides a triple live vaccine for a swine transmissible gastroenteritis virus, a swine epidemic diarrhea virus and a swine rotavirus and a preparation method thereof. The content of the three viruses is not less than 107.5 TCID50 (Tissue Culture Infectious Dose 50)/mL, and the volume ratio is 1:1:1. The triple live vaccine provided by the invention solves the problem that a multiple vaccine for effectively preventing and treating such three diseases as swine transmissible gastroenteritis, swine epidemic diarrhea and the swine rotavirus is not available on the current market, and especially realizes the prevention and control on the swine rotavirus. Compared with the existing method of inoculating with three simplex vaccines to prevent such three transmissible diseases, the triple live vaccine provided by the invention is economical to use, simplifies the immunization procedure and lowers the epidemic prevention cost, thereby providing a new simple and convenient immunization way for farms in China.