199 results about "Infectious illness" patented technology

The application discloses a disease transmission link prediction method and system based on a dynamic hypergraph neural network, aiming to comprehensively depict virus transmission paths and risk levels from multiple dimensions. First, data is collected from a gene database, mobile device logs and clinical texts, virus variation characteristics, population contact relationships and symptom semantic information are extracted respectively, and a dynamic hypergraph that integrates virus strain nodes, individual nodes and regional nodes is constructed. The hyperedge is defined according to molecular similarity, space-time contact and semantic overlap, and the weight is dynamically adjusted according to the transmission intensity of the infectious disease. A multi-modal hypergraph neural network with variation perception is introduced to jointly model and adaptively fuse multiple types of hyperedges and multi-scale features, output node propagation embedding vectors and predict potential transmission chains, perform prevention and control responses, and realize real-time deployment and feedback loop in an edge-cloud collaborative manner, ensuring efficient and accurate infectious disease transmission modeling and intervention control while ensuring data privacy.

The application discloses a set of molecular targets, primer compositions, methods and applications for identifying respiratory pathogens, the respiratory pathogens are novel coronavirus, influenza A virus and respiratory syncytial virus, and nucleotide sequences of the molecular targets are shown as SEQ ID NO:1-3. The application provides molecular targets, primers and probes for detecting three respiratory pathogens, and establishes a triple real-time RT-RAA detection technology, which can realize rapid identification and differentiation of three respiratory infectious disease pathogens with similar clinical symptoms within 30 minutes, reduces the operation threshold of the existing detection technology, realizes the target of rapidly, simply and accurately identifying and differentiating the three viruses, meets the needs of early clinical diagnosis of infection, provides technical support for precise medication, and has wide application value.

The invention belongs to the technical field of biological detection, and particularly relates to a primer probe pair, a microfluidic chip and a kit for detecting pathogens of vector infectious diseases based on a TaqMan microfluidic chip technology as well as a preparation method and application of the primer probe pair. Based on a TaqMan microfluidic chip technology, the invention provides a detection method for simultaneously detecting 28 kinds of pathogens of the disease-borne infectious diseases, and the related pathogens of the disease-borne infectious diseases comprise viruses, bacteria and parasites, and are wide in range and large in difference. The detection method provided by the invention has a low detection limit (5-20 copies / [mu] L); when the method is applied to an actual sample, the sensitivity, specificity, accuracy and precision are high, and compared with a gold standard method, the consistency is good; and compared with a traditional qPCR method, the method has the advantages that the detection time efficiency and the manpower and material consumption are greatly reduced, and the method is particularly suitable for disease monitoring and emergency disposal scenes with undefined pathogen spectrum, need of rapid and comprehensive troubleshooting and the like, and has a good application prospect.

In certain aspects, the invention provides methods and compositions for heritable immunization and their use in infectious disease control. The invention also provides methods of preparing organisms and model organisms that can heritably transfer immunization to offspring.

A kind of biotin or avidin labeled fat body and its preparation method, nano-carrier system. Biotin or avidin labeled fat body is prepared using specific amount of Bio-phospholipid or avidin-phospholipid, and the prepared fat body has the advantages of high purity, small particle size, good uniformity and high stability. Based on the biotin-avidin system, a nano-carrier system is constructed, which includes the biotin labeled fat body and the avidin modified target component. The system enables the fat body to carry any interested substance, such as viral recombinant protein, antibody and other protein drugs, nucleic acid drugs or small molecule drugs, etc., so as to be used for the treatment of diseases such as vaccines, cancer, infectious diseases and metabolic diseases.

The application relates to a fusion protein and application thereof in the field of biotechnology. A polypeptide fragment for specifically recognizing a single-molecule phospholipid membrane and a polypeptide fragment for specifically recognizing a tissue or a cell are connected to form a fusion protein which can be specifically combined to a fat body surface in a non-covalent manner, so that precise targeting of the fat body is realized. The fat body targeting peptide segment can be widely used in the fields of precise drug delivery and vaccine preparation, so as to be used for treating diseases such as cancer, infectious diseases and metabolic diseases. Lung tissues and breast cancer cells are taken as target points, and good targeting of the fat body is realized.

This invention relates to the field of intelligent training technology, specifically to an internet-based intelligent training system for the prevention and control of respiratory infectious diseases. In this invention, a long short-term memory network is used to deeply model learners' learning progress, identify weaknesses in the learning process, and accurately push corresponding content, effectively providing personalized learning path recommendations. A graph neural network-based learning resource scheduling and content push method dynamically adjusts the frequency and order of learning content pushes to match learners' progress, ensuring that learning content is pushed at the appropriate time and with suitable difficulty. By constructing an interaction graph among learners and combining it with influence assessment, key prevention and control knowledge is disseminated preferentially through learners with high influence, optimizing the knowledge dissemination path. Combined with the application of the SIR (Self-Improving Influence) propagation model, the system predicts learners' progress in learning prevention and control knowledge, identifies learning bottlenecks, and significantly improves learning effectiveness.

The invention relates to the technical field of medical treatment, in particular to a chronic infectious disease patient management system, which comprises a registration module used for registering identity information, body information, chronic infectious disease type information, chronic infectious disease condition information and other medical history information of a patient; the information database is used for storing disease condition characteristic data, historical treatment scheme data and precautions data of the chronic infectious diseases; the management platform comprises a doctor work station, a patient information station and a feedback module, and the doctor work station is used for obtaining cooperative information of a treatment scheme; the patient information station is used for generating a medicine taking scheme, a doctor seeing scheme and life precautions, and data of the patient information station is sent to the patient terminal, so that a patient obtains treatment and life related information; and the feedback module is used for inputting discomfort information of the patient. The treatment management efficiency of a hospital on the chronic infectious disease patient can be improved, and the chronic infectious disease patient can feed back own conditions in time.

The present disclosure relates to a vaccine comprising at least one peptide antigen conjugate having the formula selected from PEG-[E1]-A-[E2]-[U]-H and H-[U]-[E1]-A-[E2]-PEG, wherein E1 is an N terminal extension, E2 is a C terminal extension, A is peptide antigen, H is hydrobhobic block, wherein one or more drug molecules (D) are optionally attached to each H directly or via a suitable linker X1; U is a linker, [ ] denotes the group is optional and - denotes that the two adjacent groups are directly attached to one another by a covalent bond or indirectly to one another via a suitable linker X. The vaccine is useful in treating or preventing a cancer, an autoimmune disease, an allergy, or an infectious disease.

The utility model provides a nutrition supply pump special for patients with gastrointestinal diseases, and relates to the technical field of medical instruments. A control key and a display screen are arranged on one side of the instrument panel, and a boss is arranged on the other side of the instrument panel; according to the nutrition supply pump, a sectional infusion tube is adopted, a second tube section is clamped in a first clamping groove and a second clamping groove of an instrument panel and is clamped in a warmer after penetrating through a penetrating hole, nutrient solution is heated through the warmer before infusion, a movable connector at the tail end of the second tube section is connected with a third tube section, and the tail end of the third tube section is connected with the nasal cavity or the intestinal tract of a patient; before use, one end of the first pipe section is inserted into a nutrient solution, and the other end of the first pipe section is connected with the movable connector at the head of the second pipe section, so that the household nutrient solution supply pump has the advantages of being inserted and used at any time and convenient to use under the condition that spread of infectious diseases among different patients or large ingredient change of the nutrient solution every time does not need to be considered; the problem that an infusion tube is inconvenient to install in an existing nutrition supply pump is solved.

A health status platform includes a receiving component that receives a test result a test of a biological sample collected from a human patient. The test result includes an indication of a presence of an infectious disease in the patient, and an identification and a verification of the patient. The platform includes a certificate component that issues a certificate of origin of the biological sample; and a data merging component that cooperates with a venue access manager that controls access to a venue. The data merging component implements a distributed ledger system that stores encrypted test results of the patient and the identification and verification of the patient, and an end-to-end encryption system that receives an encrypted venue access request from a venue access manager, decrypts the access request, determines if an access request is valid, and if valid, provides an encrypted certificate of origin to the venue access manager.

Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences. The methods of the present invention may be used to predict the status of several infectious agents in a single sample from a subject. Methods are also provided for predicting a subject's HLA status using high-throughput immune receptor sequencing.

The invention relates to the technical field of veterinary drug preparation, in particular to a bovine pasteurella multocida capsular group B disease inactivated vaccine and a preparation method thereof. The inactivated vaccine comprises an adjuvant and an antigen, wherein the antigen is a bovine pasteurella multocida capsular group B NM strain; the antigen is a bovine pasteurella multocida capsular group B NM strain which is preserved in China General Microbiological Culture Collection Center (CGMCC) on July 5, 2023, and is classified and named as pasteurella multocida with the preservation number of CGMCC No.45600. The bovine pasteurella multocida capsular group B disease inactivated vaccine provided by the invention can generate an effective and stable immune protection effect on immunized cattle when the injection dosage is 2ml. The vaccine does not need to be too high in concentration, is good in safety, does not generate abscess and nodules at an injection part, can be applied to clinic, can achieve 100% protection, is high in adhesion, and provides a good prevention effect on epidemic bovine abortion infectious diseases.

1. The name of the present design product: graphic user interface of major and key infectious disease management information system for electronic equipment. 2. The use of the present design product: for electronic equipment. 3. The design points of the present design product: in the content of the graphic user interface. 4. The picture or photo that best indicates the design points: front view. 5. The present design is a planar graphic user interface, and the rear view, left view, right view, top view, bottom view and perspective view are omitted. 6. The use of the graphic user interface: for operation and management of major and key infectious disease management information system on electronic equipment. 7. The change state description of the graphic user interface: the front view is the interface after login, and the interface change state figure 1 is obtained by clicking "view report card information" on the right side.

The present application relates to the technical field of field equipment, especially to a field medical excretion collecting device. The present application comprises a matching support cavity, a portable handle fixed on the top of the matching support cavity, and an excretion collecting mechanism arranged on the inner side of the matching support cavity. Through the structural design of the excretion collecting mechanism and the portable handle, the present device can collect the excretion of patients with infectious diseases, disinfect the excretion in time, cover the matching support cavity after the collection is completed, and be convenient to carry and move through the portable handle during use, thereby increasing the convenience of use, adapting to the field environment, and through the structural design of the auxiliary sealing mechanism and the carrying limiting mechanism, the present device can heat-seal the excretion collecting bag, press and butt the buckling butt strips on both sides of the excretion collecting bag, form two-seal protection, and increase the firmness and safety of the sealing.

The utility model discloses a ceiling type air purification sterilizing device for preventing and treating infectious diseases. The ceiling type air purification sterilizing device comprises a cylindrical sterilizing box, an air guide device is arranged in the sterilizing box, a trumpet-shaped air inlet is formed in the lower end of the sterilizing box, and an exhaust port is formed in the side face of the upper end of the sterilizing box; compared with the prior art, the disinfection box has the beneficial effects that after air below the indoor disinfection box is sucked into the air inlet, the air is transversely discharged outwards from the air outlet after disinfection treatment, and the discharged air contains a disinfectant component with a certain concentration, so that viruses in public places can be effectively disinfected; meanwhile, due to the fact that the disinfecting and killing box is installed on the ceiling, air in the space below the disinfecting and killing box can be fully absorbed and treated, the exhausted air flow containing disinfectant components flows in the space from top to bottom, full-coverage and dead-corner-free disinfecting and killing are achieved, the air disinfecting and killing treatment effect is effectively improved, and a virus transmission chain is blocked.

The invention relates to the technical field of infectious disease monitoring, and discloses a respiratory infectious disease early warning method and system based on big data. The method comprises the following steps: identifying a first type of change nodes and calculating a second type of change nodes by calculating a patient number change value; a central area and a peripheral area are determined, and when it is monitored that a new case appears in the peripheral area, a first early warning signal is output based on the risk level of the central area; and defining the geographic position of the new case as a new seed location, updating the central area, and outputting a second early warning signal. According to the method, the infectious disease evolution time period is divided into at least one infectious disease development stage, so that differentiated risk assessment can be carried out for different infectious disease development stages, and when the geographical location of the infectious disease is transferred, the monitoring and early warning focus can focus on a new risk outbreak point, and the risk assessment accuracy is improved. The timeliness and geographical accuracy of early warning are ensured, and the utilization efficiency of prevention and control resources is improved.

The utility model relates to the technical field of waste liquid treatment devices, in particular to an infectious disease waste liquid treatment device. Comprising a lower barrel body, an upper barrel body, a fastening bolt, a sealing gasket, an inverted cone liquid inlet, a filtering device, an annular ultraviolet sterilizing lamp, an annular water pipe, a liquid conveying pipe, a branch guide pipe, a first valve, a water pump, a disinfectant storage barrel, a second valve, a stand column, a telescopic column, a rubber sealing pressing plate and a control device. When the infectious disease waste liquid filtering device is used, through the filtering device arranged in the upper barrel body under the inverted cone liquid inlet, the infectious disease waste liquid added through the inverted cone liquid inlet can be filtered under the action of the filtering device, so that solid impurities in the infectious disease waste liquid are separated, and the liquid flows into the lower barrel body through the filtering plate; the waste liquid can be disinfected and sterilized in a classified mode, the blocking phenomenon cannot occur when the treated waste liquid is discharged, the lower barrel body, the upper barrel body and the filtering device are designed to be of a detachable structure, and pollutants filtered and disinfected by the filtering device can be conveniently treated.

The invention relates to the technical field of infection risk prediction, in particular to a children infectious disease hospital infection risk prediction and disinfection prevention and control system. The system comprises an acquisition module used for acquiring multi-dimensional health parameter data and historical parameter data in real time; the data analysis module is used for converting the health parameter data into a time sequence event sequence for each individual; for each individual, determining a similarity score according to the time sequence event sequence of the individual and each historical cluster, and determining a health risk score in combination with the category weight of each historical cluster; determining a global risk index according to the real-time doctor seeing flow in the target area, the current individual number in the sub-area and the health risk scores of all individuals in the sub-area; the prediction and prevention and control module is used for jointly inputting the global risk index and the individual health parameter data into a prediction model to obtain a risk early warning level; and calling a preset disinfection prevention and control strategy according to the risk early warning level, thereby reducing unnecessary prevention and control operations.

The application provides an infectious disease transmission simulation method and device fusing multi-dimensional dynamic risks, and a medium, relates to the field of infectious disease transmission simulation, fundamentally changes the modeling paradigm of simplifying the infectious risk into a fixed distance threshold in the traditional simulation by introducing an individual dynamic risk vector and a dynamic environment risk field driven by multi-source external data, proposes a dynamic personal risk threshold and a risk-driven sparse contact detection mechanism, which is not an exhaustive calculation of all spatially adjacent subject pairs, but intelligently prioritizes the subject pairs with high comprehensive exposure risk for fine judgment, significantly reducing the computational complexity; through the real-time access of multiple source data such as Internet of Things and city information model through the interface, the simulation environment and the real world risk are dynamically synchronized, having dynamic perception and adaptive ability, and through the dynamic adjustment of the personal risk threshold and the adaptive update of the individual dynamic risk vector, intelligent response to different prevention and control strategies can be realized.

The invention relates to an infectious disease protection isolation device with a disinfection function, and relates to the technical field of medical equipment.The infectious disease protection isolation device comprises a main isolation plate, auxiliary isolation plates are slidably embedded in the two sides of the interior of the main isolation plate, the auxiliary isolation plates move outwards in the length direction of the main isolation plate through moving assemblies, and the infectious disease protection isolation device further comprises a spraying disinfection part; comprising a first spray head and a second spray head follow-up lifting part and is in transmission connection between the moving assembly and the first spray head, and when the moving assembly drives the auxiliary isolation plate to move outwards, the first spray head is synchronously driven by the follow-up lifting part to move upwards; through mechanical linkage of the follow-up lifting part and the moving assembly, the high-automation linkage adjusting capacity is achieved, when the isolation width is adjusted through the two-way lead screw, the first spray head can be driven by the follow-up lifting part to automatically ascend and descend, dynamic synchronization of the isolation range and the disinfection height is achieved, and it is ensured that the isolation range is not limited by the disinfection height regardless of the width of an intersection. And all disinfection areas can be uniformly covered.

The invention provides a hospital-infected infectious disease diffusion microscopic simulation method based on a contact network model, and the method comprises the steps: determining the influence space range characteristics of all people in a designated region of a hospital based on the activity data of people in the designated region of the hospital; accurate space dynamic calibration is carried out on the influence coverage range of secondary propagation possibly formed under the condition that each person is infected with infectious diseases; the method comprises the following steps: determining contact relation data among different persons based on respective influence space range characteristics of all persons in a specified area of a hospital, analyzing the contact relation data based on a propagation dynamics model, and determining propagation state information of infectious diseases among different persons; performing dynamic tracking and calibration on the real infectious disease infected persons in the designated area of the hospital; and then on the basis of the transmission state information, obtaining an infectious disease diffusion microscopic animation and personnel infection change characterization information of a hospital designated area, and dynamically displaying an infectious disease transmission change trend on a two-dimensional space level, thereby improving the prevention and control efficiency and accuracy of hospital-infected infectious diseases.

Provided is a complementary infectious disease monitoring method based on the linkage between a sample monitoring system and a citizen-participatory monitoring system. The infectious disease monitoring method according to an embodiment of the present invention: calculates an infectious disease trend by using infectious disease diagnosis data according to a sample monitoring system; predicts an infectious disease trend by using infectious disease diagnosis data according to a citizen-participatory monitoring system; and calculates a final infectious disease trend by integrating the two calculated / predicted infectious disease trends. Accordingly, by linking the sample monitoring system and the citizen-participating monitoring system to identify the infectious disease trend through mutual complementation, it is possible to quickly and reliably identify the infectious disease trend by complementing each problem of the two monitoring systems.

The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and / or immune modulator) and / or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and / or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.

The invention discloses an epidemic situation emergency response decision-making method and system, computer equipment and a storage medium. The epidemic situation emergency response decision-making method comprises the steps of fitting parameters of an infectious disease kinetic model according to an L-BFGS-B optimization algorithm to generate a Hessian matrix; carrying out ill-conditioned data detection on the Hessian matrix to remove abnormal data; and sampling the Hessian matrix after the ill-conditioned data is removed according to an adaptive MCMC algorithm, and inputting the sampled parameters in the Hessian matrix into an infectious disease dynamic model to generate a prediction curve bundle. The method and the device are used for quickly outputting the epidemic emergency response decision.

In order to take measures against livestock infectious diseases such as foot-and-mouth disease, the present invention provides an infectious disease prevention agent that has high production efficiency and that can be easily administered to livestock. Specifically, the present invention relates to an antiviral agent against foot-and-mouth disease virus (FMDV), comprising, as an active ingredient, at least one antiviral compound selected from the group consisting of sangivamycin and salts thereof, pactamycin and salts thereof, isororidin E and salts thereof, tubercidin and salts thereof, and nafuredin and salts thereof.

Provided are methods of biasing a response of a vaccine recipient's immune system toward protective sensitization. Methods include administering an agent or substance to the site of a subject of a temporally interacting cell-mediated allergic reaction to enhance the resulting level of protective sensitization.

The invention relates to the technical field of computers, and discloses a multi-mode risk layering system and method and terminal equipment. The system comprises a feature module used for carrying out feature extraction on a target part image to obtain an image feature vector; the vector module is used for determining a sign feature vector based on the static sign data and the dynamic sign data of the target object; the conversion module is used for converting the acquired inquiry information into text feature vectors according to reference semantics in an infectious disease semantic library; the fusion module is used for fusing the text feature vector, the image feature vector and the sign feature vector to obtain a fused feature vector; and the evaluation module is used for processing the fusion feature vector through a danger calculation model to obtain a danger evaluation result. By adopting the system, intelligent, multi-mode, interpretable and low-delay continuous evaluation of risk levels of patients with infectious diseases such as dengue fever and the like can be realized.

This invention discloses an emergency vehicle-mounted isolation face shield, belonging to the field of personal protective equipment technology. The face shield includes a main body, an airtight fit structure, a dual-path independent airflow module, a multi-stage virus filtration and purification unit, an external air supply interface, an anti-fog window, and quick-fix components. The main body is integrally formed from a transparent anti-fog window and flexible edging; the airtight fit structure uses a three-section silicone sealing gasket combined with a micro-groove air-guiding structure to achieve a 360° low-leakage seal; the dual-path independent airflow module achieves physical separation of inhaled and exhaled air; the multi-stage filtration unit includes a pre-filter layer, a high-efficiency nano-filter layer, a virus inactivation layer, and a deodorizing adsorption layer; the external air supply interface can be connected to a vehicle-mounted air supply system, achieving unlimited endurance and automatic air source switching. This invention solves the problems of poor airtightness, low filtration efficiency, breathing difficulties, limited endurance, and inconvenience in emergency situations found in existing face shields, and is suitable for various scenarios such as infectious disease control, fire escape, and vehicle-mounted emergency response.

The ventilation and drainage device for infectious disease ward of the present application belongs to the technical field of pipeline drainage devices, and comprises a main pipeline, a downpipe, a first ventilation pipeline, a second ventilation pipeline and a sealing mechanism. The downpipe is arranged on one side of the main pipeline, the two ends of the first ventilation pipeline are respectively communicated with the top of the main pipeline and the downpipe, the two ends of the second ventilation pipeline are respectively communicated with the bottom of the main pipeline and the downpipe, and the sealing mechanism is arranged at the connecting node of the top of the downpipe and the first ventilation pipeline. The sealing mechanism is buried in the floor of the ward toilet and communicated with the indoor environment. When the floor of the ward toilet is not flowing with water, the sealing mechanism is closed and blocks the gas circulation between the downpipe, the main pipeline and the indoor environment. When the floor of the ward toilet is flowing with water, the sealing mechanism is opened and the water flows into the main pipeline through the downpipe. The device can prevent odor from flowing back into the ward and polluting the indoor environment, and can prevent the garbage remaining on the ground from entering the pipeline and being blocked.