95 results about "Diethylenetriaminepentaacetic acid" patented technology

The invention relates to an oligomeric betanine type foam drainage agent for foam drainage gas recovery in the later period of oil and gas well development and a preparation method. The agent can improve the foaming performance and stability of a foaming agent in electrolytes and hydrocarbons. The technical scheme is as follows: the chemical name of the foam drainage agent is N,N,N''-alkyl sodium diethyletriaminepentaacetate named NDDTP; firstly, sodium hydroxide and an isopropyl alcohol aqueous solution are added to a three-neck bottle, and the solution is stirred for dissolution; then diethylenetriaminepentaacetic acid is added, the mixture reacts at the temperature of 65-75 DEG C for 15 min, and an intermediate product,namely, sodium diethylenetriaminepentaacetate, is obtained; then a bromoalkanol solution is added to the intermediate product solution while stirring, and the mixture reacts at the temperature of 75-85 DEG C for 6-8 h; finally, a coarse product is obtained through distillation of a reaction liquid, and a solid product is obtained through desalinzation with ethanol and recrystallization with acetone. A foam drainage solution is prepared through compound of the foam drainage agent and ethylene glycol, has good foaming performance and foam stability and is used for increasing gas recovery ratio.

The invention relates to a neutral blockage removing agent composition used for an oil recovery formation in an oilfield. The neutral blockage removing agent composition is prepared from the following raw materials in parts by weight: 10-14 parts of polyepoxysuccinic acid amine, 35-40 parts of diethylenetriaminepentaacetic acid amine, 33-37 parts of hydroxyl succinic acid amine, 20-25 parts of polyacrylamide, 7-10 parts of sodium polyaspartate, 10-14 parts of sodium gluconate, 10-15 parts of activated clay, 20-25 parts of potassium peroxodisulfate, 9-11 parts of hydroxyl butanedioic acid amine, 4-7 parts of sodium salicylate, 5-9 parts of hexamethylene tetramine, 0.2-0.3 part of vanadium pentoxide, 2-5 parts of starch, 5-8 parts of alpha-sulphonated fatty acid methyl ester and derivative thereof (MES) and 0.1-0.3 part ofdiethyl ethanolamine. The neutral blockage removing agent composition is used for the blockage removal of an oil pumping well and a screw pump well in the oilfield, can effectively solve the problems of cleaning blockage removal of the oil pumping well and the screw pump well in the oilfield and the corrosion of oil recovery equipment, has high blockage removing speed, is neutral and is free of corrosion; waste liquid for blockage removal can be degraded and does not need to be discharged onto the ground to be subjected to sewage treatment, no corrosion, dead angle, precipitation or secondary well blockage are generated, and more safety and more reliability are realized as compared with traditional pickling blockage removing, biological blockage removing and solvent blockage removing.

The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.

The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.

Thus, the nanoparticles according to the invention, with diameter d₁ between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C¹ DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).

The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.

The invention discloses an active targeting polymer nanoparticle magnetic resonance contrast agent and a preparation method thereof. The magnetic resonance contrast agent is prepared by chelating nanoparticles of a diethylenetriamine pentaacetic acid-polylysine-polyethylene glycol-polylactic acid copolymer and gadolinium chloride (GdCl3) and connecting a plurality of amino groups of the polylysine and a targeting factor; the structural formula of the diethylenetriamine pentaacetic acid-polylysine-polyethylene glycol-polylactic acid copolymer is shown in the specification; and the targeting factor and chelating ions are connected to the amino groups of a polylysine segment of the copolymer. The magnetic resonance contrast agent of the invention has a remarkable development enhancing function and active targeting development has the characteristics of specificity, selectivity, remarkable biological effect and the like. Poly lactic acid-polyethylene glycol-phase-locked loop-g-diethylenetriaminepentaacetic acid-Ga (PLA-PEG-PLL-g-DTPA-Gd) nanoparticles are taken as carriers of DTPA-Gd and the local concentration of the contrast at a tumor position is increased and a diagnosis effect is enhanced through an active targeting function, toxic and side effects are reduced and the aim of active targeting development is fulfilled.

A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.

The invention relates to a functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent and a preparation method thereof. The functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent is obtained by pegylation modified fifth polyamide-amine dendrimer as a polymer carrier material; connecting diethylenetriaminepentaacetic acid on the dendrimer surface through covalent grafting; coating gold nanoparticles through an in-situ synthesis method; carrying out acetylation or hydroxylation on residual surface amino groups; and marking <99m>Tc. The functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent has a very good SPECT/CT imaging effect, realizes SPECT/CT imaging of different in-vivo tissue sites of a mouse, lays good foundation for development of multi-functional tissue specific contrast agent, and has wide application prospects.

The invention provides a preparation method of layered double hydroxides (LDHs) with diethylenetriaminepentaacetic acid (DTPA) intercalation, wherein, Mg-Al LDH is taken as a matrix, and DTPA is introduced into positive charge of a layer balance Mg-Al LDH laminate panel by a coprecipitation method. The preparation method comprises the following steps: dissolving magnesium chloride hexahydrate and aluminum chloride hexahydrate into water to obtain solution A; dissolving the DTPA into ammonia water to obtain solution B; diluting ammonia water with water to obtain solution C; mixing and stirring the three types of solution, keeping standing and aging; and washing and filtering the obtained mixed solution, collecting a gel filter cake, drying the filter cake at constant temperature, and grinding to obtain the product, wherein, the product can be used as a heavy metal adsorbing material. The invention has the advantages that the adsorbing material contains a large quantity of active functional groups, thus having good adsorbing effect; the adsorbing material can obtain better effect with less consumption when in use and has low cost and no pollution; and the adsorbing material is mainly applied to repairing a heavy metal polluted water body and has obvious effect on combined pollution caused by a plurality of heavy metal elements such as lead, cadmium and the like.

The invention relates to a neutral scale remover for a gathering and transporting system and a water injection system in oilfield, and belongs to the technical field of oilfield water treatment. The neutral scale remover for the gathering and transporting system and the water injection system in the oilfield comprises, by mass, 10-20% of sodium nitrilotriacetate, 10-20% of sodium ethylenediamine tetramethylene phosphonate, 5-15% of diethylenetriaminepentaacetic acid, 5-10% of tetrakishydroxymethylphosphonium sulfate, 2-8% of potassium sodium tartrate, 0.1-1.5% of ammonium citrate, 0.5-1.5% ofAEO-9, 0.1-1.0% of OEP-70, and the balance of water. The neutral scale remover for the gathering and transporting system and the water injection system in the oilfield has a good scale and dirt removal effect, and can quickly and effectively remove calcium carbonate, calcium sulfate, barium sulfate, silicate scales, ferrous sulfide, various corrosion products, oily sludge and other pollutants deposited in the gathering and transporting system and the water injection system. The neutral scale remover has the advantages of simple components, convenience in preparation, fastness, high efficiency,low cost, high scale removal efficiency, low dosage, harmlessness to devices, environmental protection, realization of scale removal without production stopping, and small side effects.

The invention relates to a preparation method and an application of a DTPA (diethylenetriaminepentaacetic acid)-modified magnetic graphene oxide composite. Graphene oxide is taken as a substrate of the composite, and DTPA is supported on the substrate surface. The preparation method comprises the specific steps as follows: natural graphite powder is pre-oxidized, pre-oxidized graphene is obtained, and graphene oxide is prepared with a Hummer method; then magnetic graphene oxide is prepared with a coprecipitation method, DTPA is grafted to magnetic graphene oxide through diethylenetriamine as an intermediate, and the composite is obtained. In the application of the DTPA-modified magnetic graphene oxide composite prepared with the method, the composite can have a good adsorption effect on heavy metal ions in acidic wastewater with pH equal to 3 and can selectively remove Pb<2+> in mixed metal ions. The composite can be separated from an aqueous solution through a magnet and can be reused after desorption with hydrochloric acid.

The invention provides a lipid nano-particle which is easy to absorb by an intestinal tract, wherein a magnetic resonance contrast agent, namely gadolinium diethylenetriaminepentaacetic acid (Gd-DTBA) is loaded, and glyceryl monostearate and lecithin are taken as lipid materials. The invention applies lipidosome nano-particles which are easy to absorb by the intestinal tract to enveloping the magnetic resonance contrast agent, namely the gadolinium diethylenetriaminepentaacetic acid which is clinically used most commonly to ensure that the magnetic resonance contrast agent, namely the gadolinium diethylenetriaminepentaacetic acid which is not absorbed by a digestive canal can be absorbed into an intestinal wall in a large quantity to make the intestinal wall produce MRI enhancement, displays pathological changes through the difference of normal intestinal walls and the pathological changes on the absorption and distribution of the lipid nano-particle, and can reflect the absorption function condition of the lipid nano-particle caused by the pathological changes. The method has the following advantages: the local administration is performed, and no intravenous and systemic administration are needed; the method may realize the evaluation of an intestinal absorption function; the nano-particle enters cells to realize the horizontal visualization of the cells; and the nano-particle mainly adopts lymph transport and can realize lymphatic imaging which are favorable for the lymphatic target display of intestinal pathological changes.

The invention relates to the technical field of preparing a contrast agent by utilizing a hyperbranched polymer. A preparing method of the hyperbranched polymer includes reacting a lysine salt and caustic alkali in a mole ratio of 100:80-90 at 140-160 DEG C for 40-50 h in a protective atmosphere; mixing a hyperbranched polylysine skeleton and diethylenetriaminepentaacetic acid according to a mass ratio of at least 1:5 in water; reacting the mixture at room temperature for 6-8 h; mixing the first hyperbranched polylysine molecule and a gadolinium compound in water; reacting the mixture at 37-42 DEG C for 6-12 h, with the mass ratio of the first hyperbranched polylysine molecule to the gadolinium compound being 1:1-1:2; and mixing and reacting the second hyperbranched polylysine molecule and folic acid in a carbonate the pH value of which is 8-10 for 5-12 h. The hyperbranched polylysine contrast agent has good biocompatibility, low toxicity and a high relaxation rate and can be metabolized in vivo.

In the production of an aluminum etched plate (1) for an electrolytic capacitor having a high level of capacitance by subjecting an aluminum plate to alternating current etching in an etching liquid to enlarge the face, an aluminum plate having an aluminum purity of not less than 99.98% by mass, a copper content of less than 30 ppm, and an iron content of 5 to 50 ppm is subjected to alternating current etching in an etching liquid containing not less than 0.01 ppm and less than 100 ppm of an additive such as diethylenetriaminepentaacetic acid, ethylenediaminetetraacetic acid, or diethylhexyl phthalate mixed therein.

The invention discloses a method for preparing nano-crystalline cellulose by taking corn stalks as raw materials. The method comprises the following steps: carrying out prehydrolysis on the corn stalks by glacial acetic acid; steaming by adopting a sulfate method; carrying out pre-blanching treatment by diethylenetriaminepentaacetic acid; adding H2O2, NaOH, MgSO4 and Na2SiO3; introducing oxygen gas, keeping oxygen pressure to be 0.6MPa-1.0MPa and treating the materials; immersing the materials into KOH at a temperature and stirring; carrying out acidolysis for 1h-3h; carrying out ultrapure water dialysis; carrying out ultrasonic treatment in an ice water bath; and freeze-drying to obtain the nano-crystalline cellulose. The method takes agricultural waste corn stalks as the raw materials, and the nano-crystalline cellulose is prepared by adopting a prehydrolysis-sulfate method steaming-green blanching-alkali refining-acidolysis-ultrasonic treatment process; and the process has the characteristics of low raw material cost, environmental friendliness and high comprehensive utilization.

The invention discloses bioactive nanoparticles composed of chitosan, poly-glutamic acid, and diethylenetriaminepentaacetic acid for use in radionuclide decorporation during radiological emergency. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.

The invention discloses a betaine surfactant and its synthesis method and application. The method comprises mixing diethylenetriaminepentaacetic acid, alkaline liquor and a solvent, heating the mixture to 70-90 DEG C for a reaction, carrying out rotary evaporateion on the solution, carrying out recrystallization through acetone and ethanol, carrying out filtration and drying to obtain pentasodiumdiethylenetriaminepentaacetate, mixing the pentasodium diethylenetriaminepentaacetate, epichlorohydrin and a solvent, keeping system pH in 9-10, carrying out heating to 60-90 DEG C for a reaction, carrying out rotary evaporateion on the solution, carrying out washing, carrying out recrystallization through acetone and carrying out filtration and drying to obtain the betaine surfactant. The synthesis method is simple and is carried under mild reaction conditions. The product is easy to purify. The yield is high. The betaine surfactant has the advantages of good wetting property, rich and fine foam, significant bactericidal effect, high surface activity and good compatibility with other types of surfactants and can be applied in the field of detergents.

The invention discloses a high-concentration leaf vegetable water planting nutrient solution and application thereof in leaf vegetable water planting. Every liter of the water planting nutrient solution comprises 150-300g of magnesium sulfate, 20-35g of potassium sulfate, 300-380g of calcium nitrate, 150-200g of potassium nitrate, 80-100g of monopotassium phosphate, 10-25g of ammonium dihydrogen phosphate, 0.1-1.0g of EDTA (ethylene diamine tetraacetic acid) copper, 0.1-0.8g of ammonium molybdate, 15-30g of DTPA (diethylenetriaminepentaacetic acid) iron, 1.0-2.5g of EDTA zinc, 5.0-9.5g of EDTA manganese, 8-15g of boric acid and the balance of water. In addition to essential nutrient elements for leaf vegetables to grow, different metal chelates such as EDTA zinc, EDTA manganese, EDTA copper and DTPA iron are used as zinc, manganese, copper and iron trace element sources of the high-concentration leaf vegetable water planting nutrient solution, the absorption and utilization rates of zinc, manganese, copper and iron elements by leaf vegetable crops are increased, particularly the DTPA iron has ideal effects when being compared with other iron salts, and the problem that trace elements such as an inorganic zinc salt, a manganese salt, a copper salt and an iron salt in a common water planting nutrient solution in the market have low plant absorption rates can be well solved.

The invention discloses a reverse osmosis membrane scale inhibitor and a preparation method thereof. The scale inhibitor is prepared from polyepoxysuccinic acid, amino trimethylene phosphonic acid, diethylenetriamine pentaacetic acid pentasodium salt, hexadecyl tributyl phosphonium bromide, distilled water, dodecyl triphenyl phosphonium bromide, methoxymethyl triphenyl phosphonium bromide, 1, 2-benzisothiazolin-3-one, hydroxyethylidene-1,1-diphosphonic acid, polyacrylic acid and benzotriazole. The usage amount of the scale inhibitor is less and is only 1 to 5 mg/L; the effect is lasting, i.e., after the scale inhibitor is placed for one month at 60 to 80 DEG C, the scale inhibiting ratio is 96 to 100 percent; the reverse osmosis membrane scale inhibitor has a good sterilizing effect and positive effects in improving calcium scale resistance and iron dispersing property.

The invention discloses a surfactant and chelating agent ternary compound descaling agent prepared by mixing the following components in percentage by mass: 20-30% of EDTA (Ethylene Diamine Tetraacetic Acid) disodium salt, 10-40% of DTPA (Diethylenetriaminepentaacetic Acid) and the balance of OP-10. The surfactant and chelating agent ternary compound descaling agent is prepared by mixing OP-10, EDTA disodium salt and DTPA and is favorable in descaling performance; when the surfactant and chelating agent ternary compound descaling agent is used for descaling, the descaling rate is greatly increased, and the manufacturing cost is low, so that the descaling cost is greatly reduced.

The invention relates to the technical field of functional nano composite materials, and discloses a gadolinium chelated tungsten oxide fusiform nano composite material as well as a preparation methodand application thereof. The preparation method comprises the following steps of firstly synthesizing tungsten oxide by a solvothermal method; then adding the tungsten oxide and diethylenetriaminepentaacetic acid into a mixed solution of N,N-dimethylformamide and triethylamine, performing a reaction for a period of time under the protection of nitrogen, and then storing a reaction product in a Tris-HCl solution to prepare a W18O49@DTPA solution; and reacting the W18O49@DTPA solution with gadolinium nitrate hexahydrate under the protection of nitrogen to obtain the W18O49@DTPA-Gd nano composite material. The fusiform W18O49@DTPA-Gd nano composite material prepared by a microemulsion method is uniform in size and good in dispersity, the tungsten oxide is coated with DTPA-Gd to show remarkable photo-thermal performance, and the problem that free Gd ions are gathered in vivo and cannot be discharged is solved; and in addition, the fusiform nano composite material with the tungsten oxide as a matrix has the biocompatibility and the low toxicity, has a CT imaging function, and has good application potential in the field of visual photo-thermal treatment of tumors.

Disclosed is a preparation method of a polyether sulfone functional gradient composite membrane capable of efficiently disposing heavy metals. Firstly, chloroacetylated polyethersulfone with a high grafting rate is prepared by two times of chloroacetylation; secondly, subjecting chloroacetylated polyethersulfone and 3-(trimethoxysilyl)-1-propanamine and diethylenetriaminepentaacetic acid to a chemical bonding reaction so as to graft a polyaminocarboxylic acid functional group into the polyether sulfone; thirdly, preparing a polyether sulfone separation membrane with the polyaminocarboxylic acid functional group by using a phase transfer technology; and finally, coating the surface of the separation membrane with a piperazine aqueous solution and a trimesoyl chloride n-heptane solution, andforming a dense nanofiltration ultrathin layer on the surface of the separation membrane by an interfacial polymerization reaction to prepare the polyether sulfone functional gradient composite membrane. The method of the invention is simple and feasible and has little harm to human health. The prepared composite membrane organically combines the adsorption of a micro-ultrafiltration chelating membrane and the retention of a nanofiltration membrane, thereby ensuring that high-concentration heavy metal wastewater can be directly discharged because the wastewater reaches the standard or reusedafter being treated by the polyether sulfone functional gradient composite membrane.

The invention provides an efficient machine tool detergent, which is prepared from the following ingredients in parts by weight: 3 to 10 parts of methacrylate oligomers, 4 to 9 parts of sodium hexametaphosphate, 4 to 6 parts of surfactants, 2 to 5 parts of diethylenetriaminepentaacetic acid sodium, 4 to 8 parts of glutaraldehyde, 3 to 6 parts of cocamidopropyl betaine, 2 to 4 parts of sodium dihydrogen phosphate, 2 to 7 parts of ethylenediaminetetraacetic acid disodium salts, 4 to 8 parts of sucrose fatty acid esters and 2 to 6 parts of tetrachloroethylene. The efficient machine tool detergent has the beneficial effects that the cleaning efficiency of the machine tool detergent is high; meanwhile, the corrosion on the equipment is lower; and the service life of a machine tool is prolonged.