10 results about "Semicarbazone" patented technology

The present disclosure relates to novel NMNAT2 activators, semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the method by administering the novel semicarbazones and thiosemicarbazones for the treatment and / or prevention of diseases and to the use thereof for the production of a medicament for the treatment and / or prevention of diseases, especially neurodegenerative and age-associated diseases or conditions associated with NAD loss. The present disclosure also provides a method for high throughput screening of NMNAT2 activators.

A compound for corrosion inhibition of a metal is a thiosemicarbazone. A method of inhibition corrosion includes contacting a metal with the thiosemicarbazone and / or a reaction product thereof.

The invention relates to a method for synthesizing lesinurad, which comprises the following steps of: sequentially performing aldehyde-thiosemicarbazide condensation, cyclization, bromination and hydrolysis reaction on a compound 4-cyclopropyl naphthalene-1-formaldehyde as shown in a formula I serving as a raw material to obtain a compound lesinurad as shown in a formula V; according to the invention, a 1, 2, 4-triazole ring is constructed by an innovative strategy of aldehyde-thiosemicarbazide condensation-cyclization, so that tedious steps of a traditional step-by-step process are omitted, and the cyclization yield is increased from 85% to 92%; the method is mild in overall reaction condition, low in equipment damage, simple in process, green and environment-friendly, capable of ensuring continuous production of high-quality products and high in application value.

Pro-chelator compositions featuring disulfide masks that upon activation yield active chelators. The pro-chelator compositions may be activated intracellularly, for example within cells featuring metal ion dysregulation, cells that proliferate abnormally, etc. The pro-chelators of the present invention include thiosemicarbazones, semicarbazones, and aroyl hydrazones. The pro-chelator compositions of the present invention may be used for a variety of purposes including inhibiting cell proliferation, or treating conditions associated with metal ion dysregulation or abnormal cell proliferation.

The present invention provides a kind of preparation method of 3,7-dimethylxanthine, the method comprises the following steps: obtain 3-methyl-4-iminoureazines; dissolve 3-methyl-4-iminoureazines in formic acid, add sodium nitrite and boron nitrogen doped platinum carbon catalyst, collect mother liquor after completion of the reaction, concentrate the mother liquor to filter out formic acid, and obtain 3-methyl-4-amino-5-formamidoureazines; mix 3-methyl-4-amino-5-formamidoureazines, liquid caustic soda and water, add acid to neutral after completion of the reaction, and obtain 3-methylxanthine; carry out methylation reaction and refinement of the 3-methylxanthine to obtain 3,7-dimethylxanthine. The preparation method of 3,7-dimethylxanthine of the present invention has mild reaction conditions, simple operation and low energy consumption. By adopting boron nitrogen doped platinum carbon catalyst, the reaction activation energy can be effectively reduced, the reaction rate can be improved, the reaction product purity is high, and the yield is high.

The present invention provides a method for preparing 1,3-dimethylxanthine, the method comprising the following steps: obtaining 1,3-dimethyl-4-iminoureazines; dissolving 1,3-dimethyl-4-iminoureazines in formic acid, adding sodium nitrite and nitrogen-doped platinum-carbon catalyst, collecting mother liquor after completion of the reaction, concentrating the mother liquor to remove formic acid, and obtaining 1,3-dimethyl-4-amino-5-formamidoureazines; adding dilute sulfuric acid to 1,3-dimethyl-4-amino-5-formamidoureazines to adjust pH=3-6, heating to 90-100°C, decolorizing the feed liquid by ozone and cold filtering after crystallization, and obtaining 1,3-dimethylxanthines. The preparation method of 1,3-dimethylxanthines of the present invention has mild reaction conditions, simple operation and low energy consumption. By adopting nitrogen-doped platinum-carbon catalyst, the reaction activation energy can be effectively reduced, the reaction rate can be improved, the reaction product purity is high, and the yield is high.

The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, The compounds of formula (I), as well as the N-oxides, stereoisomers, tautomers and The compounds of formula (I), as well as the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof, are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

Synthesis of a phenylaminourea and its recognition of iron ions. Benzaldehyde and aminourea hydrochloride were used as raw materials, and a carbon-based solid acid was used as a catalyst to synthesize phenylaminourea by grinding in a specific molar ratio. First, A mol of benzaldehyde and C mol of carbon-based solid acid (p-toluenesulfonic acid) were ground in a mortar. Then, B mol of aminourea hydrochloride was added, and grinding continued until the reaction was complete. The reaction progress was monitored by TLC during grinding. The ratio of A:B:C was (1~1.3):1:(0.05~0.2). After the reaction was complete, a small amount of methanol was added to the reaction vessel, and the catalyst was removed by filtration. The filtrate was then distilled under reduced pressure to obtain phenylaminourea. The catalyst was recovered and could be reused up to 5 times. The synthesized probe was prepared into a test solution using a solvent. Different cations were added to the test solution, and the changes in absorbance of the compound were observed by UV-Vis absorption spectroscopy to identify iron ions. 3+ Selective detection is performed; and the probe is effective against Fe. 3+ The detection is quite sensitive and has strong anti-interference capabilities.

The invention discloses a green synthesis method of 2-amino-5-aryl-1, 3, 4-thiadiazole, and belongs to the technical field of chemical synthesis. The preparation method comprises the following specific steps: mixing aromatic aldehyde, thiosemicarbazide and ethanol, heating, precipitating a solid, carrying out suction filtration to obtain an intermediate compound, and carrying out a cyclization reaction on the intermediate compound and an ionic liquid to obtain 2-amino-5-aryl-1, 3, 4-thiadiazole with a yield of 96% or more. The method provided by the invention has the characteristics of high reaction efficiency, short reaction time, mild reaction conditions, recyclable catalyst, strong catalytic ability, greenness and energy conservation. The method solves the technical problems that in a traditional synthesis method, a catalyst cannot be recycled and is not high in catalytic capacity, a substrate is poor in adaptability in the synthesis process, and the yield and purity of a product are not high due to the fact that the chemical stability of a used compound is not high.

A method of forming a corrosion inhibiting composition is disclosed, including performing a simulation of candidate thiosemicarbazone derivative molecules to determine a solubility parameter associated with a structure of the plurality of candidate thiosemicarbazone derivative molecules, selecting one or more bulky substituent groups to react with a thiosemicarbazone based on one or more results of the simulation, adding the one or more bulky substituent group, which may include an amine-functional group, to a reaction vessel. The method also includes generating a dithiocarbamate quaternary ammonium salt including one of the bulky substituent groups and precipitating a thiosemicarbazone derivative having one of the bulky substituent groups. The one or more bulky substituent groups may include a cyclohexyl group, a 2-ethyl group, a 3-ethyl group, such as 2-ethylphenyl and 3-ethylphenyl, or a combination thereof. Additional methods incorporating polar substituent groups and corrosion inhibiting compositions and treatments are also disclosed.