The invention provides a high efficiency broad-spectrum synergistic pesticide composition based on cycloxaprid and matrine. The high efficiency broad-spectrum synergistic pesticide composition includes cycloxaprid, matrine, tea saponin and an assistant, wherein cycloxaprid is hydrophilically-modified cycloxaprid. The high efficiency broad-spectrum synergistic pesticide composition can be water dispersible granules, wettable powder, suspending agent, missible oil, microemulsion, emulsion in water or microcapsule suspension, and is used for control of aphids, whiteflies, plant hoppers, leafhoppers, scale insects, thrips, stink bugs, gall midges, stem borers, spider mites, diamondback moth and noctuid pests. The high efficiency broad-spectrum synergistic pesticide composition adopts cycloxaprid and matrine as the pesticide raw materials, can control a variety of pests at the same time, also can reach a good control effect under a small dosage, has low toxicity to human body and the environment, is partially degradable, and is a green and environment-friendly pesticide.