255 results about "Geometric isomer" patented technology

The invention relates to a PLpro protease small-molecule inhibitor for treating or preventing coronavirus infection and application of the PLpro protease small-molecule inhibitor. Specifically, the invention relates to a compound shown as a formula (I) or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof, and the use thereof in the preparation of a medicament for treating or preventing coronavirus infection or diseases or symptoms caused by coronavirus.

The invention relates to application of a benzofuran terphenyl compound in medicines, belongs to the field of medicinal chemistry, and particularly relates to a terphenyl compound which comprises a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, hydrate, solvate, metabolite and ester of the terphenyl compound. The pharmaceutically acceptable salt or the prodrug thereof and the pharmaceutical composition containing the compound are used as medicines, especially used for treating and / or preventing related diseases caused by HIF.

The invention relates to preparation and application of a trifluoroethyl thiophenylpyrimidinamine derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like. # imgabs0 #

The invention relates to preparation and application of a substituted alkyl sulfide (sulfoxide) arylamine derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and an application of the compound in preparation of an acaricide for preventing and controlling pest mites, wherein the compound is used as a substituted alkyl sulfide (sulfoxide)-based arylamine derivative. The compound can achieve a better pest mite control effect at a lower dosage.

The invention relates to preparation and application of a novel trifluoroalkyl sulfur-containing phenyl heterocyclic ring derivative. Specifically, the invention relates to a compound as shown in formula (I) containing a trifluoroalkyl thiophenyl heterocyclic derivative, an isotope labeled compound of the compound, an optical isomer, a geometric isomer, a tautomer or an isomer mixture of the compound, or a pharmaceutically acceptable salt of the compound, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests and pest mites such as tetranychus cinnabarinus, tetranychus urticae and panonychus citri.

Provided in the present invention are an oxamide compound having a structure as shown in formula (I), or a pharmaceutically acceptable salt, isotope derivative or solvate thereof, or a stereoisomer, geometric isomer or tautomer thereof, or a prodrug molecule or metabolite thereof, and a pharmaceutical composition thereof and the use thereof. The compound involved in the present invention can efficiently inhibit STAT6 phosphorylation, can be used for preparing drugs for preventing and treating inflammatory diseases, and can be used for preparing anti-tumor drugs.

Provided in the present application is a compound represented by formula (I), or an enantiomer, a diastereoisomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a nitrogen oxide, a metabolite or a pharmaceutically acceptable salt, an ester, a solvate, a hydrate, an isotope-labeled compound or a prodrug thereof. The compound represented by formula (I) of the present application has a relatively ideal inhibitory activity with regard to KAT6A and / or KAT6B.

The invention discloses a separation method or an analysis method of astaxanthin geometric isomers and corresponding optical isomers thereof, and relates to the technical field of analysis. According to the method, four geometric isomers of all-trans astaxanthin, 9-cis astaxanthin and 13-cis / 15-cis astaxanthin can be effectively separated, and effective separation and detection of three optical isomers of all-trans astaxanthin, four optical isomers of 9-cis astaxanthin and eight optical isomers of 13-cis / 15-cis astaxanthin are further realized; therefore, effective separation and analysis of optical isomers corresponding to various geometric isomers can be realized. The method is high in specificity, good in separation degree and high in analysis accuracy of geometric isomers and optical isomers, and has important significance in developing research on the accurate correlation between the astaxanthin biological activity and the isomers.

Provided in the present invention is a small molecule compound, which is characterized in that it is a compound or a stereoisomer, geometric isomer, tautomer, racemate, hydrate, solvate, metabolite, and pharmaceutically acceptable salt or prodrug of the compound as represented by the following structural formula: formula (I). The small molecule compound of the present invention is applicable as a highly efficient and specific JAK kinase inhibitor, specifically a Tyk2 inhibitor and / or a JAK1 inhibitor, and / or a JAK1 / Tyk2 dual inhibitor.

The invention relates to a substituted arylthio thiazolidone derivative as well as preparation and application thereof. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope-labeled compound, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture, or an acceptable salt of the compound, which is used as a substituted arylthio thiazolidone derivative, and application of the compound in preparation of insecticides for pest control, the compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like.

The present invention relates to a biaromatic compound acting as a PARP7 inhibitor. Specifically, the present invention relates to a compound of formula (I), or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound or prodrug thereof. The present invention also relates to a use of the compound for treating or preventing PARP7-mediated diseases, such as cancer, immune diseases, inflammation or viral infections.

Provided are a compound for recoverying a p53 mutation function and use thereof, particularly relating to a compound represented by Formula M, or an enantiomer, a diastereomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a crystal form, a nitrogen oxide, a metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound or prodrug of the compound.

The invention relates to a honeycomb-shaped novel COF (Covalent Organic Framework) functionalized silicon-based chromatographic stationary phase. Silica gel is used as a matrix, and TAPT (Triallyl Phosphate) and DMTP (Dimethyl Tricarbonyl Phosphate) are subjected to aldehyde amine condensation reaction to form a two-dimensional The synthesis method comprises the following steps: activating silica gel particles by using hydrochloric acid, and neutralizing gamma-GPTS by using the activated spherical silica gel particles and anhydrous toluene to synthesize SiO2-GPTS; tAPT and DMTP are used as raw materials, a two-dimensional covalent organic framework COF is formed through a Schiff base aldehyde amine condensation reaction, and a novel honeycomb-shaped COF functionalized silicon-based chromatographic stationary phase SiO2 (at) TAPT-DMTP-COF is formed through coordination of silicon hydroxyl and amino / aldehyde group of a COF skeleton. When the TAPT-DMTP-COF is applied to chromatographic column separation, the TAPT-DMTP-COF has a porous structure with plane pi conjugation, height orderliness and stability, and the specific structure of the TAPT-DMTP-COF enables fixed relative shape limited isomers, geometric isomers and positional isomers to show excellent selectivity and separation capacity; the surface of SiO2 is coated with the COF-modified high performance liquid chromatography stationary phase material, so that the COF-modified high performance liquid chromatography stationary phase material has a uniform honeycomb shape, and a new way is opened up for constructing the COF-modified high performance liquid chromatography (HPLC) stationary phase material with the uniform shape.

Disclosed are an anti-Helicobacter pylori compound and use thereof, which relate to the technical field of pharmaceuticals. The compound is a compound represented by formula I and further comprises a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a nitrogen oxide thereof, a hydrate thereof, a solvate thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compound exhibits a good effect in the treatment of Helicobacter pylori infection.

The present invention relates to the preparation and use of novel trifluoroalkylthiophenylpyridine derivatives. Specifically, the present invention relates to compounds of formula (I-1) or formula (I-2) as trifluoroalkylthiophenylpyridine derivatives, or isotope labeled compounds thereof, or optical isomers, geometric isomers, tautomers or mixtures of isomers thereof, or agriculturally acceptable salts thereof, as well as the use of said compounds in the preparation of insecticides for pest control. These compounds are capable of achieving better pest control effects at lower dosages, especially against pests and mites such as Tetranychus cinnabarinus, Tetranychus urticae, and Panonychus citri.

Title: Process for treating keratinous materials using at least one polyester compound with acetoacetate functionalities. The present invention relates to a process for treating keratinous materials comprising applying to said keratinous materials, in one or more successive steps, at least: i) at least one polyester of formula (I) comprising at least two acetoacetate functionalities, as well as its optical, geometric, and / or solvate isomers, such as hydrates, or a composition containing it or them: (Z)–[OC(O)-C(Ra)(Rb)-C(O)-R4]u (I), formula (I) in which Z, u, R4, Ra, and Rb are as defined in the description, and ii) optionally, at least one crosslinking agent. Figure for the abstract: None

COMPOSITION AND METHOD FOR DYEING AND / OR BRIGHTENING KERATIN FIBERS This disclosure proposes a composition comprising at least one fatty alcohol; at least one cationic polysaccharide; at least one fatty acid; at least one carboxylic acid of the formula (I) below, its optical isomers, geometric isomers, salts, solvates, or combinations thereof: R1-N-(CH(R2)COOH)2 formula (I); with at least one oxidative dye and / or at least one alkali agent. Also proposed is a method for dyeing and / or lightening keratin fibers, preferably hair, comprising applying the composition to said keratin fibers. Figure for abstract: none

The invention discloses a preparation method and application of tanshinone IIA and cryptotanshinone amide derivatives. The tanshinone IIA and cryptotanshinone amide derivatives are compounds shown in a general formula (I) or stereoisomers, racemes, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, pharmaceutically acceptable salts or prodrugs of the compounds. The tanshinone IIA and cryptotanshinone amide derivative can be used for preparing anti-inflammatory drugs, antibacterial drugs, tumor drugs, drugs for treating cardiovascular and cerebrovascular diseases, drugs for treating burns and scalds and drugs for treating infectious diseases.

Disclosed herein are phenoxido copper compounds, complexes, hydrates, solvates, geometric isomers, or salts thereof, where the compounds have a chemical structure selected from a list: (Cu2(L1)2](ClO4)2, (Cu2(L2)2](ClO4)2, [Cu2(L3)2], [Cu2(L4)2], [Cu2(L4)2], [Cu2(L5)2(H2O)]·2H2O, [Cu2(L6)2(H2O)]·2H2O, and catena-[Cu(μ-L7)]. In one specific embodiment, the method includes administering to a subject a therapeutically effective amount of the phenoxido copper compound.

The present invention relates to a method for purifying (PU) at least one aqueous medium based on at least one C-glycoside derivative corresponding to formula (I) (preferably corresponding to formula (I') or (I''), and optical or geometric isomers thereof, and / or solvates (e.g., hydrates) thereof, and at least one salt, comprising at least one step of electrodialysis (PU1) of the aqueous medium. The present invention also relates to a method for preparing (PR) at least one C-glycoside derivative as described herein, comprising at least one step of electrodialysis (PU) of at least one aqueous medium containing at least the C-glycoside derivative and at least one salt. JPEG2026518301000030.jpg41170

Disclosed are a heterocycloalkyl carboxylic acid derivative, an intermediate, a preparation method therefor, and a use thereof, relating to the technical field of pharmaceutical chemistry. The heterocycloalkyl carboxylic acid derivative of the present invention is a compound represented by formula (I) below, or a stereoisomer, geometric isomer, tautomer, N-oxide, hydrate, solvate, pharmaceutically acceptable salt or prodrug thereof. By means of in vitro activity detection and animal behavioral experiments, it has been proven that said compound has good therapeutic effects for neurological diseases such as depression and bipolar disorder, as well as metabolic diseases such as diabetes and metabolic disorders.

The invention relates to the technical field of medicines, in particular to an STAT6 inhibitor, a preparation method of the STAT6 inhibitor and application of the STAT6 inhibitor in medicines. The invention provides an oxamide compound with a structure shown in a formula (III) or pharmaceutically acceptable salt, an isotope derivative and a solvate thereof, or a stereoisomer, a geometric isomer and a tautomer thereof, or a prodrug molecule and a metabolite thereof, as well as a medicinal composition and application of the oxamide compound, the salt, the isotope derivative and the solvate of the oxamide compound, the stereoisomer, the geometric isomer and the tautomer thereof, the prodrug molecule and the metabolite of the oxamide compound. The compounds may be used to treat or prevent STAT6 mediated diseases or disorders and related diseases or disorders.

The invention discloses a heterocyclic alkyl carboxylic acid derivative, an intermediate and a preparation method and application thereof, and relates to the technical field of medicinal chemistry. The heterocycloalkyl carboxylic acid derivative is a compound as shown in the following formula, and a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, hydrate, solvate, pharmaceutically acceptable salt or prodrug of the heterocycloalkyl carboxylic acid derivative, and in-vitro activity detection and animal behavioral experiments prove that the compound has good treatment effect on neurological diseases, neurological diseases, neurological diseases, neurological diseases, neurological diseases, neurological diseases, neurological diseases, neurological diseases, neurological diseases and neurological diseases. The traditional Chinese medicine composition has a good treatment effect on diseases such as depression, bidirectional affective disorder and the like, and metabolic diseases such as diabetes mellitus, metabolic disorder and the like.

The present invention relates to novel heterocyclic compounds of formula (I) as inhibitors of PARG, their pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs, tautomers, atropisomers, optical and geometric isomers, prodrugs, deuterated including other possible isotopes, combinations and use thereof in treating cancer. Formula (I) The present invention also relates to a process for the preparation of novel heterocyclic compounds of Formula (I), pharmaceutical compositions comprising them, and their use in the treatment of cancer.

The present application provides a compound having a structure shown in Formula I, II or III or its enantiomer, diastereoisomer, racemate, stereoisomer, geometric isomer, nitroxide, metabolite or its pharmaceutically acceptable salt, ester, solvate, hydrate, isotopically labeled compound or prodrug. The non-fenofibrate 4-position ether derivative of the present application has an excellent xanthine oxidase activity inhibitory activity.

Use of a compound, microarray chip substrate, microarray chip and use and method thereof. The present application provides use of a compound, or a geometric isomer, tautomer, isotopically labeled, hydrate, solvate or salt thereof in chip surface modification. Also provided is a microarray chip substrate modified by the compound, and a microarray chip comprising the microarray chip substrate. The microarray chip substrate of the present application can greatly improve the surface modification function by surface modification, improve nucleic acid synthesis yield, amplify detection signal, and avoid non-specificity and cross-talk. It has a wide application prospect.

The invention relates to a phenylamide derivative as well as preparation and application thereof. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or an acceptable salt, and application of the compound in preparation of a pesticide for pest control, the invention also relates to the use thereof for the control of insects, arachnids and nematodes in agriculture, and for the control of ectoparasites in non-agriculture. # imgabs0 #

The present invention relates to the technical field of medicinal chemistry, and in particular to a quinoline derivative, a pharmaceutical composition thereof, and a use thereof in the preparation of drugs for preventing or treating PDE4-related diseases. The provided quinoline derivative exhibits good PDE4 inhibitory activity, and can be used for preventing or treating PDE4-related diseases, especially inflammatory diseases. The quinoline derivative is a compound represented by general formula (I), or a pharmaceutically acceptable salt, a geometric isomer, an enantiomer thereof, or a pyridine N-oxide thereof.

The invention provides a compound or an enantiomer, a diastereoisomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, nitrogen oxide, a metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope labeled compound or prodrug thereof. The invention further provides a composition containing the compound and medical application. The compound has a good patent medicine prospect in the aspect of treating or preventing PTPN2-related diseases or symptoms.