327 results about "Geometric isomer" patented technology

The invention relates to a preparation method and an application of a substituted benzimino thiazolidone derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like. # imgabs0 #

The invention relates to a PLpro protease small-molecule inhibitor for treating or preventing coronavirus infection and application of the PLpro protease small-molecule inhibitor. Specifically, the invention relates to a compound shown as a formula (I) or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof, and the use thereof in the preparation of a medicament for treating or preventing coronavirus infection or diseases or symptoms caused by coronavirus.

The invention discloses a compound derivative represented by a formula I or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof. According to the application of a double protection strategy, diversified carrier fragments are introduced to 5-hydroxyl and hydroxylamine in N4-hydroxycytidine molecules, the N4-hydroxycytidine prodrug is invented, the affinity of lung cell membranes (phospholipid membranes) is improved, and the physicochemical properties of the drug are made to meet the requirements of the physiological environment of lung tissue. Therefore, the compound disclosed by the invention has a wide application prospect in the aspect of broad-spectrum respiratory virus resistance. # imgabs0 #

The invention relates to application of a benzofuran terphenyl compound in medicines, belongs to the field of medicinal chemistry, and particularly relates to a terphenyl compound which comprises a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, hydrate, solvate, metabolite and ester of the terphenyl compound. The pharmaceutically acceptable salt or the prodrug thereof and the pharmaceutical composition containing the compound are used as medicines, especially used for treating and / or preventing related diseases caused by HIF.

Disclosed are substituted phenyl-imino thia(oxa)zolidone derivatives shown as formula (I) or isotope labeled compounds thereof, or optical isomers, geometric isomers and tautomers thereof, or an isomer mixture thereof, or agrochemically acceptable salts thereof, and the use of the compounds in the preparation of pesticides for pest control. The compounds can achieve a better pest control effect with a lower dosage, especially for control of pests of Tetranychidae, Tenuipalpidae, Eriophyidae, Tarsonemidae and Acaridae, root-knot nematodes and other pests.

The invention relates to preparation and application of a trifluoroethyl thiophenylpyrimidinamine derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like. # imgabs0 #

The invention relates to preparation and application of a substituted alkyl sulfide (sulfoxide) arylamine derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and an application of the compound in preparation of an acaricide for preventing and controlling pest mites, wherein the compound is used as a substituted alkyl sulfide (sulfoxide)-based arylamine derivative. The compound can achieve a better pest mite control effect at a lower dosage.

The invention discloses a chemokine receptor antagonist, a pharmaceutical composition and application. Specifically, the invention discloses a compound as shown in a formula I, a formula II or a formula III or pharmaceutically acceptable salt thereof, or a deuterated substance thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a prodrug or a metabolite thereof. The compound provided by the invention has better inhibitory activity on CCR4, and can be used for treating or preventing diseases mediated by CCR4. # imgabs0 #

The invention relates to preparation and application of a novel trifluoroalkyl sulfur-containing phenyl heterocyclic ring derivative. Specifically, the invention relates to a compound as shown in formula (I) containing a trifluoroalkyl thiophenyl heterocyclic derivative, an isotope labeled compound of the compound, an optical isomer, a geometric isomer, a tautomer or an isomer mixture of the compound, or a pharmaceutically acceptable salt of the compound, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests and pest mites such as tetranychus cinnabarinus, tetranychus urticae and panonychus citri.

To provide a composition containing solubilized polyhydroxyalkanoate by which a membrane having excellent cosmetic characteristics can be obtained.SOLUTION: A composition contains a) at least two kinds of different repeating polymer units selected from the following units (A) and (B): -[-O-CH(R1)-CH2-C(O)-]-unit (A) and -[-O-CH(R2)-CH2-C(O)-]-unit (B) and an optical isomer or a geometric isomer thereof, and a solvate thereof such as a hydrate; and b) a fatty medium including one or more kinds of fatty substances which are liquid preferably at 25°C and the atmospheric pressure, where it is to be understood that (A) is different from (B).SELECTED DRAWING: Figure 2

The present invention provides a compound or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound, or prodrug thereof, having good prospects in the treatment of hyperproliferative diseases, particularly cancer, more particularly cancer associated with KAT6A and / or KAT6B.

Provided in the present invention are an oxamide compound having a structure as shown in formula (I), or a pharmaceutically acceptable salt, isotope derivative or solvate thereof, or a stereoisomer, geometric isomer or tautomer thereof, or a prodrug molecule or metabolite thereof, and a pharmaceutical composition thereof and the use thereof. The compound involved in the present invention can efficiently inhibit STAT6 phosphorylation, can be used for preparing drugs for preventing and treating inflammatory diseases, and can be used for preparing anti-tumor drugs.

Provided in the present invention are modified flavone compounds and the use thereof. The compounds are compounds shown as formula (I), and pharmaceutically acceptable stereoisomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, eutectic compounds, metabolites, salts, deuterated compounds or prodrugs thereof.

The present invention discloses benzobicyclic compounds, preparation methods and applications thereof. Specifically, the present invention discloses a compound having formula (X) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof,

Provided in the present application is a compound represented by formula (I), or an enantiomer, a diastereoisomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a nitrogen oxide, a metabolite or a pharmaceutically acceptable salt, an ester, a solvate, a hydrate, an isotope-labeled compound or a prodrug thereof. The compound represented by formula (I) of the present application has a relatively ideal inhibitory activity with regard to KAT6A and / or KAT6B.

The invention discloses a separation method or an analysis method of astaxanthin geometric isomers and corresponding optical isomers thereof, and relates to the technical field of analysis. According to the method, four geometric isomers of all-trans astaxanthin, 9-cis astaxanthin and 13-cis / 15-cis astaxanthin can be effectively separated, and effective separation and detection of three optical isomers of all-trans astaxanthin, four optical isomers of 9-cis astaxanthin and eight optical isomers of 13-cis / 15-cis astaxanthin are further realized; therefore, effective separation and analysis of optical isomers corresponding to various geometric isomers can be realized. The method is high in specificity, good in separation degree and high in analysis accuracy of geometric isomers and optical isomers, and has important significance in developing research on the accurate correlation between the astaxanthin biological activity and the isomers.

The invention provides an oxime-containing compound and application thereof. The oxime-containing compound provided by the invention has a structure as shown in a formula (I) or enantiomers, diastereoisomers, racemate, tautomers, stereoisomers, geometric isomers, nitrogen oxides, metabolites or pharmaceutically acceptable salts, esters, solvates, hydrates, isotope labeled compounds or prodrugs of the structure as shown in the formula (I). The oxime-containing compound provided by the invention can be used for preventing and / or treating cancers and other hyperproliferative diseases and diseases related to Hippo pathway dysfunction. # imgabs0 #

Provided in the present invention is a small molecule compound, which is characterized in that it is a compound or a stereoisomer, geometric isomer, tautomer, racemate, hydrate, solvate, metabolite, and pharmaceutically acceptable salt or prodrug of the compound as represented by the following structural formula: formula (I). The small molecule compound of the present invention is applicable as a highly efficient and specific JAK kinase inhibitor, specifically a Tyk2 inhibitor and / or a JAK1 inhibitor, and / or a JAK1 / Tyk2 dual inhibitor.

The invention relates to a substituted arylthio thiazolidone derivative as well as preparation and application thereof. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope-labeled compound, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture, or an acceptable salt of the compound, which is used as a substituted arylthio thiazolidone derivative, and application of the compound in preparation of insecticides for pest control, the compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like.

The present invention relates to a biaromatic compound acting as a PARP7 inhibitor. Specifically, the present invention relates to a compound of formula (I), or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound or prodrug thereof. The present invention also relates to a use of the compound for treating or preventing PARP7-mediated diseases, such as cancer, immune diseases, inflammation or viral infections.

The present invention provides a compound or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope labeled compound or prodrug thereof, and also provides a composition containing the compound and a medical use. The compound has good pharmaceutical prospects in the aspect of treating or preventing diseases or disorders related to PTPN2.

Provided are a compound for recoverying a p53 mutation function and use thereof, particularly relating to a compound represented by Formula M, or an enantiomer, a diastereomer, a racemate, a tautomer, a stereoisomer, a geometric isomer, a crystal form, a nitrogen oxide, a metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound or prodrug of the compound.

The invention relates to a honeycomb-shaped novel COF (Covalent Organic Framework) functionalized silicon-based chromatographic stationary phase. Silica gel is used as a matrix, and TAPT (Triallyl Phosphate) and DMTP (Dimethyl Tricarbonyl Phosphate) are subjected to aldehyde amine condensation reaction to form a two-dimensional The synthesis method comprises the following steps: activating silica gel particles by using hydrochloric acid, and neutralizing gamma-GPTS by using the activated spherical silica gel particles and anhydrous toluene to synthesize SiO2-GPTS; tAPT and DMTP are used as raw materials, a two-dimensional covalent organic framework COF is formed through a Schiff base aldehyde amine condensation reaction, and a novel honeycomb-shaped COF functionalized silicon-based chromatographic stationary phase SiO2 (at) TAPT-DMTP-COF is formed through coordination of silicon hydroxyl and amino / aldehyde group of a COF skeleton. When the TAPT-DMTP-COF is applied to chromatographic column separation, the TAPT-DMTP-COF has a porous structure with plane pi conjugation, height orderliness and stability, and the specific structure of the TAPT-DMTP-COF enables fixed relative shape limited isomers, geometric isomers and positional isomers to show excellent selectivity and separation capacity; the surface of SiO2 is coated with the COF-modified high performance liquid chromatography stationary phase material, so that the COF-modified high performance liquid chromatography stationary phase material has a uniform honeycomb shape, and a new way is opened up for constructing the COF-modified high performance liquid chromatography (HPLC) stationary phase material with the uniform shape.

Disclosed are an anti-Helicobacter pylori compound and use thereof, which relate to the technical field of pharmaceuticals. The compound is a compound represented by formula I and further comprises a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a nitrogen oxide thereof, a hydrate thereof, a solvate thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compound exhibits a good effect in the treatment of Helicobacter pylori infection.

The present invention relates to a composition, in particular a cosmetic or dermatological composition, comprising:a) at least one merocyanine compound corresponding to formula (3) below, and also the geometric isomer forms, in particular E / E or E / Z geometric isomer forms, thereof:wherein:A is —O— or —NH—;R is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, it being possible for said groups to be interrupted by one or more O; andb) dipropylene glycol.The present invention also relates to a non-therapeutic cosmetic process for caring for and / or making up a keratin material, comprising the application, to the surface of said keratin material, of at least one composition as defined above.

The present invention relates to the preparation and use of novel trifluoroalkylthiophenylpyridine derivatives. Specifically, the present invention relates to compounds of formula (I-1) or formula (I-2) as trifluoroalkylthiophenylpyridine derivatives, or isotope labeled compounds thereof, or optical isomers, geometric isomers, tautomers or mixtures of isomers thereof, or agriculturally acceptable salts thereof, as well as the use of said compounds in the preparation of insecticides for pest control. These compounds are capable of achieving better pest control effects at lower dosages, especially against pests and mites such as Tetranychus cinnabarinus, Tetranychus urticae, and Panonychus citri.

Title: Process for treating keratinous materials using at least one polyester compound with acetoacetate functionalities. The present invention relates to a process for treating keratinous materials comprising applying to said keratinous materials, in one or more successive steps, at least: i) at least one polyester of formula (I) comprising at least two acetoacetate functionalities, as well as its optical, geometric, and / or solvate isomers, such as hydrates, or a composition containing it or them: (Z)–[OC(O)-C(Ra)(Rb)-C(O)-R4]u (I), formula (I) in which Z, u, R4, Ra, and Rb are as defined in the description, and ii) optionally, at least one crosslinking agent. Figure for the abstract: None

COMPOSITION AND METHOD FOR DYEING AND / OR BRIGHTENING KERATIN FIBERS This disclosure proposes a composition comprising at least one fatty alcohol; at least one cationic polysaccharide; at least one fatty acid; at least one carboxylic acid of the formula (I) below, its optical isomers, geometric isomers, salts, solvates, or combinations thereof: R1-N-(CH(R2)COOH)2 formula (I); with at least one oxidative dye and / or at least one alkali agent. Also proposed is a method for dyeing and / or lightening keratin fibers, preferably hair, comprising applying the composition to said keratin fibers. Figure for abstract: none

The invention discloses a preparation method and application of tanshinone IIA and cryptotanshinone amide derivatives. The tanshinone IIA and cryptotanshinone amide derivatives are compounds shown in a general formula (I) or stereoisomers, racemes, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, pharmaceutically acceptable salts or prodrugs of the compounds. The tanshinone IIA and cryptotanshinone amide derivative can be used for preparing anti-inflammatory drugs, antibacterial drugs, tumor drugs, drugs for treating cardiovascular and cerebrovascular diseases, drugs for treating burns and scalds and drugs for treating infectious diseases.