55 results about "Premature birth" patented technology

Systems and methods of predicting future medical events are based on the processing of medical images. The prediction of premature birth and estimation of gestational age based on ultrasound images are presented as illustrative examples. The new abilities to estimate the probability of future medical events, before they otherwise could be predicted, provides new avenues for the development of preventative treatments.

The present invention relates to the field of biomedical technology, and more specifically to a method and system for assisting in predicting the risk of premature birth during pregnancy. The method comprises obtaining the physical data and delivery cycles of historical pregnant women, determining the degree of premature birth of the historical pregnant women based on the delivery cycles, and determining the degree of premature birth correlation of different types of physical data of the historical pregnant women based on the differences in the degree of premature birth between different historical pregnant women and the differences in the deviation changes of the same type of physical data during each physical examination. The historical pregnant women are clustered based on the deviation time differences of the same type of physical data between different historical pregnant women, and the overall correlation of each type of physical data is determined based on the number of pregnant women in the cluster and the degree of premature birth correlation of the corresponding type of physical data, thereby screening out the physical data of the target type. A premature birth prediction model is constructed based on the physical data of the target type during different physical examinations of the historical pregnant women to perform premature birth prediction. The present invention effectively improves the accuracy of premature birth prediction.

The present invention relates to an incubation system for liquid-based incubation of prematurely born infants, comprising: —an inner chamber forming an amniotic basin comprising amniotic fluid, said basin being configured for holding said infant and being made from a flexible material configured for expanding said inner chamber volume in correspondence with the growth of said infant; —an outer chamber enclosing said inner chamber and comprising a temperature regulation fluid, —a fetal connection port, arranged for connecting with the umbilical cord of said infant, said umbilical cord providing a port in said inner chamber to said infant for providing dialyzation and nutrition compounds to said infant via said umbilical cord; —a fetal control unit, connected to said fetal connection port for control of said dialyzation and control of said provided nutrition by monitoring and controlling one or more of a pressure, flow and temperature thereof; an amniotic fluid circulation unit, arranged for connecting with an inlet / outlet port of said inner chamber and comprising a pump for circulating said amniotic fluid from said inner chamber and through a purification system located outside said inner chamber; and —a temperature regulation fluid control unit, arranged for connecting with an inlet / outlet port of said outer chamber and comprising a pump for circulating said temperature regulation fluid from said outer chamber and through a heat exchanger system located outside said inner chamber.

A system configured to enclose a premature fetus within an extracorporeal environment to promote growth of the fetus and increase viability of the fetus, The system includes a chamber having an interior space configured to enclose the fetus, a first fluid circuit that delivers sterile fluid to the chamber, and a second fluid system that transfers oxygen to the fetus. The system chamber includes a stop mechanism including a clamp and an actuator, the clanip positioned in the interior space, the actuator coupled to the clamp such that movement of the actuator moves the clamp, and the actuator positioned at least partially outside the interior space. A method of using the system to treat hyperbilirubinemia is also provided.

The invention discloses an excrement metabolism marker for predicting spontaneous premature delivery based on UHPLC-MS (Ultra High Performance Liquid Chromatography-Mass Spectrometry) and application, and belongs to the technical field of biological medicines. According to the premature pregnant woman excrement metabolite specific biomarker and the application thereof, the premature pregnant woman excrement metabolite specific biomarker is screened out through a non-targeted metabonomics technology, and the marker is 1-hydroxyl vitamine d2, Mirtazapine n-oxide, Tetraethene glycol or a combination of the 1-hydroxyl vitamine d2, the Mirtazapine n-oxide and the Tetraethene glycol. A premature delivery prediction model established by using the marker is high in sensitivity and good in specificity, and a reference basis is provided for early prediction and accurate prevention of spontaneous premature delivery.

The application discloses application of TCTP protein in preparation of noninvasive premature birth diagnosis products and relates to the technical field of biological medicine. The application can estimate the premature birth risk by detecting the TCTP protein content or the TCTP gene expression quantity in peripheral blood of a pregnant woman, the method only needs 0.5ml peripheral blood of the mother, is safe for the mother and infant, and has the advantages of simplicity, high sensitivity, low cost and simple operation. In 126 sample examples in the embodiment of the application, the premature birth detection rate of the method is 91%, and in the control group, the false positive rate is 8.6% (5 examples / 58 examples), so the method has high accuracy.

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.

A device for retarding birth, forming a lumen for surrounding a uterine cervix, the device including an upper ring for surrounding the uterine cervix, and an anchoring mechanism for anchoring the device on the cervix. A tool for inserting a device for retarding birth, the device including a device lumen for surrounding a uterine cervix, the tool including a plurality of rods attached to two rings, forming a longitudinal tool lumen, each rod including a connector for attaching to the device for retarding birth at a distal end of the rod, and a mechanism at a proximal end of the rod, for detaching the device for retarding birth at the distal end of the rod. Related apparatus and methods are also described.

The invention discloses application of oridonin or a derivative thereof in preparation of a medicine for inhibiting premature delivery. Aiming at the perinatal period problem that the survival rate of newborn piglets is low due to premature delivery of sows, a large number of experimental exploration shows that the premature delivery of the sows can be effectively inhibited by applying oridonin or derivatives thereof to the sows at the end of pregnancy, and the survival rate of the piglets is increased. The composition and the method can effectively improve sow delivery and increase the survival rate of piglets, have great value in promoting batch production and efficient breeding of sows, and have great significance in solving the problem of premature delivery in the perinatal period in the reproductive field.

According to the premature delivery prediction method and device based on the uterus vector electromyographic signals and the processing equipment, through a specially-designed novel electrode arrangement scheme, the collected uterus vector electromyographic signals are different from traditional uterus surface electromyographic signals, the spatial characteristics of uterus contraction activities can be reflected more comprehensively, and the premature delivery prediction accuracy is improved. Compared with the prior art, the premature delivery detection method has the advantages that the premature delivery detection method contains more signal characteristics related to premature delivery, so that high premature delivery prediction precision can be achieved under the condition of fewer measuring electrodes, and clinical application value is achieved.

The invention discloses a vagina microbial marker combination, which is characterized in that the vagina microbial marker combination is composed of Lactobacillus indices and Bifidobacterium dentium, and the vagina microbial marker combination is used for assisting in evaluating the premature delivery risk of a pregnant woman suffering from cervical insufficiency and subjected to transvaginal cervical cerclage. Therefore, the premature delivery can be predicted based on the vagina microbial marker combination, so that decisions and help are provided for clinicians to judge whether the pregnant woman is premature delivery or not.

This invention discloses a resveratrol derivative or its pharmaceutical salt, with the following general structural formula:; This invention also discloses the application of the resveratrol derivative or its pharmaceutical salt in the preparation of drugs for preventing and treating premature birth.

A polynucleotide, a kit, an isothermal detection method and a method for predicting premature birth, the method for predicting premature birth comprising: analyzing the expression profile of any one or at least two gene sets in a maternal sample, and predicting whether the subject will have premature birth according to the expression profile. The present application detects the expression amount of the marker gene in the serum of pregnant women for the first time, which is used for the prediction of premature birth risk of pregnant women without clinical symptoms. The main advantage is serological detection, no need to make an appointment in advance like ultrasound, non-invasive detection, no need for vaginal or cervical sampling, and good detection process experience.

This invention belongs to the field of microbial technology, specifically disclosing a probiotic composition and its application. The probiotic composition provided by this invention includes at least two of the following: prebiotics, vitamin K, and zinc, as well as *Bifidobacterium longum* subsp. infantis i18. The probiotic composition provided by this invention can not only effectively promote the growth and development of premature mice, but also optimize the intestinal flora structure and promote intestinal development in premature infants by reducing the abundance of harmful bacteria and increasing the relative abundance of beneficial bacteria; simultaneously, it can downregulate the levels of pro-inflammatory factors TNF-α and IL-6, reducing intestinal inflammation and lowering the risk of necrotizing enterocolitis in premature infants. This invention can be applied to the preparation of products that improve the intestinal flora of premature infants, promote their growth, or prevent intestinal inflammation.

Methods and devices to control movement of microorganisms, sperm or viruses within a female reproductive system, including methods and devices for preventing infection or pregnancy. Devices may include a cervical barrier that is configured to allow biological fluids to exit the uterus and cervical canal while preventing the ascension of microorganisms, sperm or viruses into the cervical canal and uterus.

The invention belongs to the technical field of obstetrics and gynecology disease prediction, and particularly relates to a premature fetal membrane premature rupture prediction marker based on maternal circulation exosome microRNA and an application kit. According to the invention, placentas, fetal membranes and plasma exosomes of pregnant women with full-term birth and premature birth premature rupture of fetal membranes are collected for sequencing, the fetal membrane-derived exosome hsa-miR-145-3p which can be detected in the plasma exosomes is screened out in combination with a verification set, and the cell source and the premature birth promoting effect of the fetal membrane-derived exosome hsa-miR-145-3p are respectively clarified at a cell level and an animal level; and finally, by detecting the level of the plasma exosome hsa-miR-145-3p of the pregnant 12 (+ 1)-17 (+ 6) perimaternal body, the efficiency (AUC = 0.833) of the exosome in predicting the occurrence of premature rupture of fetal membranes in premature delivery is illustrated. According to the method, the high-risk crowd of the pPROM can be predicted through a noninvasive method in the early and middle stages of pregnancy, and the method has guiding significance for subsequent prevention and intervention of the high-risk crowd.

Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system.

The invention relates to the field of medicine, in particular to a pregnant woman premature delivery prediction system based on uterus electromyographic signals. Body surface electrodes are used for detecting the uterus electromyographic signals of the abdomen of a puerpera; the analog / digital converter is electrically connected with the body surface electrode, and the analog / digital converter receives electric signals of the body surface electrode and converts the electric signals into digital signals. And the memory is arranged on the microprocessor and is used for storing data. The microprocessor is electrically connected with the analog / digital converter, receives data of the analog / digital converter and stores the data into the memory; a computer program is stored on the memory, and the following method for predicting the premature delivery of the pregnant woman based on the uterine electromyographic signals is realized when the computer program is executed by the processing device.

The invention discloses a manufacturing method of a hygienic product suitable for premature infants, which belongs to the technical field of hygienic product manufacturing and comprises the steps of raw material preselection, surface layer preparation, absorption core layer preparation, bottom layer preparation and composite forming treatment. The composite equipment body comprises a feeding unit, a spraying unit, a pressing unit, a slitting unit and a discharging unit which are sequentially arranged from front to back, the feeding unit and the discharging unit each comprise a material frame, and a mounting opening is formed in the side face of each material frame. The characteristics that the premature infant is delicate in skin and prone to infection are focused through raw material selection, the stimulation risk is reduced through raw materials of the medical-grade surface layer, the water absorption efficiency and softness are balanced through the absorption core layer, the gradient thinning design is matched with the body type of the premature infant, and integrated production from raw material conveying to finished product output is achieved through the five-unit layout of the composite equipment body. The three material rollers in the feeding unit correspond to the surface layer raw material, the absorption core layer raw material and the bottom layer raw material respectively, the synchronous feeding requirement of composite production is met, and the operation efficiency is effectively improved.

The application provides a method and application for inhibiting premature birth of sows or shortening delivery process, and particularly discloses a method and application for inhibiting premature birth of sows or shortening delivery process of sows by using vitamin B6 or derivatives thereof. The application aims at the perinatal period problem of low survival rate of newborn piglets caused by premature birth or long delivery process of sows, and vitamin B6 or derivatives thereof is applied to sows in the late gestation period, and the result shows that the vitamin B6 or derivatives thereof can effectively inhibit premature birth of sows, shorten delivery process of sows and improve the survival rate of piglets, and is an effective method for improving delivery of sows and improving survival of piglets, and provides great value for promoting batch production of sows and high-efficiency breeding, and has important significance for solving the perinatal period premature birth problem in the field of reproduction.

Spontaneous preterm birth (sPTB) is premature delivery prior to 37 weeks of pregnancy and is a leading cause of infant mortality worldwide. sPTB is associated with a unique gene expression profile. Identified herein are numerous safe and proven therapeutic compositions used for unrelated indications that have the biological effect of reversing, in part, the gene expression profile of sPTB and which can be used in preventative or interventional treatments to prevent, delay, or ameliorate sPTB. The repurposed drugs include several Class A and Class B therapeutics that are regarded as safe or low risk in pregnant subjects.

The present invention relates to a feed additive for promoting reproduction of pregnant sows, a preparation method thereof and an application thereof. The components of the feed additive for promoting reproduction of pregnant sows include: a fermented Chinese herbal medicine complex, a compound fat powder, ergothioneine, yeast selenium and a carrier material; the raw materials for preparing the compound fat powder include glycerol butyrate, lipoic acid, nicotinamide and a wall material; the fermented Chinese herbal medicine complex is a product obtained by fermenting a Chinese herbal medicine fermentation substrate with a compound bacterium and a compound enzyme. This feed additive solves the problems that pregnant sows in the previous stage have follicular cysts, the quality of oocytes decreases, embryonic development is damaged, resulting in high rates of miscarriage, premature birth, malformation rate, mummy rate, etc. due to oxidative stress and other reasons, thereby significantly improving the reproductive performance of pregnant sows.

The invention relates to a device for preventing dysmenorrhea and early uterine contractions that can lead to premature birth, in the form of an anti-static fabric pad, composed of pockets filled with an anti-static material, which is placed between the underwear and the abdomen to reduce the ionic charge of the uterus and neutralize static electricity therein that causes menstrual cramps or early uterine contractions at the end of pregnancy, which can be responsible for premature birth.

Provided are a protein marker related to premature delivery, a method for constructing a premature delivery risk assessment and prediction model, a prediction model, a prediction system, a method for predicting a premature delivery risk and a delivery time, and related applications thereof. Several protein markers related to premature delivery are found, and the protein markers are applied to the field of premature delivery prediction. Moreover, the application of LUM and / or TIMP1 in premature delivery prediction is also found. LUM and / or TIMP1 in a sample of a pregnant woman is tested, then a test result is compared with a predetermined threshold value, and on the basis of a comparison result, whether the pregnant woman has a premature delivery risk or whether the pregnant woman is about to deliver within a predetermined timeframe is determined. Therefore, a premature delivery risk and a delivery time can be accurately predicted 1-2 weeks in advance by means of only collecting cervical and vaginal secretions of the pregnant woman and by using a non-invasive method.

The invention relates to a flora prediction model for detecting premature delivery risk and a kit and application thereof. Through early-stage mNGS data collection and analysis, premature related strains are obtained, and through a large number of experimental screening and optimization, a set of optimal primer probe group is finally determined. The invention relates to a premature delivery risk calculation method, which comprises the following steps of: selecting 12 floras, namely lactobacillus crispatus, lactobacillus gasseri, lactobacillus inertus, lactobacillus jensenii, escherichia coli, enterococcus faecalis, enterobacter aerogenes, group B hemolytic streptococcus, ureaplasma parvum, chlamydia trachomatis, diplococcus gonorrhoeae and gardnerella vaginalis, and establishing a fluorescent quantitative PCR (Polymerase Chain Reaction) method and a premature delivery risk calculation model aiming at the detection of the 12 floras. Compared with an existing detection method, the method is simple, convenient, rapid, high in sensitivity and high in specificity, the false positive and false negative risk is reduced, and the purpose of batch detection is achieved. Clinically, the change of microbial flora in the reproductive system of a pregnant woman can be rapidly detected, corresponding treatment measures are taken, the risk of PTB occurrence is reduced, and the kit has a good application prospect.

The application discloses albendazole and ivermectin premix and a preparation method thereof. The premix comprises albendazole 8-15%, ivermectin 0.2-0.4%, double-layer inclusion carrier 20-30% and various auxiliary materials in percentage by mass. The application adopts the double-layer inclusion carrier formed by inner layer hydroxypropyl-beta-cyclodextrin and outer layer hydroxypropyl methylcellulose phthalate and povidone K30 to form an enteric barrier. The preparation method comprises the steps of inner layer inclusion, outer layer dispersion, mixing and granulation. The relative bioavailability of the premix reaches 203%-221%, the pig ascarid drive rate is 98.7%-99.5%, the scabies mite negative conversion rate is 98%-100%, the diarrhea incidence is only 2%-3%, the premix is safe for pregnant sow groups, and no adverse reactions such as abortion, premature birth and loss of appetite occur in all test pigs during the test period. The problems of uneven mixing, low bioavailability and large side effects of traditional preparations are solved, and the premix is suitable for livestock and poultry parasite prevention and treatment.

The invention belongs to the technical field of animal models, and particularly relates to an ECMO-removed artificial uterine animal model and a construction method thereof. The animal model comprises an animal maternal body, an in-vitro fetus and an artificial uterus, the fetus is from the animal maternal body, blood circulation is established between the animal maternal body and the fetus, the blood circulation starts from the internal carotid artery of the animal maternal body, is connected to the umbilical vein of the fetus through a pipeline and enters the body of the fetus, and after the fetal circulation, the artificial uterus enters the fetal body. Starting from the fetal umbilical artery, entering the internal jugular vein of the animal maternal body through a pipeline; the fetus is located in the artificial uterus, and the artificial uterus provides a sterile artificial amniotic fluid environment for the fetus and maintains the body temperature of the fetus. According to the method, the ECMO-removed artificial uterine animal model is successfully constructed through the pregnant sheep, and the ECMO-removed artificial uterine animal model is maintained for about 90 minutes at most. A feasible animal model is provided for early surgical treatment of fetal congenital diseases and life maintenance of premature fetuses, and a foundation is laid for future clinical transformation.

The invention provides a quilt suitable for premature infants, which comprises a quilt body, a cap sewn on the top of the quilt body, a film sheet arranged in the middle of the quilt body, a disposable T-shaped built-in paper diaper pasted on the surface of the film sheet, a magic sub-tape sewn on one side of the quilt body, and a magic mother tape sewn on the surface of the other side of the quilt body, the wrapping quilt comprises a wrapping quilt body, a heart rate patch is arranged on the wrapping quilt body, a hook-and-loop fastener is arranged on the top of the wrapping quilt body, the hook-and-loop fastener is adhered to the hook-and-loop fastener, a first zipper strip is arranged on one side of the top of the wrapping quilt body, a second zipper strip is connected to the outer side of the first zipper strip in a meshed mode, and a heart rate displayer is arranged on one side of the second zipper strip. The heart rate of an infant is displayed through the heart rate displayer, the finger detection part of the infant is clamped through the detection clamp, the blood oxygen content is displayed through the oxygen saturation displayer, and vital signs of a critical premature newborn can be conveniently detected.

A positioner includes a bottom layer, an intermediate element, and a top layer. The top layer can move laterally over the bottom layer, while the intermediate element limits the extent to which the top layer can move over the bottom layer. The top layer, the bottom layer, and the ability of the top layer to move across the bottom layer may impart the positioner with characteristics that mimic a human uterus, enabling the positioner to be used to support premature infants. Methods of using the positioner are also disclosed.