7 results about "Premature birth" patented technology

This invention discloses a resveratrol derivative or its pharmaceutical salt, with the following general structural formula:; This invention also discloses the application of the resveratrol derivative or its pharmaceutical salt in the preparation of drugs for preventing and treating premature birth.

This invention belongs to the field of microbial technology, specifically disclosing a probiotic composition and its application. The probiotic composition provided by this invention includes at least two of the following: prebiotics, vitamin K, and zinc, as well as *Bifidobacterium longum* subsp. infantis i18. The probiotic composition provided by this invention can not only effectively promote the growth and development of premature mice, but also optimize the intestinal flora structure and promote intestinal development in premature infants by reducing the abundance of harmful bacteria and increasing the relative abundance of beneficial bacteria; simultaneously, it can downregulate the levels of pro-inflammatory factors TNF-α and IL-6, reducing intestinal inflammation and lowering the risk of necrotizing enterocolitis in premature infants. This invention can be applied to the preparation of products that improve the intestinal flora of premature infants, promote their growth, or prevent intestinal inflammation.

The application discloses albendazole and ivermectin premix and a preparation method thereof. The premix comprises albendazole 8-15%, ivermectin 0.2-0.4%, double-layer inclusion carrier 20-30% and various auxiliary materials in percentage by mass. The application adopts the double-layer inclusion carrier formed by inner layer hydroxypropyl-beta-cyclodextrin and outer layer hydroxypropyl methylcellulose phthalate and povidone K30 to form an enteric barrier. The preparation method comprises the steps of inner layer inclusion, outer layer dispersion, mixing and granulation. The relative bioavailability of the premix reaches 203%-221%, the pig ascarid drive rate is 98.7%-99.5%, the scabies mite negative conversion rate is 98%-100%, the diarrhea incidence is only 2%-3%, the premix is safe for pregnant sow groups, and no adverse reactions such as abortion, premature birth and loss of appetite occur in all test pigs during the test period. The problems of uneven mixing, low bioavailability and large side effects of traditional preparations are solved, and the premix is suitable for livestock and poultry parasite prevention and treatment.

The present application relates to the field of medical data analysis, and more particularly to a method for dynamically predicting the risk of pre-eclampsia premature birth based on monitoring indicators during pregnancy, which comprises: obtaining an individual measured time series set and a basic time weighted average feature; obtaining a recent transient decompensation momentum factor by performing recent deterioration dynamics analysis on monitoring data near the current evaluation time; obtaining a steady-state fracture and barrier breakdown factor by jointly evaluating the evolution trend and fluctuation potential of the historical monitoring sequence; obtaining a reconstructed fusion feature vector by fusing and reconstructing the basic time weighted average feature and the steady-state fracture and barrier breakdown factor; and obtaining a dynamic prediction result of the risk of premature birth by inputting the reconstructed fusion feature vector into a Cox proportional hazards model for risk prediction, thereby solving the problem that the existing prediction method based on time weighted average and linear feature fusion cannot effectively identify recent decompensation deterioration signals and maternal-fetal state deviation risks.

This invention belongs to the field of pharmaceutical technology and relates to a novel medical use of caffeine for premature infants, specifically its application in improving jaundice in premature infants. This invention analyzes clinical data from premature infants, constructs a mouse model of jaundice, and conducts in vivo imaging and gene knockout verification experiments in premature mice. It was found that clinical caffeine treatment can effectively reduce serum bilirubin levels in premature infants; in jaundice mice and premature mouse models, caffeine intervention significantly reduces brain tissue and serum bilirubin concentrations; gene knockout mouse experiments confirmed that caffeine enhances hepatic bilirubin uptake by upregulating OATP1A / 1B. The caffeine in this invention shows a significant effect in improving neonatal jaundice. Furthermore, caffeine is a commonly used medication for premature infants, is easy to use, and is readily accepted by medical staff and families, making it suitable for relieving apnea combined with jaundice symptoms in premature infants.

The present application relates to the technical field of molecular biology, and particularly relates to a primer group and a kit for detecting multiple pathogens through multiplex amplification targeted sequencing; the primer group comprises primers with nucleotide sequences shown in SQE ID NO. 1-SQE ID NO. 442, which are designed according to highly conserved and specific genomic regions of each pathogen, so as to ensure the specificity of amplification and the coverage of different variant strains; the primer group is suitable for prenatal TORCH screening, detection of pathogenic microorganisms of pregnant women with premature birth indications, screening of pathogenic microorganisms of suspected intrauterine infections, and detection of pathogenic microorganisms of unexplained abortion, and can simultaneously detect pathogenic microorganisms such as viruses, bacteria, fungi and parasites, and has high sensitivity and specificity.