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48 results about "Diplococcus" patented technology

A diplococcus (plural diplococci) is a round bacterium (a coccus) that typically occurs in the form of two joined cells. Examples of gram-negative diplococci are Neisseria spp., Moraxella catarrhalis, and Acinetobacter spp. Examples of gram-positive diplococci are Streptococcus pneumoniae and Enterococcus spp.

Medicinal composition for treating diarrhea and preparation thereof

The invention discloses a composition for treating diarrhea and a preparation thereof, relating to a medicinal composition for stopping the diarrhea. The invention also relates to a preparation of the medicinal composition for stopping the diarrhea. The medicinal composition is mainly prepared from the main raw materials of 1 part of Racecadotril and 0.25-25 parts of berberine hydrochloride as well as 0.01-250 parts of auxiliary materials in proportion. The medicinal composition has scientific and reasonable prescription, and can be used for inhibiting the rise of calcium ion concentration in colon smooth muscle cells and improving the motion functional coordination of the intestinal tract to realize the effect on stopping the diarrhea mainly by inhibiting the activity of enkephalinase and further inhibiting the excessive secretion of water and electrolyte via the Racecadotril, and simultaneously by the stronger bactericidal effect of the berberine hydrochloride on escherichia coli, Streptococcus hemolyticus, Diplococcus pneumoniae and the like.
Owner:KUNMING BANGYU PHARMA

Staining kit and preparation method, staining method, and use thereof

The present invention relates to a staining kit and its preparation method, staining method and its application in several detection items for detecting canceration cell, red blood cell, campylobacteriosis, vaginal cleaning degree, estrogen level, garlandosus, trichomoniasis, mycosis, diplococcus gonorrhoeae and chlamydi trachomatis on a cervical smear. Said invented kit is formed from fixatino fluid, staining solution and differentiatino solution. Its staining method includes the steps of fixation, staining, differentiation and water-washing. Its film-making speed is quick, only has need oftwo main, and its detection accuracy rate is high, can be up to 98%.
Owner:裴芳君

Traditional Chinese medicinal antibacterial finishing agent

The invention discloses a traditional Chinese medicinal antibacterial finishing agent. The traditional Chinese medicinal antibacterial finishing agent comprises the following raw materials in percentage by mass: 30%-60% of traditional Chinese medicinal antibacterial solution and 10%-20% of waterborne polyurethane (WPU), wherein, the traditional Chinese medicinal antibacterial solution comprises the following raw materials in percentage by mass: 5-70% of chinaroot greenbier rhizome extract, 15%-80% of fibrauretin, 2%-5% of OP-10 and the balance of ethanol; and the WPU is rosin-based WPU, and the solid content of the WPU is 40wt%. The traditional Chinese medicinal antibacterial finishing agent has the beneficial effects that the chinaroot greenbier rhizome and common fibraurea stem extracts are taken as antibacterial components, wherein, chinaroot greenbier rhizome has obvious bacteriostatic action on staphylococcus aureus, diplococcus gonorrhoeae and Escherichia coli (particularly for the staphylococcus aureus), and also has a function of activating blood circulation to dissipate blood stasis; and the chinaroot greenbier rhizome has different degrees of inhibitory action on a plurality of fungi such as coriolis epidermophyton and the like, and a good curative effect on superficial or deep infection caused by candida albicans as well as gynecological inflammation.
Owner:WUJIANG ZHENGMING TEXTILE

Macleaya cordata injection and preparation thereof

The invention provides a pink plumepoppy herb injection and a preparation method thereof; the pink plumepoppy herb injection is prepared by the raw materials with the following parts by weight: 30-40 parts of pink plumepoppy herb extract, 0-30 parts of latent solvent, 0.5-5 parts of anodyne and 25-70 parts of dispersion medium; the pink plumepoppy herb extract is prepared by the following procedure: pink plumepoppy herb is percolated with sulphuric acid, the percolate is subject to alcohol precipitation and is filtered and then ethanol is recycled; the pink plumepoppy herb injection of the invention can effectively restrain the growth of Gram-positive bacteria and has stronger bacteriostatic action than berberine, and diplococcus pneumoniae, staphylococcus aureus and bacillus subtilis are sensitive to the pink plumepoppy herb injection; meanwhile, the pink plumepoppy herb injection also has the function of resisting nematodes and leptospira and can inhibit and slow the body temperature raise caused by diplococcus pneumoniae; furthermore, the pink plumepoppy herb injection has the efficacies of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation; the indications are yellow and white scour of piglets; the preparation method has convenient operation, high yield, low cost and strong stability of finished products.
Owner:ZHENGZHOU HOUYI PHARMA

Grass carp enteritis treatment drug composition and preparation method thereof

The present invention discloses a grass carp enteritis treatment drug composition, which contains, by weight, 10-30 parts of humulus scandens, 20-30 parts of humifuse euphorbia herb, 2-10 parts of melia azedarach leaf, 20-25 parts of heartleaf houttuynia herb, 2-10 parts of arborvitae leaf, and 2-7 parts of garlic. The invention further discloses a preparation method for the drug composition. According to the grass carp enteritis treatment drug composition, honeysuckle provides an anti-pathogenic microorganism effect, a certain inhibition effect is provided for a variety of pathogenic bacteria such as staphylococcus aureus, hemolytic streptococcus, escherichia coli, shigella dysenteriae, vibrio cholerae, typhoid bacillus, paratyphoid bacillus and the like, and a certain inhibition effect is further provided for pneumococcus, meningococcus, pseudomonas aeruginosa, and tubercle bacillus. The preparation method is simple and easy to perform, and is suitable for mass production.
Owner:泰州市春达动物药业饲料有限公司

Private nursing solution as well as preparation method and use method thereof

The invention specifically provides a private nursing solution consisting of the following materials in percentage by mass: 5.62% of agaric, 11.24% of rhizome of swordlike atractylodes, 11.24% of sessile stemona root, 8.99% of common cnidium fruit, 5.62% of glabrous greenbrier rhizome, 5.62% of light yellow sophora root, 11.24% of common macrocarpium fruit, 11.24% of chrysanthemum, 11.24% of pomegranate rind, 11.24% of slender dutchmanspipe root, 5.62% of white alum, 0.56% of an apple essence and 0.56% of benzoic acid. The effect of the private nursing solution provided by the invention is mainly reflected in preventing diseases and cleaning bodies; and by virtue of detection, the private nursing solution has a very strong ability of killing diplococcus gonorrhoeae, staphylococcus aureus, escherichia coli and herpes viruses. Particularly, the private nursing solution used for cleaning private parts before and after a sexual intercourse can eliminate peculiar smells, can achieve clean and comfortable feelings after being used, and can improve the female sexual capacity. Moreover, the private nursing solution provided by the invention cannot cause any irritation and toxic or side effects.
Owner:SHENYANG YIRENBAO BIOCHEM PROD

Preparation method of living disinfectant

The invention relates to a preparation method of a living disinfectant. The method comprises preparation of raw materials, preparation of stable chlorine dioxide and preparation of the product of the living disinfectant. By using the product of the living disinfectant produced by the method provided by the invention, the diplococcus gonorrhoeae, colibacillus, staphylococcus aureus, candida albicans, bacillus subtilis virus, hepatitis B virus, influenza virus, fungus, mould and transmissible pathogenic bacteria can be quickly killed; the product is colorless, tasteless and nontoxic, does not produce secondary pollution, generate resistance to drugs and stimulate eyes, skin and mucosa of a respiratory tract, is an environment-friendly product and can be applied to disinfection for object surfaces, traumatic inflammation and red and swollen vulva suffering pruritus so as to clear the peculiar smell.
Owner:韶关蓝威消毒药业有限公司

Combined vaccine for preventing meningitis in children and preparation method of combined vaccine

The invention relates to a combined vaccine for preventing meningitis in children and a preparation method of the combined vaccine. The vaccine contains polysaccharide protein conjugates of diplococcus meningitidis, streptococcus pneumoniae and haemophilus influenza, is applied to immunization of children over 6 weeks, and is used for preventing meningitis in children caused by diplococcus meningitidis, streptococcus pneumoniae and haemophilus influenza and simultaneously for preventing other infectious diseases caused by these pathogenic bacteria.
Owner:BEIJING ZHIFEI LVZHU BIOPHARM

Pharmaceutical composition for resisting human papilloma virus and resisting gynecological inflammation, gel preparation and application

The invention discloses a pharmaceutical composition for resisting human papilloma virus and resisting gynecological inflammation. The pharmaceutical composition is prepared from the following components in parts by weight: 20 to 60 parts of Chinese prickly ash, 20 to 60 parts of folium artemisiae argyi, 6 to 10 parts of flos chrysanthemi indici, 6 to 10 parts of aloe and 6 to 10 parts of flos campsis. The invention further discloses a gel preparation prepared from the composition, a preparation method of the gel preparation and application of a composition and the gel preparation. The pharmaceutical composition and the gel preparation, provided by the invention, can be used for effectively preventing and treating the human papilloma virus (HPV) and treating the gynecological inflammationcaused by various reasons, and have a good inhibition effect on staphylococcus aureus, escherichia coli, mildew, diplococcus gonorrhoeae and candida albicans.
Owner:吉林省正肽生物科技有限公司

Traditional Chinese medicinal liquid preparation and indications thereof

The invention discloses a traditional Chinese medicinal liquid preparation suitable for preventing and treating the hand-foot-and-mouth disease and external infection diseases. The traditional Chinese medicinal preparation is prepared by carrying out a scientific processing technology on honeysuckle flower, Weeping Forsythia, Wrinkled Gianthyssop, tarragon, mint, Lithospermum erythrorhizon and raw licorice. The traditional Chinese medicinal preparation for preventing and treating the hand-foot-and-mouth disease and the external infection diseases caused by the exogenous evil utilizes the traditional Chinese medicinal theory and is clinically demonstrated. The preparation of the invention, which has a traditional Chinese medicinal preparation formula, has obvious inhibition effects on staphylococcus aurei, hemolytic streptococcocci, dysentery, typhoid, diplococcus meningitides, diplococcus pneumoniae, green plus, influenza viruses and the like.
Owner:HAINAN MEILAN SMITH KLINE PHARMA

Mesoporous bioactive glass/lasiosphaera composite material, preparation and applications

The invention discloses a mesoporous bioactive glass / lasiosphaera composite material, preparation and applications, and belongs to the biomedical material field. The composite material is mainly composed of mesoporous bioactive glass and lasiosphaera. The preparation technology method is advantaged by simple preparation, controllable technological parameters, convenient operation and low cost. The obtained composite material has good hemostatic effects. In addition, the composite material has certain inhibition effects on staphylococcus aureus, pseudomonas aeruginosa, proteusbacillus vulgaris, diplococcus pneumonia, typhoid bacillus and escherichia coli, has inhibition effects on few pathogenic fungi, has good biological activity, and can be used as an integrated composite material of antibiosis, hemostasis and promoting tissue regeneration.
Owner:CHENGDU UNIV

Preparation method of traditional Chinese medicine spray

The invention discloses a preparation method of a traditional Chinese medicine spray, and in particular relates to a preparation method of a traditional Chinese medicine spray related with traditional Chinese medicine. The traditional Chinese medicine spray provided by the invention comprises the following traditional Chinese medicine raw materials of eupatorium, Agastache rugosus, rhizoma atractylodis, Mangnolia officinalis, radix sophorae flavescentis and folium artemisiae argyi at the weight ratio of 10 to 10 to 20 to 10 to 20 to 7. The medicine liquid prepared by the invention is capable of effectively killing and restraining multiple viruses such as a common cold virus, a staphylococcus, a streptococcus, a dysentery bacillus, a Bacillus anthraci, alpha-streptococcus hemolyticus, a corynebacterium diphtheria, a lung class diplococcus, staphylococcus aureus; the use is safe, the smell is fragrance, the medicine liquid is harm for a human body, and does not corrode an article.
Owner:刘平

Bromo-2, 4'-dihydroxy diphenyl ether compound and its synthesizing method

The inventiona relates to bromo-2, 4í»-dihydroxyl diphenyl ether compound and its synthesizing method, using 2-methoxy phenol and 4-methoxy chlorobenzene as raw materials, and it is an antimicrobial obtained by three-step reaction, and has better antimicrobial activity to Escherichia coli, catarrh diplococcus, Staphylococcus aureus, Staphylococcus Albus, bacillus proteus, etc. and avoids producing highly toxic dioxin compound in the producing and using course, avoiding environmental pollution and damaging human health; and also overcomes the shortages that natural bromic2, 4í»-dihydroxyl diphenyl ether antimicrobial can form highly toxic dioxin compound in use on certain conditions, and the natural bromic2, 4í»-dihydroxyl diphenyl ether antimicrobial has limited source, complex extracting course and high cost..
Owner:SICHUAN UNIV

Hand liquid disinfectant having moisturizing and deodorizing functions and preparation method of liquid disinfectant

The invention discloses a hand liquid disinfectant having moisturizing and deodorizing functions and a preparation method of the liquid disinfectant. The liquid disinfectant includes the following components in percentages by weight: 60-80% of 95% medical ethanol, 0.2-0.5% of glycerol, 0.05-0.5% of ethylhexylglycerin, 0.2-0.6% of polyhexamethylene biguanide hydrochloride, 0.2-1% of vitamin E, 0.2-1% of vitamin C, 0.2-1% of vitamin A, 0.2-0.5% of aloe extract, and the balance of deionized water. The preparation method includes the following steps: 1, preparing an ethanol solution; and 2, preparing the liquid disinfectant. Compared with a current hand liquid disinfectant, the hand liquid disinfectant provided by the invention has the advantages of a broad-spectrum antibacterial spectrum, a good killing effect on escherichia coli and staphylococcus aureus, inhibitory effects on dysentery bacillus, typhoid bacillus, pertussis bacillus, corynebacterium diphtheria, pseudomonas aeruginosa anddiplococcus pneumonia, and an anti-influenza virus effect.
Owner:抚顺东科新能源科技有限公司

Bromo nitryl dihydroxy diphenyl ether compound and its synthesis method

The invention discloses a bromonitro dihydroxy diphenyl ether compound and synthesizing method, which is characterized by the following: adopting 4, 4'-dihydroxy diphenyl ether as raw material; reacting through three-step to obtain bromo-2-nitro-4, 4'-dihydroxy diphenyl ether compound; selecting large intestine Escherichia and kala diplococcus to detect bacteriostatic activity to synthesize bromodihydroxy diphenyl ether; avoiding the fault of high toxic dioxins compound.
Owner:CHENGDU MEDICAL COLLEGE

Spray preparation for treating quail diseases

The invention relates to a spray preparation for treating quail diseases. The spray preparation mainly comprises 5-7 parts of honeysuckle flowers, 3-6 parts of fructus forsythiae, 7-9 parts of honey-fried licorice roots, 10-30 parts of isatis roots, 15-25 parts of white poria, 2-8 parts of plantain seeds, 2-6 parts of codonopsis pilosula, 1-3 parts of milkvetch roots, 2-4 parts of bighead atractylodes rhizome and 3-6 parts of blackberrykiky rhizome. According to the spray preparation for treating the quail diseases, through large-scale applications, it is verified that the curative effect is good, the efficacy is rapid, the prevalence rate of the pullorum disease, the diplococcus disease, the escherichia coli and the Marek's disease of quails can be effectively reduced, the pharmaceutical composition belongs to pure traditional Chinese medicine preparations, compared with western medicines, drug residues do not exist, toxic and side effects do not occur, and the immunity of the quails is improved.
Owner:DALIAN LINGQIAN AGRI PROFESSIONAL COOP

Medicinal composition containing zinc gluconate for resisting diplococcus pnenmonia

The present invention relates to a medicine composition containing zinc gluconate for resisting pneumonia diplococcus. Said medicine composition includes paracetamol, zinc gluconate, isothiazine hydrochloride, isatis root extract, lonicera and others. It can quickly obtain therapeutic effect, and its therapeutic effect is high.
Owner:上海倍艺医药科技有限公司

Sterilizing water-free hand sanitizer and preparation method thereof

The invention relates to the technical field of hand sanitizers, in particular to a sterilizing water-free hand sanitizer and a preparation method thereof. In the first respect, the sterilizing water-free hand sanitizer provided by the invention comprises preparation raw materials in percentage by weight of 0.5-0.05% of a humectant, 0.1-0.6% of capo, 45-70% of ethanol, 0.01-0.1% of triethanolamineand the balance deionized water. The sterilizing water-free hand sanitizer provided by the invention has broad antibiogram, has favorable destroying effects on escherichia coli and staphylococcus aureus, has restraining effects on dysentery bacillus, typhoid bacillus, bacillus pertussis, Klebs-Loeddler bacillus, pseudomonas aeruginosa, tubercle bacillus, streptococcus, diplococcus pneumoniae andthe like, further has effect of resisting influenza viruses, besides, has good stability, is non-irritating to skin, and has the efficacy of moisturizing and caring skin.
Owner:河北翰林生物科技有限公司

Application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions

The invention discloses application of aspongopus total alkaloids in preparation of medicines or health care products with antibacterial, anti-inflammatory, antipyretic and immunological enhancement functions. The biological activity detection result of the aspongopus total alkaloids proves that the aspongopus total alkaloids have the inhibition effects of different degrees on diplococcus pneumoniae, staphylococcus aureus, type A streptococcus pyogens, type B streptococcus pyogens and proteusbacillus vulgaris, have obvious inhibition effects on the diplococcus pneumoniae and staphylococcus aureus, have the obvious anti-inflammatory effect on ear swell of mice caused by dimethylbenzene and have the obvious antipyretic effect on exothermic reaction of rats caused by dried yeasts, the phagocytic function of the reticuloendothelial system of the mice can be obviously enhanced, and the aspongopus total alkaloids have the immunological enhancement function and are low in toxicity and safe to use.
Owner:THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA

Preparation method of clean sterilizing tissue

The invention relates to antibacterial tissue, which is prepared from the following components in parts by mass: 100 to 150 parts of log paper pulp, 0.1 to 0.2 part of nanoscale titanium dioxide, 0.2to 0.4 part of chitosan, 0.1 to 0.3 part of a biquaternary ammonium salt bactericide, 5 to 8 parts of a herba hedyotidis diffusae extract, 5 to 8 parts of a fructus forsythiae extract and 5 to 8 partsof a folium artemisiae argyi extract. According to the invention, the nanoscale titanium dioxide, the chitosan and the biquaternary ammonium salt bactericide have good broad-spectrum antibacterial property, and are added into the pulp preparation pool in the preparation process of the antibacterial tissue in cooperation with the herba hedyotidis diffusae extract, the fructus forsythiae extract and the folium artemisiae argyi extract, so that the antibacterial tissue has a remarkable killing effect on pathogenic bacteria such as diplococcus pneumoniae, mycobacterium tuberculosis, haemophilus influenzae and the like; the plant fibers contained in the herba hedyotidis diffusae extract guarantee the diversity of the tissue cellulose, so that the paper is not prone to powder falling; and the natural plant pigments contained in the folium artemisiae argyi extract enable the paper to be slightly green in color and rich in modern aesthetic concept.
Owner:彭宝全

Chili sauce capable of preventing sour taste change and preparation method thereof

The invention discloses a chilli sauce capable of preventing sour taste change and a preparation method thereof, and relates to the technical field of chilli sauce. The chili sauce is prepared from the following raw materials in parts by weight: 200 to 400 parts of fresh chilies, 50 to 120 parts of vegetable oil, 5 to 10 parts of spices, 5 to 20 parts of white granulated sugar, 5 to 30 parts of dandelions, 10 to 50 parts of herba portulacae, 30 to 60 parts of pickled bamboo shoots, 20 to 50 parts of edible salt, 3 to 5 parts of green onion sections, 3 to 8 parts of tender ginger and 5 to 10 parts of garlic. According to the chili sauce capable of preventing acid flavor change and the preparation method of the chili sauce, the dandelion has a relatively strong bactericidal effect on staphylococcus aureus drug-resistant strains and hemolytic streptococcus, has a certain bactericidal effect on diplococcus pneumoniae, meningococcus, various bacilli and catarrha cocci, can inhibit bacterium breeding, and has a good effect on preventing acid flavor change. In addition, the purslane has a relatively strong inhibition effect on escherichia coli, shigella dysenteriae, typhoid bacillus and the like, and the purslane and the chilli sauce are matched for use, so that the chilli sauce can be prevented from going bad and changing taste, and the shelf life of the chilli sauce is prolonged.
Owner:MAANSHAN SHIYUEFENG FOOD

Compound josamycin nano-emulsion antibacterial drug and preparation method thereof

The invention discloses a compound josamycin nano-emulsion antibacterial drug and a preparation method of the drug. The components of the compound josamycin nano-emulsion comprise josamycin, trimethoprim, glacial acetic acid, a surfactant, a cosurfactant, oil and distilled water; the particle size of the drug is 1nm-100nm, and the drug takes on light yellow or colorless clear transparent liquid and has the advantages of being high in bioavailability, small in toxic and side effects, low in viscosity, good in mobility, good in dispersibility, quick in absorption, stable in property and the like. The drug is mainly used for treating diseases caused by staphylococcus, streptococcus, pneumococcus, diplococcus meningitides and bordetella pertussis, clostridium difficile, corynebacterium diphtheria, bacillus anthracis, brucella, legionella, helicobacter, mycoplasma, rickettsia, chlamydia and the like.
Owner:NORTHWEST A & F UNIV

Medicament for treating swelling and pain in throat and preparation method thereof

The invention discloses a medicament for treating swelling and pain in throat and a preparation method thereof, aiming at solving the problems of easy opacity or precipitation, instable preparation quality to influence curative effect, and reduced commodity value for current medicaments; the medicament comprises the following components by weight: 15-25 parts of phellodendron, 5-10 parts of mint, 3-5 parts of radix scrophulariae, 6-12 parts of subprostrate sophora, and 5-15 parts of ligusticum wallichii. Tests show that the medicament of the invention has obvious inhibition effect on staphylococcus aureus, diplococcus pneumonia, diplococcus meningitides, Corynebacterium diphtheria, and mycobacterium tuberculosis, and has good swelling and pain relieving efficacy when used clinically. Meanwhile, the preparation method of the invention adopts alcohol or alcohol-containing aqueous solutions to extract natural products, and the medicament is used as a medicinal throat pain-relieving traditional Chinese medicine preparation, and can prevent precipitation of leached components.
Owner:CHENGDU JIANJIANG PHARMA FACTORY

Cleaning and sterilizing tissue

The antibacterial tissue is prepared from the following components in parts by mass: 100 to 150 parts of log paper pulp, 0.1 to 0.2 part of nanoscale titanium dioxide, 0.2 to 0.4 part of chitosan, 0.1to 0.3 part of biquaternary ammonium salt bactericide, 5 to 8 parts of hedyotis diffusa extract, 5 to 8 parts of fructus forsythiae extract and 5 to 8 parts of folium artemisiae argyi extract. The nanoscale titanium dioxide, the chitosan and the biquaternary ammonium salt bactericide have good broad-spectrum antibacterial property; meanwhile, the hedyotis diffusa extract, the fructus forsythiae extract and the folium artemisiae argyi extract are matched and added into a pulp preparation pool in the preparation process of the antibacterial tissue, so that the tissue has a remarkable killing effect on pathogenic bacteria such as diplococcus pneumoniae, mycobacterium tuberculosis and haemophilus influenzae, plant fibers contained in the hedyotis diffusa extract guarantee the diversity of tissue cellulose, the tissue is not prone to powder falling, and natural plant pigments contained in the folium artemisiae argyi extract enable the tissue to be slightly green in color and richer in modern aesthetic concept.
Owner:彭宝全

Chinese medicinal solid preparation and indications thereof

The invention discloses a Chinese medicinal preparation which is suitable for preventing hand-foot-and-mouth disease and external infection diseases and treating sub-clinical diseases. The Chinese medicinal preparation consists of honeysuckle flower, weeping forsythia, wrinkled gianthyssop herb, argy wormwood leaf, mint, Sinkiang arnebia root and raw liquoric root and is prepared by a scientific processing process. By clinical demonstration, the Chinese medicinal preparation is used for preventing and treating the hand-foot-and-mouth disease and the external infection diseases, which are caused by exogenous evil according to the theory of traditional Chinese medical science. The Chinese medicinal preparation has an obvious inhibiting effect on staphylococcus aureus, hemolytic streptococcus, dysentery, typhoid fever, diplococcus meningitides, diplococcus pneumoniae, pyocyanosis, influenza virus and the like.
Owner:HAINAN MEILAN SMITH KLINE PHARMA

A kind of novel antibiotic containing antibody mimetic and its preparation method and application

The present invention belongs to field of biology and medicine, and especially relates to a novel antibiotic comprising a mimetic antibody, its preparation methods and uses thereof. The novel antibiotic comprising comprising an antibody mimetic and a colicin,or comprising an antibody mimetic and a channel-forming domain of a colicin, the antibody mimetic covalently bonded to the carboxyl end of the polypeptide of the colicin or the channel-forming domain of the colicin, wherein the colicin is selected from a group consisting of colicin E1, Ia, Ib, A, B, N; wherein said antibody mimetic being yielded by fusing two complementarity determining regions (CDRs), V H CDR 1 ) and V L CDR through a cognate framework region (V H FR 2 ) of an immunoglobulin; wherein the immunoglobulin specifically recognizes bacterium porins. Its antibacterial ability is a thousandfold powerful than normal antibiotics. Due to its unique action mechanism, drug resistance resulted in mutation can hardly be acquired by pathogenic bacteria. And the antibiotic will not hurt normal human cells when it kills pathogenic bacteria. Therefore, it can be used for manufacturing antibacterial medicament of killing Diplococcus intracellularis, vancomycin-resistant enterococci, Methicillin-resistant Staphylococcus aureus, or multidrug resistant Pseudomonas aeruginosa.
Owner:PHEROMONICIN BIOTECHNOLOGY LTD

Traditional Chinese medicine formula bacteriostatic paste gel and preparation method thereof

The invention discloses a traditional Chinese medicine formula bacteriostatic paste gel and a preparation method thereof. The preparation method comprises the following steps: weighing herba polygoni cymosi, flos lonicerae, radix et caulis opuntiae dillenii, herba artemisiae scopariae, and radix asparagi in corresponding quantities in a prescription, carrying out mixing and crushing, sieving the mixture with a 10-mesh sieve, distilling the sived mixture by adopting a steam distillation method, and collecting 840 ml of distillate for later use; and weighing eucalyptus leaves in corresponding quantities in the prescription, and extracting volatile oil by adopting the steam distillation method for later use. The traditional Chinese medicine formula bacteriostatic paste gel has remarkable curative effects on burns and scalds, skin ulcer, eczema, pustule and the like. Tests prove that the product is non-toxic and free of side effects, can be used by children and pregnant women, can be used for conveniently solving the skin problem of patients, has different degrees of bacteriostatic effects on staphylococcus aureus, diplococcus pneumoniae, streptococcus hemolyticus, corynebacterium diphtheria, pseudomonas aeruginosa and bacillus anthracis, effectively improves the effects of sterilization, bacteriostasis, inflammation resistance and allergy resistance, improves the treatment effect and is convenient to use.
Owner:山东瑞和药业有限公司

A kind of xuanmai tangerine composition and its preparation method

The invention relates to a novel Xuanmaiganju composition (composition consisting of radix scrophulariae, radix ophiopogonis, liquorice root and radix platycodonis) and a preparation method of the composition. The composition is mainly prepared from 10 parts of the radix scrophulariae, 10 parts of the radix ophiopogonis, 10 parts of the liquorice root and 10 parts of the radix platycodonis; and the preparation method comprises such steps as extracting four raw materials, namely the radix scrophulariae, the radix ophiopogonis, the liquorice root and the radix platycodonis, conducting alcohol precipitation, refining extracts by virtue of a macroporous resin column and the like. Modern pharmacological researches show that both the radix scrophulariae and the radix ophiopogonis have a bacteriostatic effect and have an obvious effect on inhibiting diplococcus pneumoniae, streptococcus hemolyticus, bacillus influenzae and the like. The liquorice root has functions of resisting inflammation and resisting allergy. The radix platycodonis is capable of promoting the secretion of respiratory mucosa and taking effects of eliminating phlegm and relieving sore throat. The composition provided by the invention adopts an effective composition group, and various components fully develop a synergistic effect, so that the curative effect of the medicine (the composition) is enhanced; and animal tests show that the composition provided by the invention has a good effect of preventing and treating throat diseases.
Owner:SHINEWAY PHARMA GRP LTD

Composite microbial preparation for degrading kitchen garbage and preparation device

The invention discloses a composite microbial preparation for degrading kitchen garbage, which is prepared from the following components in parts by mass: 75 to 80 parts of microbial mixed fermentation liquor, 1 to 3 parts of fatty alcohol polyoxyethylene, 0.1 to 0.3 part of urea, 0.1 to 0.3 part of diammonium hydrogen phosphate and 18.8 to 21.4 parts of distilled water. The microorganism mixed fermentation liquor is prepared from pseudomonas aeruginosa fermentation liquor, diplococcus fermentation liquor, bacillus subtilis fermentation liquor and bacillus amyloliquefaciens fermentation liquor according to the mass ratio of 1: 1: 1: 1. After kitchen waste is treated by the composite microbial preparation, the content of grease in discharged waste water is reduced, a cleaning effect on a drainage pipe network is achieved, grease is not accumulated, and the pipe network is not blocked; meanwhile, the volume of the kitchen waste is rapidly reduced, the reduction is obvious, and large organic waste in the kitchen waste is degraded into organic particle liquid with the particle size being 2 mm or below within 18 h.
Owner:上海艾尔天合环境科技有限公司

A kind of method for extracting avelamycin

The invention discloses a method for extracting avilamycin from avilamycin fermentation broth. The avilamycin is prepared through the steps of performing solid-liquid separation on the avilamycin fermentation broth, performing drying, performing decoloring, and the like. The method has the advantages of high production efficiency, low cost, less environmental pollution, and good finished product quality. The avilamycin is an oligosaccharide antibiotic belonging to an orthosomycin family. The avilamycin has an inhibitory effect on various gram-positive bacteria, including some pathogenic bacteria such as vancomycin antagonistic enterococcus, methicillin antagonistic staphylococci and penicillin antagonistic diplococcus pneumoniae. Moreover, the avilamycin has an indirect effect on colibacillus, and can not only influence adhesion of bacterial flagella and bacteria but also achieve inhibition of bacterial infection by inhibiting the bacteria from adhering to surfaces of host mucosal cells, thereby inhibiting infection of diseases.
Owner:HEBEI SHENGXUE DACHENG PHARMA
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