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Compound josamycin nano-emulsion antibacterial drug and preparation method thereof

A technology of josamycin and antibacterial drugs, which is applied in the field of preparation of compound josamycin nanoemulsion antibacterial drugs, can solve problems such as skin rashes and gastrointestinal side effects, and achieve clear and transparent appearance, good dispersion, and bioavailability high degree of effect

Inactive Publication Date: 2012-07-11
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it can cause skin rashes and gastrointestinal side effects

Method used

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  • Compound josamycin nano-emulsion antibacterial drug and preparation method thereof
  • Compound josamycin nano-emulsion antibacterial drug and preparation method thereof

Examples

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Effect test

Embodiment 1

[0037] Example 1 The preparation method of compound recipe josamycin nanoemulsion antimicrobial drug of the present invention specifically comprises the following steps:

[0038] (1) Weigh josamycin API, trimethoprim API, glacial acetic acid, surfactant, co-surfactant, oil, distilled water, etc. for later use;

[0039] (2) Preparation of the oil phase: add the josamycin and trimethoprim into glacial acetic acid and stir until completely dissolved, then add oil and stir evenly to form the oil phase;

[0040] (3) Preparation of the surfactant phase: Mix the surfactant and co-surfactant in the formulated amount, stir evenly, and use it as a mixed surfactant;

[0041] (4) Add the surfactant phase to the oil phase and mix well, then use distilled water as the water phase, and slowly add the formula amount to the mixed surfactant phase and oil phase at 20°C to 25°C distilled water and fully stirred to obtain clear and transparent yellow or colorless and transparent compound josam...

Embodiment 2

[0043] Josamycin 0.4g, trimethoprim 0.1g, glacial acetic acid 1.5g, IPM 0.01g, 1,2-propanediol 0.5g, EL-40 2g, distilled water 5.49g.

Embodiment 3

[0045] Josamycin 0.1g, trimethoprim 0.02g, glacial acetic acid 0.6g, ethyl acetate 0.05g, oleic acid 0.05g, absolute ethanol 1g, RH-40 3g, distilled water 5.18g.

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Abstract

The invention discloses a compound josamycin nano-emulsion antibacterial drug and a preparation method of the drug. The components of the compound josamycin nano-emulsion comprise josamycin, trimethoprim, glacial acetic acid, a surfactant, a cosurfactant, oil and distilled water; the particle size of the drug is 1nm-100nm, and the drug takes on light yellow or colorless clear transparent liquid and has the advantages of being high in bioavailability, small in toxic and side effects, low in viscosity, good in mobility, good in dispersibility, quick in absorption, stable in property and the like. The drug is mainly used for treating diseases caused by staphylococcus, streptococcus, pneumococcus, diplococcus meningitides and bordetella pertussis, clostridium difficile, corynebacterium diphtheria, bacillus anthracis, brucella, legionella, helicobacter, mycoplasma, rickettsia, chlamydia and the like.

Description

technical field [0001] The invention belongs to the field of medicine, relates to a new dosage form of compound nano-medicine, in particular to a preparation method and application of a stable and transparent compound josamycin nano-emulsion antibacterial drug. Background technique [0002] Josamycin is a single-component 14-membered ring macrolide antibiotic, which is white or off-white crystalline powder, hardly soluble in water, but soluble in organic solvents. Its mechanism of action is to combine with the 50S subunit of ribonucleosomes, inhibit peptidyltransferase, affect the translocation process of ribonucleosomes, hinder the growth of peptide chains, and inhibit the synthesis of bacterial proteins. The antibacterial spectrum and antibacterial effect of josamycin are similar to those of erythromycin. The role, unlike erythromycin, is that it does not induce staphylococcus resistance to macrolide antibiotics. Oral absorption of josamycin is rapid, the distribution in...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/505A61K9/107A61P31/04
CPCY02A50/30
Inventor 欧阳五庆刘梅雪李洋普布琼达
Owner NORTHWEST A & F UNIV
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