59 results about "Trichomoniasis" patented technology

The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.

The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.

The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of these substrates by vaginal fluid at a low pH. Selective assays for trichomoniasis are also obtained by removing particulate matter from a sample of vaginal fluid to extract a fraction devoid of particles greater than a selected size, and where desired, combining the extracted fraction with any of certain specified hydrolase inhibitors, then testing the fraction for enzymatic hydrolase activity. These qualities of trichomoniasis are the basis for a series of diagnostic tests and test devices that produce results that are detectable by visual and other means with a high degree of accuracy.

The present invention relates to a staining kit and its preparation method, staining method and its application in several detection items for detecting canceration cell, red blood cell, campylobacteriosis, vaginal cleaning degree, estrogen level, garlandosus, trichomoniasis, mycosis, diplococcus gonorrhoeae and chlamydi trachomatis on a cervical smear. Said invented kit is formed from fixatino fluid, staining solution and differentiatino solution. Its staining method includes the steps of fixation, staining, differentiation and water-washing. Its film-making speed is quick, only has need oftwo main, and its detection accuracy rate is high, can be up to 98%.

The invention relates to a method for preparing a new gynecological anti-bacterial anti-inflammatory drug, namely dithiazole vaginal effervescent tablet and a method for quality control. The dithiazole vaginal effervescent tablet is used for treating gynecopathy, anorectal diseases and skin commonly-encountered diseases such as pelvic inflammatory disease, cervical erosion, vaginitis and the like caused by anaerobic bacteria, aerobic bacteria, trichomoniasis, pure or mixed fungal infections. The dithiazole vaginal effervescent tablet is characterized in that lactic acid and a calcium lactate buffer system are added to the formulation so that the pH value of the drug is between 3.5 and 4.0 similar to the vaginal physiological pH and is advantageous to remove pathogen and infusorian, provide living conditions suitable for vaginal beneficial bacterium group of lactic acid bacteria, and promote the illness rehabilitation. Besides, the dithiazole vaginal effervescent tablet uses pharmaceutical acceptable water-soluble polymer materials such as water-soluble polymer polyethylene glycol, polyvidone K30 and the like to enwrap acidic or alkaline components of an effervescent disintegrant so as to avoid the occurrence of hidden spots or even collapsing phenomenon on the surface of the tablet caused by gas production reaction resulted from small amount of water in the storage process, and uses a ethanol solution with adhesives and surface-active agents for granulation so that the hydrolysis of clotrimazole can be prevented, the infiltration of moisture is promoted in use, the uniform collapse is accelerated, and gas bubbles are homogeneous and stable.

The present invention generally relates to methods and compositions for treating pathogenic vaginal biofilms. More specifically, the invention relates to pharmaceutical compositions comprising a combination of boric acid and diethylaminetetracetic acid (EDTA) and to methods of using such compositions to treat or prevent biofilm formation associated with vaginal infections, such as bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), trichomoniasis or mixed infections.

The invention discloses a traditional Chinese medicinal prescription for preventing and treating trichomonad of pigeon, as well as a preparation method and application thereof. The traditional Chinese medicinal prescription comprises the following traditional Chinese medicines in parts by weight: 40-60 parts of fructus cnidii, 40-60 parts of sweet wormwood, 40-60 parts of fructus quisqualis, 30-50 parts of sophora flavescens, 30-50 parts of stemona, 20-40 parts of divaricate saposhnikovia root, 20-40 parts of semen arecae, 10-30 parts of common carpesium fruit, and 10-30 parts of desmodium triquetrum. The traditional Chinese medicinal prescription for preventing and treating trichomonad of pigeon can play the effects of traditional Chinese medicines from multiple aspects, can be used for strengthening the body immunity and improving the laying performance of pigeons, can be used for preventing and treating trichomonad of pigeon, and has an important application value to development of green animal husbandry and promotion of yield improvement of pigeon products.

Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro organisms. For example, when applied topically, proguanil is particularly effective against Propionibacterium acnes, a bacteria that causes acne; Corynebacterium minutissimum, a bacteria that causes erythrasma, Gardnerella vaginalis, a bacteria that causes vaginosis; Trichomonas vaginalis, a protozoan that causes trichomoniasis and C. albicans, a fungus (a form of yeast).

The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.

The present invention provides quantitative polymerase chain reaction (PCR) methods and kits for diagnosing trichomoniasis.

The Xiaomi Huayu Capsule of the present invention is a traditional Chinese medicine capsule preparation for treating inflammatory diseases such as vaginitis, cervicitis, ovariitis, and mastitis. If it is completely cured, when the body is weak and the vaginal environment is suitable, candida and trichomonas are very easy to multiply in large numbers, causing relapses, lingering and repeated, and even prolonged treatment. Traditional Chinese medicine believes that it belongs to the category of "itching of vulva" and "leukorrhagia". It is considered to be caused by deficiency of the spleen to produce dampness, dampness and heat betting, damp accumulation and insects, or exogenous damp pathogens, pathogenic poisons invading, and worms eating into the yin. The pathological properties are deficiency in origin and excess in superficiality, deficiency of the spleen as the foundation, and exogenous pathogenic infection as the standard. Treatment treats both symptoms and root causes. The "Xiaomi Huayu Capsule" of the present invention invigorates the spleen and removes dampness, regulates the whole body, relieves vaginal discharge and restrains dampness, cleans the genitals, kills insects and sterilizes, clears away heat and detoxifies. The present invention directly acts on the body, can obviously regulate the overall function, enhance immunity, resist the invasion of evil poison, improve microcirculation, and promote the absorption of inflammation, so the cure rate is high and the curative effect is good.

A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5 - 40%, b) at least one cellulose ether in preferred amounts of 30 - 90% and c) at least one disintegrant in preferred amounts of 2 - 50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. The matrix is used in solid formulations in amounts of about 5 - 60%, preferably 20-40%, and the active principle in amounts of about 2- 70 %, preferably 5-50% with respect to the weight of the formulation.

The invention discloses a traditional Chinese medicine gynecological bacterium killing effervescent agent for treating bacterial infectious diseases. The effervescent agent for treating the bacterial infectious diseases comprises the following components by mass percentage: 1-99% of fructus cnidii, 1-99% of radix sophorae flavescentis, 1-99% of radix stemonae, 1-99% of amoorcorn tree bark, 1-99% of clove, 1-99% of realgar and 1-99% of borneol. The agent is a novel preparation developed based on traditional Chinese medicine theories, previous experience, and experience continuously summarized from long-term clinical practice of treating female vaginitis and trichomoniasis. Clinical verification proves that the traditional Chinese medicine gynecological bacterium killing effervescent agent has an obvious curative effect of treating the acute bacterial vaginitis. The agent has a good effect of treating the vaginitis and the trichomoniasis, can treat the vaginitis and the trichomoniasis thoroughly without recurrence, and has no safety risk, and no side effects on a human body.

The invention provides a freeze-dried preparation for treating gynecological diseases as well as a preparation method and an application thereof. The freeze-dried preparation for treating gynecological diseases includes gynecological disease treating freeze-dried powder and a gynecological disease treating basic solution, wherein the freeze-dried powder consists of the following components in percentage by mass: 0.1-8% of human beta-defensin and 1-15% of a stabilizer; the basic solution consists of the following components in percentage by mass: 0.01-0.4% of hyaluronic acid, 0.5-4% of methyl propanediol, 0.5-5% of a honey extract, 0.5-5% of PCA sodium, 0.5-5% of dissolved protease, 0.3-0.7% of 1,2-hexanediol, 1.5-6% of oat beta-glucan, 1-5% of soy isoflavone and the balance of de-ionized water or injection water. The freeze-dried preparation for treating gynecological diseases disclosed by the invention is suitable for sterilizing, diminishing inflammation, and treating such gynecological diseases as trichomoniasis, vaginal itching and swelling, fungus, gonococcus, bacterial cervicitis, chronic cervicitis, cervical erosion, papillary hyperplasia, pelvic inflammation and endometritis.

The invention discloses a drug for vagina contracting and gynecological inflammation and a preparation method of the drug and relates to the technical field of traditional Chinese medicine. The drug comprises, by weight, 8-20 parts of radix angelicae dahuricae, 3-10 parts of flos caryophyll, 8-20 parts of fructus cnidii, 8-20 parts of radix aucklandiae, 15-30 parts of psidium guajava, 10-30 parts of flos chrysanthemi indici, 10-30 parts of herba taraxaci, 12-25 parts of cortex phellodendri and 8-20 parts of radix et rhizoma rhei. The raw materials and the drug are reasonably compatible, which has the functions of antisepsis and anti-inflammation, removing dampness and destroying parasites, tonifying the liver and the kidney and increasing muscle tension and has significant curative effect on vaginitis, cervicitis, vulvar pruritus, burning heat, increased secretion and other gynecological inflammation caused by bacteria, viruses, mold, trichomoniasis and the like, diffuse hyperemia, mucous membrane injury and superficial ulcer caused by viginal inflammation, cervical erosion and cervical erosion can be repaired effectively, dry and astringent symptoms are relieved, regenerating capacity of vaginal mucous membrane cells is improved, and the role of removing the inflammation and contracting the vagina is played; the drug is prepared from natural Chinese herbal medicine, and long-term use without any toxic and side effects, quick effect and good curative effect are achieved.

The invention discloses a preparation method and applications of gastric floating tablets containing ornidazole, belonging to a novel technical field of medicament and relating to a novel medicament form of ornidazole. 1. The gastric floating tablets are used to treat a plurality of diseases caused by bacteroides fragilis, bacteroides distasonis, bacteroides oval window, etc.; (2) oral cavity infections: pericoronitis, periapical periodontitis, pericoronitis, acute ulcerouse gingivitis etc.; (3) gynae infections: endometritis, myometritis, oviduct or ovarian abscess, pelvic cavity soft tissue infection, haemophilis vaginitis etc.; (4) surgical infections: wound infection, abscess of epidermis, bedsore ulcerouse infection, cellulites, gas gangrene etc.; (5) brain infections: meningitis, brain abscess; (6) septicaemia and severe general infections etc. 2. The gastric floating tablets are used to prevent infections before an operation and treat anaerobic infections after an operation. 3. The gastric floating tablets are used to treat urogenital canal trichomonas and giardia lamblia infections, such as trichomoniasis etc. 4. The gastric floating tablets are used to treat alimentary system amebiasis, such as amebic dysentery, amoebic liver abscess etc. The new medicament form is characterized in that the surface thereof is hydrated into gel after contacting with gastric juice at body temperature so as to cause volume expansion because the gastric floating tablets contain a plurality of hydrophilic macromolecule materials. Weight of the tablets is less than floating force of the gastric juice, so the tablets float on the gastric juice so as to prolong time in a stomach.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

Methods and compositions for detection of vulvovaginal candidiasis (VVC), trichomoniasis and bacterial vaginosis (BV) are disclosed herein. In some embodiments, the presence or absence of VVC-associated Candida, Trichomonas vaginalis, and a plurality of BV-related bacteria in a sample is determined using multiplex nucleic acid-based testing methods.

The present invention provides a kind of benzoyl metronidazole suspension preparation and preparation method thereof, the following components are included in the described per 1000mL benzoyl metronidazole suspension preparation: 40-70g benzoyl metronidazole, 2-8g xanthan Glue, 1-4g sweetener, 1-5g dispersant, 0.1-0.5g fruit essence, 0.1-3g stabilizer and the balance purified water. The present invention can make the insoluble benzoylmetronidazole form a stable suspension in water through the selection of the raw material components in the benzoylmetronidazole suspension preparation, which is easy to absorb and can be easily absorbed in the gastrointestinal tract. The distribution area is large, the absorption is fast, the bioavailability is high, and it is not as difficult to swallow as a tablet, which improves the patient's medication compliance, and is suitable for children to take, safe and effective. It can be used for treating diseases caused by anaerobic bacteria, reproductive system trichomoniasis, gingivitis, etc., and has remarkable effect, and the preparation method of the invention is simple and suitable for industrial production.

The invention discloses an external pure Chinese traditional medicine preparation for treating scabies, which comprises the following raw materials in parts by weight: 10-20 parts of chinaberry bark, 5-15 parts of kuhseng, 5-15 parts of fructus kochiae, 10-20 parts of common cnidium fruit, 1-5 parts of rhizoma arisaematis, 5-15 parts of radix stemonae and 80-130 parts of substrate. The preparation can be prepared into a spray, ointment or liquid medicine, wherein when the preparation is prepared into the spray, 75% alcohol or water is used as the substrate; and when the preparation is prepared into the ointment or liquid medicine, castor oil or sesame oil is used as the substrate. In the invention, various Chinese traditional medicine raw materials supplement each other, and have obvious functions of clearing heat, killing pests, relieving itching and eliminating toxicity. The preparation disclosed by the invention has the advantages of good treatment effect and short course of treatment, is convenient to use and does not have toxic side effects, and the raw materials are cheap and can be acquired easily. In 56 clinical scabies cases (24 men and 32 women among whom the oldest is 62 years old and the youngest is 3 years old), the total effective rate is 100%, and the cure rate is 94.6%. In 72 clinical female trichomoniasis cases, the total effective rate is 100%, and the cure rate is 94.6%.

The invention relates to use of a hydrophilic matrix comprising a polyacrylic acid derivative, a cellulose ether and a disintegrant for the manufacture of a medicament for treating female genital disorders. A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5-40%, b) at least one cellulose ether in preferred amounts of 30-90% and c) at least one disintegrant in preferred amounts of 2-50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. The matrix is used in amounts of about 5-60%, preferably 20-40%, and the active principle in amounts of about 2-70%, preferably 5-50%, with respect to the weight of the formulation.

The invention discloses a Chinese herbal medicine compound preparation for controlling dove trichomoniasis and a preparing method thereof. The compound preparation comprises at least one of radix dichroa, fructus cnidii, cortex phellodendri, radix stemonae, pericarpium zanthoxyli, herba schizonepetae, cortex dictamni, herba patriniae, radix astragali, radix glycyrrhizae, polygala tenuifolia, radixsophorae flavescentis, notopterygium root, radix sileris, gallnut, rhizoma atractylodis macrocephalae, Artemisia apiacea, Chinese pulsatilla root, Chinese prickly ash, lumbricus, herba artemisiae scopariae and rhizoma polygonati. The preparing method includes: crushing the raw materials; decocting; performing freeze drying; placing freeze-dried powder into purified water to obtain a traditional Chinese medicine suspension. The Chinese herbal medicine compound preparation is natural, green, free of pollution, capable of guaranteeing animal health, capable of killing and controlling trichomonadand increasing animal immunity at the same time, capable of lowering medicine side effects, capable of lowering mortality and capable of increasing animal productivity. The preparing method is simpleand applicable in process flow, capable of saving energy, environmentally friendly, incapable of generating wastewater, waste gas and waste residues and harmless to environments.

Several parasites responsible for mammalian diseases are dependent on cysteine proteases for various life-cycle functions. Inhibition or decreasing function of specific cysteine proteases can be useful in the treatment and / or prevention of these parasitic diseases including trichomoniasis, histomoniasis, coccidiosis, trypanosomiasis (trypamonosis) and cryptosporidiosis. Compounds of formula I of the invention are capable of treating and / or preventing the above-identified diseases in mammals, e.g. in avian species as Galliformes including chickens, turkeys, ducks, geese, grouse, guinea fowl, peafowl, quail, partridges, and pheasants, Falconiformes, Passiformes, Columbiformes (i.e. Columba livia domestica), Psittaciformes, and in domestic mammals such as cattle, sheep, goats, horses, pigs, camels, lamas, alpacas, cats and dogs.