The invention discloses a drug for vagina contracting and gynecological inflammation and a preparation method of the drug and relates to the technical field of traditional Chinese medicine. The drug comprises, by weight, 8-20 parts of radix angelicae dahuricae, 3-10 parts of flos caryophyll, 8-20 parts of fructus cnidii, 8-20 parts of radix aucklandiae, 15-30 parts of psidium guajava, 10-30 parts of flos chrysanthemi indici, 10-30 parts of herba taraxaci, 12-25 parts of cortex phellodendri and 8-20 parts of radix et rhizoma rhei. The raw materials and the drug are reasonably compatible, which has the functions of antisepsis and anti-inflammation, removing dampness and destroying parasites, tonifying the liver and the kidney and increasing muscle tension and has significant curative effect on vaginitis, cervicitis, vulvar pruritus, burning heat, increased secretion and other gynecological inflammation caused by bacteria, viruses, mold, trichomoniasis and the like, diffuse hyperemia, mucous membrane injury and superficial ulcer caused by viginal inflammation, cervical erosion and cervical erosion can be repaired effectively, dry and astringent symptoms are relieved, regenerating capacity of vaginal mucous membrane cells is improved, and the role of removing the inflammation and contracting the vagina is played; the drug is prepared from natural Chinese herbal medicine, and long-term use without any toxic and side effects, quick effect and good curative effect are achieved.