9 results about "Tinidazole" patented technology

The invention discloses a tinidazole sodium chloride injection difficult to crystallize at low temperature as well as a preparation method and application of the tinidazole sodium chloride injection. Belongs to the technical field of pharmaceutical preparations. The preparation method of the tinidazole sodium chloride injection is adjusted and improved, the tinidazole at a specific nano level is prepared by performing high-pressure homogenization treatment on the tinidazole, and then the tinidazole is dissolved in a specific solvent to prepare a tinidazole solution. The preparation method comprises the following steps: preparing a tinidazole solution, pretreating the tinidazole solution with a polyvinyl alcohol modified solution, and finally mixing the tinidazole solution with a sodium chloride solution to prepare the tinidazole sodium chloride injection, so that the temperature stability of the injection is effectively improved, and the injection is not easy to crystallize at low temperature; according to the invention, the content of tinidazole in the injection is ensured not to be greatly changed, the number of particles is kept at a certain level, the quality of the product is effectively improved, and the safety is improved.

This invention discloses a type of N-doped carbon nanodots and their application in the detection of tinidazole, belonging to the field of analytical detection. The preparation method of the N-doped carbon nanodots in this invention is as follows: L-lysine, ethylenediamine, and water are mixed to form a mixture, which is then heated to react. After the reaction, the N-doped carbon nanodots are purified. This invention is the first to use L-lysine and ethylenediamine as precursors to prepare carbon nanodots and achieve quantitative detection of tinidazole. It is low-cost, highly sensitive, and suitable for rapid on-site detection, possessing high practical value and promising prospects for widespread application.

The application develops an application of an electrochemical sensor in metronidazole antibiotic detection, the electrochemical sensor is that graphene oxide nanosheet is placed in a mixed solution of ultrapure water-ethanol, pH value is adjusted to 1-5, ultrasonic is obtained, and a protonated graphene oxide colloidal solution is obtained; platinum chlorate is put into the protonated graphene oxide colloidal solution, and [PtCl6] 2‑ -GO colloidal is prepared after ultrasonic at 2-5 DEG C; [PtCl6] 2‑ -GO colloidal is dropped on the surface of a pretreated electrode, then the electrode is dried, the electrode is placed in a PBS buffer solution after drying, and the electrochemical sensor is obtained by cyclic voltammetry scanning; the electrochemical sensor has high sensitivity, low detection limit and can selectively recognize metronidazole.

The invention belongs to the technical field of biological medicines, and relates to a compound for enhancing the targeting property of an antitumor drug as well as a preparation method and application of the compound. The invention provides a compound for enhancing the targeting property of an anti-tumor drug. The compound is composed of a carrier, the anti-tumor drug and a targeting drug, the targeted drugs are tinidazole and methimazole; in the compound, the proportion of the targeted drug is not less than 3% based on the carrier dosage; the carrier is albumin; the antitumor drug is fluvastatin. The invention provides an intervention strategy for synchronously targeting lipid raft metabolism and mitochondrial respiration so as to realize effective activation of T cells in a tumor microenvironment. The compound constructed by the invention is based on a dual response targeting mechanism of tinidazole and methimazole to a tumor microenvironment, so that the targeting property of fluvastatin to tumors is improved, and more solutions are provided for the fluvastatin to safely and effectively regulate and control a metabolic pathway of tumor cells.

This invention discloses a compound oral rinse composition and its preparation method, relating to the field of oral rinse technology. The compound oral rinse composition comprises the following components: a complex active ingredient, a mucosal repair agent, an anti-inflammatory synergist, a moisturizer, a solubilizer, a flavoring agent, a pH adjuster, and water, with the sum of all components being 100 wt%. The complex active ingredient is povidone-iodine and tinidazole, and the mucosal repair agent is at least one selected from chitosan, zinc hyaluronic acid, and silk fibroin. This invention enhances therapeutic efficacy through the synergistic effect of the complex active ingredient and the mucosal repair agent, effectively improving the oral environment and achieving anti-inflammatory and mucosal repair effects.

The present application relates to a kind of carbon quantum dots, preparation method, application, the component identification method and concentration detection method of to be measured liquid, comprising: urea and ammonium citrate are dissolved in solvent, then transfer to reaction kettle and carry out heating reaction.The carbon quantum dots provided by the present application not only have lower preparation cost itself, but also the detection method of chlorogenic acid and tinidazole is relatively simple, conducive to the low-cost detection of chlorogenic acid and tinidazole.

Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and / or is suffering with metronidazole-resistant trichomoniasis and / or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.

The invention discloses a compound oral gargle composition and a preparation method thereof, and relates to the technical field of oral gargle. The compound oral gargle composition comprises the following components: a compound active component, a mucous membrane repairing agent, an anti-inflammatory synergist, a humectant, a solubilizer, a flavoring agent, a pH regulator and water, the content sum of the components is 100 wt%, the compound active component is povidone iodine and tinidazole, and the mucous membrane repairing agent is at least one of chitosan, zinc hyaluronate and silk fibroin. Through the synergistic effect of the composite active ingredients and the mucous membrane repairing agent, the curative effect is improved, the oral environment can be effectively improved, and the effects of diminishing inflammation, repairing mucous membranes and the like are achieved.

The present invention relates to the technical field of drug stirring, and discloses a stirring device for the preparation of tinidazole suppositories, which includes a stirring cylinder, a feed pipe and a discharge pipe arranged on the side wall of the stirring cylinder, and a control console arranged on the outer wall of the stirring cylinder. It also includes a stirring unit arranged in the stirring cylinder, and the stirring unit includes a degassing component and a stirring component arranged in the stirring cylinder; the degassing component includes a limiting groove opened on the inner wall of the stirring cylinder, a plurality of connecting rods arranged at the lower end of the limiting plate, and an extrusion disk arranged at the lower ends of the plurality of connecting rods. In this application, by setting an extrusion disk and a gas permeable membrane, the gas is extruded from between the drug molecules by compression, and at the same time flows out of the stirring cylinder through the gas permeable membrane, so as to reduce the bubbles generated during the stirring process. At the same time, by continuously sliding the stirring sliding frame in the vertical direction during the stirring process, the stirring blind area during the stirring process is reduced, and the stirring efficiency and uniform mixing degree of the drug in the stirring cylinder are improved.