The invention relates to a
tinidazole and
sodium chloride injection and a preparation method thereof. The injection is prepared from the following raw materials in percentage by weight / volume: 0.4 percent of
tinidazole, 0.9 percent of
sodium chloride, 0.005 to 0.5 percent of stabilizer, 0.01 to 0.05 percent of
activated carbon, a proper amount of pH value
regulator (the pH value is 3.5 to 5.5), and the balance of water for injection. The preparation method comprises the following steps of: putting the
sodium chloride into a thick
mixing tank, stirring the sodium chloride and water and dissolving to form a solution at the concentration of between 20 and 22 percent (g / ml), adding 50 percent of the
activated carbon, stirring, boiling, cooling, performing pressure
filtration, performing internal circulation for 10 minutes, and transferring into a thin mixing pot; putting the
tinidazole into a container, adding water, stirring and dissolving, and transferring into the thin mixing pot; putting the stabilizer into the thin mixing pot, adding water, adding the residual
activated carbon, adding water until the mixture reaches certain volume, stirring, refluxing for 15 minutes, and regulating the pH value to be 3.5 to 5.5 by using the pH value
regulator; sampling, detecting the sodium chloride and the tinidazole, and cooling to 20 to 40 DEG C after the content of the sodium chloride and the tinidazole is qualified; and sequentially performing four-stage
filtration and filling, sterilizing at the temperature of 121 DEG C, and warehousing after the product is proved to be qualified through light inspection. The problems that a tinidazole and
sodium chloride injection is low in
clarity qualification rate and is easy to crystallize in winter are solved.