Tinidazole compound nano silver microemulsion antibacterial medicine
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An antibacterial drug, tinidazole technology, applied in the field of medicine, can solve the problems of incapable of fully exerting antibacterial effect, low solubility, difficult tinidazole and the like, and achieves the effects of increasing treatment cost, solving easy agglomeration and improving solubility
Inactive Publication Date: 2008-07-30
NORTHWEST A & F UNIV
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However, because tinidazole is insoluble in water and has low solubility, it is difficult to quickly exert its therapeutic effect.
For example, after tinidazole suppositories are disintegrated after being inserted into the reproductive tract, due to its insoluble nature, the drug cannot fully contact with pathogenic bacteria, and cannot fully exert its antibacterial effect, and the drug alone cannot cure endometritis, etc. disease
At the same time, nano-silver is prone to agglomeration, and the biological activity of nano-materials is closely related to the particle size, so its therapeutic effect is weakened to a certain extent.
The above disadvantages limit the clinical application of these two drugs
Method used
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Embodiment 1
[0035] 1) Weigh 24.00g of polyoxyethylene ether (40) hydrogenated castor oil, 2.00g of isopropyl myristate, 1.37g of dimethyl sulfoxide (containing tinidazole), 3.64g of nano-silver sol, and 54.00g of distilled water g, standby;
[0036] 2) Stir and mix polyoxyethylene ether (40) hydrogenated castor oil, isopropyl myristate, dimethyl sulfoxide and nano-silver sol as an oil phase;
[0037] 3) Stir the oil phase rapidly at normal temperature, and at the same time slowly add the water phase dropwise, and keep stirring until the system becomes a transparent liquid, which is the tinidazole composite nano-silver microemulsion antibacterial drug of the present invention.
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Abstract
The invention discloses a tinidazole nano-composite silver micro-emulsified antibiotics, 0.10 to 1.50 units of tinidazole and 0.008 to 0.020 units of nano-silver being regarded as medical components, and 96.92 to 99.67 units of micro-emulsified substrate and 0.30 to 3.00 units of auxiliary materials are evenly mixed together with a certain percentage, then the tinidazole complex nano-silver micro-emulsified antibiotics can be got which has a yellow outlook, the diameter of grains is 1nm to 100nm, the invention is stable, which can not only disturb the synthesis of DNA, but also be able to combine with oxygen metabolic enzyme (-SH) to interrupt the respiration metabolism process, so as to kill the aerobic and anaerobic pathogens and improve the recovery of wounds, and diseases such as vaginitis, endometritis can be quickly and effectively cured, and the preparation method of the invention is simple and safe.
Description
technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of antibacterial drugs, in particular to a tinidazole composite nano-silver microemulsion antibacterial drug. Background technique [0002] Vaginitis and other gynecological diseases have brought a lot of inconvenience to women in work and life, and caused great damage to the body. They are mainly divided into four types: bacterial, fungal, trichomonal, and candidal vaginitis. At the same time, animal endometritis and vaginitis have also brought huge economic losses to the breeding industry. The main pathogenic bacteria include Escherichia coli, Staphylococcus aureus, Streptococcus and other aerobic bacteria, Bacteroides fragilis, and Necroptosis. and other anaerobic bacteria. Endometritis is mostly a mixed infection of bacteria, and it mostly occurs in the secondary infection caused by postpartum and vaginitis, leading to abortion, infertility, infertility, etc. of female...
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