122 results about "Reproductive tract" patented technology

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention relates to the technical field of microorganisms, and provides lactobacillus mucilaginosus for maintaining genital tract health and preventing genital tract infection and application of lactobacillus mucilaginosus. Fermented mucus lactobacillus for maintaining genital tract health and preventing genital tract infection is named as FMTA1113H and is preserved in China General Microbiological Culture Collection Center (CGMCC) on April 22, 2025, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO.34291. The invention further discloses a preparation method of the fermented mucus lactobacillus for maintaining genital tract health and preventing genital tract infection. According to the technical scheme, the problems that female genital tracts are prone to infection and relapse is prone to occurring after infection in the prior art are solved.

The invention provides an ewe estrus stage identification method and system, and relates to the technical field of precise and intelligent breeding, and the method comprises the steps: based on the ewe estrus stage identification method, obtaining genital tract physiological parameters and multi-dimensional motion data of ewes in a target breeding region, processing the genital tract physiological parameters and multi-dimensional motion data, constructing an estrus stage feature matrix, and carrying out estrus stage identification on the ewes in the target breeding region; and constructing a preset ewe estrus stage identification model based on a bionic element network algorithm, inputting the estrus stage feature matrix into the preset ewe estrus stage identification model, performing training, verification and testing, adjusting weight parameters according to a verification result, performing model evaluation according to a test result, and finally obtaining the ewe estrus stage identification model. And continuously acquiring new genital tract physiological parameters and multi-dimensional motion data in real time, constructing a new estrus stage feature matrix, and inputting the new estrus stage feature matrix into the ewe estrus stage identification model to obtain the estrus stage of the ewes in the target breeding area. The estrus stage of the ewe can be identified timely and accurately.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The multi-channel electrochemical micro-fluidic chip detection platform provided by the invention realizes rapid, high-throughput, low-cost, high-sensitivity and specific detection on genital tract pathogens. Specifically, when a target exists, a target recognition probe Cas12a-crRNA compound specifically recognizes a target and forms a Cas12a-crRNA-Target triad, the trans-cleavage activity is activated, an activated Cas12a system cuts a G1 / G2 single-chain region in the signal amplification probe, then encapsulated methylene blue is released, the methylene blue further promotes a methyl bromide redox reaction, signal transduction is promoted, and the target recognition probe Cas12a-crRNA compound can be used for recognizing the target. Therefore, high-sensitivity and high-specificity quantitative detection of pathogens is realized. On the basis, through a multi-channel micro-fluidic chip, high-sensitivity detection of multiple targets can be realized at the same time by placing different crRNA sequences in reaction tanks respectively. In the embodiment of the invention, the multi-target ultra-sensitive detection of CT, CA, TV and NG is successfully realized, and the detection limit is as low as 0.8 fM.

The invention relates to a primer composition for detecting genital tract infection related pathogens and drug-resistant genes thereof and application of the primer composition, and detection targets of the primer composition cover 69 genital tract infection related pathogens including HPV virus, candida disease, trichomoniasis, sexually transmitted diseases and the like. And an antibiotic strong associated drug resistance site for neisseria gonorrhoeae and mycoplasma genitalium. The primers in the primer composition not only can be independently used for PCR amplification, but also can be used for multiple PCR amplification in the same detection system, mutual interference among the primers is little, no obvious non-specific amplification exists, one-tube multiple PCR amplification reaction is efficiently realized under the condition that the number of the primers is up to 150, and the detection efficiency is high. Comprehensive screening of pathogens related to complex genital tract infection and drug resistance detection of neisseria gonorrhoeae and mycoplasma genitalium can be achieved through one-time detection, and the method has the advantages of being good in specificity, high in sensitivity and high in accuracy.

The invention discloses antibacterial gel for female private part nursing and a preparation method of the antibacterial gel, and belongs to the technical field of female nursing gel. The gel provided by the invention has good biocompatibility and biological adhesion, is convenient to form a gel state under the action of body temperature, is tightly adhered to the surface of a mucous membrane to form a protective hydrated film, can physically isolate pathogens, and is used for preventing female genital tract infection and maintaining vagina health. The performance of the chitosan is improved through grafting modification, a plurality of carboxyl, guanidyl and siloxane structural units are introduced to the chitosan at the same time, guanidyl can effectively adsorb and destroy bacteria and fungi usually carrying negative charges, and the water solubility and biocompatibility of molecules are enhanced through the carboxyl and siloxane structure; the siloxane structure can improve the spreadability and adhesion of molecules on the mucous membrane surface and prolong the drug residence time, and the functional monomers are grafted to the chitosan skeleton through amido bonds to ensure the structural stability and function durability of the modified polymer.

Delivery systems for providing occlusive hydrogels in a tube lumen or void space within the body including but not limited to a reproductive tract such as the vas deferens or fallopian tubes for contraception are described. The delivery systems contain mechanisms that confirm proper placement of the system in the bodily lumen prior to the delivery of the occlusive material. The systems also can contain a confirmatory mechanism that demonstrates the blockage or occlusion in the bodily lumen has been achieved following the deposition of the occlusive material. Another aspect of this application is to provide a removal system that delivers dissolving material, agitates, aspirates, and confirms the patency of the bodily lumen following the removal of the occlusive material if so desired by the patient for the return to fertility.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifen, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The invention belongs to the technical field of medicines, and particularly relates to a gynecological postoperative wound nursing dressing and a preparation method thereof. The wound surface nursing dressing after the gynecologic operation is prepared from the following components in percentage by mass: 0.002 to 0.004 percent of stem cell factor freeze-dried powder, 0.005 to 0.01 percent of phosphoethanolamine, 0.05 to 0.1 percent of cecropin antibacterial peptide, 0.03 to 0.08 percent of aralia elata acid, 2 to 6 percent of carboxymethyl chitosan, 0.1 to 0.5 percent of polyethylene glycol, 0.5 to 1.5 percent of glycerol and the balance of water. The wound dressing not only can inhibit the growth of harmful bacteria, but also does not influence the growth of beneficial bacteria such as lactobacillus, is beneficial to the stabilization and regulation of genital tract micro-ecology, creates a healthier and more stable environment for wound healing, plays a role in the wound repairing process, accelerates wound healing and shortens the treatment time.

The invention belongs to the technical field of microorganisms, and particularly relates to combined lactobacillus salivarius and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231719, and the strain has good bacteriostatic ability and dendritic cell (DC) maturation / activation stimulation ability, has no potential safety problem, can regulate vaginal micro-ecological balance, prevent infection caused by exogenous bacteria, effectively improve tumor immunosuppression microenvironment, and has good application prospects. And the method has very important significance on prevention / treatment of vaginal dysbacteriosis patients, gynecological tumors and precancerous lesions thereof.

The invention relates to the technical field of microorganisms, in particular to probiotics for improving female genital tract infection and application. The probiotics provided by the invention comprise at least one of plant lactobacillus plantarum VM-2, lactobacillus gasseri VL-3 and lactobacillus crispatus VX-4. The three strains have the effects of prevention and adjuvant therapy of female genital tract infectious diseases, and have very high probiotic potential. The invention also provides a combined product of the three strains, and growth inhibition experiments among the component strains ensure that the three strains can fully exert probiotic functions.

The present disclosure relates to devices and methods for accessing the reproductive tract of an animal, particularly via the animal's vagina, and deploying reproductive material within the uterus. The device and methods of the disclosure may be particularly suited for embryo transfer processes, such as performed in livestock e.g., cattle.

This invention discloses a primer set, kit, and application for high-throughput sequencing of pathogens of reproductive tract infections. This method utilizes multiplex PCR combined with high-throughput sequencing to identify microorganisms and associated drug-resistance genes within the detection range with high sensitivity. The application of this detection technology to the identification of pathogens of reproductive tract infections has important clinical significance, simplifying the operation steps, reducing testing costs, and improving detection efficiency.

The present invention is an absorbent product that provides both a thermal effect, such as cooling, and absorbency for receiving bodily exudates, such as released from the female urogenital tract, whilst providing the thermal effect, such as cooling, for this region.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.

The invention relates to fermented lactobacillus mucus FMTA1124J with the function of improving the health degree of female genital tracts and application of the fermented lactobacillus mucus FMTA1124J. The classified name of the fermented lactobacillus mucus FMTA1124J is Limosilicilla fermentum, and the preservation number of the fermented lactobacillus mucus FMTA1124J is CGMCC No.34963. The fermented lactobacillus mucus FMTA1124J can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to adjust the environment of the genital tracts and improve the health degree; and the traditional Chinese medicine composition has good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as Escherichia coli, staphylococcus aureus, Gardneria vaginalis and Candida albicans. Therefore, the fermented lactobacillus mucus FMTA1124J strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention discloses a delivery teaching aid for gynaecology and obstetrics, which comprises a lower genital tract model and a form change device, the lower genital tract model comprises a vagina and a cervical canal, the front end of the cervical canal is provided with a cervix vagina part, a vagina dome is connected between the cervix vagina part and the vagina, and the form change device comprises a plurality of support arms, a driving module and an air bag. The supporting arm is of a three-connecting-rod structure and comprises a front rod, a middle rod and a rear rod, the front rod is in pivot connection with the middle rod, the middle rod is in pivot connection with the rear rod, the driving module is connected with the rear end of the rear rod, the inner side of the front rod is connected with the outer wall of the cervical canal in a matched mode, and the air bag is connected between the outer side of the front rod and the inner side of the middle rod. The front ends of the front rods and the front ends of the middle rods are connected with the cervix uteri and vagina portion in a matched mode, first elastic restraining rings are connected between the connecting positions of the front rods and the middle rods, and second elastic restraining rings are connected between the connecting positions of the middle rods and the rear rods. The childbirth teaching aid for the obstetrics and gynecology department can truly simulate the shape change of the cervical canal in the childbirth process and is suitable for finger touch training.

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

The invention relates to a nucleic acid combination product, a kit for detecting genital tract infection pathogens and a detection method. The nucleic acid combination product provided by the invention comprises a composition of a plurality of groups of primer pairs and detection probes, is wide in detection coverage and high in inclusiveness, can simultaneously detect a plurality of genital tract infection pathogens in a single-tube reaction system, and has relatively high sensitivity and specificity; the kit is a genital tract infection pathogen detection product with comprehensive detection targets at present, can quickly and accurately provide a basis for clinical diagnosis, and provides support for prevention, control and treatment of genital tract infection.

The present invention relates to assays for assessing the presence, absence or development of cancer of the female reproductive tract in an individual, in particular endometrial cancer. The cancer is detected based on methylation of regions in GYPC and ZSCAN12. The invention also relates to in vitro methods of assaying DNA and detecting methylation of the DNA therein, including amplificationbased assay and detection methods such as PCR. The invention also relates to kits and systems for performing the assay and detection methods. The invention also relates to methods of treating and / or preventing cancer of the female reproductive tract in an individual, and methods of monitoring the cancer status and / or the risk of cancer development in an individual wherein the cancer is of the female reproductive tract.

This invention discloses an antibacterial gel for feminine hygiene and its preparation method, belonging to the field of feminine hygiene gel technology. The gel provided by this invention has good biocompatibility and bioadhesion, easily forming a gel state under body temperature, tightly adhering to the mucosal surface to form a protective hydration film, physically isolating pathogens, and is used to prevent female reproductive tract infections and maintain vaginal health. This invention improves the performance of chitosan through graft modification, simultaneously introducing multiple carboxyl, guanidine, and siloxane structural units onto chitosan. Guanidine groups can effectively adsorb and destroy bacteria and fungi that are usually negatively charged. Carboxyl and siloxane structures enhance the water solubility and biocompatibility of the molecule, while the siloxane structure improves the spreadability and adhesion of the molecule on the mucosal surface, prolonging drug residence time. By grafting the above functional monomers onto the chitosan backbone through amide bonds, the structural stability and functional durability of the modified polymer are ensured.

An improved long-acting injectable depot suspension formulation of LB displaying progestational effects which overcomes the aggregation and physical instability of LB injectable depot products, and also provides a longer duration of action of at least 4 months. Potential uses of this formulation include but are not limited to contraception and treatment or prevention of progestin / progesterone-sensitive reproductive tract dysfunctions and disorders.

1. The name of the design product: positioning guide. 2. The use of the design product: for female internal genital tract after-loading implantation radiotherapy medical instrument. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

An improved long-acting injectable depot suspension formulation of LB displaying progestational effects which overcomes the aggregation and physical instability of LB injectable depot products, and also provides a longer duration of action of at least 4 months. Potential uses of this formulation include but are not limited to contraception and treatment or prevention of progestin / progesterone-sensitive reproductive tract dysfunctions and disorders.

According to the primer for detecting the drug-resistant genes of the genital tract pathogenic microorganisms and the design method of the primer, the obtained primer group can cover main drug-resistant genes and drug-resistant sites of various main genital tract pathogenic microorganisms, and multi-target rapid detection of the drug-resistant genes and mutation sites is achieved; the optimally designed primer avoids non-specific amplification, improves the detection reliability, and is suitable for various detection platforms such as targeted pathogen sequencing, real-time fluorescent PCR, digital PCR and the like.

The utility model discloses a semen collection device for breeding excellent varieties, which mainly comprises a semen collection tube and is characterized in that a detachable semen collection head is designed at the depth end of the semen collection tube. By means of the design, the semen collection head can be easily taken down from the semen collection pipe and is convenient to clean and replace, and therefore the use efficiency and sanitation of the semen collection device are improved. The top of the semen collection head is provided with a soft cushion which is made of soft materials and can be tightly attached to and adapt to the internal structure of the genital tract of a female donkey or a mare. Due to the design of the built-in semen collector, semen can be collected under the condition that wild animals are not directly contacted, so that the risk to operators and animals is reduced; by using the built-in semen collector, the semen collection process is simplified, so that the semen can be effectively collected even under the condition that wild animals are not easy to domesticate. The wild animals do not need to be directly captured or limited, so that natural behaviors of the animals can be protected and interference to the animals can be reduced by using the built-in semen collection device.

The invention relates to application of orlistat in serving as or preparing a medicine for treating chlamydia infection, and belongs to the technical field of new application of medicines. The invention proposes that orlistat has a good treatment effect on genital tract infection caused by chlamydia trachomatis for the first time. In-vitro experiments and in-vivo experiments show that orlistat has a good effect of treating chlamydia genital tract infection. In addition, through conjoint analysis of transcriptomics and morphological results, key genes are screened out. The invention aims to clarify the effect of orlistat in treatment of genital tract Ct infection, further explore the specific mechanism of orlistat in inhibition of Ct growth and development, reveal the important role of part of chlamydia protein in Ct growth and development, and provide direction and possibility for promoting development of novel anti-Ct drugs.