95 results about "Reproductive tract" patented technology

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention relates to the technical field of microorganisms, and provides lactobacillus mucilaginosus for maintaining genital tract health and preventing genital tract infection and application of lactobacillus mucilaginosus. Fermented mucus lactobacillus for maintaining genital tract health and preventing genital tract infection is named as FMTA1113H and is preserved in China General Microbiological Culture Collection Center (CGMCC) on April 22, 2025, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO.34291. The invention further discloses a preparation method of the fermented mucus lactobacillus for maintaining genital tract health and preventing genital tract infection. According to the technical scheme, the problems that female genital tracts are prone to infection and relapse is prone to occurring after infection in the prior art are solved.

The invention discloses antibacterial gel for female private part nursing and a preparation method of the antibacterial gel, and belongs to the technical field of female nursing gel. The gel provided by the invention has good biocompatibility and biological adhesion, is convenient to form a gel state under the action of body temperature, is tightly adhered to the surface of a mucous membrane to form a protective hydrated film, can physically isolate pathogens, and is used for preventing female genital tract infection and maintaining vagina health. The performance of the chitosan is improved through grafting modification, a plurality of carboxyl, guanidyl and siloxane structural units are introduced to the chitosan at the same time, guanidyl can effectively adsorb and destroy bacteria and fungi usually carrying negative charges, and the water solubility and biocompatibility of molecules are enhanced through the carboxyl and siloxane structure; the siloxane structure can improve the spreadability and adhesion of molecules on the mucous membrane surface and prolong the drug residence time, and the functional monomers are grafted to the chitosan skeleton through amido bonds to ensure the structural stability and function durability of the modified polymer.

The invention belongs to the technical field of medicines, and particularly relates to a gynecological postoperative wound nursing dressing and a preparation method thereof. The wound surface nursing dressing after the gynecologic operation is prepared from the following components in percentage by mass: 0.002 to 0.004 percent of stem cell factor freeze-dried powder, 0.005 to 0.01 percent of phosphoethanolamine, 0.05 to 0.1 percent of cecropin antibacterial peptide, 0.03 to 0.08 percent of aralia elata acid, 2 to 6 percent of carboxymethyl chitosan, 0.1 to 0.5 percent of polyethylene glycol, 0.5 to 1.5 percent of glycerol and the balance of water. The wound dressing not only can inhibit the growth of harmful bacteria, but also does not influence the growth of beneficial bacteria such as lactobacillus, is beneficial to the stabilization and regulation of genital tract micro-ecology, creates a healthier and more stable environment for wound healing, plays a role in the wound repairing process, accelerates wound healing and shortens the treatment time.

The invention belongs to the technical field of microorganisms, and particularly relates to combined lactobacillus salivarius and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231719, and the strain has good bacteriostatic ability and dendritic cell (DC) maturation / activation stimulation ability, has no potential safety problem, can regulate vaginal micro-ecological balance, prevent infection caused by exogenous bacteria, effectively improve tumor immunosuppression microenvironment, and has good application prospects. And the method has very important significance on prevention / treatment of vaginal dysbacteriosis patients, gynecological tumors and precancerous lesions thereof.

The present disclosure relates to devices and methods for accessing the reproductive tract of an animal, particularly via the animal's vagina, and deploying reproductive material within the uterus. The device and methods of the disclosure may be particularly suited for embryo transfer processes, such as performed in livestock e.g., cattle.

This invention discloses a primer set, kit, and application for high-throughput sequencing of pathogens of reproductive tract infections. This method utilizes multiplex PCR combined with high-throughput sequencing to identify microorganisms and associated drug-resistance genes within the detection range with high sensitivity. The application of this detection technology to the identification of pathogens of reproductive tract infections has important clinical significance, simplifying the operation steps, reducing testing costs, and improving detection efficiency.

The present invention is an absorbent product that provides both a thermal effect, such as cooling, and absorbency for receiving bodily exudates, such as released from the female urogenital tract, whilst providing the thermal effect, such as cooling, for this region.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.

The invention relates to fermented lactobacillus mucus FMTA1124J with the function of improving the health degree of female genital tracts and application of the fermented lactobacillus mucus FMTA1124J. The classified name of the fermented lactobacillus mucus FMTA1124J is Limosilicilla fermentum, and the preservation number of the fermented lactobacillus mucus FMTA1124J is CGMCC No.34963. The fermented lactobacillus mucus FMTA1124J can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to adjust the environment of the genital tracts and improve the health degree; and the traditional Chinese medicine composition has good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as Escherichia coli, staphylococcus aureus, Gardneria vaginalis and Candida albicans. Therefore, the fermented lactobacillus mucus FMTA1124J strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

The invention relates to a nucleic acid combination product, a kit for detecting genital tract infection pathogens and a detection method. The nucleic acid combination product provided by the invention comprises a composition of a plurality of groups of primer pairs and detection probes, is wide in detection coverage and high in inclusiveness, can simultaneously detect a plurality of genital tract infection pathogens in a single-tube reaction system, and has relatively high sensitivity and specificity; the kit is a genital tract infection pathogen detection product with comprehensive detection targets at present, can quickly and accurately provide a basis for clinical diagnosis, and provides support for prevention, control and treatment of genital tract infection.

This invention discloses an antibacterial gel for feminine hygiene and its preparation method, belonging to the field of feminine hygiene gel technology. The gel provided by this invention has good biocompatibility and bioadhesion, easily forming a gel state under body temperature, tightly adhering to the mucosal surface to form a protective hydration film, physically isolating pathogens, and is used to prevent female reproductive tract infections and maintain vaginal health. This invention improves the performance of chitosan through graft modification, simultaneously introducing multiple carboxyl, guanidine, and siloxane structural units onto chitosan. Guanidine groups can effectively adsorb and destroy bacteria and fungi that are usually negatively charged. Carboxyl and siloxane structures enhance the water solubility and biocompatibility of the molecule, while the siloxane structure improves the spreadability and adhesion of the molecule on the mucosal surface, prolonging drug residence time. By grafting the above functional monomers onto the chitosan backbone through amide bonds, the structural stability and functional durability of the modified polymer are ensured.

1. The name of the design product: positioning guide. 2. The use of the design product: for female internal genital tract after-loading implantation radiotherapy medical instrument. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

An improved long-acting injectable depot suspension formulation of LB displaying progestational effects which overcomes the aggregation and physical instability of LB injectable depot products, and also provides a longer duration of action of at least 4 months. Potential uses of this formulation include but are not limited to contraception and treatment or prevention of progestin / progesterone-sensitive reproductive tract dysfunctions and disorders.

The utility model discloses a semen collection device for breeding excellent varieties, which mainly comprises a semen collection tube and is characterized in that a detachable semen collection head is designed at the depth end of the semen collection tube. By means of the design, the semen collection head can be easily taken down from the semen collection pipe and is convenient to clean and replace, and therefore the use efficiency and sanitation of the semen collection device are improved. The top of the semen collection head is provided with a soft cushion which is made of soft materials and can be tightly attached to and adapt to the internal structure of the genital tract of a female donkey or a mare. Due to the design of the built-in semen collector, semen can be collected under the condition that wild animals are not directly contacted, so that the risk to operators and animals is reduced; by using the built-in semen collector, the semen collection process is simplified, so that the semen can be effectively collected even under the condition that wild animals are not easy to domesticate. The wild animals do not need to be directly captured or limited, so that natural behaviors of the animals can be protected and interference to the animals can be reduced by using the built-in semen collection device.

The invention relates to application of orlistat in serving as or preparing a medicine for treating chlamydia infection, and belongs to the technical field of new application of medicines. The invention proposes that orlistat has a good treatment effect on genital tract infection caused by chlamydia trachomatis for the first time. In-vitro experiments and in-vivo experiments show that orlistat has a good effect of treating chlamydia genital tract infection. In addition, through conjoint analysis of transcriptomics and morphological results, key genes are screened out. The invention aims to clarify the effect of orlistat in treatment of genital tract Ct infection, further explore the specific mechanism of orlistat in inhibition of Ct growth and development, reveal the important role of part of chlamydia protein in Ct growth and development, and provide direction and possibility for promoting development of novel anti-Ct drugs.

The present invention relates to a method for diagnosing, predicting disease development, disease progression and / or disease outcome, predicting sensitivity to treatment and / or classifying in the context of female genital tract diseases or conditions, in particular endometriosis, in which biomarkers in Table 1, e.g., CCL5 and / or NEAT1, are determined. The invention further relates to a pharmaceutical product for a patient stratified according to the method of the invention and to a composition comprising an agent for detecting a biomarker in Table 1 for diagnosing a female genital tract disease or condition.

The invention belongs to the technical field of compound microorganism compositions, and particularly relates to a female health conditioning composition based on Lactobacillus complex flora and a medicinal fungus extract, the composition comprises compound lactic acid bacteria composed of Lactobacillus crispatus, Lactobacillus jensenii and Lactobacillus reuteri according to a specific ratio, and the compound lactic acid bacteria comprise Lactobacillus crispatus, Lactobacillus jensenii and Lactobacillus reuteri according to a specific ratio. According to the invention, a prebiotic compound formed by galactooligosaccharide, fructo-oligosaccharide and inulin is matched, extracts of lucid ganoderma, hericium erinaceus, poria cocos, cordyceps sinensis and inonotus obliquus are combined, and cranberry extract powder and pineapple powder are supplemented. Lactic acid bacteria form a double-layer microcapsule through electrostatic spraying, the three functional components construct a three-layer composite structure through layered pressing, and finally microcapsule powder is formed. Through targeted regulation of vaginal microecology, inhibition of inflammatory response and repair of mucosal barrier, the composition has the characteristics of stable structure, synergistic components and remarkable conditioning effect, and is suitable for health management of female genital tracts.

This invention provides a kit and detection method for detecting the Siglec fusion mutation gene and the GBS pathogenic gene. It is used for rapid combined detection of the Siglec5 / 14 fusion mutation gene, a preterm birth susceptibility gene, and the GBS pathogenic gene. It can effectively assess the risk of gynecological reproductive tract infections, preterm birth in pregnant women, and infection in newborns. It solves the problem that existing kits only detect the conditionally pathogenic bacteria and have poor specificity for disease association. The detection using this kit is faster and more sensitive. The detection process is closed-loop, avoiding the additional operation of electrophoresis differentiation. It is low-cost and easy to promote.

The utility model discloses an auxiliary tool for female genital tract pathological change gynecological ultrasonic screening, and solid coupling agent is arranged between support body and cladding, provides medium for sound wave conduction, and the support body can effectively push away vaginal wall, reduces the sound wave shielding caused by vaginal natural closure or tissue folding, thereby prevent the false image caused by vaginal wall collapse, and the space after strutting apart makes the probe can pass through ultrasonic wave detection target area, avoids the interference imaging of tissue overlapping, the acoustic impedance of solid coupling agent is close to human tissue, significantly reduces the reflection and attenuation of sound wave in the vagina, improves the signal-to-noise ratio, and makes the ultrasonic imaging clearly show the relationship between pelvic cavity tumor and vaginal surrounding tissue.

The invention discloses a special veterinary B-ultrasonic system for pig follicle AI intelligent detection, and relates to the technical field of veterinary medical instruments. The device comprises a handle seat, the tail end of the handle seat is provided with a connecting wire seat, the front end of the handle seat is provided with an adjustable detection assembly, and the adjustable detection assembly comprises a connector. According to the invention, through a thread transmission mechanism formed by the adjusting screw rod, the threaded pipe and the limiting plate, manual rotation operation is converted into linear telescopic motion of the detection head assembly, and continuous, stable and adjustable working length of the probe is realized. The mechanical structure overcomes the defects that a universal probe in the prior art is generally insufficient in length and cannot adapt to the bending of the genital tract of a pig, so that the probe can be accurately adjusted to the optimal detection depth according to the body type and anatomical structure difference of different pigs and can go deep along a physiological bending track, thereby eliminating a detection blind area and improving the detection accuracy. The follicle image acquisition rate and definition are improved, and the risk of operation injury is reduced.

The invention relates to lactobacillus crispatus and application thereof, and belongs to the technical field of microorganisms. The lactobacillus crispatus Lcris-CD6 disclosed by the invention is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC M 2025370. The lactobacillus crispatus Lcris-CD6 is free of toxic factors and drug-resistant genes, free of hemolysis and good in safety, and has the beneficial effects that the lactobacillus crispatus Lcris-CD6 can produce various organic acids, has tolerance to an acid environment and can adapt to and maintain the acid environment of a female genital tract; the reproduction of pathogenic bacteria is inhibited; the composition has a repairing effect on local tissues of mice with candida albicans vaginitis; the relative abundance of the vagina microbial flora after the mouse is infected by the candida albicans vaginitis is regulated, and the vagina microbial flora environment is recovered; and the diversity and richness of vaginal microbiota are improved.

The invention relates to the technical field of biological detection, and discloses an oligonucleotide composition for detecting pathogens in a female lower genital tract, a kit and application. The oligonucleotide composition disclosed by the invention can be used for rapidly and simultaneously detecting a plurality of pathogens in gardnerella vaginalis, atriurella vaginalis, prevotella vulgaris, campylobacter mobilis, bacteroides, trichomonas vaginalis and mycoplasma in a sample in a high-specificity manner, and has high sensitivity and high stability; and a rapid, non-invasive, accurate and convenient detection method is provided for female reproductive health detection.

The invention relates to the technical field of microorganisms, in particular to lactobacillus mucilaginosus for inhibiting multiple female vaginal pathogenic bacteria and application of the lactobacillus mucilaginosus. According to the present invention, the fermentation lactobacillus mucus VL9 is separated from the female genital tract at the healthy childbearing age, and the preservation number of the fermentation lactobacillus mucus VL9 is CGMCC No.36415; the strain has good human body compatibility and environmental adaptability, can effectively maintain the acidic environment of the vagina, and has an efficient bacteriostatic effect on pathogenic bacteria in a female urogenital system. The in-vitro culture condition of the fermented lactobacillus mucus VL9 is simple, the cost of the culture medium is low, the method is suitable for a conventional production system, and large-scale preparation can be realized on the premise that the cost is not obviously increased.

Disclosed in the present application is the use of a traditional Chinese medicine compound composition in preparing a drug for treating inflammations in the female reproductive tract. The traditional Chinese medicine compound composition comprises 50 parts of phellodendri amurensis cortex, 50 parts of cnidii fructus, 30 parts of sophorae flavescentis radix, 20 parts of catechu, 10 parts of dried alum, and 8 parts of coptidis rhizoma. In the use disclosed in the present application, on the basis of the syndrome differentiation in traditional Chinese medicine, the traditional Chinese medicine compound composition for external use having the effects of clearing heat, drying dampness and removing toxins is formulated. The traditional Chinese medicine compound composition not only possesses an inhibitory effect on various pathogenic microorganisms in the female reproductive tract, but also can keep the activity of probiotics in the female reproductive tract compared with antibiotics, thereby achieving a better therapeutic effect on restoring a healthy microecology of the reproductive tract.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.