49 results about "Reproductive tract" patented technology

The invention belongs to the technical field of microorganisms, and particularly relates to combined lactobacillus salivarius and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231719, and the strain has good bacteriostatic ability and dendritic cell (DC) maturation / activation stimulation ability, has no potential safety problem, can regulate vaginal micro-ecological balance, prevent infection caused by exogenous bacteria, effectively improve tumor immunosuppression microenvironment, and has good application prospects. And the method has very important significance on prevention / treatment of vaginal dysbacteriosis patients, gynecological tumors and precancerous lesions thereof.

The present invention is an absorbent product that provides both a thermal effect, such as cooling, and absorbency for receiving bodily exudates, such as released from the female urogenital tract, whilst providing the thermal effect, such as cooling, for this region.

The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

This invention discloses an antibacterial gel for feminine hygiene and its preparation method, belonging to the field of feminine hygiene gel technology. The gel provided by this invention has good biocompatibility and bioadhesion, easily forming a gel state under body temperature, tightly adhering to the mucosal surface to form a protective hydration film, physically isolating pathogens, and is used to prevent female reproductive tract infections and maintain vaginal health. This invention improves the performance of chitosan through graft modification, simultaneously introducing multiple carboxyl, guanidine, and siloxane structural units onto chitosan. Guanidine groups can effectively adsorb and destroy bacteria and fungi that are usually negatively charged. Carboxyl and siloxane structures enhance the water solubility and biocompatibility of the molecule, while the siloxane structure improves the spreadability and adhesion of the molecule on the mucosal surface, prolonging drug residence time. By grafting the above functional monomers onto the chitosan backbone through amide bonds, the structural stability and functional durability of the modified polymer are ensured.

1. The name of the design product: positioning guide. 2. The use of the design product: for female internal genital tract after-loading implantation radiotherapy medical instrument. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The utility model discloses a semen collection device for breeding excellent varieties, which mainly comprises a semen collection tube and is characterized in that a detachable semen collection head is designed at the depth end of the semen collection tube. By means of the design, the semen collection head can be easily taken down from the semen collection pipe and is convenient to clean and replace, and therefore the use efficiency and sanitation of the semen collection device are improved. The top of the semen collection head is provided with a soft cushion which is made of soft materials and can be tightly attached to and adapt to the internal structure of the genital tract of a female donkey or a mare. Due to the design of the built-in semen collector, semen can be collected under the condition that wild animals are not directly contacted, so that the risk to operators and animals is reduced; by using the built-in semen collector, the semen collection process is simplified, so that the semen can be effectively collected even under the condition that wild animals are not easy to domesticate. The wild animals do not need to be directly captured or limited, so that natural behaviors of the animals can be protected and interference to the animals can be reduced by using the built-in semen collection device.

The invention belongs to the technical field of compound microorganism compositions, and particularly relates to a female health conditioning composition based on Lactobacillus complex flora and a medicinal fungus extract, the composition comprises compound lactic acid bacteria composed of Lactobacillus crispatus, Lactobacillus jensenii and Lactobacillus reuteri according to a specific ratio, and the compound lactic acid bacteria comprise Lactobacillus crispatus, Lactobacillus jensenii and Lactobacillus reuteri according to a specific ratio. According to the invention, a prebiotic compound formed by galactooligosaccharide, fructo-oligosaccharide and inulin is matched, extracts of lucid ganoderma, hericium erinaceus, poria cocos, cordyceps sinensis and inonotus obliquus are combined, and cranberry extract powder and pineapple powder are supplemented. Lactic acid bacteria form a double-layer microcapsule through electrostatic spraying, the three functional components construct a three-layer composite structure through layered pressing, and finally microcapsule powder is formed. Through targeted regulation of vaginal microecology, inhibition of inflammatory response and repair of mucosal barrier, the composition has the characteristics of stable structure, synergistic components and remarkable conditioning effect, and is suitable for health management of female genital tracts.

The utility model discloses an auxiliary tool for female genital tract pathological change gynecological ultrasonic screening, and solid coupling agent is arranged between support body and cladding, provides medium for sound wave conduction, and the support body can effectively push away vaginal wall, reduces the sound wave shielding caused by vaginal natural closure or tissue folding, thereby prevent the false image caused by vaginal wall collapse, and the space after strutting apart makes the probe can pass through ultrasonic wave detection target area, avoids the interference imaging of tissue overlapping, the acoustic impedance of solid coupling agent is close to human tissue, significantly reduces the reflection and attenuation of sound wave in the vagina, improves the signal-to-noise ratio, and makes the ultrasonic imaging clearly show the relationship between pelvic cavity tumor and vaginal surrounding tissue.

The invention discloses a special veterinary B-ultrasonic system for pig follicle AI intelligent detection, and relates to the technical field of veterinary medical instruments. The device comprises a handle seat, the tail end of the handle seat is provided with a connecting wire seat, the front end of the handle seat is provided with an adjustable detection assembly, and the adjustable detection assembly comprises a connector. According to the invention, through a thread transmission mechanism formed by the adjusting screw rod, the threaded pipe and the limiting plate, manual rotation operation is converted into linear telescopic motion of the detection head assembly, and continuous, stable and adjustable working length of the probe is realized. The mechanical structure overcomes the defects that a universal probe in the prior art is generally insufficient in length and cannot adapt to the bending of the genital tract of a pig, so that the probe can be accurately adjusted to the optimal detection depth according to the body type and anatomical structure difference of different pigs and can go deep along a physiological bending track, thereby eliminating a detection blind area and improving the detection accuracy. The follicle image acquisition rate and definition are improved, and the risk of operation injury is reduced.

The invention relates to the technical field of biological detection, and discloses an oligonucleotide composition for detecting pathogens in a female lower genital tract, a kit and application. The oligonucleotide composition disclosed by the invention can be used for rapidly and simultaneously detecting a plurality of pathogens in gardnerella vaginalis, atriurella vaginalis, prevotella vulgaris, campylobacter mobilis, bacteroides, trichomonas vaginalis and mycoplasma in a sample in a high-specificity manner, and has high sensitivity and high stability; and a rapid, non-invasive, accurate and convenient detection method is provided for female reproductive health detection.

The invention relates to the technical field of microorganisms, in particular to lactobacillus mucilaginosus for inhibiting multiple female vaginal pathogenic bacteria and application of the lactobacillus mucilaginosus. According to the present invention, the fermentation lactobacillus mucus VL9 is separated from the female genital tract at the healthy childbearing age, and the preservation number of the fermentation lactobacillus mucus VL9 is CGMCC No.36415; the strain has good human body compatibility and environmental adaptability, can effectively maintain the acidic environment of the vagina, and has an efficient bacteriostatic effect on pathogenic bacteria in a female urogenital system. The in-vitro culture condition of the fermented lactobacillus mucus VL9 is simple, the cost of the culture medium is low, the method is suitable for a conventional production system, and large-scale preparation can be realized on the premise that the cost is not obviously increased.

Disclosed in the present application is the use of a traditional Chinese medicine compound composition in preparing a drug for treating inflammations in the female reproductive tract. The traditional Chinese medicine compound composition comprises 50 parts of phellodendri amurensis cortex, 50 parts of cnidii fructus, 30 parts of sophorae flavescentis radix, 20 parts of catechu, 10 parts of dried alum, and 8 parts of coptidis rhizoma. In the use disclosed in the present application, on the basis of the syndrome differentiation in traditional Chinese medicine, the traditional Chinese medicine compound composition for external use having the effects of clearing heat, drying dampness and removing toxins is formulated. The traditional Chinese medicine compound composition not only possesses an inhibitory effect on various pathogenic microorganisms in the female reproductive tract, but also can keep the activity of probiotics in the female reproductive tract compared with antibiotics, thereby achieving a better therapeutic effect on restoring a healthy microecology of the reproductive tract.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

This invention belongs to the field of biological detection technology, and particularly relates to a reproductive tract HPV-mRNA-E6 / E7 detection system and method based on nanopore sequencing. The system includes a sample pretreatment module, an RNA extraction and purification module, a reverse transcription module, a nanopore sequencing module, and a bioinformatics analysis module. The method includes the following steps: (1) reproductive tract sample collection and pretreatment; (2) extraction and purification of HPV-mRNA in the sample; (3) reverse transcription of the purified HPV-mRNA into cDNA; (4) nanopore sequencing of the cDNA to obtain raw sequencing data; (5) filtering, comparing, and annotating the sequencing data through the bioinformatics analysis module to achieve HPV type identification and quantitative analysis of E6 / E7 gene expression levels. This invention utilizes the advantages of nanopore sequencing, such as long read length and real-time detection, combined with the specificity of E6 / E7 mRNA as a biomarker of active infection. It can directly detect latent and active HPV infection, improve detection sensitivity, accurately distinguish infection types, and shorten the detection cycle. It enables rapid, accurate, and high-throughput detection of active HPV infection in the genital tract, providing reliable technical support for early screening, disease monitoring, and prognostic assessment of HPV-related diseases such as cervical cancer.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The utility model relates to the technical field of reproductive medicine, in particular to an artificial insemination transplantation device for reproductive medicine, which comprises an injector, the injector is slidably connected with a first support cylinder, one end of the first support cylinder is fixedly connected with an expansion component, the injector is communicated with a guide component, and a limiting component is arranged on the surface of the first support cylinder; the expansion assembly comprises a second supporting cylinder and a first rotating cylinder, the first rotating cylinder is provided with a rotating ring, the first rotating cylinder is fixedly connected with a second rotating cylinder, the second supporting cylinder is fixedly connected with a guiding ring, a plurality of guiding grooves are formed in the guiding ring, the second rotating cylinder is rotationally connected with a plurality of expansion pieces, and the bottoms of the expansion pieces are fixedly connected with blocking pieces. The second supporting cylinder is hinged to a plurality of arc-shaped opening pieces. According to the female genital tract dilator, through cooperation of the guide ring, the dilation piece and the arc-shaped dilation piece, the dilation degree of the female genital tract dilator can be adjusted according to the actual situation at different positions in the female genital tract, and therefore a doctor can conveniently conduct artificial insemination operation.

The utility model discloses a puncture needle, relates to the technical field of embryo transplantation, and aims to solve the problem that embryo transplantation cannot be realized when the genital tract of a patient is abnormal by a transplantation tube in the related technology. The puncture needle is used for embryo transplantation and comprises a needle tube, and the needle tube is a rigid tube; the first end face of one end of the needle tube in the length direction is obliquely arranged relative to the axis of the needle tube to form a needle tip, and the needle tip is used for entering a life body; a first included angle between the first end face and the axis of the needle tube is 15-20 degrees.

The invention relates to the technical field of microorganisms, and particularly discloses lactobacillus acidophilus PIS4 capable of improving dysmenorrhea and application of the lactobacillus acidophilus PIS4. The lactobacillus acidophilus PIS4 is separated from genital tracts of healthy women, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.34554, and the preservation date is May 15, 2025. The lactobacillus acidophilus PIS4 is used for preparing the lactobacillus acidophilus PIS4. The lactobacillus acidophilus strain PIS4 provided by the invention is proved to be capable of inhibiting the gene expression of prostaglandin E synthase 2 (pges-2) and reducing the synthesis of prostaglandin E2 and prostaglandin F2alpha, and has effective relieving and improving effects on primary dysmenorrhea.

The present invention relates to a method for diagnosing, predicting, predicting susceptibility to treatment, and / or classifying the onset, progression, and / or outcome of diseases or disorders of the female reproductive tract, particularly in the context of endometriosis, wherein the method determines biomarkers in Table 1, such as CCL5 and / or NEAT1. The present invention further relates to a pharmaceutical product for use in patients stratified according to the method of the present invention, and a composition comprising reagents for detecting biomarkers in Table 1 for the diagnosis of diseases or disorders of the female reproductive tract.

The invention relates to an artificial assistance and cattle mating method. The artificial assistance and cattle mating method comprises the steps that genital tract microenvironment parameters of to-be-mated cattle are monitored in real time, and the microenvironment parameters at least comprise the pH value, the temperature, the oxygen content and the metabolite concentration; collecting multi-dimensional data of the physiological state of the cattle to be hybridized, and preprocessing the multi-dimensional data and the microenvironment parameters through an edge calculation unit; analyzing the embryonic development state based on metabonomics and evaluating the quality; a micro-fluidic technology is combined to realize accurate regulation and control of a microenvironment; a hierarchical time memory network model and a Bayesian network are applied to construct an early pregnancy state prediction model, and high-precision pregnancy result prediction within 7-10 days after hybridization is achieved; according to the artificial assistance and cattle mating method, through multi-dimensional monitoring and accurate regulation and control, the pregnancy success rate is remarkably increased, and the breeding management cost is reduced.

The invention relates to lactobacillus gasseri and application thereof, and belongs to the technical field of microorganisms. The lactobacillus gasseri GY40-1 is preserved in the China Center for Type Culture Collection, and the preservation number of the lactobacillus gasseri GY40-1 is CCTCC (China Center for Type Culture Collection) NO: M2025371. The lactobacillus gasseri GY40-1 disclosed by the invention is free of toxic factors, free of hemolysis and good in safety, and has the beneficial effects that the lactobacillus gasseri GY40-1 can produce various organic acids, has tolerance to an acid environment and adapts to and maintains the acid environment of a female genital tract; the bacterium has effective bacteriostatic ability to escherichia coli, staphylococcus aureus, candida albicans and the like, and can improve vagina inflammation; the traditional Chinese medicine composition has an immune regulation function, can improve the expression level of an anti-inflammatory factor IL-10, reduces the expression level of a proinflammatory factor IL-1beta, enhances treatment of mouse vaginitis, and can repair local tissues of the mouse with candida albicans vaginitis and recover the vagina microbial flora environment.

This invention discloses a strain of *Lactobacillus crispatus* push, classified as *Lactobacillus crispatus* push, deposited at the China General Microbiological Culture Collection Center (CGMCC) with accession number CGMCC No. 35610, on August 13, 2025. The culture conditions were: 37°C, anaerobic, and 48 hours. This *Lactobacillus crispatus* strain exhibits significant advantages in inhibiting the growth of HPV-infected cervical epithelial cells and shows great potential in the treatment of HPV infection in the female lower genital tract.

The application discloses a lactobacillus gasseri for efficiently producing indole-3-lactic acid from tryptophan and application thereof, and has the characteristics that the strain is named as lactobacillus gasseri, the preservation number is CGMCC No.37546, the strain metabolically produces indole-3-lactic acid after anaerobic fermentation in a culture medium containing tryptophan, and the application of the lactobacillus gasseri in preparing products for relieving constipation, regulating emotional state and improving the microecological balance of female reproductive tract is provided, and the application of the strain in preparing pathogenic bacteria inhibitors and antioxidants is further provided. Lactobacillus gasseri The strain can efficiently produce indole-3-lactic acid from tryptophan, has inhibiting effects on escherichia coli, staphylococcus aureus and gardnerella vaginalis, can eliminate superoxide anions, DPPH free radicals and ABTS free radicals, and has good antioxidant performance.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus crispatus and application thereof in female genital tract health. The preservation number of the strain is CCTCC NO: M20231720, and the strain is excellent in antibacterial ability and vaginal mucosa adhesion ability, can effectively generate hydrogen peroxide, has no potential safety problem, and plays an important role in regulating genital tract micro-ecological balance and preventing and treating exogenous pathogenic bacterium infection.

The application discloses a kind of underwater beluga model semen collection devices, including female beluga model and semen collector;The abdominal genital split area of female beluga model is provided with the false vagina being communicated with outside;Semen collector is placed in female beluga model removably, temperature control module is arranged in the semen collector, the semen collector is provided with at least the collection bin of preventing semen leakage backflow and the waterproof conduit that can insulate water body, the collection bin is removably connected with waterproof sleeve pipe, and the waterproof conduit is communicated with false vagina.This application sets up the inner wall of silica gel and temperature control system, can simulate female Yangtze River beluga genital tract from touch comfortable degree and temperature environment, promote the ejaculation behavior of male genital organ, improve underwater semen collection rate;Setting waterproof cover film, silica gel cover and elastic band, guarantee the sealing property of semen collector whole, will not occur water body immersion when being put into water, pollute the internal environment of device, realize the underwater semen collection of device.

1. Name of the product in this design: Obstetric and Gynecological Drug Delivery Device (Obstetric and Gynecological Nursing). 2. Purpose of this design: This design is used to precisely deliver medication to specific parts of the female reproductive tract (such as the vagina, cervix, etc.) during obstetric and gynecological care. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifen, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

This invention discloses a rapid multiplex nucleic acid detection method and application for reproductive tract pathogens based on RPA-CRISPR / Cas12a technology, belonging to the field of biodetection technology. The method uses HPV, UU, CT, and MG as detection targets. It designs and screens corresponding RPA primers and crRNAs targeting the specific target genes of each pathogen, optimizing the optimal primer pairs such as HPV-F2 / R2 and the optimal crRNAs such as HPV-crRNA2. Furthermore, it optimizes the CRISPR / Cas12a reaction system with a Cas12a to crRNA molar ratio of 0.9:1 and a final concentration of 500 nM for the fluorescent ssDNA reporter molecule. This integrates RPA isothermal amplification with CRISPR / Cas12a targeted detection, constructing a closed two-stage reaction system to achieve single-tube multiplex detection. This method can complete the test within 45 minutes. The detection limit for HPV / CT / MG is 10 copies / µL, and for UU it is 10² copies / µL. It has no specific cross-reactivity, and the clinical validation shows up to 100% consistency with qPCR. It does not require sophisticated instruments, and the endpoint detection method can be adapted to rapid on-site testing and can also be extended to other nucleic acid testing scenarios.