The invention relates to a composition for dispelling alcohol effect and protecting liver. The composition is prepared from the following raw materials: flos pueraria, centella asiatica, radix paeoniae alba, dendrobium nobile, poria cocos, pawpaw, dandelion, sea-buckthorn, Chinese magnoliavine, clove, dolichos lablab L., scaphium wallichii, radix glycyrrhizae, fructus aurantii immaturus, pinellia ternate, ligustrum lucidum, gynostemma pentaphylla, turmeric, nepeta cataria, bamboo leaves, cassia twig, fructus lycii and polygala tenuifolia. The above medicinal materials cooperate with each other and complement each other, the composition is capable of accelerating metabolism of alcohol in human body, increasing alcohol draining and enhancing alcohol endurance capacity of human body, and the composition is capable of improving and treating headache, dizziness, nausea and other discomfort symptoms caused by drunkenness after being eaten by a drunk person, and gives play to alcohol effect dispelling effect. The composition is substantial and reliable in treatment effect and wide in application prospect.