42 results about "Irritable bowel" patented technology

The invention relates to the technical field of microorganisms, and discloses bifidobacterium adolescentis and an application thereof. The collection number of the bifidobacterium adolescentis CCFM8630 is CGMCC No.14395. The bifidobacterium adolescentis CCFM8630 has the advantages that the level of neurotransmitter 5-hydroxytryptamine in peripheral blood of rats can be remarkably upgraded by the bifidobacterium adolescentis CCFM8630; the increased level of hormones such as testosterone in the peripheral blood of the rats due to high-glucose and high-fat diet and anomaly of abundance of Blautiaand Turicibacter in intestinal floras of the rats can be recovered; simulated gastrointestinal fluid can be tolerated, the bifidobacterium adolescentis can be quickly colonized in intestinal tracts,accordingly, rat livers with metabolic syndromes, pathological injury of duodenums and increase of the contents of triglyceride and total cholesterol in serum due to the high-glucose and high-fat dietand oral glucose tolerance can be remarkably improved, and the bifidobacterium adolescentis can be used for preventing, relieving or treating metabolic disorder such as the metabolic syndromes, irritable bowel syndromes and psychological illnesses such as anxiety and depression which are related to the metabolic syndromes.

The invention belongs to the field of biological agents and discloses triple probiotics viable bacteria powder obtained by whole oat mixed solid-state fermentation utilizing various probiotics direct-adding reagents. The triple probiotics viable bacteria powder contains bifidobacterium lactis V9, lactobacillus plantarum P-8 and lactobacillus casei Zhang, and is prepared by taking whole oat powder as a fermentation substrate, and has excellent gastrointestinal tract digestive juice endurance capacity, is capable of improving a bacterial community structure of human intestinal tracts, capable of regulating blood lipid metabolism and capable of improving pathogenic infection resistance of intestinal tracts, and effectively prevents and relieves irritable bowel syndromes such as diarrhea, constipation, stomachache, abdominal distension.

A method of treating a disorder by nasally administering methylcobalamin, with or without folinic acid. The disorders addressed are: a) attention deficit hyperactivity disorder (ADHD); b) anxiety, depression, stress and chronic stress; c) socialization problems, mood problems, behavior problems, memory problems; d) dislexia, depth perception problems, color viewing problems, visual and auditory processing problems, light modulation problems, night vision problems; e) speech problems such as finding words, apraxia, and articulation problems, sleep regulation problems, eye or muscle movement problems; and f) chronic fatigue problems, digestion problems, sensitivity to chemicals, viral infection, inflammatory conditions such as rheumatoid arthritis, sciatica, and fibromyalgia, asthma, irritable bowel, colitis, tinnitus, migraines, nail biting, autoimmune problems. In some embodiments, the disorders that are particularly addressed are ADHD, anxiety, stress and chronic stress, and irritable bowel.

A method of treating a disorder by lollipop administering methylcobalamin, with or without folinic acid by direct delivery to the trigeminal nerve. The disorders addressed are: a) attention deficit hyperactivity disorder (ADHD); b) anxiety, depression, stress and chronic stress; c) socialization problems, mood problems, behavior problems, memory problems; d) dyslexia, depth perception problems, color viewing problems, visual and auditory processing problems, light modulation problems, night vision problems; e) speech problems such as finding words, apraxia, and articulation problems, sleep regulation problems, eye or muscle movement problems; and f) chronic fatigue problems, digestion problems, sensitivity to chemicals, viral infection, inflammatory conditions such as rheumatoid arthritis, sciatica, and fibromyalgia, asthma, irritable bowel, colitis, tinnitus, migraines, nail biting, autoimmune problems. In some embodiments, the disorders that are particularly addressed are ADHD, anxiety, stress and chronic stress, and irritable bowel. A lollipop for treating a psychological or neuro-physiological disorder and method of making thereof.

The invention discloses an intestine-moistening and bowel-relaxing composition. The intestine-moistening and bowel-relaxing composition comprises a probiotic compound and a prebiotic compound, whereinthe probiotic compound comprises the following components in parts by weight: 1-5 parts of lactobacillus acidophilus, 0.5-2 parts of bifidobacterium lactis, 0.5-4 parts of pediococcus acidilactici, 0.5-4 parts of bifidobacterium longum and 0.5-2 parts of lactobacillus plantarum; and the prebiotic compound comprises the following components in parts by weight: 3 to 40 parts of fructo-oligosaccharide, 2 to 30 parts of galacto-oligosaccharide, 0 to 30 parts of resistant dextrin, 0 to 20 parts of xylooligosaccharide, 0 to 30 parts of isomalto-oligosaccharide, 1 to 15 parts of inulin and 1 to 8 parts of stachyose. The invention also discloses an application of the composition and an intestine-moistening and bowel-relaxing solid beverage containing the composition. According to the composition,probiotics and prebiotics are combined, so that adhesion of pathogenic bacteria can be relieved, intestinal flora can be adjusted, and the incidence rate of irritable bowel comprehensive symptoms canbe remarkably reduced; and crowd food tasting experiments show that the composition has the effects of promoting defecation and relieving abdominal pain, abdominal distension and diarrhea symptoms.

The invention provides a plaster for treating deficiency-cold irritable bowel syndrome type diarrhea. By the plaster, the treatment problems of diarrhea and abdominal distension recurrence both caused by diarrhea type irritable bowel syndromes can be solved effectively. The plaster comprises traditional Chinese medicine including cloves, fructus evodiae, peppers and white vinegar. The plaster is attached to Shenque acupoint during treatment, drugs stimulate channel qi through the acupoint, channels are dredged, qi-blood circulation is promoted, the drugs can reach focuses directly through channel circulation, and absorptivity is improved; yin and yang of human bodies and viscera functions are regulated, and accordingly, the objective of treating diseases is achieved. The plaster has the advantages of low cost, convenience, practicability, rapidness in diarrhea stopping, convenience in use and simplicity in operation; curative effect of the plaster is obvious, and the total effective rate is 100%.

The invention discloses a traditional Chinese medicine composition for treating diarrhea-type irritable bowel syndrome. The traditional Chinese medicine composition comprises the following components,by weight: 15 to 25 parts of radix pseudostellariae, 5 to 15 parts of rhizoma atractylodis macrocephalae, 15 to 25 parts of poria cocos, 3 to 10 parts of honey-fried licorice root, 5 to 15 parts of the root of fangfeng, 10 to 20 parts of white paeony root, 3 to 10 parts of steamed dried tangerine or orange peel, 3 to 10 parts of the rhizome slices of Chinese goldthread and 5 to 15 parts of commonaucklandia root. The traditional Chinese medicine composition is proved to have an obvious analgesic effect on physical pain and chemical pain and can play an antidiarrheal role in inhibiting intestinal motility; the intestinal hypersensitivity state can be improved obviously; the moisture content of excrement can be reduced; the mucous membrane barrier function can be enhanced; and the intestinal flora can be improved. The traditional Chinese medicine formula which is safe, effective, free of drug dependence, mild and easy to take can be provided for diarrhea-type irritable bowel patients; and the traditional Chinese medicine formula has important medical values for improving the clinical cure rate of IBS-D, relieving clinical symptoms and standardizing and managing diseases.

Disclosed are exendin-3 or exendin-4 derivatives modified with biotin, a preparation method thereof and a pharmaceutical composition containing the same. More specifically, disclosed are exendin-3 or exendin-4 derivatives in which the lysine residue of exedin is modified with biotin. The disclosed exendin-3 or exendin-4 derivatives modified with biotin show biological activity similar to that of native exendin and at the same time, have increased in vivo stability and are easily absorbed through the mucosa. Thus, biotin-modified exendin-3 or exendin-4 derivatives are useful for treating diseases, which can be caused by the excessive secretion of insulin, the lowering of plasma glucose, the inhibition of gastric or intestinal motility, the inhibition of gastric or intestinal emptying or the inhibition of food intake. Particularly, the biotin-modified exendin-3 or exendin-4 derivatives are useful for the treatment of diabetes, obesity and irritable bowel syndromes.

The invention discloses a pharmaceutical composition, which is prepared from the effective parts of kudzu vine root, baical skullcap root and coptis root. In the pharmaceutical composition, in terms of weight ratio, the isoflavone of the kudzu vice root accounts for 10 to 70%, the total flavonoids of the baical skullcap root accounts for 5 to 60%, and the total alkaloids of the coptis root accounts for 5 to 70%, preferably, the kudzu vine root accounts for 40%, the baical skullcap root accounts for 20% and the coptis root accounts for 40%. The composition is mainly used for the treatment of diabetes and complications thereof, and the treatment of irritable bowel syndromes.

The invention provides a rhizoma nardostachyos birthwort alkane sesquiterpene compound and a preparation method and application thereof. The rhizoma nardostachyos birthwort alkane sesquiterpene compound is obtained through separation and purification from rhizomes of a nardostachys chinensis batal plant of rhizoma nardostachyos, and the compound has 5-serotonin transporter (S-ERT) to enhance activity, belongs to rare SERT activity promoters, can be used for preparing drugs for treating depression, anxiety disorder, schizophrenia, obsessive-compulsive disorder, the neurodegenerative disease, drug addiction and other neuropsychological diseases, and drugs for treating slow transit constipation, irritable bowel syndromes, functional bloating and other dysfunction diseases of the digestive system, and has important medicine development value.

The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I).Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and / or exacerbated respiratory disorders and urological disorders.

The invention discloses a traditional Chinese medicine capsule for treating irritable bowel syndromes. The traditional Chinese medicine capsule comprises components: by weight, 20-45 parts of radix bupleuri, 20-45 parts of radix scutellariae, 20-45 parts of pericarpium citri reticulatae, 20-45 parts of plum carbon, 20-30 parts of roasted rhizoma atractylodis macrocephalae, 20-30 parts of radix paeoniae alba, 20-30 parts of Chinese yam, 20-30 parts of angelica sinensis, 15-30 parts of tuber fleeceflower stems, 15-30 parts of lilium brownie, 15-30 parts of fried white hyacinth beans, 10-15 parts of platycodon grandiflorum, 10-15 parts of fructus amomi, 10-15 parts of costustoot, 10-15 parts of rhizoma cimicifugae, 10-20 parts of haws, 10-15 parts of plantain seeds, 20-30 parts of sugared ginseng, 2-4 parts of lungwortlike lobaria herbs and 10-20 parts of divaricate saposhnikovia roots. The components are prepared into the orally-taken capsule. The components of the traditional Chinese medicine capsule bring synergistic effect into play to enable the traditional Chinese medicine capsule to have effects of soothing liver, dispelling melancholy, strengthening the spleen and stomach, activating qi and relieving pain. In addition, the traditional Chinese medicine capsule has good effects of easing intestinal spasm and correcting intestinal disorders and is low in cost of raw materials, good in curative effect and free of toxic and side effects.

The invention discloses an intelligent regulation system for intestinal peristalsis. The intelligent regulation system comprises an implanted functional part and an external functional part, wherein the implanted functional part comprises an intestinal peristalsis detection module, a neural connector, an implanted function control module and an internal power supply module. The external functionalpart comprises a heart rate detection module, a display module, an external function control module and an external power supply module. The provided intelligent regulation system for intestinal peristalsis is ingenious and reasonable in structural design, can monitor and control the rhythm of intestinal peristalsis in real time, plays good treatment roles in functional dyspepsia and irritable bowel syndromes caused by gastrointestinal movement dysfunction, greatly improves the clinical tretament effects on the gastrointestinal movement dysfunction, relieves pain of patients, avoids toxic andside effects and liver and kidney function impairment caused by long-term drug therapy, and reduces medical costs of patients suffering from gastrointestinal movement dysfunction and the society. Besides, the intelligent regulation system is simple and compact in overall structure, easy to implement, lower in cost and convenient to widely promote and apply.

The invention provides application of polaprezinc in preparation of a medicine for treating or alleviating alimentary tract complications and irritable bowel syndromes caused by chemoradiotherapy. By the aid of the polaprezincr, rising of emesis-related neurotransmitters incluiding 5-hydroxy tryptamine and NF-kB in blood and brain tissues, which is caused by the chemoradiotherapy, can be lowered, stimulations and hurts to the alimentary tract from the chemoradiotherapy can be reduced, and related symptoms of 5-hydroxy tryptamine related irritable bowel syndromes can be alleviated; proved by clinical tests, the polaprezincr is capable of alleviating symptoms of emesis and alimentary injuries of a patient effectively and is remarkably effective in treatment of 5-hydroxy tryptamine related irritable bowel syndromes.

The invention discloses a traditional Chinese medicine for treating irritable bowel syndromes and relates to a traditional Chinese medicine. The traditional Chinese medicine for treating the irritable bowel syndromes is characterized by being prepared from the following Chinese herbal medicines in parts by weight: 30-90 parts of roots of glutinous rice, 4.5-15 parts of lotus seed meat, 1.5-60 parts of furnace soil, 1.5-30 parts of rungia pectinata herb, 1.5-6 parts of dried ginger and 1.5-9 parts of liquorice roots. The traditional Chinese medicine has the actions of regulating gastrointestinal motility function and internal consumption feeling, correcting abnormity of the internal consumption feeling and resisting depression and anxiety, has the efficacy of nourishing heart, tranquilizing mind, harmonizing liver and spleen, reinforcing the earth to reduce the water, warming middle and harmonizing stomach and can effectively treat the irritable bowel syndromes in various types.

The invention relates to a traditional Chinese medicine for treating diarrhea-predominant pattern irritable bowel syndromes, and is used for effectively solving the medication problems of treatment of the diarrhea-predominant pattern irritable bowel syndromes. According to the technical scheme, the traditional Chinese medicine comprises the following components in parts by weight: 1-10 parts of cutch, 1-12 parts of rhizoma corydalis, 0.5-6 parts of rheum officinale charcoal, 1-12 parts of pomegranate bark and 1-10 parts of blast-fried ginger. The preparation method comprises the following steps: mixing the cutch, rhizoma corydalis, rheum officinale charcoal, pomegranate bark and blast-fried ginger, grinding into fine powder which can pass through a 100mesh sieve, disinfecting, and filling capsules with the powder. The traditional Chinese medicine disclosed by the invention is scientific and reasonable in composition, rich in raw materials and easy to produce, has the effects of warming middle-Jiao and removing stagnation, promoting blood circulation to arrest pain and relieving diarrhea with astringents, is effectively used for treating the diarrhea-predominant pattern irritable bowel syndromes, is convenient to take and good in effect and has actual clinical application values.

The invention discloses a periostracum cicadae acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome. A preparation method of the periostracum cicadae acetyldopamine polymer composition comprises the following steps that periostracum cicadae medicinal materials are taken firstly, crushed and then subjected to reflux extraction through ethanol, filtering isconducted, filtrate is merged, ethanol extraction liquid is recovered, vacuum concentration is conducted, and thus periostracum cicadae extractum is obtained; the periostracum cicadae extractum is puton a D101 type macroporous resin column, flushing is conducted through distilled water firstly, then ethanol with the volume concentration being 25%, ethanol with the volume concentration being 50%,and ethanol with the volume concentration being 95% are sequentially used for elution, the part eluted through the ethanol with the volume concentration being 95% is collected, vacuum concentration isconducted, and thus the periostracum cicadae acetyldopamine polymer composition is obtained. Through a large number of experiment screening, it is found that the periostracum cicadae acetyldopamine composition can decrease the plasma SP level and the plasma CGRP level of an irritable bowel syndrome model mouse, decrease the content of colon VIP and colon 5-HT, can improve irritable bowel syndromevisceral hypersensitivity at multiple levels and multiple links, and has a great effect of treating the irritable bowel syndrome.

The present invention relates to a composition useful for preventing or treating irritable bowel syndrome, and to a method for treating or preventing irritable bowel syndrome. The present invention uses an Atractylodes japonica rhizome extract, preferably an Atractylodes japonica rhizome extract using an aqueous ethanol solution, and more preferably an Atractylodes japonica rhizome extract using an aqueous ethanol solution of 35 to 65 v / v%, as an active ingredient to treat or prevent irritable bowel syndrome. The atractylodes japonica extract exhibits superior effects of inhibiting bowel irritation and enhancement for dyschezia caused by stresses or irritable bowel.

The invention provides a biological agent for repairing irritable bowel mucosa damage and a preparation method thereof. The method comprises the steps that brewer's yeast, lactobacillus acidophilus and lactobacillus plantarum are mixed to obtain mixed bacteria; the mixed bacteria are added to a brown sugar water culture medium, airtight culture is carried out till the pH is smaller than 4.00, then culture continues to be carried out for 20-30 days, and compound bacteria are obtained; kudzu vine roots, sea-buckthorns, grape seeds, brown sugar and water are mixed to obtain a compound medium; the compound bacteria are added to the compound medium, airtight culture is carried out for 30-45 days, and a compound fermentation product is obtained; then soaking, elution, concentrating, sterilizing and forming are carried out, and the biological agent is obtained. The effective ingredients of plants are converted through the microorganism compound fermentation technology, and therefore the product has the advantages of being easier to absorb and utilize, remarkable in treatment effect and the like, especially free radicals can be scavenged, intestinal flora balance can be adjusted, repairing of the irritable bowel mucosa damage is promoted, and the biological agent for repairing the irritable bowel mucosa damage is natural.

Disclosed herein are compositions comprising clostridium consortia, and methods of treating obesity, metabolic syndrome, irritable bowel disease, and reducing weight gain and inhibiting lipid absorption in the small intestine by administering the compositions to a subject.

A method for therapy of diarrhea-predominant irritable bowel disorders comprising as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic group or a pharmaceutically acceptable acid addition salt thereof is disclosed. The method for therapy of diarrhea-predominant irritable bowel disorders comprises as an effective ingredient a morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, having a specific structure, such as N-(17-cyclopeopylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-3,4,5,6-tetrahydrophthalimide tartaric acid salt (Compound 10).

The invention discloses an oral Chinese medicinal composition for treating irritable bowel syndrome, which consists of the following components in parts by weight: Bupleurum bupleurum 20-45, Scutellaria baicalensis 20-45, Chenpi 20-45, Gallic charcoal 20-45, Radix Glycyrrhizae 20-30, Paeoniae Alba 20-30, Atractylodes Rhizoma 20-30, Angelica 20-30, Teng Yejiao 15-30, Lily 15-30, Black Plum Charcoal 15-30, Cyperus 10- 15. Fangfeng 10-15, Woody Fragrance 10-15, Cimicifuga 10-15. Made into an oral dosage form, orally. The traditional Chinese medicine composition of the present invention is combined with various medicines to exert a synergistic effect, soothe the liver and relieve stagnation, invigorate the spleen and harmonize the stomach, promote qi and relieve pain, have good effects on relieving intestinal spasms and correcting intestinal disorders, and the cost of raw materials is low , good curative effect, no toxic side effects.

The invention provides a kind of Keshuan Yishou medicinal wine, which is collected respectively from S. After screening, cleaning, processing, and crushing, 10-15 grams of live Shouwu, 28-5 grams of cypress fruit, 35-48 grams of saffron, 12-17 grams of canna root, 15-18 grams of chuanyunshi gram, 10-12 grams of Guangqian money, 20-30 grams of Salvia miltiorrhiza, 8-10 grams of Evergreen root, 20-28 grams of poppy shell, 15-20 grams of Shichangpu, 10-15 grams of lotus root, 10-18 grams of Panax notoginseng, 6-10 grams of Jiegu Dan and 15-20 grams of honey were soaked in 400-500 ml of liquor solution of 50-53 degrees, soaked at room temperature of 25-30 ℃ for 28-35 days, taken out, filtered to remove residue, and prepared by sterilization made. It can remove wind and dehumidify, regulate qi and blood, dissolve thrombosis and reduce lipids, invigorate the stomach, enhance sleep, resist disease and strengthen the body, delay aging, and has no toxic side effects and is not easy to rebound. Not only has a significant effect on cerebral embolism, cerebral thrombosis, hyperlipidemia hypertension, but also has a significant effect on rheumatic diseases, women's irregular menstruation and alcohol allergic enteritis.

The invention discloses a method for evaluating the curative effect of a compound glutamine formula on diarrhea-predominant irritable bowel syndromes. The method mainly comprises the following steps:I, establishing a diarrhea-predominant irritable bowel syndrome animal model; II, performing medicine application; III, performing index detection and scoring (including general clinical observation,excrement and urine detection, intestinal motility influence observation, visceral sensitivity evaluation and colon tissue pathological examination); and IV, performing counting and evaluation. With the adoption of the scheme, the compound glutamine formula with different dosage forms and different use doses can be accurately evaluated in the aspect of treating diarrhea-predominant irritable bowelsyndromes; and preposed basis and valuable guidance are provided for subsequent continuous optimization of dosage form rationality and dosage use of the compound glutamine formula, and further betterin-depth clinical treatment and research of the diarrhea-predominant irritable bowel syndromes and continuous clarification of IBS curative effects.

The invention discloses a traditional Chinese medicine capsule for treating irritable bowel syndromes. The traditional Chinese medicine capsule comprises components: by weight, 20-45 parts of radix bupleuri, 20-45 parts of radix scutellariae, 20-45 parts of pericarpium citri reticulatae, 20-45 parts of plum carbon, 20-30 parts of roasted rhizoma atractylodis macrocephalae, 20-30 parts of radix paeoniae alba, 20-30 parts of Chinese yam, 20-30 parts of angelica sinensis, 15-30 parts of tuber fleeceflower stems, 15-30 parts of lilium brownie, 15-30 parts of fried white hyacinth beans, 10-15 parts of platycodon grandiflorum, 10-15 parts of fructus amomi, 10-15 parts of costustoot, 10-15 parts of rhizoma cimicifugae, 10-20 parts of haws, 10-15 parts of plantain seeds, 20-30 parts of sugared ginseng, 2-4 parts of lungwortlike lobaria herbs and 10-20 parts of divaricate saposhnikovia roots. The components are prepared into the orally-taken capsule. The components of the traditional Chinese medicine capsule bring synergistic effect into play to enable the traditional Chinese medicine capsule to have effects of soothing liver, dispelling melancholy, strengthening the spleen and stomach, activating qi and relieving pain. In addition, the traditional Chinese medicine capsule has good effects of easing intestinal spasm and correcting intestinal disorders and is low in cost of raw materials, good in curative effect and free of toxic and side effects.