Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases

A composition and technology of Clostridia, applied in the direction of microorganism-based methods, biochemical equipment and methods, metabolic diseases, etc., can solve problems such as unknown organisms, affecting host metabolism and obesity

Pending Publication Date: 2022-03-29
UNIV OF UTAH RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Microbiota influences host metabolism and obesity, but organisms that protect against disease remain unknown

Method used

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  • Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases
  • Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases
  • Clostridium consortium compositions and methods of treating obesity, metabolic syndrome and irritable bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Example 1: T cell-mediated modulation of the microbiota to prevent obesity

[0147] Abstract: The microbiota influences host metabolism and obesity, but the organisms that protect against disease remain unknown. Microbiota-driven age-related development of metabolic syndrome has been observed in studies interrogating immune pathways that regulate microbiota composition. In this model, expansion of Desulfovibrio and loss of Clostridia are important features associated with obesity, and replacement of Clostridia rescues obesity. T cell-dependent events are required to prevent the loss of Clostridia and the expansion of Desulfovibrio. Inappropriate Clostridia IgA targeting and increased Desulfovibrio species antagonize beneficial Clostridia colonization. Transcriptional and metabolic profiling reveals enhanced lipid uptake in obese hosts. Clostridia but not Desulfovibrio colonization of germ-free animals downregulates the expression of genes that control lipid uptake an...

Embodiment 2

[0201] Example 2: Four Clostridium strains rescue obesity, insulin resistance and inflammatory bowel disease

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Abstract

Disclosed herein are compositions comprising clostridium consortia, and methods of treating obesity, metabolic syndrome, irritable bowel disease, and reducing weight gain and inhibiting lipid absorption in the small intestine by administering the compositions to a subject.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of the filing date of U.S. Provisional Application No. 62 / 875,194, filed July 17, 2019. The content of this prior filed application is hereby incorporated by reference in its entirety. [0003] References to Sequence Listings [0004] The sequence listing filed herein as a text file named "21101_0401P1_SL.txt" created on July 16, 2020 and sized at 24,576 bytes is hereby incorporated by reference pursuant to 37 C.F.R. §1.52(e)(5) . Background technique [0005] The microbiota influences host metabolism and obesity, but the organisms that protect against disease remain unknown. Contents of the invention [0006] Disclosed herein are bacterial consortia. Disclosed herein are Clostridium consortia. [0007] Disclosed herein are compositions comprising a supernatant from a Clostridium consortium. [0008] Disclosed herein are compositions comprising a Clostridium consortium. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K35/74A61K35/741A61K35/742A61K35/745A61K45/06
CPCA61K45/06A61K35/742A61K2035/115A61K2300/00A61P3/04A61P3/06A61P3/10A61P29/00A61P1/00A61P9/12C12R2001/145C12N1/20
Inventor J·L·朗德
Owner UNIV OF UTAH RES FOUND
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