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Periostracum cicadae acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome, and application of periostracum cicadae acetyldopamine polymer composition

A technology of acetyldopamine polymer and irritable bowel syndrome, which is applied in the directions of medical preparations containing active ingredients, drug combinations, active ingredients of heterocyclic compounds, etc., to achieve the effect of improving visceral hypersensitivity

Active Publication Date: 2019-11-19
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the use of cicada acetyldopamine polymers in the prevention and treatment of irritable bowel syndrome

Method used

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  • Periostracum cicadae acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome, and application of periostracum cicadae acetyldopamine polymer composition
  • Periostracum cicadae acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome, and application of periostracum cicadae acetyldopamine polymer composition
  • Periostracum cicadae acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome, and application of periostracum cicadae acetyldopamine polymer composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A cicada slough acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome, which is prepared by the following method:

[0022] (1) After taking the cicada slough medicinal material and pulverizing it, add ethanol with a volume concentration of 95% at a solid-to-liquid ratio of 1:10, heat and reflux for extraction twice, each time for 3 hours; filter, combine the filtrates, recover the ethanol extract, and concentrate under reduced pressure To a relative density of 1.04 cicada slough extract;

[0023] (2) get the cicada slough extract that step (1) obtains, go up D101 type macroporous resin column, at first rinse with distilled water, flow velocity is 1.5BV / h, then use the ethanol that volume concentration is 25%, 50% and 95% successively Elute at a flow rate of 1.5BV / h, collect the eluted parts with a volume concentration of 95% ethanol, concentrate under reduced pressure, and obtain the cicada acetyldopamine polymer composition.

...

Embodiment 2

[0026] Example 2 Therapeutic effect of cicada slough acetyldopamine polymer composition on visceral hypersensitivity rats with irritable bowel syndrome

[0027] (1) Experimental method

[0028] 1. Preparation of visceral hypersensitivity rat model of irritable bowel syndrome and group administration

[0029] Suckling rats born from pregnant rats were stimulated with a Φ2.5mm arterial dilator for rectal stimulation from the 8th day to the 14th day after birth, and a pressure of 60mmHg (about 3mL water) was given in the rectum for 1min. Re-stimulate once after 30min. From the newborn 15d to 21d, the Φ3.5mm coronary artery dilator was used to stimulate the rectum according to the above steps. Co-stimulation 14d.

[0030] Ordinary feed was normally fed to after the 60th day of birth, and 60 male rats were randomly divided into blank control group, model control group, trimebutine maleate group (positive control group) according to body weight, and embodiment 1 cicada slough ace...

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Abstract

The invention discloses a periostracum cicadae acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome. A preparation method of the periostracum cicadae acetyldopamine polymer composition comprises the following steps that periostracum cicadae medicinal materials are taken firstly, crushed and then subjected to reflux extraction through ethanol, filtering isconducted, filtrate is merged, ethanol extraction liquid is recovered, vacuum concentration is conducted, and thus periostracum cicadae extractum is obtained; the periostracum cicadae extractum is puton a D101 type macroporous resin column, flushing is conducted through distilled water firstly, then ethanol with the volume concentration being 25%, ethanol with the volume concentration being 50%,and ethanol with the volume concentration being 95% are sequentially used for elution, the part eluted through the ethanol with the volume concentration being 95% is collected, vacuum concentration isconducted, and thus the periostracum cicadae acetyldopamine polymer composition is obtained. Through a large number of experiment screening, it is found that the periostracum cicadae acetyldopamine composition can decrease the plasma SP level and the plasma CGRP level of an irritable bowel syndrome model mouse, decrease the content of colon VIP and colon 5-HT, can improve irritable bowel syndromevisceral hypersensitivity at multiple levels and multiple links, and has a great effect of treating the irritable bowel syndrome.

Description

technical field [0001] The invention relates to a cicada ecdylide acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome. Background technique [0002] Cicada slough comes from the shell shed by the nymph Cryptotympana atrata of the family Cicadae when it emerges. Cicada slough medicinal material contains acetyldopamine dimer, trimer, tetramer, pentamer. Studies have shown that such ingredients have strong activity and are the main active substances of cicada slough. [0003] Irritable bowel syndrome is a chronic disease characterized by intestinal dysfunction. It is a group of clinical syndromes including abdominal pain, bloating, changes in bowel habits, abnormal stool properties, and mucus stools. It persists or recurs . The symptoms of patients with irritable bowel syndrome are mainly abdominal pain, diarrhea, and constipation. Diarrhea is more common, often accompanied by abdominal distension, unclean defecation, and defecation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/36A61P1/00
CPCA61K31/36A61P1/00A61K35/64A61K2300/00
Inventor 毛茜李松林曹馨慈
Owner TIANJIN TASLY PHARMA CO LTD
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