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A cicada slough acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome and its application

A technology for acetyldopamine polymer and irritable bowel syndrome, which is applied in the directions of medical preparations containing active ingredients, drug combinations, active ingredients of heterocyclic compounds, etc., to achieve the effect of improving visceral hypersensitivity

Active Publication Date: 2022-06-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the use of cicada acetyldopamine polymers in the prevention and treatment of irritable bowel syndrome

Method used

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  • A cicada slough acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome and its application
  • A cicada slough acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome and its application
  • A cicada slough acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A cicada ecdysis acetyldopamine polymer composition for preventing and treating irritable bowel syndrome, which is prepared by the following method:

[0022] (1) After pulverizing the medicinal materials of Cicada officinalis, add ethanol with a volume concentration of 95% at a solid-to-liquid ratio of 1:10, and extract by heating and refluxing for 2 times, 3 hours each time; filter, combine the filtrates, recover the ethanol extract, and concentrate under reduced pressure To the relative density of 1.04 cicada slough extract;

[0023] (2) Take the cicada slough extract obtained in step (1), put it on a D101 type macroporous resin column, first rinse with distilled water, the flow rate is 1.5BV / h, and then use the ethanol with volume concentration of 25%, 50% and 95% in turn Elution was carried out at a flow rate of 1.5 BV / h, and the eluted part of 95% ethanol by volume was collected, and concentrated under reduced pressure to obtain a cicada slough acetyldopamine polym...

Embodiment 2

[0026] Example 2 Therapeutic effect of cicada ecdysis acetyldopamine polymer composition on irritable bowel syndrome visceral hypersensitivity rats

[0027] (1) Experimental method

[0028] 1. Preparation and group administration of visceral hypersensitivity rat model of irritable bowel syndrome

[0029] From the 8th day to the 14th day of the newborn, the suckling mice born from the pregnant rats were stimulated by the arterial dilator of Φ2.5mm, and the pressure of 60mmHg (about 3mL water) was given in the rectum for 1min. Re-stimulate after 30 min. From the newborn 15d to 21d, the coronary artery dilator of Φ3.5mm was used for rectal stimulation according to the above steps. 14d of co-stimulation.

[0030] After the normal feed was fed to the 60th day after birth, 60 male rats were randomly divided into blank control group, model control group, trimebutine maleate group (positive control group) according to body weight. Body composition low, medium and high dose groups,...

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Abstract

The invention discloses a cicada slough acetyldopamine polymer composition capable of preventing and treating irritable bowel syndrome. Firstly, the cicada slough medicinal material is pulverized, then extracted with ethanol reflux, filtered, and the filtrates are combined, the ethanol extract is recovered, and concentrated under reduced pressure to obtain the cicada slough Extraction: on the D101 type macroporous resin column, rinse with distilled water first, then use ethanol with a volume concentration of 25%, 50% and 95% to elute successively, collect the eluting parts with a volume concentration of 95%, concentrate under reduced pressure, and obtain Cicada slender acetyldopamine polymer composition. Through a large number of experimental screenings, the present invention finds that the cicada slough acetyldopamine composition can reduce the levels of plasma SP and plasma CGRP in irritable bowel syndrome model mice; reduce the contents of colon VIP and colon 5-HT, and can improve intestinal irritable bowel syndrome from multiple levels and links. Visceral hypersensitivity in irritable bowel syndrome has a good effect on the treatment of irritable bowel syndrome.

Description

technical field [0001] The invention relates to a cicada ecdysis acetyldopamine polymer composition for preventing and treating irritable bowel syndrome. Background technique [0002] Cicada slough is derived from the shells of the nymphs of the black grasshopper Cryptotympana atrata, which are eclosion, and has the functions of dispersing wind-heat, soothing throat, exposing rash, improving eyesight and relieving nebula, and relieving spasm. Cicada slough medicinal materials contain acetyldopamine dimer, trimer, tetramer and pentamer. Studies have shown that such components have strong activity and are the main active substances of cicada slough. [0003] Irritable Bowel Syndrome (IBS) is a chronic disease characterized by intestinal dysfunction. It is a group of clinical syndromes including abdominal pain, bloating, changes in bowel habits, abnormal stools, and mucus, which persist or recur. . The symptoms of irritable bowel syndrome patients are mainly abdominal pain, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/36A61P1/00
CPCA61K31/36A61P1/00A61K35/64A61K2300/00
Inventor 毛茜李松林曹馨慈
Owner TIANJIN TASLY PHARMA CO LTD
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