2151 results about "Ethanol extracts" patented technology

The invention relates to uses of Bombay canary and its alcohol extract in preparing medicine for treatment of inflammation, specifically, for treating cervical erosion, ulcerative colitis, fig wart after operation, said invention belongs to medicine field.

The invention discloses a process for preparing gardenin comprising the steps of, A. airing cape jasmine dried fruits, disintegrating and sieving, B. charging petroleum benzene, supersonic extracting, and combining the filter liquor, reclaiming petroleum benzene to obtain vegetable oil, C. ethanol supersonic extracting, filtering, reclaiming ethanol, obtaining ethanol extract, D. eluting the ethanol extract with deionized water, E. depigmenting with ethanol, reclaiming the ethanol to obtain crude gardenin, F. removing impurities with 5% ethanol elution, E. depigmenting with 10% ethanol, concentrating the ethanol, drying and dewatering, thus obtaining gardenin.

The invention discloses heart nourishing and nerve soothing functional electronic cigarette juice which comprises, by mass, 50-70 percent of propylene glycol, 5-10 percent of glycerin, 5-15 percent of deionized water, 5-15 percent of heart nourishing and nerve soothing medicament, 2-6 percent of cigarette extract, 2-6 percent of tobacco essence and 2-6 percent of thickener. The heart nourishing and nerve soothing medicament is an extracting liquid obtained by extracting a plant mixture through steam distillation or through ethanol extracting, and the plant mixture is made of poria with hostwood, lavender, bodhi leaves, lily, jasmine, liquorice, cortex albiziae, chrysanthemum, spina data seeds, caulis Polygoni multiflori and agilawood. The heart nourishing and nerve soothing functional electronic cigarette juice can meet the smoking requirement of smokers, in addition, the efficacy of nourishing the heart and soothing the nerves is achieved, mental fatigue is relieved, and sleeping is improved.

A method for extracting hyperin comprises the following steps: a crude product of an extracting solution of a maniod eibish flower is obtained through extracting the concentrated solution of a maniod eibish flow ethanol extracting solution by normal butanol or ethyl acetate or through the column chromatography of an HPD100 or HPD600 macroscopic absorbent resin; and then hyperin with the content of between 90 and 98 percent in weight percentage is obtained through purification and recrystallization by using a solvent. Hyperin preparations comprise freeze-dried powder injection, liquid drugs injection, transfusions, dropped pills, tablets, capsules, or soft capsules prepared by using hyperin as an active component and pharmaceutical adjuvant. The hyperin is used for preparing the medicines for treating cerebral ischemia.

The invention relates to a Chinese magnoliavine fruit monomer composition separation preparation method; ethanol extracts from Chinese magnoliavine fruit are extracted by petroleum ether, chromatography is carried out to the petroleum ether extracts by a silicagel column, and then the petroleum ether is eluted by petroleum ether-ethylacetate, and HPLC is used for monitoring, and then crude extract A and crude extract B are fraction-collected, and eluted; the volume ratio of eluant petroleum ether and ethylacetate is 3-5:1, the crude extract A and crude extract B are respectively applied to a high-speed counter-current chromatography for separation, so as to obtain SCHisanhenol, deoxyschizandrin, schizandrin B, schisandrin C, schizandrol A, schizandrol B and schisantherrin B monomers, and the purity is higher than 98 percent.

Extracts of various species of the Leguminosae family have estrogenic properties. For example, aqueous and ethanolic extracts of Pueraria lobata Willd. Ohwi of the Leguminosae family species possess estrogenic properties in both ERα+ and ERβ+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

The invention discloses a method for preparing the ursolic acid with the paulownia leaves as raw materials, comprising the following steps that: 1. the dry paulowina leaf powders with a particle size ranging from 20 to 60 meshes are taken and 3 to 5 times amount of the ethanol with a concentration over 90 percent is added in the dry paulowina leaf powders with carrying out the reflux extraction; the reflux extraction is conducted for 1 to 2 hours each time and goes for altogether 3 times; the ethanol-extracts are combined and are filtered so as to remove the impurities; the filtrates are driven to rest for over 12 hours after the ethanol is recycled and the precipitates are collected after filtration; the precipitates are dried and then the brown grey or black brown crude products of the ursolic acids are obtained. 2. the crude products of the ursolic acids are dissolved using the ethanol with a concentration ranging from 50 percent to 70 percent and the macroporous adsorption resin is used with carrying out the dynamic absorption; the solution is subject to the absorption till the solution approaches the saturated state before the solution is washed using 2 to 3 times of the deionized water by resin concentration for 3 to 5 times and then the obtained solution is eluted using the ethanol solvent with a concentration ranging from 85 percent to 99 percent; the precipitates are decolored using the activated carbon before the precipitates are crystalized for 2 to 3 times using the double solvents of the ethanol so as to obtain the target products. The advantages of the invention lie in that the goal of the industrialized batch production of the ursolic acids is realized with the paulownia leaves having wide sources as raw materials, and the purity and stability of the products both exceed 95 percent and no discharge of waste gas, waste residue and organic solvents exists in the invention.

The invention discloses an asiaticoside and a preparation method thereof. The Centella asiatica is adopted as the raw material and is extracted by water or low-carbon ethanol; the extract is separated and purified by column chromatography, the resin is decolored, and the extract is crystallized, recrystallized and dried and finally the extractive mainly composed of by the asiaticoside is obtained, wherein, the weight of the asiaticoside acounts for not less than 95 percent. The preparation method utilizes the modern biological extraction technology and adopts the technology processes of aqueous extract or ethanol extract, separation and purification by column chromatography, decoloring, crystallization and recrystallization to extract the asiaticoside from the hydrocotyle asiatica; the purity of the asiaticoside is improved by the resin column chromatography and recrystallization to lead the extractive contain more than 95 percent of the asiaticoside (determined by HPLC method); in addition, the technology process is simple, the production period is short, the consumption of organic solvent is less, and the production cost is low, thus being applicable to the commercial production.

Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Ligustrum lucidum Ait. of the Oleaceae Family possess estrogenic properties in both ERα+ and ERβ+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

The invention discloses a ginkgo fruit composite preservative and a preservation method. The ginkgo fruit composite preservative comprises a film coating agent, an antibacterial agent and a fumigation agent, wherein each liter of the film coating agent comprises the following components in parts by weight: 10-15g of chitosan, 0.2-0.5g of nano-SiO2, 15-18g of glycerine and solvent, namely acetic acid in the volume concentration of 10%; each liter of the antibacterial agent comprises the following components in parts by weight: 0.1-0.5g of ginkgo exocarp ethanol extract and the solvent, namely water; each liter of the fumigation agent comprises the following gas components: 0.5-1.0mu L of 1-methyl cyclopropene and the balance of air. By using the composite preservative for treating ginkgo fruits, the mildew phenomenon of the ginkgo fruits during the storage period can be effectively inhibited, the problem of water loss of the ginkgo fruits can be simultaneously greatly reduced, the storage and preservation period of the ginkgo fruits can be prolonged to the greatest extent, the fruit hardening of the ginkgo fruits can be prevented and the occurrence of calcification phenomenon can be also prevented.

An extract from Sunset Abelmoschus, containing 50-75wt% of total flavone counted by hyperin, wherein, the contents of hyperin, isoquercitrin and quercetin-3'-glucoside are 10.0-15.0wt%, 7.0-12.0wt% and 8.0-12.0wt% respectively, and a total flavone finger-print is provided. The extract is obtained by the following steps: a concentrated solution of a Sunset Abelmoschus ethanol extract undergoes chromatography through an HPD400 or HPD700 macroporous absorbent resin column to derive a crude extract or is extracted by normal butanol to derive the crude extract; a refined extract is obtained by refluxing extraction with ethyl acetate-ethanol azeotropic mixture or ethyl acetate-methanol mixture; the refined extract goes through pressure reducing exsolution and drying. Corresponding contents and a method for detecting finger-print are also provided. The extract preparation is a dripping pill, tablet, capsule or soft capsule obtained through processing with the extract as an active ingredient and pharmaceutical excipients. The extract can be used for preparing a medicine preparation for treating cardiac anencephalohemia diseases.

The invention discloses a multicomponent traditional Chinese medicine containing composition for increasing bone mineral density and a preparation method thereof. The composition comprises the traditional Chinese medicine raw materials in parts by weight: 400-500 parts of herba epimedii, 400-500 parts of Rhizoma Drynariae, 300-400 parts of achyranthes root and also comprises the following nutritional substances in parts by weight: 75-95 parts of calcium carbonate, 40-60 parts of fish collagen powder, 20-38 parts of chondroitin sulfate, 5-6.2 parts of glucosamine hydrochloride, 10-13 parts of vitamin C and 0.0003-0.0004 parts of vitamin D. According to conventional process, an oral solid preparation is prepared by extracting herba epimedii, Rhizoma Drynariae and achyranthes root by ethanol and mixing the ethanol extract and the nutritional substances and appropriate amount of auxiliary materials. The medical composition provided by the invention has the function of increasing bone mineral density and can be used for prevention and assistant treatment of osteoporosis.

The invention discloses caper extract and a preparation method thereof. The method comprises the following steps: medicinal materials are crushed, decocted in water or subjected to heating reflux extraction by utilization of ethanol with different concentrations, and added with the ethanol for impurity precipitation after concentration of extract; supernatant or more than 80 percent ethanol extract is subjected to concentration at reduced pressure; extract 1 is obtained after recovery of the ethanol, dried and dissolved in water, subjected to deesterification by utilization of petroleum ether, and extracted by ethyl acetate; an extracted position and a water-soluble position of the ethyl acetate are subjected to vacuum concentration and drying respectively and prepared into extract 2 and extract 3 respectively; the extract 1 contains 30 compounds including 5 novel compounds such as caper alkali A, and so on; the extract 2 contains 18 compounds such as a para hydroxybenzoic acid, and so on ; and the extract 3 contains 18 compounds including 5 novel compounds such as the caper alkali A, and so on. As proved by pharmacodynamic experiments, the extract 1, the extract 2 and the extract 3 have analgesic and anti-inflammatory activity, and can be used for preparing medicines for treating rheumatic arthritis, rheumatoid inflammation or scapulohumeral periarthritis.

The invention discloses a total triterpenoid extract of inonotus obliquus with a hypoglycemic function, which is prepared through the following steps: (1) crushing and sieving inonotus obliquus, adding ethanol aqueous solution for immersion, carrying out ultrasonic extraction, separating the supernatant, and concentrating and drying the supernatant, thereby obtaining ethanol extract; (2) dispersing the ethanol extract into distilled water, oscillating and extracting with petroleum ether, and separating the extract from water-phase residues generated in extraction; and (3) oscillating and extracting the water-phase residues with n-butanol, separating the extract, mixing, concentrating and drying, thereby obtaining the total triterpenoid extract of the inonotus obliquus with the hypoglycemic function, wherein the content of the triterpenoid is 70-300mg/g. the total triterpenoid extract of the inonotus obliquus with the hypoglycemic function provided by the invention can obviously reduce the fasting blood glucose level of mouse with hyperglycemia, can significantly ease the diabetes symptoms of the mouse with hyperglycemia, and has no significant toxicity to major organs.

The invention discloses periplaneta Americana L. and gel externally applied medicinal composition and a preparation method and use thereof in preparation of externally applied medicines for treating scalding. The periplaneta Americana L. gel externally applied medicinal composition is prepared from ethanol extract of dried periplaneta Americana L. and a water soluble gel substrate according to weight ratio of the ethanol extract of dried periplaneta Americana L. to the water soluble gel substrate of (0.1-2.5):100, preferably 0.5:100. The preparation method comprises: grinding dried periplaneta Americana L. into coarse powder or preparing non-ground dried periplaneta Americana L.; extracting the periplaneta Americana L. in 70-to-95-percent ethanol for several times; combining extract, recovering ethanol, adding purified water for defatting, concentrating the defatted solution till thick paste with a relative density of 1.35; preparing water soluble gel substrate; and uniformly adding the thick paste of the extract into the water soluble gel substrate according to a ratio. When the periplaneta Americana L. and gel externally applied medicinal composition is used as an externally applied medicine, the dosage of the periplaneta Americana L. is 2.0g/kg.d, and two doses are taken. The periplaneta Americana L. and gel externally applied medicinal composition can treat scalding effectively, and is a good preparation with a development value.

The invention discloses water, ethanol and ethanol aqueous extracts of traditional Chinese medicine pithecellobium clypearia and application of corresponding petroleum ether, ethyl acetate, normal butanol and a water extractants in preparation of medicines for treating methicillin-resistant staphylococcus aureus (MRSA) and antibiotics anti-MRSA sensitization medicines. Meanwhile, the invention further discloses a preparation method of the extracts or extractants. Experimental results show that water, 10% ethanol, 30% ethanol, 60% ethanol, 95% ethanol extracts of pithecellobium clypearia and corresponding ethyl acetate, normal butanol and water extractants have stronger anti-MRSA effect, wherein the activity of the ethyl acetate extracting part of the 60% ethanol extract of pithecellobium clypearia is the strongest, and the ethyl acetate extracting part of the 60% ethanol extract of pithecellobium clypearia has sensitization effect on erythrocin, ceftriaxone sodium, levofloxacin for treating MRSA.

An object of the present invention is to provide a tryptanthrin-containing indigo-plant leaf extract particularly suitable for application to the skin. The present invention provides a method for producing a tryptanthrin-containing indigo-plant leaf extract, the method comprising filtering a mixture of a concentrated ethanol extract of indigo-plant leaves and a polyhydric alcohol, and collecting the filtrate. The present invention further provides an indigo-plant leaf extract produced by this method.

The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of <italic>Argemone mexicana </highlight>plant, optionally containing the extracts of the fruits of <italic>Cuminum cyminum</highlight>, which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of <italic>Argemone mexicana </highlight>plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, MEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of <italic>Cuminum cyminum </highlight>plant.

The invention discloses a method for separating triptolide from thunder god vine leaves. Thunder god vine leave powders are extracted by ethanol, the ethanol is firstly distributed by an ethyl acetate-water system, the top phase is steamed to obtain ethyl acetate extractive matter, the extractive matter is then distributed by a sherwood oil- methanol system, and the bottom phase is steamed to obtain methanol extractive matter. The sampling amount of column chromatography step is reduced by the twice distribution. The eluent is steamed by simple column chromatography to obtain the crude product of triptolide, the crude product of triptolide is distributed by a quaternionic biphase system, impurities such as coloring matter, and the like are removed, the sampling amount of high-speed reverse-current coloring matter step is reduced, and the competitive product of triptolide is obtained by refining high-speed reverse-current coloring matter. The purity of the competitive product of triptolide is about 95%, and the yield is 0.008% higher than leaves. The solvent in the method does not contain chloro-solvent which is harmful to environment and human bodies.

The invention belongs to the field of natural plant extraction and application, and particularly relates to a chive seed extract, a preparation method and application thereof to cigarette production. The extract is produced by the following method: chive seeds, as the raw material, are weeded, dried and shattered; with ethanol as the extractant or the entrainer, the raw material is processed through heating circumfluence or carbon dioxide supercritical extraction to get an ethanol extracting solution; the ethanol extracting solution is concentrated to get the chive seed extract. Added to cigarettes, the chive seed extract of the invention can significantly improve the sensory quality of the cigarettes and, in addition, has some potential effect on reducing the cigarette harm and enriching the cigarette function.