55 results about "End diastole" patented technology

The invention comprises a method and apparatus for generating a synthetic echocardiographic image. The method comprises first obtaining, for a plurality of pathologically similar reference hearts, a reference echocardiographic image of each reference heart at end-systole and at end-diastole. Next, the coupled epicardial and endocardial borders are identified in each echocardiographic image. An epicardial / endocardial border pair is then modeled from the identified borders. The method then locates a plurality of predetermined features in the reference echocardiographic images. The predetermined features are then located in the subject echocardiographic image from the location of the predetermined features in the reference echocardiographic images. The modeled epicardial / endocardial border pair is then mapped onto the subject echocardiographic image relative to the location of the predetermined features in the subject echocardiographic image. The apparatus generally comprises an echocardiographic machine for obtaining the echocardiographic images that are then processed by a computing system. In one aspect of the invention, the invention comprises such a computing system programmed to perform the autonomous portions of the method. In another aspect, the invention comprises a program storage medium encoded with instructions that perform the autonomous portions of the method when executed by a computer.

Certain embodiments of the present invention disclose an implant with electrode line connections for the connection of intracardial and / or epicardial electrode lines, wherein the electrode line connections have together at least three electrical contacts of which at least one is associated with a right-ventricular electrode and another is associated with a left-ventricular electrode, an impedance determining unit (IMP) which has a current or voltage source (I) and a measuring device (U) for a corresponding voltage or current measurement operation, which is connected to the electrical contacts and possibly a housing electrode of the implant, in such a way as to afford a tri- or quadrupolar impedance measuring arrangement which includes exclusively ventricular electrodes and in addition possibly the housing electrode, wherein the impedance measuring arrangement produces impedance measurement values and is connected to an evaluation unit (EVAL) and the evaluation unit (EVAL) is adapted to ascertain a minimum of the impedance measurement values within a first time window (defined relative to a ventricular event) as end-diastolic impedance (EDZ) and a maximum of the impedance measurement values within a second time window as end-systolic impedance (ESZ).

A system and method to acquire 3D ultrasound-based images during the end-systole and end-diastole time points of a cardiac cycle to allow determination of the change and percentage change in left ventricle volume at the time points.

A method, apparatus and computer program product for machine-based segmentation of the cardiac chambers in a four-dimensional magnetic resonance image data that contains at least short-axis cine sequences. The segmenting is based on temporal variations in the data set and on features extracted from the image data. In particular, the method and apparatus process the image data to automatically segment an endocard based on fuzzy object extraction and to automatically segment an epicard through finding a radial minimum cost with dynamic sign definition and tissue classification. In addition, image data is preferably preprocessed to eliminate high local image variances and inhomogeneity. The image data is also preferably processed to identify positions of a base slice, an apex slice, an end-diastole, an end-systole and an LVRV connection.

An apparatus implantable in a heart ventricle includes a frame configured to engage an inner circumferential periphery of the ventricle and to expand and contract between an expanded state corresponding to a desired end diastolic diameter of the ventricle and a contracted state corresponding to a desired end systolic diameter of the ventricle. A bistable structure is operatively associated with the frame. The bistable structure mechanically assists movement of the ventricle toward both an end systolic diameter during systole and an end diastolic diameter during diastole. The bistable structure may be integrally formed of the frame. A method of implanting the apparatus in a heart ventricle includes surgically accessing a ventricle, inserting the apparatus in the ventricle and attaching the device to a portion of myocardium defining an inner circumferential periphery of the ventricle.

A method includes receiving a multi-phase axial cardiac dataset, receiving a selection of a phase from a user, when the received selection is systole, generating an endocardial volume of a left ventricle at an end systole phase without further user intervention, and when the received selection is diastole, generating an endocardial volume of the left ventricle at an end diastole phase without further user intervention.

A system and method to acquire 3D ultrasound-based images during the end-systole and end end-diastole time points of a cardiac cycle to allow determination of the change and percentage change in left ventricle volume at the time points.

Methods and a system are disclosed for processing an echocardiogram video of a patient's heart. The echocardiogram comprises at least a first sequence of consecutive video frames corresponding to a first view of the patient's heart concatenated with a second sequence of consecutive video frames corresponding to a second view of the patient's heart. The end-diastole phase of the patient's heart is monitored in each frame by detecting the electrocardiograph wave, and a key frame is selected upon the occurrence of the R-wave peak in the electrocardiograph wave in each of the first sequence of consecutive video frames and in the second sequence of consecutive video frames. The shape and color content of the echocardiogram image window is monitored in certain video frames, and a transition is detected when there is a change in the first feature between adjacent frames. A summary is generated which comprises by the video frames corresponding to the end-diastole phase.

In the case where a tracking process of a moving tissue performing a contraction movement and an expansion movement and represented by a cardiac wall is performed for one heartbeat from the ED1 to the ED2, a contour position (tracking point) initially set at the ES (End-Systole) is tracked until ED1 in accordance with movement information, the tracking point is rearranged and a position of a middle layer is set at the ED (End-Diastole), the rearranged tracking point including the position of the middle layer is tracked in accordance with the movement information already obtained, and then the tracking point is further tracked in the normal direction until the ED2. Alternatively, an initial reverse tracking process is performed from the ES to the ED1 by using plural middle layer path candidates, and a path passing through the tracking point existing on the middle layer or contours of inner and outer layers and rearranged at the ED1 is searched, thereby accurately creating and evaluating movement information of each of an endocardium and an epicardium of a cardiac wall.

The ultrasonic diagnostic system estimates a desired time phase or one cycle period of a moving region (e.g., a heart) that repeats contraction and relaxation cyclically and which can be specified by a presystole, an end systole, a prediastole, an end diastole, and other clinical characteristics for one cycle of the moving region on the basis of the velocity information on multiple positions of the moving region which is obtained for each time phase. More specifically, assuming that, for example, the end systole phase=a time phase in which the myocardial velocity comes to zero or close to zero, the system calculates |myocardial velocity| for each time phase in a predetermined period, and estimates a time phase in which this value comes closest to zero as an end systole phase.

Methods and a system are disclosed for processing an echocardiogram video of a patient's heart. The echocardiogram comprises at least a first sequence of consecutive video frames corresponding to a first view of the patient's heart concatenated with a second sequence of consecutive video frames corresponding to a second view of the patient's heart. The end-diastole phase of the patient's heart is monitored in each frame by detecting the electrocardiograph wave, and a key frame is selected upon the occurrence of the R-wave peak in the electrocardiograph wave in each of the first sequence of consecutive video frames and in the second sequence of consecutive video frames. The shape and color content of the echocardiogram image window is monitored in certain video frames, and a transition is detected when there is a change in the first feature between adjacent frames. A summary is generated which comprises by the video frames corresponding to the end-diastole phase.

A device and method for determining at least the left ventricular end diastolic volume LVEDV of a beating heart of in particular a human being, is disclosed, the device comprising a current source supply electrodes, for supplying alternating current to the body, measuring electrodes, for receiving an impedance signal, measuring means, for measuring said impedance signal, a processing unit, for processing and outputting the value of said impedance signal and the first time derivative thereof, and means for determining the duration DFT of a heartbeat, and wherein the processing unit is designed for determining and outputting the value of LVEDV in dependence of both said duration DFT and said impedance and the change of the first time derivative of said impedance during the pre-ejection period.

An ultrasound diagnosis apparatus which performs ultrasonic diagnosis with respect of a fetal heart. An area change measurement section calculates an area of a specific heart chamber (left ventricle) in the fetal heart in frame units. Further, the area change measurement section generates a graph representing the area which is calculated in frame units. The maximum value and the minimum value are specified in the graph to thereby specify end-diastole and end-systole. Based on this information, a heart rate and a cardiac cycle with regard to the fetal heart are calculated. Further, an ejection fraction is also calculated from an end-diastolic area and an end-systolic area.

A method includes receiving a multi-phase axial cardiac dataset, receiving a selection of a phase from a user, when the received selection is systole, generating an endocardial volume of a left ventricle at an end systole phase without further user intervention, and when the received selection is diastole, generating an endocardial volume of the left ventricle at an end diastole phase without further user intervention.

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

A method for measuring ventricular dimensions from M-mode echocardiograms, includes providing a digitized M-mode echocardiogram image, running a plurality of local classifiers, where each local classifier trained to detect a landmark on either an end-diastole (ED) line or an end-systole (ES) line in the image, recording all possible landmarks detected by the classifiers, where a search range in an N-dimensional parameter space defined by the landmarks for each dimension is reduced to a union of subsets, where each dimension of the parameter space corresponds a landmark, for each combination of possible landmarks, checking if an order of the landmarks is consistent with a known ordering of the landmarks, and if the order is consistent, running a global detector on each consistent combination of landmarks to find a landmark combination with a highest detection probability as a confirmed landmark detection, where the landmarks are used for measuring ventricular dimensions.

A medical imaging apparatus includes: an output unit configured to display a magnetic resonance (MR) image matrix in which MR images, obtained by performing magnetic resonance imaging on a heart, are arranged in columns and rows; and an image processor configured to display at least one first indicator which indicates a column of the MR image matrix corresponding to at least one of end diastole and end systole and display at least one second indicator which indicates a row of the MR image matrix corresponding to at least one of an apex and a base of the heart, wherein the columns of the MR image matrix are arranged according to time when MR images included in the columns are captured, and the rows of the MR image matrix are arranged according to a position on a longitudinal axis of the heart corresponding to MR images included in the rows.

The invention discloses a method for segmenting the endocardium and the epicardium in a heart cardiac function magnetic resonance image. The method comprises positioning the diastasis in heart magnetic resonance images I<NP> including several lamellas of the left ventricular myocardium and in different cardiac cycle phases, and obtaining a coarse segmentation result of blood pools of magnetic resonance images of N lamellas in the diastasis; converting image data in the left ventricle region-of-interest in the magnetic resonance image of each lamella in the diastasis into a two-dimension polar coordinate conversion image by means of ray scanning based on a polar coordinate conversion method; detecting the endocardium and the epicardium in the two-dimension polar coordinate conversion image based on a bidynamic programming method; obtaining the endocardium and the epicardium in an original lamella image by means of polar coordinate inverse conversion, calculating the convex hull and smoothing the convex hull, and completing segmentation of the endocardium and the epicardium in the magnetic resonance images of the N lamellas in the diastasis; and deriving the segmentation result of the in the endocardium and the epicardium in the magnetic resonance images in the diastasis to the endocardium and the epicardium in the magnetic resonance images in other cardiac cycle phases.

An apparatus for determining a patient's circulatory fill status is adapted to provide a dilution curve and is capable to derive the ratio between the patient's global end-diastolic volume GEDV and the patient's intra thoracic thermo volume ITTV from the dilution curve. Further, a computer program for determining a patient's circulatory fill status has instructions adapted to carry out the steps of generating the dilution curve on basis of provided measurement data of dilution versus time, deriving the ratio between the patient's global end-diastolic volume GEDV and the patient's intra thoracic thermo volume ITTV from the dilution curve, and determining the patient's circulatory fill status on basis of the ratio between the patient's global end-diastolic volume GEDV and the patient's intra thoracic thermo volume ITTV, when the computer program is run on a computer. A method is also provided.

The present invention relates to a method for determining right ventricle stroke volume comprising the steps of: providing a plurality of three-dimensional images of right cardiac ventricle of a patient over a cardiac cycle; identically slicing each of the plurality of images; selecting an image from the plurality of images, for each time unit of the cardiac cycle; determining a region of interest in each slice of the selected images, wherein the region of interest shows the right ventricle of the patient; determining area of the region of interest; determining volume of the region of interest; determining total volume of the region of interest for each time unit, wherein the maximum total volume is end diastolic volume and the minimum total volume is end systolic volume; and determining the right ventricle stroke volume using an equation:Right Ventricle Stroke Volume=end diastolic volume−end systolic volume   (3).

An ultrasound imaging system is for determining stroke volume and / or cardiac output. The imaging system may include a transducer unit for acquiring ultrasound data of a heart of a subject (or an input for receiving the acquired ultrasound data), and a controller. The controller is adapted to implement a two-step procedure, the first step being an initial assessment step, and the second being an imaging step having two possible modes depending upon the outcome of the assessment. In the initial assessment procedure, it is determined whether regurgitant ventricular flow is present. This is performed using Doppler processing techniques applied to an initial ultrasound data set. If regurgitant flow does not exist, stroke volume is determined using segmentation of 3D ultrasound image data to identify and measure the volume of the left or right ventricle at each of end systole and end-diastole, the difference between them giving a measure of stroke volume. If regurgitant flow does exist, stroke volume is determined using Doppler techniques applied to ultrasound data continuously collected throughout a cardiac cycle.

Data acquisition based on the same MRI encoding pattern is repeated at least once for each R wave occurring at time T0 used as a trigger. The necessary number of data for image reconstruction are extracted as subsets of a complete MRI data set from the resulting plural sets of acquired MRI by temporally retrospecting from the next R wave occurrence time (time T1) after the R wave (time T0) used as the trigger. The extracted data subsets are then rearranged to generate a complete composite MRI data set which is then used for image reconstruction of heart movement associated with end-diastole after the occurrence of the triggering R wave.

Heart failure with preserved ejection fraction (HFpEF) is a disease condition characterized by heart failure (HF) signs and symptoms, but with normal or near normal left ventricular ejection fraction (LVEF) and is not responsive to standard therapy for treatment of HF. Described herein are compositions and methods related to use of cardiosphere derived cells (CDCs) and their exosomes to improve left ventricular structure, function and overall outcome. Administration of CDCs led to improved LV relaxation, lower LV end-diastolic pressure, decreased lung congestion and enhanced survival. Lower risk of arrhythmias in HFpEF was also observed following CDC administration. Improvement of diastolic dysfunction following administration of CDC-derived exosomes was observed, along with decreased mortality. In view of these salutary effects, CDCs and CDC-derived exosomes are beneficial in the treatment of HFpEF.

The invention relates to a device for assessing physiological indexes of the human body. The device comprises a blood pressure detection unit, a calculation unit, an assessment unit and a display unit. The blood pressure detection unit is used for acquiring pulse wave signals of the human body. The calculation unit is connected with the blood pressure detection unit and is used for calculating the physiological parameter set including end-diastolic volume, myocardial contractility, mean arterial pressure, stroke volume, cardiac output, left ventricle compliance, myocardial oxygen consumption and endocardium blood supply rate according to the pulse wave signals. The assessment unit is connected with the calculation unit and is used for assessing the pressure index and the fatigue index of the human body according to the physiological parameter set. The display unit is connected with the assessment unit and is used for displaying the pressure index and the fatigue index.