357 results about "Left ventricle wall" patented technology

Various systems, devices, and methods are disclosed herein for treating acute myocardial infarction (AMI) patients using a heart pump controlled in a manner that maximizes mechanical unloading of the left ventricle in the presence of cardiovascular instability and minimizes myocardial oxygen consumption (MVO2) and consequentially infarct size to prevent the development of subsequent heart failure. In a closed feedback system, the system can include a sensor configured to generate an output used to measure or calculate a left ventricular systolic pressure (LSVP) within the left ventricle of a heart and a controller coupled to a heart pump. The controller can be configured to measure or calculate the LVSP based on the output of the sensor and to control an operation of the heart pump to maximize mechanical unloading of the left ventricle based on the measured or calculated LVSP.

A device comprises an implantable blood pump receivable in a sheath for percutaneous delivery. The implantable blood pump comprises a collapsible impeller mounted in a collapsible impeller cage, and a drive device mounted in a housing. The housing is in connection between a first end of a catheter and the collapsible impeller cage. The drive device is adapted for rotating the collapsible impeller. A retractable support structure is adapted to extend from the catheter. The extended retractable support structure is adapted to engage with the wall of the aorta for allowing the implantable blood pump to be secured in the left ventricle. The collapsible impeller cage comprises an inlet and an outlet. The inlet is adapted to receive blood from the left ventricle. The outlet directs blood in the direction of the atrioventricular valve.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

Apparatus and methods are described including a ventricular assist device that includes an impeller configured to be placed inside a left ventricle of a subject. A driving magnet is coupled to a motor and is rotated by the motor. A driven magnet is magnetically coupled to the driving magnet and is rotated by the driving magnet. A drive cable extends from the driven magnet and imparts rotational motion from the driven magnet to the impeller. A set of sensors is configured to detect a magnetic phase difference between the driven magnet and the driving magnet. A computer processor receives the detected magnetic phase difference and determines a physiological parameter of the subject, at least partially in response thereto. Other applications are also described.

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

The invention relates to a hypertrophic obstructive cardiomyopathy virtual resection operation curative effect evaluation method based on individualized computational fluid mechanics, which can give visual postoperative hemodynamic indexes, predict postoperative curative effects, find an optimal resection scheme and realize preoperative accurate intelligent evaluation. Comprising the following steps of: acquiring coronary artery enhanced computed tomography image data, acquiring a coronary artery enhanced computed tomography image of a patient, and outputting and storing the coronary artery enhanced computed tomography image in a DICOM (Digital Imaging and Communications in Medicine) format; preprocessing image data, and segmenting and reconstructing a left ventricle-outflow tract structure three-dimensional model; setting a virtual excision scheme at the fleshy part; constructing a surgical resection model, and importing the model into finite element analysis software for solving; and the virtual postoperative curative effect is visualized. Verification and curative effect prediction of a patient excision scheme can be realized, and the operation success rate of a hypertrophic obstructive cardiomyopathy patient is improved.

The invention provides an echocardiogram video abstraction method based on a hierarchical space-time attention mechanism, and the method comprises the steps: obtaining an echocardiogram, inputting the echocardiogram into an anatomy and physiological basic model of a key frame recognition task, and obtaining key frame information; inputting the key frame information into a multi-dimensional spatial-temporal feature extraction model to obtain feature information and frequency domain information; fusing the feature information and the frequency domain information; performing key frame enhancement processing on the fusion information by adopting an SE channel attention mechanism to obtain key frame anatomical feature expression; processing the key frame anatomical feature expression by adopting a key frame backtracking strategy and a classification network to obtain a key frame identification classification result; performing left ventricle segmentation on the classified image by adopting an improved U-Net left ventricle region segmentation network; estimating the area and volume of the left ventricle based on a segmentation result; fusing the estimated left ventricular area and volume by adopting a hierarchical attention mechanism and a cross-layer information fusion strategy to obtain a ventricular volume result; according to the method, through abstract extraction of the key information of the ultrasonic cardiac video, the clinical practicability of intelligent screening and auxiliary diagnosis of cardiovascular diseases based on ultrasonic is improved.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

The invention discloses a double-balloon type left ventricle auxiliary device which comprises an inlet tube, an outer balloon, an elastic support, an inner balloon, a catheter and a connecting piece. The inlet pipe is provided with a plurality of inflow windows and a one-way valve for controlling one-way flow of blood; the outer balloon has a folded state and an expanded state, in the conveying process, the outer balloon is in the folded state and can be contained in the conveying sleeve, and when the outer balloon reaches a designated position, the outer balloon is in the expanded state; the elastic support is attached to the surface of the external balloon, the elastic deformation of the elastic support enables the external balloon to be switched between a folded state and an expanded state, and the elastic support can provide radial supporting force in the expanded state, so that the external balloon is expanded and keeps a fixed volume; the internal balloon is arranged inside the external balloon, and contraction and expansion are realized by injecting gas or liquid, so that the volumes of inner cavities of the internal balloon and the external balloon are periodically changed, and the internal balloon and the external balloon are used for sucking and discharging blood; the catheter is provided with a medium cavity and a guide wire cavity, and the medium cavity is communicated with the internal balloon.

A method of delivering a pacing lead may include locating a potential implantation site adjacent to or within the triangle of Koch region of a patient's heart. The method may include advancing a pacing lead to the potential implantation site. The pacing lead has an elongate body and a fixation element coupled to a distal portion and attachable to the right-atrial endocardium adjacent to or within the triangle of Koch region. The method may include implanting the pacing lead at the potential implantation site to or sense electrical activity of the left ventricle in the basal and / or septal region of the left ventricular myocardium of the patient's heart. The pacing lead may include a lumen configured to receive a guide wire. A sheath of a delivery system used to deliver the pacing lead may include two or more curves to facilitate implanting the pacing lead at the implantation site.

A method, for use at a mitral valve of a heart of a subject, is provided which includes advancing a transluminal sheath into a femoral vein of the subject, through an inferior vena cava of the subject, into a right atrium of the subject, and transseptally into a left atrium of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of the mitral valve. An anchor is implanted by advancing the anchor out of the surrounding-sheath into a left ventricle of the subject, such that the anchor helically wraps around left ventricular mitral valve tissue. The surrounding-sheath is then extracted from the heart and then, a guide wire is advanced through the transluminal sheath. Other embodiments are also described.

An injectable hydrogel for heart failure treatment with myocardial tissue repair function and its preparation method and use are disclosed. The hydrogel is prepared by chelating alginic acid and multivalent cations. The hydrogel is loaded with an active substance for repairing cardiac injury. The active substance is recombinant humanized collagen type III. The hydrogel is administrated into the left ventricle free wall by transendocardial injection. Implanting the hydrogel in the myocardium can increase the thickness of the left ventricular wall, adjust the stress of the ventricular wall, affect the morphology of the left ventricle, and prevent or reverse left ventricular enlargement. Further, the hydrogel is loaded with a new recombinant humanized collagen material that has the function of repairing cardiac tissue injury to further improve cardiac function and promote cardiac repair.

Methods and systems are provided for identifying cardiac cycles for evaluating left ventricle function using only image data. In one example, a method includes obtaining a sequence of medical image frames of a heart of a patient over a plurality of cardiac cycles, wherein each medical image frame depicts the same apical view of the heart, using a timing model to generate an output that is useable to label each frame of the sequence by cardiac cycle subphase and using the output to determine the suitability of each cardiac cycle for performing an automated measurement. The method may further include using the suitability of each cycle to determine if an automated measurement should be performed on each cycle, where automated measurements are performed on medical image frames corresponding to suitable cycles and automated measurements are not performed on medical image frames corresponding to unsuitable cycles.

The invention discloses a hypertrophic cardiomyopathy (HCM) preoperative planning and operation effect evaluation method based on accurate digital labeling. The method comprises the following steps: performing digital labeling on the thickness of each wall of a left ventricle of a preoperative heart 3D digital model; according to the digital labeling result of the preoperative heart 3D digital model and the normal value of the thickness of the left ventricular wall, a doctor manually depicts the predicted resection range and confirms the predicted retention thickness; measuring the predicted resection volume, the predicted resection area and the left ventricular end diastolic volume after the predicted resection volume is resected; digitally marking the thickness of each wall of the left ventricle of the postoperative heart 3D digital model, and measuring the volume of the corresponding left ventricle in the end diastole; and taking the predicted resection range, the predicted retention thickness, the predicted resection volume, the predicted resection area and the predicted volume as first evaluation data, taking corresponding parameters of the postoperative heart 3D digital model as second evaluation data, and generating an operation evaluation result according to the conformity of the first evaluation data and the second evaluation data.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium, through the mitral valve, and into the left ventricle. A ventricular anchor is deployed from the catheter and into a wall of the left ventricle, leaving a ventricular suture attached to the ventricular anchor and extending proximally through the catheter. A leaflet anchor is deployed to secure a mitral valve leaflet to a leaflet suture, with the leaflet suture extending proximally through the catheter. The leaflet suture is secured to the ventricular suture to limit a range of travel of the leaflet in the direction of the left atrium. Also disclosed is an assembled in situ mitral valve leaflet restraint, having a neo papillary muscle and a neo chordae tendinea.

A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.

The invention discloses a double-balloon in-aorta balloon counterpulsation device, and relates to the technical field of medical equipment. The balloon catheter comprises a control host, a catheter shaft, a main balloon and an auxiliary balloon, the catheter shaft is arranged on the control host, and the main balloon and the auxiliary balloon are arranged at the other end of the catheter shaft; the main balloon is a long-strip-shaped hollow air bag, the auxiliary balloon is any one of a cylindrical hollow air bag, a conical hollow air bag and a hemispherical hollow air bag, and an inner cavity of the main balloon is larger than an inner cavity of the auxiliary balloon. A guide wire channel is arranged in the catheter shaft and penetrates through the auxiliary balloon and the main balloon; by arranging the main balloon and the auxiliary balloon, when the left ventricle begins to contract and the aortic valve is opened, the main balloon begins to contract, and meanwhile, the auxiliary balloon delays to start to contract, so that the suction resistance to the telecentric end when the main balloon contracts is increased, the reverse blood flow extracted from the telecentric end is reduced, the suction effect on the proximal end is improved, and the cardiac output is increased.

Existing techniques fail to propose a method for improving model parameters optimization and seamless integration of clinical data with computational model required for personalized cardiac hemodynamic model development. This disclosure relates to a system and method, which receives one or more model parameters comprising height, active pressure components and passive pressure components specific to left ventricle from cardiac hemodynamic model. The first set of values corresponding to one or more input parameters comprising end systolic diameter and end diastole diameter are received from subject specific Echo data. The second set of values corresponding to one or more model parameters are estimated using one or more input parameters. The estimated second set of values are optimized using a Particle swarm optimization to obtain one or more optimized values. Select at least a subset of optimized one or more values corresponding to one or more model parameters for personalization.

Systems, devices and methods are provided for supporting cardiac function. A device comprises an elongate housing configured for implantation into a patient exterior to the chest cavity. The housing includes a first inlet and an outlet that define a primary blood flow path from the left atrium through at least a portion of the housing within the right atrium, and to the aorta. The housing comprises a motor disposed within the housing and an impeller coupled to the motor for pumping blood from the first inlet to the outlet of the housing through the primary blood flow path. The device bypasses the left ventricle by drawing freshly oxygenated blood from the left atrium and propelling this blood directly into the aorta. Implanting the pump exterior to the chest cavity is less invasive and allows the pump to be quickly and easily repaired, cleaned, repositioned and or replaced without removing or replacing the tubes that are anchored to sensitive tissue structures within the thoracic cavity.

The invention relates to a catheter pump position judgment device and method, a catheter pump, a ventricular assist system, a storage medium and equipment.The catheter pump position judgment device comprises a sampling module, a processing module and a judgment module, and the sampling module is configured to collect operation data of a driving motor of the catheter pump in the conveying process; the operation data at least comprises rotating speed data; the processing module is configured to determine a range value of the rotating speed data; the judgment module is configured to determine the position state of the catheter pump according to the comparison result of the range value and a preset threshold value. The method does not need to depend on an additional pressure sensor or multiple times of radiography, and can judge whether the catheter pump is located in the aorta, the transvalvular position or the left ventricle by collecting the rotating speed data of the driving motor and analyzing the range value of the rotating speed data.

The invention provides a heart function auxiliary analysis system based on a neural network, and belongs to the technical field of heart assistance, and the system comprises a preprocessing module which is used for preprocessing a heart ultrasound image; the waveform recognition module is used for performing waveform detection and multi-scale feature recognition on a waveform curve in the preprocessed ultrasonic image, positioning a peak value and a valley value of a waveform, and recognizing a diastolic frame and a systolic frame in a cardiac ultrasonic period; the three-dimensional reconstruction module is used for performing three-dimensional reconstruction on the heart region by using a deep learning technology; the calculation module is used for calculating the volume and ejection fraction of the left ventricle according to the reconstructed heart area; and the auxiliary reminding module is used for carrying out abnormal value verification and elimination on the ejection fractions obtained in the plurality of periods through an abnormal value elimination algorithm to obtain an accurate value, and outputting the cardiac function information of the patient for auxiliary reminding. The cardiac function condition of a patient can be accurately reflected, an accurate basis is provided for auxiliary reminding, and effective support is provided for clinical diagnosis.

Disclosed is a valve balloon suction catheter, comprising a tip, a balloon, a catheter, and a handle base in sequence from a distal end to a proximal end, the catheter being provided with a fluid passage lumen. The balloon consists of at least four balloon bodies, which are distributed circumferentially around the catheter to form a circular configuration, so as to create a blood flow channel in the center of the balloon, the blood flow channel being arranged in the axial direction of the balloon. A micro axial flow pump is provided in the blood flow channel and is arranged on the catheter, and a guidewire conduit penetrating through the micro axial flow pump is provided in the micro axial flow pump. A distal end of the guidewire conduit passes through the blood flow channel and is fixedly connected to the tip, and a proximal end of the guidewire conduit penetrates through the handle base. A guidewire lumen is provided in the guidewire conduit. The micro axial flow pump is connected to an external impeller drive interface arranged at a proximal end of the handle base. Compared with the prior art, the combination of balloon dilatation and mechanical circulatory assistance establishes a drainage pathway from the left ventricle to the ascending aorta, enabling cardiac blood circulation and improving the safety of the procedure.

A computer-implemented method (100) of identification regions of ischemia areas in the left ventricle, the method comprising: receiving (105) a CT Coronary Angiogram scan data representing a 3D volume of a region of anatomy that includes a pericardium; segmenting (110) the CT scan data to obtain a cardiac anatomical model; applying (110) a cardiac anatomical model to a machine-learning algorithm to identify a region of ischemia, while the machine-learning model is trained on a data sets comprising a spatially aligned CT and perfusion data.

The invention belongs to the technical field of medical image segmentation, and discloses a medical image segmentation method, system and device based on a twin network and multi-view fusion, and a medium, and the method comprises the steps: obtaining the sequence slice data of a heart magnetic resonance image; inputting the sequence slice data into a medical image segmentation model for image segmentation to obtain a segmentation result corresponding to each slice data; the segmentation result comprises segmentation masks of the left ventricle, the right ventricle and the cardiac muscle; the medical image segmentation model is constructed based on an encoder-decoder network, an encoder comprises a plurality of encoder branches with the same structure and unshared weights, and the encoder branches comprise an original slice image encoding branch, a region constraint slice encoder branch, a high-frequency information encoding branch and a low-frequency information encoding branch. The decoder comprises a plurality of decoding blocks with bottleneck structures. According to the invention, the accuracy and efficiency of segmentation are improved, and the robustness and applicability of the model are enhanced.

The invention provides a processing method and device based on a heart three-dimensional image, equipment and a medium. The processing method comprises the steps of obtaining three-dimensional image data of a heart; performing heart chamber segmentation according to the three-dimensional image data to obtain structure information of each area of the heart; determining the long axis of the left ventricle and the inner diameter and the outer diameter of the cardiac muscle according to the structural information; constructing a three-dimensional mapping of the myocardial wall thickness, and reflecting the form distribution of the myocardium in the space; segmenting the myocardium according to the three-dimensional mapping of the myocardial wall thickness and the long axis to generate segmented region data; and training and outputting a cardiomyopathy classification model through a pre-trained classification model in combination with the segmented region data. According to the method, feature vectors after dimension reduction are utilized to train a cardiomyopathy classification model. By generating a detection report containing an abnormal region position and classification confidence, the method improves the accuracy and efficiency of cardiomyopathy auxiliary detection by fusing image processing, feature extraction and machine learning technologies.

A system for percutaneous ventriculoplasty. Anchors can be placed in the ventricular septum and the ventricular wall. Sutures tethered to the anchors can be tensioned to reduce the size of a dilated left ventricle. Multiple anchors can be positioned in the ventricular wall and the sutures can be independently tensioned to allow tailored treatment of the dilated ventricle.

The invention belongs to the technical field of medical instruments, and particularly relates to a ventricular assist device rotating speed regulation and control method and system based on deep learning. The ventricular assist device rotating speed regulation and control method based on deep learning comprises the steps of collecting current pressure information and current pump speed information of a left ventricle, sending the current pressure information and the current pump speed information into a trained long-short-term memory network model, obtaining to-be-regulated and controlled pump speed information through the long-short-term memory network model, and obtaining to-be-regulated and controlled pump speed information through the long-short-term memory network model; and sending the to-be-regulated pump speed information to the ventricle auxiliary device. According to the invention, the monitoring module of the human body LVAD can automatically adjust the control target of the rotating speed of the pump according to the hemodynamic change, and the LVAD can realize adaptive control for individual patients.

Disclosed are a method for presenting cardiac myocardial strain and an ultrasound imaging apparatus, comprising: acquiring image data of myocardial segments of both left and right ventricles, and processing this data to obtain motion parameters of both left and right ventricular myocardial segments. A composite bull's-eye plot containing left and right ventricular bull's-eye subplots is displayed, wherein the left ventricular bull's-eye subplot comprises multiple left ventricular myocardial regions corresponding to the left ventricular myocardial segments and presenting motion parameters of the left ventricular myocardial segment; and the right ventricular bull's-eye subplot comprises a right ventricular myocardial region corresponding to the right ventricular myocardial segments that exclude some / all shared segments with the left ventricle and presenting motion parameters of the right ventricular myocardial segment. This configuration enables users to observe motion parameters of both ventricular myocardial segments, thereby providing comprehensive understanding of cardiac myocardial strain while enhancing clinical efficiency for doctors.

According to the catheter pump with the oxygenation function, the myocardial anoxia condition can be directly improved, the near end of a motor is connected with a catheter, the far end of the motor is coaxially connected with an impeller, the periphery of the impeller is covered with a blood outflow cage, the far end of the blood outflow cage is fixed to the near end of a blood inflow cage through a sleeve, and the far end of the blood inflow cage is further connected with a pigtail pipe; an oxygenation unit is arranged on the blood inflow cage, and the oxygenation unit is used for generating oxygen in the left ventricle on time and on demand according to the physiological signals collected by the sensing unit and releasing the oxygen into the blood of the left ventricle. The oxygenation unit enters the left ventricle along with the blood inflow cage, oxygen is directly produced in situ in the left ventricle, oxygen is supplied to blood of the left ventricle, the myocardial anoxia condition is rapidly improved, and heart recovery is promoted. The oxygenation unit is integrated on the catheter pump and intervenes through a blood vessel together with the catheter pump, operation is easy, and damage to the blood vessel can be reduced. By means of the oxygen supply mode, the myocardial anoxia condition can be directly improved, and the aortic valve regurgitation condition and the systemic circulation oxygen supply condition can also be improved.