102 results about "Left ventricle wall" patented technology

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

Methods and systems are provided for identifying cardiac cycles for evaluating left ventricle function using only image data. In one example, a method includes obtaining a sequence of medical image frames of a heart of a patient over a plurality of cardiac cycles, wherein each medical image frame depicts the same apical view of the heart, using a timing model to generate an output that is useable to label each frame of the sequence by cardiac cycle subphase and using the output to determine the suitability of each cardiac cycle for performing an automated measurement. The method may further include using the suitability of each cycle to determine if an automated measurement should be performed on each cycle, where automated measurements are performed on medical image frames corresponding to suitable cycles and automated measurements are not performed on medical image frames corresponding to unsuitable cycles.

The invention discloses a hypertrophic cardiomyopathy (HCM) preoperative planning and operation effect evaluation method based on accurate digital labeling. The method comprises the following steps: performing digital labeling on the thickness of each wall of a left ventricle of a preoperative heart 3D digital model; according to the digital labeling result of the preoperative heart 3D digital model and the normal value of the thickness of the left ventricular wall, a doctor manually depicts the predicted resection range and confirms the predicted retention thickness; measuring the predicted resection volume, the predicted resection area and the left ventricular end diastolic volume after the predicted resection volume is resected; digitally marking the thickness of each wall of the left ventricle of the postoperative heart 3D digital model, and measuring the volume of the corresponding left ventricle in the end diastole; and taking the predicted resection range, the predicted retention thickness, the predicted resection volume, the predicted resection area and the predicted volume as first evaluation data, taking corresponding parameters of the postoperative heart 3D digital model as second evaluation data, and generating an operation evaluation result according to the conformity of the first evaluation data and the second evaluation data.

To provide suitable devices, systems, and methods for percutaneous pneumatic cardiac support. [Solution] The cardiac support system includes a pneumatic effector implanted beneath the pericardium and across the myocardial surface covering the patient's left ventricle. A port receives an implanted, percutaneously introduced cannula. The port is connected to supply the drive gas received from the cannula to the pneumatic effector. An external drive unit includes a pump assembly and a control circuit that operates the pump to activate the pneumatic effector in response to the patient's sensed cardiac rhythm. A connecting tube has a pump end connected to the pump and a percutaneous port connection end attached to the implantable port.

A deep learning model for the detection of obstructive coronary artery disease (CAD) can take a set of polar maps and patient information as input, then output obstructive CAD scoring data, such as probabilities of obstructive CAD associated with various cardiac territories, as well as an attention map and a CAD scoring map. The model can operate agnostic of camera type used to capture the set of polar maps. The attention map indicates regions of the polar maps important to the deep learning process for that particular set of polar maps. The attention map and obstructive CAD scoring data can be used to generate a CAD scoring map showing CAD probability by segment on a standard 17-segment model of a left ventricle. The attention map and / or CAD scoring map can act as easily explainable tools for interpreting the results of a myocardial perfusion imaging study.

The invention discloses a method for measuring the pressure in the heart cavity of a mouse, and relates to the technical field of experimental animal medical detection, and the method comprises the following steps: cutting an incision of about 1cm in the neck of the mouse; placing two sutures below the common carotid artery, and ligating the common carotid artery by using the suture at the distal end; the other section of suture line is placed in the middle of the right common carotid artery, the carotid artery is lifted up, the blood filling condition is observed, an opening is formed in the blood vessel, a pressure volume catheter is inserted, and meanwhile the suture line at the telecentric end is slightly pulled backwards to prevent bleeding; the pressure volume catheter is inserted into the left ventricle through the right common carotid artery, and the left ventricle pressure maximum rising rate and the left ventricle pressure maximum falling rate are collected. By means of the carotid artery approach, serious trauma caused by thoracotomy can be prevented, and the cardiac physiology can be possibly affected by the operation. Therefore, the carotid artery approach is more suitable for a long-time pressure collection experiment.

Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. Based on the received signals, the progress of contraction of the heart is determined. Based on the progress of contraction, the chamber of the heart may then be stimulated at a plurality of locations. In another embodiment, a plurality of electrodes are implanted in the left ventricle to stimulate at multiple locations in the left ventricle for the purpose of improving hemodynamic performance and increasing cardiac output in a patient who is suffering from congestive heart failure.

A method of cardiac treatment to provides a synergetic therapeutic effect of lowering the hyperactive sympathetic response observed in microvascular disease (MVD) and heart failure (HF) pathologies and promoting cardiac remodeling of left ventricular hypertrophy in a patient. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, delivering cardiac pacing to induce remodeling of hypertrophy of the left ventricle of the patient's heart, and stimulating a vagus nerve of the patient to induce an anti-inflammatory reflex in the patient's heart. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, and stimulating carotid baroreceptors of the patient to downregulates sympathetic tone and upregulates parasympathetic tone.

The utility model relates to the technical field of medical instruments, in particular to a left ventricle volume reduction device which comprises a base, an isolation disc and a connecting component, the isolation disc comprises a plurality of memory supporting pieces and memory weaving wires, and the memory supporting pieces are sequentially arranged with the connecting component as the center and connected with the connecting component; a radial basic framework is formed; the basic framework and the base are sequentially arranged in a spaced mode from top to bottom in the first preset direction. The memory weaving wires are woven on the basic framework to form a tray top face and tray side faces, the free ends of the memory weaving wires on the tray side faces are connected with the base, and the free ends of the memory weaving wires on the tray top face are connected with the connecting components. It can be seen that the outer disc face formed by the memory woven wires is good in flexibility and not prone to damaging the inner wall of the ventricle, the memory supporting piece is high in strength and hardness and better in supporting effect, the basic skeleton has the memory characteristic and can be automatically opened, a balloon does not need to be used for expansion, and operation steps are simplified.

An ultrasound imaging and backscatter system includes an ICE ultrasound catheter having an ultrasound pMUT transducer array disposed within a distal end of the ultrasound catheter and including a plurality of transducer array elements disposed on a substrate. One end of the catheter shaft is connected to the handle assembly and the other end is connected to the ultrasonic transducer array. The catheter shaft accommodates an electronic flexible cable in communication with the signal trace and directs each of the plurality of transducer array elements to transmit and receive an ultrasound beam, receives at least one signal from the plurality of transducer array elements, and constructs at least one image characterizing one or more tissue components of the scanned object. An ultrasound imaging system is used to measure tissue thickness, tissue scar, and lesion assessment for left atrium, right atrium, left ventricle, and right ventricle tissue wall characteristics and other intracardiac tissue anomalies.

The invention provides application of a sodium-glucose co-transporter 2 inhibitor in preparation of a medicine for preventing or treating senescence. In an aging animal model, it is found that the sodium-glucose co-transporter 2 inhibitor empagliflozin can improve heart aging, enhance heart functions caused by aging and increase the ejection fraction of left ventricle; meanwhile, the memory function caused by senescence can be improved, and the expression levels of senescence factors p16, p21 and p53 are improved. The sodium-glucose co-transporter 2 inhibitor empagliflozin has a prospect of being developed as an anti-aging drug.

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and / or improved means for positioning the replacement heart valve. A heart valve prosthesis is provided with a stent and at least one locator. The locator has an adapted design for positioning within a cusp of the native aortic valve for implantation at the native heart valve site. Placement of the locators within the cusps preferably prevents movement from the native heart valve site post-implantation, including proximal movement of the prosthesis into the left ventricle.

The utility model provides a transmission shaft of a left ventricle auxiliary device. The transmission shaft comprises a mandrel and a twisting shell arranged outside the mandrel in a sleeving mode. The near end of the mandrel is in transmission connection with a mandrel driving module of the driving control mechanism, and the far end of the mandrel is fixedly connected with the far end of a pump head impeller of the micro pump head. The near end of the twisting shell is in transmission connection with a twisting shell driving module of the driving control mechanism, the far end of the twisting shell is fixedly connected with the near end of a pump head impeller of the micro pump head, and the mandrel driving module drives the mandrel and the twisting shell to rotate synchronously so as to drive the far end and the near end of the pump head impeller to rotate together, so that the pump head impeller rotates at a fixed outer diameter; and driving the twisting shell to rotate relative to the mandrel through a twisting shell driving module so as to drive the near end of the pump head impeller to rotate relative to the far end, so that the pump head impeller is folded or unfolded. The transmission shaft provided by the utility model can reduce the overall volume of the micro pump head entering the body of a patient, so as to improve the use safety and convenience, and reduce the use cost of the whole auxiliary device at the same time.

A method of pacing a heart includes implanting a subcutaneously implantable device on a xiphoid process and / or a sternum of a patient. The subcutaneously implantable device includes a housing, a prong extending away from the housing, and a first electrode at a distal end of the prong. The method further includes contacting a Manicka Zone of Pacing on an anterior surface of the heart with the first electrode on the distal end of the prong. The Manicka Zone of Pacing is defined as an area of the heart extending 3 centimeters (1.1811 inches) laterally outward from either side of a left anterior descending artery of the heart. A pacing signal is delivered to the Manicka Zone of Pacing of the heart through the first electrode. A right ventricle and a left ventricle of the heart are synchronously paced with the pacing signal received in the Manicka Zone of Pacing.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

Systems, devices and methods are provided for supporting cardiac function. A device comprises a catheter having a shaft with a distal end portion configured for advancing through an aortic valve to a left ventricle of a patient and an impeller coupled to the distal end portion of the catheter. One or more inlets are positioned distal of the impeller and coupled to an internal lumen within the catheter to draw blood from the left ventricle through the inlets and into the internal lumen. One or more outlets positioned proximal of the impeller and coupled to the internal lumen to pump the blood through the outlets and into the aorta. The device further includes an extracorporeal motor coupled to a proximal end portion of the catheter and a drive member extending through the catheter shaft and coupling the impeller with the motor to rotate the impeller. The motor may comprise a non-contact motor that generates a magnetic field to rotate the drive member.

A method of estimating a patient's cardiac preload in a patient having an implantable blood pump. The method includes generating a current waveform from operation of the implanted blood pump. A beat-to-beat pump filling index (PFI) is calculated, the PFI is calculated by dividing a current amplitude component by a time component, the amplitude component being calculated by subtracting a trough of the current waveform from an inflection point divided by an amplitude difference of peak to trough of the waveform, the time component being calculated by dividing a time between the trough and the inflection point by a time between the peak and the trough. An alert is generated if the PFI deviates from predetermined thresholds.

The invention discloses an operation method suitable for electrophysiological detection in cardiac cavities of rats / mice, and relates to the technical field of experimental animal medical detection, and the operation method comprises the following steps: anesthesia of rats / mice, supine position fixation, and neck skin preparation and hair removal; separating the neck artery of the rat / mouse, ligating the artery blood vessel at the telecentric end, and clamping the artery blood vessel at the proximal end by using an artery clamp; the artery blood vessel in the middle section is temporarily retained after being punctured by an L-shaped guide needle, and the electrophysiology catheter is inserted along the notch; slowly moving the electrode catheter into the left ventricle, fixing the electrode catheter, and performing electrophysiological detection. According to the method, the detection electrode is inserted from the neck artery, the detection electrode is sent into the heart cavity of the rat / mouse, the integrity of the heart organ is not damaged, the risk of cardiac bleeding is avoided, accurate electrocardio data can be detected for a long time, meanwhile, after one carotid artery is cut off, the rat / mouse can maintain basic physiological activities through the other carotid artery, and therefore the detection effect is good. Continuous electrocardio detection can be carried out so as to complete the whole set of electrocardio recording.

A system for lacerating heart valve leaflets (20) includes a coronary guidewire (110) and a laceration device including an ablative cutting element (122). A system may include a first guidewire for insertion into a left ventricle and a guide catheter configured to translate along the first guidewire. The guide catheter may include a steering element configured to direct the coronary guidewire toward the coronary artery. The laceration device cooperates with the coronary guidewire to align the ablative cutting element with a nadir of a heart valve leaflet. A method of lacerating heart valve leaflets includes advancing the coronary guidewire into a coronary artery, translating the laceration device along the coronary guidewire to a position adjacent a heart valve leaflet, positioning the ablative cutting element in contact with a nadir of the heart valve leaflet, and lacerating the heart valve leaflet from the nadir to a free edge of the heart valve leaflet.

A method of estimating a patient's cardiac preload in a patient having an implantable blood pump. The method includes generating a current waveform from operation of the implanted blood pump. A beat-to-beat pump filling index (PFI) is calculated, the PFI is calculated by dividing a current amplitude component by a time component, the amplitude component being calculated by subtracting a trough of the current waveform from an inflection point divided by an amplitude difference of peak to trough of the waveform, the time component being calculated by dividing a time between the trough and the inflection point by a time between the peak and the trough. An alert is generated if the PFI deviates from predetermined thresholds.

The utility model belongs to the technical field of artificial heart-left ventricle auxiliary circulation equipment, and particularly discloses an LVAD motor stator system, which comprises an outer stator, an inner stator and a winding arranged between the outer stator and the inner stator, the inner stator is formed by stacking a plurality of silicon steel ring sheets, an axial modulation groove is arranged along the circumferential direction of the inner side of the inner stator, and the inner side of the inner stator is connected with the winding. According to the utility model, the modulation grooves are arranged in the inner stator, so that the harmonic amplitude is reduced, and the fluctuation of the torque is reduced. The utility model also discloses a motor which is filled with epoxy resin, so that the relative positions of related parts are ensured, the coaxiality and dynamic balance of the related parts are ensured, the motor is stable in high-speed operation, the vibration can be reduced, the motor has relatively good biological safety, relatively high heat conductivity coefficient and chemical stability, and the heat is quickly dissipated when the motor is in high-speed operation. The device is suitable for being placed in a human body.

Apparatus and methods are provided for use with a left-ventricular assist device (20) including a pump-outlet tube (24) configured for insertion, through an aorta of a subject, into a left ventricle of a heart of the subject such that a proximal section of the pump-outlet tube is disposed within the aorta and a distal section of the pump-outlet tube is disposed within the left ventricle. A pressure sensor (206) outputs a signal indicative of an aortic pressure within the aorta over an interval. A processor (25) compares an indication of the minimum of the aortic pressure to an indication of the peak-to-peak amplitude of the estimated pressure gradient between the aorta and the left ventricle over an interval, and, in response thereto, outputs an indication that the pump-outlet tube (24) is positionally biased toward the aorta. Other applications are also described.

The application discloses a kind of near-field coherent heart radio frequency sensing method and system based on code division multiple access, comprising: 4-way frequency f synchronous baseband signal is configured, 4-way synchronous chip is configured, synchronous baseband signal is multiplied with corresponding synchronous chip to modulate, and 4-way digital baseband signal is obtained;4-way digital baseband signal is handled to obtain 4-way heart measurement signal;4-way heart measurement signal is respectively transmitted to corresponding antenna by radio frequency transceiver and is emitted;The antenna is respectively arranged in left ventricle, left atrium, right ventricle, right atrium;Antenna receives reflected signal, and is recorded as heart sensing signal;Heart sensing signal is transmitted to radio frequency transceiver, and after processing, the baseband signal containing heart chamber beat information is obtained;The baseband signal containing heart chamber beat information is multiplied with corresponding synchronous chip to demodulate, band-pass filter, and the demodulation signal corresponding to heart chamber beat information is obtained respectively.

The invention relates to a blood flow flexible membrane and an interventional foldable left ventricle auxiliary device, the far end of the flexible membrane covers a foldable stent to form a blood flow channel, the near end area of the flexible membrane is provided with a bleeding part, the bleeding part comprises at least two spiral openings formed by cutting a flexible membrane body, and the spiral openings are communicated with the blood flow channel. A connecting band is formed between every two adjacent spiral openings, and the width of each connecting band gradually changes in the axial direction of the flexible film. Due to the arrangement of the spiral opening, blood flow can be efficiently and smoothly guided, blood rotation kinetic energy is efficiently converted into axial flow pressure energy, the flow velocity gradient, shear stress and vortex intensity of an outlet area are remarkably reduced, and the hemolysis index of the outlet area is reduced by more than 36%. The connecting belt with the gradually-changed width provides the strongest support at the outlet of the near end, most needing to be reinforced, of the covering film, unexpected swing and local displacement of the covering film in the working process are greatly restrained, and the maximum total deformation is averagely reduced by about 95%.

The embodiment of the invention relates to the technical field of instruments for removing obstruction in blood vessels, in particular to a coronary thrombolysis catheter and a coronary thrombolysis assembly suitable for an ultrasonic guided intervention technology. The catheter includes a catheter assembly disposed to enter the aorta and extend into the left ventricle. The medicine conveying pipe is arranged in the catheter assembly and is arranged to be capable of conveying thrombolytic medicine into the thrombus of the coronary artery through the catheter assembly. The balloon is arranged outside the catheter assembly and can expand after being filled with water, so that the space between the catheter assembly and the aorta is sealed, the thrombolytic medicine cannot flow out of the coronary artery, and thrombus is dissolved. The catheter assembly is configured to allow blood within the left ventricle to flow out through the catheter assembly. According to the catheter, the thrombolytic drug can stay in the coronary artery for a long time, so that the thrombolytic effect and targeting performance are improved, the thrombolytic drug conveyed to the coronary artery is prevented from leaking to the whole body through the aorta, the influence of the thrombolytic drug on the whole body blood coagulation mechanism is reduced, the risk of cerebral hemorrhage and bleeding of other visceral organs is reduced, and the safety of thrombolytic treatment is improved.

A veno-arterial extracorporeal membrane oxygenation system includes a dual lumen drainage cannula configured for withdrawing blood from a patient's vasculature in a manner that provides a perfusion of oxygenated blood with reduced carbon dioxide content while unloading the left ventricle, with two points of access to the patient's vasculature. The dual lumen drainage cannula has a first drainage tube and a second drainage tube co-axially aligned with the first drain-age tube. The first and second drainage tubes are fluidly coupled to a connector. A blood pump having a pump inlet is configured for fluidly connecting with the connector, while an oxygenator having an oxygenator inlet is configured for fluidly connecting with a pump outlet. An infusion cannula is configured for fluidly connecting with an oxygenator outlet for infusing oxygenated blood into a patient's bloodstream.

The subject of the invention is a device (1) for measuring and recording the squeezing force of the heart ventricle exerted by the inner surface of the heart ventricle wall, which device (1) comprises a stabilizing system (2) with at least one measuring arm (3) extending therefrom, on which a sensor (9) is placed. The device (1) has a spatial design adapted to the interior of the left ventricle, allowing for multi-point contact with the endocardial surface. The subject of the invention is also a computer-implemented method of measuring and recording the squeezing force measured using a device (1) for measuring and recording the squeezing force of the heart ventricle.

The application discloses a kind of heart dynamic simulation in-vitro experimental device, it is related to the field of computer tomography (CT), including: heart simulation device contains heart model and blood vessel model, the inner surface of the top end of left ventricle of heart model, bottom end inner surface is attached to a pair of first parallel ring;The inner surface of the top end of right ventricle, bottom end inner surface is attached to another pair of second parallel ring;Control device includes single-chip microcomputer, it has for inputting the input module of human heart real movement form electrocardiogram and for the output module of periodic control signal;Motor, it is connected with the output module of single-chip microcomputer for receiving control signal;Piston is connected with motor and does reciprocating motion, drive heart simulation device to occur contraction movement when inhale or occur diastolic movement when inflate;Many thin lines, make a pair of first parallel ring and another pair of second parallel ring rotate around vertical central axis.The application can accurately simulate human heart real movement form and then effectively carry out image calibration.

The application provides a ventricular assist pump blood instrument and system, and relates to the technical field of medical instruments.The ventricular assist pump blood instrument comprises an in-vivo component, the in-vivo component comprises a support cover and an impeller mechanism; the in-vivo component has a folded state and an unfolded state, when being arranged at a position where the aorta is connected with the left ventricle or in the left ventricle, the in-vivo component is arranged in the unfolded state, a blood flow channel is formed by the covering film and the support cover, the impeller mechanism is rotated to increase the pressure of the blood in the blood flow channel, and then the in-vivo component can be used as a blood pump to promote the blood flow in the left ventricle to the aorta; meanwhile, the in-vivo component has a folded state, in the folded state, the impeller mechanism and the support cover are folded, the volume is small, the in-vivo component can be implanted into the position where the aorta is connected with the left ventricle or the left ventricle through a catheter, and a thoracotomy operation is not needed, so that the operation time is short, the trauma is small, and the patient recovers quickly.