The invention relates to a laser cleaning machine for a cylindrical nickel screen, and belongs to the technical field of laser cleaning devices. The laser cleaning machine comprises a machine body front portion, a machine body rear portion, a cylindrical nickel screen rotating mechanism, a tail bracket mechanism, a laser emission mechanism, a motor driving mechanism, a cleaning mechanism and a transmission mechanism. By using three groups of reflectors, through the reflective cooperation of the reflectors, the directions of the beams emitted by laser tubes are changed. In the cleaning process,the cylindrical nickel screen is rotated simply by moving the cleaning mechanism, and the space occupation of the device is reduced by fixing the laser tubes and changing the arrangement way of the laser tubes. An original arrangement way that the laser tubes are perpendicular to the nickel screen is replaced. The transverse distance between the beam focuses when lasers reach the cylindrical nickel screen is shortened, that is, when the cylindrical nickel screen is cleaned, the cleaning mechanism can move a shorter distance, and by means of the structure, the cleaning efficiency can be effectively improved. By using the cleaning structure which can move independently without moving the laser tubes or a power supply thereof, the load of a motor is greatly reduced, therefore, the motor which has lower technical parameters can be selected, and the cost is saved.